Incidental Mutation 'R6230:Or8b54'
| ID |
504621 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or8b54
|
| Ensembl Gene |
ENSMUSG00000049926 |
| Gene Name |
olfactory receptor family 8 subfamily B member 54 |
| Synonyms |
MOR165-8, GA_x6K02T2PVTD-32478047-32478988, Olfr921 |
| MMRRC Submission |
044359-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R6230 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
38684384-38687650 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 38687073 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Serine
at position 174
(I174S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150844
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071681]
[ENSMUST00000213958]
[ENSMUST00000217114]
|
| AlphaFold |
Q7TRC0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000071681
AA Change: I174S
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000071604
Gene: ENSMUSG00000049926
AA Change: I174S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
308 |
9.8e-51 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
1.3e-21 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000213958
AA Change: I174S
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000217114
AA Change: I174S
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.1%
|
| Validation Efficiency |
100% (49/49) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adnp |
T |
C |
2: 168,024,452 (GRCm39) |
T948A |
probably benign |
Het |
| Arhgef12 |
T |
C |
9: 42,900,261 (GRCm39) |
I871V |
probably benign |
Het |
| Atf1 |
T |
C |
15: 100,130,705 (GRCm39) |
V25A |
possibly damaging |
Het |
| Atp23 |
G |
A |
10: 126,723,431 (GRCm39) |
H224Y |
probably benign |
Het |
| Ccpg1 |
A |
G |
9: 72,919,638 (GRCm39) |
T418A |
probably benign |
Het |
| Col27a1 |
T |
C |
4: 63,142,519 (GRCm39) |
I69T |
probably damaging |
Het |
| Cspp1 |
T |
C |
1: 10,147,422 (GRCm39) |
S328P |
probably benign |
Het |
| Cttnbp2nl |
C |
T |
3: 104,918,655 (GRCm39) |
E62K |
probably damaging |
Het |
| Cyp2c39 |
T |
C |
19: 39,525,246 (GRCm39) |
F183S |
probably damaging |
Het |
| Dync2li1 |
T |
C |
17: 84,955,078 (GRCm39) |
S246P |
probably damaging |
Het |
| Ext2 |
A |
G |
2: 93,592,965 (GRCm39) |
I413T |
probably damaging |
Het |
| Fam174a |
T |
C |
1: 95,241,951 (GRCm39) |
V137A |
probably damaging |
Het |
| Flg |
T |
A |
3: 93,186,782 (GRCm39) |
V78E |
probably damaging |
Het |
| Fn3krp |
C |
A |
11: 121,316,418 (GRCm39) |
H111N |
probably damaging |
Het |
| Focad |
T |
C |
4: 88,260,441 (GRCm39) |
I899T |
unknown |
Het |
| Foxq1 |
T |
C |
13: 31,743,491 (GRCm39) |
Y198H |
probably damaging |
Het |
| Gm21060 |
A |
T |
19: 61,285,449 (GRCm39) |
M20K |
probably benign |
Het |
| Kif16b |
A |
T |
2: 142,691,832 (GRCm39) |
N217K |
probably damaging |
Het |
| Klkb1 |
A |
G |
8: 45,736,252 (GRCm39) |
Y162H |
probably benign |
Het |
| Kntc1 |
T |
A |
5: 123,927,072 (GRCm39) |
|
probably null |
Het |
| Madd |
C |
T |
2: 90,973,866 (GRCm39) |
|
probably null |
Het |
| Mast2 |
T |
A |
4: 116,183,295 (GRCm39) |
H258L |
probably damaging |
Het |
| Musk |
T |
C |
4: 58,367,576 (GRCm39) |
V598A |
probably damaging |
Het |
| Nexn |
T |
A |
3: 151,943,912 (GRCm39) |
Q539L |
probably damaging |
Het |
| Nf2 |
T |
C |
11: 4,758,262 (GRCm39) |
K130E |
possibly damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,781,024 (GRCm39) |
I74F |
probably benign |
Het |
| Omg |
T |
C |
11: 79,393,784 (GRCm39) |
I25V |
probably benign |
Het |
| Or56b35 |
A |
G |
7: 104,963,289 (GRCm39) |
H26R |
possibly damaging |
Het |
| Parp4 |
A |
G |
14: 56,844,990 (GRCm39) |
D627G |
probably damaging |
Het |
| Pdia6 |
A |
G |
12: 17,327,214 (GRCm39) |
E126G |
probably benign |
Het |
| Ppp1r2 |
T |
A |
16: 31,079,418 (GRCm39) |
D127V |
possibly damaging |
Het |
| Pramel17 |
T |
A |
4: 101,694,411 (GRCm39) |
E157D |
probably damaging |
Het |
| Rgs22 |
A |
G |
15: 36,100,176 (GRCm39) |
S304P |
probably benign |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Rptn |
C |
G |
3: 93,305,437 (GRCm39) |
H923Q |
possibly damaging |
Het |
| Ryr2 |
T |
C |
13: 11,674,993 (GRCm39) |
Y3378C |
probably damaging |
Het |
| Shoc1 |
T |
C |
4: 59,099,345 (GRCm39) |
N116D |
probably benign |
Het |
| Slitrk5 |
GACTAC |
GACTACTAC |
14: 111,917,248 (GRCm39) |
|
probably benign |
Het |
| Smurf2 |
T |
C |
11: 106,759,330 (GRCm39) |
|
probably null |
Het |
| Tanc1 |
T |
C |
2: 59,672,375 (GRCm39) |
F1348L |
probably damaging |
Het |
| Tars3 |
A |
T |
7: 65,336,184 (GRCm39) |
|
probably null |
Het |
| Tmem213 |
A |
T |
6: 38,091,551 (GRCm39) |
S52C |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,749,778 (GRCm39) |
D3757G |
probably benign |
Het |
| Usp16 |
C |
T |
16: 87,261,686 (GRCm39) |
P101S |
possibly damaging |
Het |
| Usp19 |
G |
A |
9: 108,379,140 (GRCm39) |
M1318I |
probably damaging |
Het |
| Vmn1r75 |
G |
A |
7: 11,614,966 (GRCm39) |
A233T |
probably damaging |
Het |
| Vsir |
A |
T |
10: 60,193,857 (GRCm39) |
N107Y |
probably damaging |
Het |
| Zfp160 |
T |
C |
17: 21,246,707 (GRCm39) |
V419A |
probably benign |
Het |
| Zfp808 |
A |
T |
13: 62,320,136 (GRCm39) |
H455L |
probably benign |
Het |
|
| Other mutations in Or8b54 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00948:Or8b54
|
APN |
9 |
38,687,108 (GRCm39) |
nonsense |
probably null |
|
|
IGL01016:Or8b54
|
APN |
9 |
38,686,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01391:Or8b54
|
APN |
9 |
38,686,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01451:Or8b54
|
APN |
9 |
38,687,225 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02250:Or8b54
|
APN |
9 |
38,686,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0026:Or8b54
|
UTSW |
9 |
38,686,892 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0334:Or8b54
|
UTSW |
9 |
38,686,535 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0655:Or8b54
|
UTSW |
9 |
38,686,850 (GRCm39) |
nonsense |
probably null |
|
|
R1024:Or8b54
|
UTSW |
9 |
38,686,631 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3522:Or8b54
|
UTSW |
9 |
38,687,016 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3967:Or8b54
|
UTSW |
9 |
38,686,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3968:Or8b54
|
UTSW |
9 |
38,686,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3969:Or8b54
|
UTSW |
9 |
38,686,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4761:Or8b54
|
UTSW |
9 |
38,687,133 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4796:Or8b54
|
UTSW |
9 |
38,686,670 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4880:Or8b54
|
UTSW |
9 |
38,686,843 (GRCm39) |
nonsense |
probably null |
|
|
R5237:Or8b54
|
UTSW |
9 |
38,687,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5756:Or8b54
|
UTSW |
9 |
38,686,554 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R6487:Or8b54
|
UTSW |
9 |
38,686,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Or8b54
|
UTSW |
9 |
38,686,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7573:Or8b54
|
UTSW |
9 |
38,686,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7755:Or8b54
|
UTSW |
9 |
38,687,073 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8195:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8196:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8197:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8199:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8211:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8212:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8236:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8239:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8279:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8282:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8283:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R9207:Or8b54
|
UTSW |
9 |
38,686,960 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
| Predicted Primers |
|
| Posted On |
2018-02-28 |
Incidental Mutation