Incidental Mutation 'R6230:Vmn1r75'
ID 504616
Institutional Source Beutler Lab
Gene Symbol Vmn1r75
Ensembl Gene ENSMUSG00000043308
Gene Name vomeronasal 1 receptor 75
Synonyms V1rg6
MMRRC Submission 044359-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R6230 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 11614270-11615187 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 11614966 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 233 (A233T)
Ref Sequence ENSEMBL: ENSMUSP00000154577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]
AlphaFold Q8R289
Predicted Effect probably damaging
Transcript: ENSMUST00000057229
AA Change: A233T

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: A233T

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.9e-10 PFAM
Pfam:V1R 35 293 1e-29 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226622
AA Change: A233T

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000226855
AA Change: A233T

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227611
AA Change: A191T

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000228268
AA Change: A191T

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000228463
AA Change: A233T

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000228646
AA Change: A191T

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.1%
Validation Efficiency 100% (49/49)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp T C 2: 168,024,452 (GRCm39) T948A probably benign Het
Arhgef12 T C 9: 42,900,261 (GRCm39) I871V probably benign Het
Atf1 T C 15: 100,130,705 (GRCm39) V25A possibly damaging Het
Atp23 G A 10: 126,723,431 (GRCm39) H224Y probably benign Het
Ccpg1 A G 9: 72,919,638 (GRCm39) T418A probably benign Het
Col27a1 T C 4: 63,142,519 (GRCm39) I69T probably damaging Het
Cspp1 T C 1: 10,147,422 (GRCm39) S328P probably benign Het
Cttnbp2nl C T 3: 104,918,655 (GRCm39) E62K probably damaging Het
Cyp2c39 T C 19: 39,525,246 (GRCm39) F183S probably damaging Het
Dync2li1 T C 17: 84,955,078 (GRCm39) S246P probably damaging Het
Ext2 A G 2: 93,592,965 (GRCm39) I413T probably damaging Het
Fam174a T C 1: 95,241,951 (GRCm39) V137A probably damaging Het
Flg T A 3: 93,186,782 (GRCm39) V78E probably damaging Het
Fn3krp C A 11: 121,316,418 (GRCm39) H111N probably damaging Het
Focad T C 4: 88,260,441 (GRCm39) I899T unknown Het
Foxq1 T C 13: 31,743,491 (GRCm39) Y198H probably damaging Het
Gm21060 A T 19: 61,285,449 (GRCm39) M20K probably benign Het
Kif16b A T 2: 142,691,832 (GRCm39) N217K probably damaging Het
Klkb1 A G 8: 45,736,252 (GRCm39) Y162H probably benign Het
Kntc1 T A 5: 123,927,072 (GRCm39) probably null Het
Madd C T 2: 90,973,866 (GRCm39) probably null Het
Mast2 T A 4: 116,183,295 (GRCm39) H258L probably damaging Het
Musk T C 4: 58,367,576 (GRCm39) V598A probably damaging Het
Nexn T A 3: 151,943,912 (GRCm39) Q539L probably damaging Het
Nf2 T C 11: 4,758,262 (GRCm39) K130E possibly damaging Het
Nlrp14 A T 7: 106,781,024 (GRCm39) I74F probably benign Het
Omg T C 11: 79,393,784 (GRCm39) I25V probably benign Het
Or56b35 A G 7: 104,963,289 (GRCm39) H26R possibly damaging Het
Or8b54 T G 9: 38,687,073 (GRCm39) I174S possibly damaging Het
Parp4 A G 14: 56,844,990 (GRCm39) D627G probably damaging Het
Pdia6 A G 12: 17,327,214 (GRCm39) E126G probably benign Het
Ppp1r2 T A 16: 31,079,418 (GRCm39) D127V possibly damaging Het
Pramel17 T A 4: 101,694,411 (GRCm39) E157D probably damaging Het
Rgs22 A G 15: 36,100,176 (GRCm39) S304P probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rptn C G 3: 93,305,437 (GRCm39) H923Q possibly damaging Het
Ryr2 T C 13: 11,674,993 (GRCm39) Y3378C probably damaging Het
Shoc1 T C 4: 59,099,345 (GRCm39) N116D probably benign Het
Slitrk5 GACTAC GACTACTAC 14: 111,917,248 (GRCm39) probably benign Het
Smurf2 T C 11: 106,759,330 (GRCm39) probably null Het
Tanc1 T C 2: 59,672,375 (GRCm39) F1348L probably damaging Het
Tars3 A T 7: 65,336,184 (GRCm39) probably null Het
Tmem213 A T 6: 38,091,551 (GRCm39) S52C probably damaging Het
Ttn T C 2: 76,749,778 (GRCm39) D3757G probably benign Het
Usp16 C T 16: 87,261,686 (GRCm39) P101S possibly damaging Het
Usp19 G A 9: 108,379,140 (GRCm39) M1318I probably damaging Het
Vsir A T 10: 60,193,857 (GRCm39) N107Y probably damaging Het
Zfp160 T C 17: 21,246,707 (GRCm39) V419A probably benign Het
Zfp808 A T 13: 62,320,136 (GRCm39) H455L probably benign Het
Other mutations in Vmn1r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01901:Vmn1r75 APN 7 11,614,739 (GRCm39) missense probably damaging 1.00
IGL02175:Vmn1r75 APN 7 11,614,774 (GRCm39) missense probably damaging 1.00
IGL02399:Vmn1r75 APN 7 11,615,093 (GRCm39) missense possibly damaging 0.82
IGL02648:Vmn1r75 APN 7 11,615,091 (GRCm39) missense probably benign 0.04
IGL03372:Vmn1r75 APN 7 11,614,496 (GRCm39) missense probably benign 0.29
R0538:Vmn1r75 UTSW 7 11,614,797 (GRCm39) missense probably damaging 0.97
R0599:Vmn1r75 UTSW 7 11,615,189 (GRCm39) splice site probably null
R3910:Vmn1r75 UTSW 7 11,614,757 (GRCm39) missense possibly damaging 0.92
R4491:Vmn1r75 UTSW 7 11,614,909 (GRCm39) missense probably damaging 0.97
R5566:Vmn1r75 UTSW 7 11,614,407 (GRCm39) missense probably damaging 1.00
R6051:Vmn1r75 UTSW 7 11,614,978 (GRCm39) missense probably damaging 1.00
R6490:Vmn1r75 UTSW 7 11,615,003 (GRCm39) missense probably damaging 1.00
R6570:Vmn1r75 UTSW 7 11,614,883 (GRCm39) missense probably damaging 0.98
R7184:Vmn1r75 UTSW 7 11,614,915 (GRCm39) nonsense probably null
R7189:Vmn1r75 UTSW 7 11,614,475 (GRCm39) missense possibly damaging 0.93
R7501:Vmn1r75 UTSW 7 11,614,997 (GRCm39) missense possibly damaging 0.67
R7973:Vmn1r75 UTSW 7 11,614,961 (GRCm39) missense probably benign 0.04
R7997:Vmn1r75 UTSW 7 11,614,600 (GRCm39) missense probably damaging 1.00
R8372:Vmn1r75 UTSW 7 11,614,657 (GRCm39) missense probably benign 0.10
R8812:Vmn1r75 UTSW 7 11,614,630 (GRCm39) missense possibly damaging 0.54
R8932:Vmn1r75 UTSW 7 11,614,838 (GRCm39) missense probably damaging 1.00
R9089:Vmn1r75 UTSW 7 11,614,453 (GRCm39) missense probably damaging 1.00
R9129:Vmn1r75 UTSW 7 11,614,513 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- TCAGGCAATGTGGCAACTG -3'
(R):5'- GGAGGAAGTTACCGCTTACC -3'

Sequencing Primer
(F):5'- GCAATGTGGCAACTGCACTATATATG -3'
(R):5'- CTTACCAAAGCAGGGTAAAAATGGGC -3'
Posted On 2018-02-28