Incidental Mutation 'R6652:Wnt10a'
ID 543564
Institutional Source Beutler Lab
Gene Symbol Wnt10a
Ensembl Gene ENSMUSG00000026167
Gene Name wingless-type MMTV integration site family, member 10A
Synonyms
MMRRC Submission 044773-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6652 (G1)
Quality Score 47.0072
Status Validated
Chromosome 1
Chromosomal Location 74831178-74843335 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 74842613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000006718]
AlphaFold P70701
Predicted Effect probably damaging
Transcript: ENSMUST00000006718
AA Change: N363S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000006718
Gene: ENSMUSG00000026167
AA Change: N363S

DomainStartEndE-ValueType
signal peptide 1 41 N/A INTRINSIC
WNT1 63 417 4.97e-143 SMART
Predicted Effect probably null
Transcript: ENSMUST00000187238
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.7%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit taurodontism, supernumerary molars, small molars and misshapened crowns. Mice homozygous for a conditional allele activated in Krt14+ cells also exhibit decreased basal cell proliferation affecting the tongue, sweat glands and nails. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,846,164 (GRCm39) D605G probably damaging Het
Cfh A T 1: 140,071,806 (GRCm39) I294N probably benign Het
Clk3 A G 9: 57,669,078 (GRCm39) S49P probably damaging Het
Cmya5 A G 13: 93,229,403 (GRCm39) V1895A probably benign Het
Cmya5 T C 13: 93,229,547 (GRCm39) D1847G probably damaging Het
Cwf19l1 T C 19: 44,103,138 (GRCm39) D359G probably benign Het
Dag1 A T 9: 108,086,289 (GRCm39) M284K probably damaging Het
Ergic2 T C 6: 148,091,079 (GRCm39) Y211C probably damaging Het
Espnl A C 1: 91,272,421 (GRCm39) I594L probably benign Het
Fam193b A G 13: 55,690,603 (GRCm39) S226P probably damaging Het
Fat2 T A 11: 55,143,088 (GRCm39) I4254L probably benign Het
Fhdc1 T C 3: 84,371,631 (GRCm39) Y108C probably damaging Het
Fut9 G C 4: 25,620,619 (GRCm39) T65S probably benign Het
Gm9507 A T 10: 77,647,493 (GRCm39) probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Grap2 A T 15: 80,532,723 (GRCm39) N297Y probably damaging Het
Igfn1 A G 1: 135,891,609 (GRCm39) F2302S probably damaging Het
Ighv1-81 T A 12: 115,884,051 (GRCm39) I67F probably damaging Het
Kidins220 T A 12: 25,060,059 (GRCm39) probably null Het
Kti12 T A 4: 108,705,730 (GRCm39) S215T probably benign Het
Mc1r G A 8: 124,134,370 (GRCm39) G41D probably damaging Het
Mov10l1 A G 15: 88,878,105 (GRCm39) Y129C probably damaging Het
Mthfsd A T 8: 121,825,560 (GRCm39) L337Q probably damaging Het
Musk C T 4: 58,368,977 (GRCm39) A629V probably damaging Het
Nadsyn1 A T 7: 143,364,955 (GRCm39) M250K probably benign Het
Ncapd2 G A 6: 125,163,233 (GRCm39) H92Y probably benign Het
Or4e5 C T 14: 52,728,250 (GRCm39) R57Q probably benign Het
Or6y1 G A 1: 174,276,627 (GRCm39) C146Y probably damaging Het
Plec A T 15: 76,063,974 (GRCm39) V2100E probably damaging Het
Prss37 C A 6: 40,496,090 (GRCm39) probably benign Het
Sebox A T 11: 78,394,631 (GRCm39) E32V probably damaging Het
Senp7 C A 16: 55,944,257 (GRCm39) Q194K probably benign Het
Sfxn3 G A 19: 45,038,354 (GRCm39) probably null Het
Spart G A 3: 55,032,248 (GRCm39) E361K probably benign Het
Stn1 T C 19: 47,496,017 (GRCm39) T334A probably benign Het
Stoml1 A G 9: 58,164,017 (GRCm39) D112G probably damaging Het
Thap2 T A 10: 115,212,441 (GRCm39) D28V probably damaging Het
Ubap2 A T 4: 41,196,743 (GRCm39) N872K possibly damaging Het
Vezt A G 10: 93,806,141 (GRCm39) F757L probably damaging Het
Vmn1r204 T C 13: 22,740,573 (GRCm39) I68T probably damaging Het
Yipf7 A G 5: 69,698,504 (GRCm39) M1T probably null Het
Zdhhc19 T C 16: 32,316,047 (GRCm39) F48S probably damaging Het
Zfp317 C T 9: 19,558,335 (GRCm39) T183I probably damaging Het
Other mutations in Wnt10a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0347:Wnt10a UTSW 1 74,832,702 (GRCm39) missense probably damaging 0.97
R2312:Wnt10a UTSW 1 74,842,589 (GRCm39) missense possibly damaging 0.74
R3941:Wnt10a UTSW 1 74,842,656 (GRCm39) splice site probably null
R4683:Wnt10a UTSW 1 74,842,296 (GRCm39) missense unknown
R4719:Wnt10a UTSW 1 74,842,762 (GRCm39) missense probably damaging 1.00
R5218:Wnt10a UTSW 1 74,832,754 (GRCm39) missense probably benign
R5244:Wnt10a UTSW 1 74,842,454 (GRCm39) missense probably damaging 0.99
R5813:Wnt10a UTSW 1 74,839,755 (GRCm39) missense probably damaging 1.00
R7278:Wnt10a UTSW 1 74,832,641 (GRCm39) missense possibly damaging 0.92
R7637:Wnt10a UTSW 1 74,832,633 (GRCm39) nonsense probably null
R8293:Wnt10a UTSW 1 74,842,376 (GRCm39) missense probably damaging 1.00
R9446:Wnt10a UTSW 1 74,842,728 (GRCm39) missense possibly damaging 0.52
Predicted Primers PCR Primer
(F):5'- AGAACATGCGGCGTAAGTGC -3'
(R):5'- AGCTTGGGTCTGCTCACTTG -3'

Sequencing Primer
(F):5'- CGGCGTAAGTGCAAATGCC -3'
(R):5'- TCACTTGCAGACGCTGAC -3'
Posted On 2019-03-06