Incidental Mutation 'R6520:Itgal'
| ID |
521129 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Itgal
|
| Ensembl Gene |
ENSMUSG00000030830 |
| Gene Name |
integrin alpha L |
| Synonyms |
Ly-21, Ly-15, Cd11a, LFA-1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.143)
|
| Stock # |
R6520 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
126895432-126934310 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 126929503 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 1140
(Q1140L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113396
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106306]
[ENSMUST00000117762]
[ENSMUST00000118405]
[ENSMUST00000120857]
[ENSMUST00000170971]
|
| AlphaFold |
P24063 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106306
|
| SMART Domains |
Protein: ENSMUSP00000101913
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1043 |
1059 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1087 |
1109 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1110 |
1124 |
5.8e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117762
|
| SMART Domains |
Protein: ENSMUSP00000113946
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1109 |
1123 |
5.8e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118405
|
| SMART Domains |
Protein: ENSMUSP00000112591
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
Int_alpha
|
2 |
54 |
4.21e-3 |
SMART |
|
Int_alpha
|
58 |
113 |
9.6e-7 |
SMART |
|
Int_alpha
|
119 |
172 |
3.58e-15 |
SMART |
|
Int_alpha
|
179 |
228 |
1.28e1 |
SMART |
|
low complexity region
|
646 |
662 |
N/A |
INTRINSIC |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
713 |
727 |
2.1e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120857
AA Change: Q1140L
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000113396
Gene: ENSMUSG00000030830
AA Change: Q1140L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170971
|
| SMART Domains |
Protein: ENSMUSP00000131847
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1109 |
1123 |
1.2e-6 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.5%
- 20x: 92.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700093K21Rik |
T |
C |
11: 23,467,285 (GRCm39) |
D116G |
possibly damaging |
Het |
| Adam22 |
C |
T |
5: 8,166,635 (GRCm39) |
V699M |
probably damaging |
Het |
| Adh7 |
A |
G |
3: 137,929,771 (GRCm39) |
Y149C |
probably damaging |
Het |
| Adissp |
G |
T |
2: 130,989,174 (GRCm39) |
H111N |
probably damaging |
Het |
| Angptl3 |
A |
C |
4: 98,926,085 (GRCm39) |
N405T |
probably benign |
Het |
| Ank3 |
A |
G |
10: 69,824,217 (GRCm39) |
H180R |
probably damaging |
Het |
| Apob |
T |
A |
12: 8,033,124 (GRCm39) |
I159N |
probably damaging |
Het |
| Arhgap24 |
T |
C |
5: 103,028,659 (GRCm39) |
V185A |
probably benign |
Het |
| Atf6 |
A |
T |
1: 170,695,238 (GRCm39) |
H11Q |
probably benign |
Het |
| Atxn3 |
C |
A |
12: 101,900,660 (GRCm39) |
D208Y |
probably damaging |
Het |
| Brd9 |
G |
A |
13: 74,090,913 (GRCm39) |
R273K |
probably benign |
Het |
| Cbfa2t3 |
T |
A |
8: 123,362,540 (GRCm39) |
R302W |
probably benign |
Het |
| Ccdc175 |
C |
A |
12: 72,186,804 (GRCm39) |
G347C |
probably damaging |
Het |
| Ccdc87 |
A |
G |
19: 4,891,817 (GRCm39) |
K770E |
probably damaging |
Het |
| Ccl17 |
T |
C |
8: 95,537,178 (GRCm39) |
F27L |
probably benign |
Het |
| Cd3g |
A |
T |
9: 44,882,613 (GRCm39) |
|
probably null |
Het |
| Cep350 |
A |
G |
1: 155,809,082 (GRCm39) |
V498A |
probably benign |
Het |
| Cfap45 |
A |
G |
1: 172,368,151 (GRCm39) |
D381G |
probably damaging |
Het |
| Cfap46 |
A |
G |
7: 139,194,321 (GRCm39) |
|
probably null |
Het |
| Cnrip1 |
T |
A |
11: 17,028,536 (GRCm39) |
M156K |
probably damaging |
Het |
| Col23a1 |
T |
C |
11: 51,440,552 (GRCm39) |
|
probably null |
Het |
| Col4a1 |
C |
T |
8: 11,269,152 (GRCm39) |
G933S |
probably damaging |
Het |
| Col5a3 |
C |
T |
9: 20,685,348 (GRCm39) |
V1443I |
unknown |
Het |
| Col6a6 |
T |
C |
9: 105,663,024 (GRCm39) |
E171G |
possibly damaging |
Het |
| Dennd1a |
A |
T |
2: 37,851,759 (GRCm39) |
|
probably null |
Het |
| Dlk2 |
C |
T |
17: 46,613,438 (GRCm39) |
T188I |
probably damaging |
Het |
| Dusp8 |
A |
G |
7: 141,637,418 (GRCm39) |
I203T |
probably damaging |
Het |
| Eno2 |
C |
T |
6: 124,744,678 (GRCm39) |
R56H |
probably damaging |
Het |
| Erich3 |
A |
T |
3: 154,469,102 (GRCm39) |
T1185S |
probably damaging |
Het |
| Evi5l |
A |
T |
8: 4,255,906 (GRCm39) |
Q575L |
possibly damaging |
Het |
| Fam187a |
T |
A |
11: 102,776,701 (GRCm39) |
H168Q |
possibly damaging |
Het |
| Fat2 |
T |
A |
11: 55,175,814 (GRCm39) |
E1633V |
probably damaging |
Het |
| Fbln2 |
G |
A |
6: 91,236,641 (GRCm39) |
D719N |
probably damaging |
Het |
| Fbn2 |
A |
T |
18: 58,235,462 (GRCm39) |
S672T |
probably damaging |
Het |
| Gas8 |
C |
G |
8: 124,253,213 (GRCm39) |
A187G |
probably benign |
Het |
| Gm2696 |
G |
A |
10: 77,672,332 (GRCm39) |
|
probably benign |
Het |
| Gnl1 |
A |
T |
17: 36,293,845 (GRCm39) |
K272M |
probably benign |
Het |
| Gtf2h3 |
C |
T |
5: 124,722,360 (GRCm39) |
T121I |
probably benign |
Het |
| Hemgn |
T |
G |
4: 46,396,466 (GRCm39) |
K257Q |
probably damaging |
Het |
| Hgsnat |
T |
C |
8: 26,443,328 (GRCm39) |
Y474C |
probably damaging |
Het |
| Hoxc4 |
T |
C |
15: 102,943,380 (GRCm39) |
S78P |
probably benign |
Het |
| Igkv14-100 |
T |
A |
6: 68,496,218 (GRCm39) |
L37Q |
probably damaging |
Het |
| Iqck |
A |
T |
7: 118,540,854 (GRCm39) |
K251M |
probably damaging |
Het |
| Itpka |
A |
G |
2: 119,581,259 (GRCm39) |
R431G |
probably benign |
Het |
| Jade1 |
A |
G |
3: 41,558,917 (GRCm39) |
N333D |
possibly damaging |
Het |
| Jmjd7 |
A |
G |
2: 119,861,800 (GRCm39) |
H181R |
probably damaging |
Het |
| Jmy |
A |
G |
13: 93,590,547 (GRCm39) |
S519P |
probably benign |
Het |
| Klra10 |
T |
A |
6: 130,252,755 (GRCm39) |
H173L |
probably benign |
Het |
| Krt72 |
T |
G |
15: 101,689,481 (GRCm39) |
I284L |
probably benign |
Het |
| Krt78 |
C |
A |
15: 101,860,206 (GRCm39) |
V237F |
probably benign |
Het |
| Mapkapk3 |
G |
A |
9: 107,134,648 (GRCm39) |
T296M |
probably damaging |
Het |
| Mcmbp |
A |
C |
7: 128,314,451 (GRCm39) |
V255G |
possibly damaging |
Het |
| Mcoln1 |
T |
G |
8: 3,555,855 (GRCm39) |
M50R |
probably damaging |
Het |
| Mocos |
T |
A |
18: 24,799,447 (GRCm39) |
V227E |
probably benign |
Het |
| Mpeg1 |
A |
G |
19: 12,439,322 (GRCm39) |
E260G |
probably benign |
Het |
| Mrc1 |
A |
T |
2: 14,312,760 (GRCm39) |
N894I |
probably damaging |
Het |
| Mroh7 |
A |
G |
4: 106,578,460 (GRCm39) |
S73P |
probably benign |
Het |
| Myo3a |
A |
T |
2: 22,404,737 (GRCm39) |
I690L |
possibly damaging |
Het |
| Naa50 |
T |
G |
16: 43,979,872 (GRCm39) |
F87V |
probably damaging |
Het |
| Ndufs6 |
G |
T |
13: 73,476,471 (GRCm39) |
T32K |
probably damaging |
Het |
| Nfe2l2 |
A |
G |
2: 75,506,912 (GRCm39) |
V396A |
probably benign |
Het |
| Nptn |
A |
G |
9: 58,551,017 (GRCm39) |
E348G |
probably damaging |
Het |
| Nsun4 |
A |
T |
4: 115,901,935 (GRCm39) |
L177Q |
probably damaging |
Het |
| Or56b1b |
A |
G |
7: 108,164,046 (GRCm39) |
*319Q |
probably null |
Het |
| Or8d6 |
T |
C |
9: 39,853,658 (GRCm39) |
I34T |
possibly damaging |
Het |
| Or8k36-ps1 |
A |
G |
2: 86,437,462 (GRCm39) |
L151P |
unknown |
Het |
| Plekha7 |
A |
G |
7: 115,763,717 (GRCm39) |
V233A |
probably benign |
Het |
| Polq |
C |
A |
16: 36,880,739 (GRCm39) |
Q968K |
possibly damaging |
Het |
| Prmt7 |
C |
T |
8: 106,961,516 (GRCm39) |
T143M |
probably damaging |
Het |
| Ptprc |
G |
A |
1: 138,007,881 (GRCm39) |
Q886* |
probably null |
Het |
| Rbp7 |
C |
A |
4: 149,537,371 (GRCm39) |
V36L |
possibly damaging |
Het |
| Rev3l |
A |
T |
10: 39,698,698 (GRCm39) |
N1065I |
probably benign |
Het |
| Scamp5 |
A |
T |
9: 57,354,489 (GRCm39) |
|
probably null |
Het |
| Sec16a |
A |
G |
2: 26,316,118 (GRCm39) |
S1698P |
probably damaging |
Het |
| Spr |
C |
A |
6: 85,114,474 (GRCm39) |
R85L |
probably benign |
Het |
| Sptlc2 |
A |
C |
12: 87,402,436 (GRCm39) |
N163K |
probably benign |
Het |
| Stk10 |
C |
T |
11: 32,538,839 (GRCm39) |
T226M |
probably damaging |
Het |
| Sv2c |
A |
G |
13: 96,123,229 (GRCm39) |
Y415H |
probably benign |
Het |
| Tet1 |
A |
G |
10: 62,715,792 (GRCm39) |
M1T |
probably null |
Het |
| Tnnt1 |
T |
A |
7: 4,512,060 (GRCm39) |
K150* |
probably null |
Het |
| Trappc10 |
C |
T |
10: 78,037,287 (GRCm39) |
V839M |
probably benign |
Het |
| Ubap2 |
T |
C |
4: 41,195,155 (GRCm39) |
N1131S |
probably damaging |
Het |
| Upk2 |
T |
C |
9: 44,364,803 (GRCm39) |
E132G |
probably damaging |
Het |
| Vmn2r117 |
A |
T |
17: 23,679,193 (GRCm39) |
V677D |
probably damaging |
Het |
| Vps13a |
A |
T |
19: 16,702,943 (GRCm39) |
L670H |
probably damaging |
Het |
| Wwc1 |
C |
T |
11: 35,744,264 (GRCm39) |
E853K |
probably benign |
Het |
| Zfp512 |
G |
A |
5: 31,623,984 (GRCm39) |
R67H |
probably damaging |
Het |
| Zfp804b |
T |
A |
5: 6,819,283 (GRCm39) |
H1260L |
probably damaging |
Het |
| Zzef1 |
C |
A |
11: 72,716,891 (GRCm39) |
N360K |
probably damaging |
Het |
|
| Other mutations in Itgal |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00987:Itgal
|
APN |
7 |
126,901,183 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01300:Itgal
|
APN |
7 |
126,913,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01345:Itgal
|
APN |
7 |
126,900,128 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01826:Itgal
|
APN |
7 |
126,901,318 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02202:Itgal
|
APN |
7 |
126,929,351 (GRCm39) |
nonsense |
probably null |
|
|
IGL02212:Itgal
|
APN |
7 |
126,900,152 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02513:Itgal
|
APN |
7 |
126,927,844 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02608:Itgal
|
APN |
7 |
126,909,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02946:Itgal
|
APN |
7 |
126,913,540 (GRCm39) |
missense |
probably damaging |
0.99 |
|
sunglow
|
UTSW |
7 |
126,927,919 (GRCm39) |
missense |
probably null |
0.89 |
|
R0069:Itgal
|
UTSW |
7 |
126,909,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0069:Itgal
|
UTSW |
7 |
126,909,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0107:Itgal
|
UTSW |
7 |
126,927,731 (GRCm39) |
splice site |
probably benign |
|
|
R0331:Itgal
|
UTSW |
7 |
126,905,853 (GRCm39) |
splice site |
probably null |
|
|
R0350:Itgal
|
UTSW |
7 |
126,921,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Itgal
|
UTSW |
7 |
126,909,923 (GRCm39) |
nonsense |
probably null |
|
|
R0537:Itgal
|
UTSW |
7 |
126,910,445 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0546:Itgal
|
UTSW |
7 |
126,909,486 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0594:Itgal
|
UTSW |
7 |
126,913,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Itgal
|
UTSW |
7 |
126,900,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1377:Itgal
|
UTSW |
7 |
126,921,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1575:Itgal
|
UTSW |
7 |
126,900,060 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1690:Itgal
|
UTSW |
7 |
126,901,289 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1693:Itgal
|
UTSW |
7 |
126,904,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Itgal
|
UTSW |
7 |
126,904,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1720:Itgal
|
UTSW |
7 |
126,906,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1774:Itgal
|
UTSW |
7 |
126,908,794 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Itgal
|
UTSW |
7 |
126,913,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1878:Itgal
|
UTSW |
7 |
126,909,843 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1951:Itgal
|
UTSW |
7 |
126,929,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2265:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2267:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2269:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2276:Itgal
|
UTSW |
7 |
126,927,919 (GRCm39) |
missense |
probably null |
0.89 |
|
R2570:Itgal
|
UTSW |
7 |
126,913,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3925:Itgal
|
UTSW |
7 |
126,923,709 (GRCm39) |
splice site |
probably benign |
|
|
R4225:Itgal
|
UTSW |
7 |
126,904,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4377:Itgal
|
UTSW |
7 |
126,927,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4466:Itgal
|
UTSW |
7 |
126,927,684 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4579:Itgal
|
UTSW |
7 |
126,904,466 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4656:Itgal
|
UTSW |
7 |
126,921,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Itgal
|
UTSW |
7 |
126,927,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5012:Itgal
|
UTSW |
7 |
126,898,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5328:Itgal
|
UTSW |
7 |
126,910,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5365:Itgal
|
UTSW |
7 |
126,904,522 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5579:Itgal
|
UTSW |
7 |
126,906,101 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5849:Itgal
|
UTSW |
7 |
126,916,492 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5955:Itgal
|
UTSW |
7 |
126,904,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6254:Itgal
|
UTSW |
7 |
126,924,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6269:Itgal
|
UTSW |
7 |
126,929,389 (GRCm39) |
missense |
probably null |
1.00 |
|
R6541:Itgal
|
UTSW |
7 |
126,910,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7049:Itgal
|
UTSW |
7 |
126,895,573 (GRCm39) |
unclassified |
probably benign |
|
|
R7168:Itgal
|
UTSW |
7 |
126,929,385 (GRCm39) |
missense |
probably benign |
|
|
R7419:Itgal
|
UTSW |
7 |
126,906,047 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7424:Itgal
|
UTSW |
7 |
126,916,537 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Itgal
|
UTSW |
7 |
126,926,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7567:Itgal
|
UTSW |
7 |
126,898,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7696:Itgal
|
UTSW |
7 |
126,929,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Itgal
|
UTSW |
7 |
126,927,470 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7987:Itgal
|
UTSW |
7 |
126,927,470 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8118:Itgal
|
UTSW |
7 |
126,910,417 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8297:Itgal
|
UTSW |
7 |
126,929,638 (GRCm39) |
missense |
unknown |
|
|
R8418:Itgal
|
UTSW |
7 |
126,929,454 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8477:Itgal
|
UTSW |
7 |
126,900,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Itgal
|
UTSW |
7 |
126,928,607 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8789:Itgal
|
UTSW |
7 |
126,904,421 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8838:Itgal
|
UTSW |
7 |
126,910,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Itgal
|
UTSW |
7 |
126,929,541 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8923:Itgal
|
UTSW |
7 |
126,895,533 (GRCm39) |
unclassified |
probably benign |
|
|
R9070:Itgal
|
UTSW |
7 |
126,927,873 (GRCm39) |
missense |
probably null |
0.98 |
|
R9104:Itgal
|
UTSW |
7 |
126,910,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9173:Itgal
|
UTSW |
7 |
126,896,789 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9179:Itgal
|
UTSW |
7 |
126,905,883 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9407:Itgal
|
UTSW |
7 |
126,921,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9545:Itgal
|
UTSW |
7 |
126,929,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9681:Itgal
|
UTSW |
7 |
126,929,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAGATGCTTCACGTGTACG -3'
(R):5'- CGCCCTTATCTTTTGAGGCA -3'
Sequencing Primer
(F):5'- TACGTACTCAGCGGCATTG -3'
(R):5'- GTCTCCATTACAGGTTCCAGAGTAG -3'
|
| Posted On |
2018-06-06 |
Incidental Mutation