Incidental Mutation 'R8881:Itgal'
| ID |
676919 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Itgal
|
| Ensembl Gene |
ENSMUSG00000030830 |
| Gene Name |
integrin alpha L |
| Synonyms |
Ly-21, Ly-15, Cd11a, LFA-1 |
| MMRRC Submission |
068749-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.143)
|
| Stock # |
R8881 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
126895432-126934310 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 126929541 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 1153
(V1153M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113396
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106306]
[ENSMUST00000117762]
[ENSMUST00000118405]
[ENSMUST00000120857]
[ENSMUST00000170971]
|
| AlphaFold |
P24063 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106306
|
| SMART Domains |
Protein: ENSMUSP00000101913
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1043 |
1059 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1087 |
1109 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1110 |
1124 |
5.8e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117762
|
| SMART Domains |
Protein: ENSMUSP00000113946
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1109 |
1123 |
5.8e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118405
|
| SMART Domains |
Protein: ENSMUSP00000112591
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
Int_alpha
|
2 |
54 |
4.21e-3 |
SMART |
|
Int_alpha
|
58 |
113 |
9.6e-7 |
SMART |
|
Int_alpha
|
119 |
172 |
3.58e-15 |
SMART |
|
Int_alpha
|
179 |
228 |
1.28e1 |
SMART |
|
low complexity region
|
646 |
662 |
N/A |
INTRINSIC |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
713 |
727 |
2.1e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120857
AA Change: V1153M
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000113396
Gene: ENSMUSG00000030830
AA Change: V1153M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170971
|
| SMART Domains |
Protein: ENSMUSP00000131847
Gene: ENSMUSG00000030830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1109 |
1123 |
1.2e-6 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.5%
|
| Validation Efficiency |
100% (69/69) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
G |
A |
7: 120,074,794 (GRCm39) |
C612Y |
probably benign |
Het |
| Adam21 |
T |
C |
12: 81,606,650 (GRCm39) |
T371A |
probably benign |
Het |
| Akap9 |
T |
C |
5: 4,011,279 (GRCm39) |
S661P |
|
Het |
| Anxa11 |
C |
T |
14: 25,874,687 (GRCm39) |
R233C |
probably damaging |
Het |
| Capza3 |
A |
C |
6: 139,987,521 (GRCm39) |
D40A |
probably damaging |
Het |
| Caskin1 |
C |
A |
17: 24,718,273 (GRCm39) |
N294K |
probably damaging |
Het |
| Cdh1 |
T |
C |
8: 107,392,904 (GRCm39) |
V796A |
probably benign |
Het |
| Cfap251 |
C |
T |
5: 123,462,438 (GRCm39) |
P1249L |
probably damaging |
Het |
| Cped1 |
A |
T |
6: 22,119,578 (GRCm39) |
T346S |
possibly damaging |
Het |
| Crisp4 |
A |
T |
1: 18,185,902 (GRCm39) |
V278D |
probably damaging |
Het |
| Ddx60 |
A |
C |
8: 62,474,343 (GRCm39) |
D1477A |
possibly damaging |
Het |
| Dmrtb1 |
T |
C |
4: 107,537,922 (GRCm39) |
D82G |
possibly damaging |
Het |
| Dnah11 |
T |
C |
12: 118,077,647 (GRCm39) |
N1282S |
probably benign |
Het |
| Dnah11 |
C |
T |
12: 118,090,550 (GRCm39) |
V1104M |
probably benign |
Het |
| Dot1l |
A |
G |
10: 80,621,429 (GRCm39) |
E630G |
probably damaging |
Het |
| Dppa4 |
C |
A |
16: 48,108,299 (GRCm39) |
T28K |
|
Het |
| Dusp5 |
T |
A |
19: 53,529,745 (GRCm39) |
S383T |
probably benign |
Het |
| Eef2k |
C |
T |
7: 120,472,548 (GRCm39) |
A87V |
probably damaging |
Het |
| Epha1 |
T |
C |
6: 42,337,961 (GRCm39) |
Y828C |
probably damaging |
Het |
| Erbb4 |
A |
C |
1: 68,382,997 (GRCm39) |
|
probably null |
Het |
| Fam151b |
T |
A |
13: 92,604,630 (GRCm39) |
M120L |
probably benign |
Het |
| Fam237b |
A |
C |
5: 5,625,379 (GRCm39) |
D25A |
possibly damaging |
Het |
| Fez2 |
T |
C |
17: 78,689,051 (GRCm39) |
D366G |
probably damaging |
Het |
| Frmd4b |
G |
T |
6: 97,272,735 (GRCm39) |
H886N |
probably benign |
Het |
| Galnt17 |
T |
C |
5: 130,906,635 (GRCm39) |
H511R |
probably benign |
Het |
| Grpel1 |
C |
A |
5: 36,626,816 (GRCm39) |
Q33K |
possibly damaging |
Het |
| Gzmm |
A |
C |
10: 79,530,819 (GRCm39) |
|
probably null |
Het |
| Hmcn1 |
C |
A |
1: 150,525,723 (GRCm39) |
L3333F |
probably damaging |
Het |
| Il21r |
A |
T |
7: 125,231,498 (GRCm39) |
T309S |
probably benign |
Het |
| Kdf1 |
G |
A |
4: 133,257,654 (GRCm39) |
A390T |
possibly damaging |
Het |
| Lcn11 |
G |
T |
2: 25,669,296 (GRCm39) |
R151L |
probably benign |
Het |
| Lgi3 |
T |
A |
14: 70,770,282 (GRCm39) |
Y116N |
probably damaging |
Het |
| Llgl2 |
A |
G |
11: 115,743,866 (GRCm39) |
H731R |
probably benign |
Het |
| Lrp5 |
A |
T |
19: 3,641,015 (GRCm39) |
S1482T |
probably damaging |
Het |
| Meis2 |
T |
C |
2: 115,889,116 (GRCm39) |
D212G |
probably benign |
Het |
| Mrgpra9 |
A |
G |
7: 46,885,242 (GRCm39) |
C142R |
possibly damaging |
Het |
| Mrgprf |
A |
G |
7: 144,861,999 (GRCm39) |
H187R |
probably benign |
Het |
| Mvd |
A |
G |
8: 123,164,564 (GRCm39) |
|
probably null |
Het |
| Neb |
T |
C |
2: 52,096,999 (GRCm39) |
I4938M |
possibly damaging |
Het |
| Nipal4 |
A |
T |
11: 46,042,177 (GRCm39) |
M168K |
probably benign |
Het |
| Nr1h4 |
A |
G |
10: 89,319,351 (GRCm39) |
Y158H |
probably damaging |
Het |
| Nrxn2 |
T |
C |
19: 6,554,920 (GRCm39) |
I1133T |
probably benign |
Het |
| Numa1 |
T |
C |
7: 101,650,684 (GRCm39) |
Y1472H |
probably benign |
Het |
| Or10ak8 |
A |
G |
4: 118,774,571 (GRCm39) |
V31A |
probably benign |
Het |
| Or12j3 |
A |
G |
7: 139,952,698 (GRCm39) |
V275A |
probably benign |
Het |
| Or2y10 |
G |
A |
11: 49,455,209 (GRCm39) |
V154M |
probably benign |
Het |
| Or3a1d |
T |
C |
11: 74,237,471 (GRCm39) |
D313G |
probably benign |
Het |
| Or52h7 |
A |
G |
7: 104,213,619 (GRCm39) |
M64V |
possibly damaging |
Het |
| Pate7 |
T |
A |
9: 35,689,384 (GRCm39) |
|
probably benign |
Het |
| Pcdha6 |
G |
T |
18: 37,101,484 (GRCm39) |
V226F |
probably damaging |
Het |
| Pnpla6 |
G |
A |
8: 3,581,489 (GRCm39) |
M605I |
probably benign |
Het |
| Ppp1r13l |
G |
A |
7: 19,105,194 (GRCm39) |
R322H |
probably damaging |
Het |
| Sgtb |
T |
C |
13: 104,258,046 (GRCm39) |
|
probably null |
Het |
| Skint6 |
T |
C |
4: 112,672,716 (GRCm39) |
K1086E |
possibly damaging |
Het |
| Slc4a11 |
T |
C |
2: 130,527,457 (GRCm39) |
E646G |
probably damaging |
Het |
| Speg |
G |
T |
1: 75,377,795 (GRCm39) |
R851L |
possibly damaging |
Het |
| Spns3 |
T |
G |
11: 72,429,912 (GRCm39) |
D172A |
probably damaging |
Het |
| Srgap3 |
A |
G |
6: 112,700,098 (GRCm39) |
V984A |
probably benign |
Het |
| Syne1 |
A |
T |
10: 5,223,639 (GRCm39) |
D3080E |
probably damaging |
Het |
| Taf5l |
T |
C |
8: 124,730,101 (GRCm39) |
H196R |
possibly damaging |
Het |
| Tmem229a |
G |
C |
6: 24,955,587 (GRCm39) |
R56G |
probably damaging |
Het |
| Tmprss6 |
A |
C |
15: 78,327,987 (GRCm39) |
*582G |
probably null |
Het |
| Trip13 |
C |
A |
13: 74,077,795 (GRCm39) |
R173L |
possibly damaging |
Het |
| Trpm7 |
A |
T |
2: 126,661,883 (GRCm39) |
V1055E |
probably damaging |
Het |
| Utrn |
A |
G |
10: 12,423,737 (GRCm39) |
I2T |
possibly damaging |
Het |
| V1rd19 |
T |
A |
7: 23,703,081 (GRCm39) |
S182R |
possibly damaging |
Het |
| Vmn2r58 |
C |
A |
7: 41,486,609 (GRCm39) |
G762V |
probably benign |
Het |
| Zfp874b |
T |
C |
13: 67,622,141 (GRCm39) |
K386E |
probably damaging |
Het |
|
| Other mutations in Itgal |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00987:Itgal
|
APN |
7 |
126,901,183 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01300:Itgal
|
APN |
7 |
126,913,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01345:Itgal
|
APN |
7 |
126,900,128 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01826:Itgal
|
APN |
7 |
126,901,318 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02202:Itgal
|
APN |
7 |
126,929,351 (GRCm39) |
nonsense |
probably null |
|
|
IGL02212:Itgal
|
APN |
7 |
126,900,152 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02513:Itgal
|
APN |
7 |
126,927,844 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02608:Itgal
|
APN |
7 |
126,909,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02946:Itgal
|
APN |
7 |
126,913,540 (GRCm39) |
missense |
probably damaging |
0.99 |
|
sunglow
|
UTSW |
7 |
126,927,919 (GRCm39) |
missense |
probably null |
0.89 |
|
R0069:Itgal
|
UTSW |
7 |
126,909,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0069:Itgal
|
UTSW |
7 |
126,909,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0107:Itgal
|
UTSW |
7 |
126,927,731 (GRCm39) |
splice site |
probably benign |
|
|
R0331:Itgal
|
UTSW |
7 |
126,905,853 (GRCm39) |
splice site |
probably null |
|
|
R0350:Itgal
|
UTSW |
7 |
126,921,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Itgal
|
UTSW |
7 |
126,909,923 (GRCm39) |
nonsense |
probably null |
|
|
R0537:Itgal
|
UTSW |
7 |
126,910,445 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0546:Itgal
|
UTSW |
7 |
126,909,486 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0594:Itgal
|
UTSW |
7 |
126,913,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Itgal
|
UTSW |
7 |
126,900,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1377:Itgal
|
UTSW |
7 |
126,921,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1575:Itgal
|
UTSW |
7 |
126,900,060 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1690:Itgal
|
UTSW |
7 |
126,901,289 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1693:Itgal
|
UTSW |
7 |
126,904,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Itgal
|
UTSW |
7 |
126,904,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1720:Itgal
|
UTSW |
7 |
126,906,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1774:Itgal
|
UTSW |
7 |
126,908,794 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Itgal
|
UTSW |
7 |
126,913,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1878:Itgal
|
UTSW |
7 |
126,909,843 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1951:Itgal
|
UTSW |
7 |
126,929,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2265:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2267:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2269:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2276:Itgal
|
UTSW |
7 |
126,927,919 (GRCm39) |
missense |
probably null |
0.89 |
|
R2570:Itgal
|
UTSW |
7 |
126,913,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3925:Itgal
|
UTSW |
7 |
126,923,709 (GRCm39) |
splice site |
probably benign |
|
|
R4225:Itgal
|
UTSW |
7 |
126,904,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4377:Itgal
|
UTSW |
7 |
126,927,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4466:Itgal
|
UTSW |
7 |
126,927,684 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4579:Itgal
|
UTSW |
7 |
126,904,466 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4656:Itgal
|
UTSW |
7 |
126,921,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Itgal
|
UTSW |
7 |
126,927,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5012:Itgal
|
UTSW |
7 |
126,898,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5328:Itgal
|
UTSW |
7 |
126,910,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5365:Itgal
|
UTSW |
7 |
126,904,522 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5579:Itgal
|
UTSW |
7 |
126,906,101 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5849:Itgal
|
UTSW |
7 |
126,916,492 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5955:Itgal
|
UTSW |
7 |
126,904,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6254:Itgal
|
UTSW |
7 |
126,924,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6269:Itgal
|
UTSW |
7 |
126,929,389 (GRCm39) |
missense |
probably null |
1.00 |
|
R6520:Itgal
|
UTSW |
7 |
126,929,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6541:Itgal
|
UTSW |
7 |
126,910,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7049:Itgal
|
UTSW |
7 |
126,895,573 (GRCm39) |
unclassified |
probably benign |
|
|
R7168:Itgal
|
UTSW |
7 |
126,929,385 (GRCm39) |
missense |
probably benign |
|
|
R7419:Itgal
|
UTSW |
7 |
126,906,047 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7424:Itgal
|
UTSW |
7 |
126,916,537 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Itgal
|
UTSW |
7 |
126,926,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7567:Itgal
|
UTSW |
7 |
126,898,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7696:Itgal
|
UTSW |
7 |
126,929,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Itgal
|
UTSW |
7 |
126,927,470 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7987:Itgal
|
UTSW |
7 |
126,927,470 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8118:Itgal
|
UTSW |
7 |
126,910,417 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8297:Itgal
|
UTSW |
7 |
126,929,638 (GRCm39) |
missense |
unknown |
|
|
R8418:Itgal
|
UTSW |
7 |
126,929,454 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8477:Itgal
|
UTSW |
7 |
126,900,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Itgal
|
UTSW |
7 |
126,928,607 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8789:Itgal
|
UTSW |
7 |
126,904,421 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8838:Itgal
|
UTSW |
7 |
126,910,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8923:Itgal
|
UTSW |
7 |
126,895,533 (GRCm39) |
unclassified |
probably benign |
|
|
R9070:Itgal
|
UTSW |
7 |
126,927,873 (GRCm39) |
missense |
probably null |
0.98 |
|
R9104:Itgal
|
UTSW |
7 |
126,910,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9173:Itgal
|
UTSW |
7 |
126,896,789 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9179:Itgal
|
UTSW |
7 |
126,905,883 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9407:Itgal
|
UTSW |
7 |
126,921,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9545:Itgal
|
UTSW |
7 |
126,929,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9681:Itgal
|
UTSW |
7 |
126,929,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTACGTACTCAGCGGCATTG -3'
(R):5'- CGCCCTTATCTTTTGAGGCA -3'
Sequencing Primer
(F):5'- ATTGGGGGCCTCGTGCTTC -3'
(R):5'- GTCTCCATTACAGGTTCCAGAGTAG -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation