Incidental Mutation 'R0612:Vmn1r58'
ID54811
Institutional Source Beutler Lab
Gene Symbol Vmn1r58
Ensembl Gene ENSMUSG00000078808
Gene Namevomeronasal 1 receptor 58
SynonymsV3R4, V1rd4
MMRRC Submission 038801-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #R0612 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location5401681-5413396 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 5410619 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 204 (H204R)
Ref Sequence ENSEMBL: ENSMUSP00000154393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108569] [ENSMUST00000228728]
Predicted Effect probably damaging
Transcript: ENSMUST00000108569
AA Change: H204R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104209
Gene: ENSMUSG00000078808
AA Change: H204R

DomainStartEndE-ValueType
Pfam:TAS2R 1 296 7.8e-13 PFAM
Pfam:7tm_1 20 279 4.4e-7 PFAM
Pfam:V1R 31 296 7.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209136
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226315
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227549
Predicted Effect probably damaging
Transcript: ENSMUST00000228728
AA Change: H204R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.7235 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 99.0%
  • 10x: 97.2%
  • 20x: 93.5%
Validation Efficiency 98% (92/94)
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210407C18Rik A G 11: 58,611,973 probably null Het
Abca15 T C 7: 120,337,255 L181P probably damaging Het
Aldh3a1 A T 11: 61,214,619 I184F probably damaging Het
Arl6ip4 A G 5: 124,116,533 S30G probably benign Het
Atp9b T C 18: 80,753,956 E891G possibly damaging Het
Brsk1 T C 7: 4,707,426 L478P possibly damaging Het
Btaf1 G A 19: 36,969,137 V448I probably damaging Het
C330027C09Rik C T 16: 48,999,039 A112V probably benign Het
Cab39 T C 1: 85,818,515 probably null Het
Cacna2d4 G T 6: 119,281,718 probably benign Het
Capzb C T 4: 139,291,029 S253L probably benign Het
Ccdc174 A G 6: 91,890,892 probably benign Het
Ccdc180 C T 4: 45,927,969 A1168V probably damaging Het
Cdh19 T C 1: 110,893,170 probably benign Het
Cdh8 T C 8: 99,400,914 T22A probably benign Het
Cdk10 T C 8: 123,230,680 V181A probably benign Het
Ceacam15 A C 7: 16,673,520 L24* probably null Het
Cftr A C 6: 18,198,126 T20P probably benign Het
Clstn3 T C 6: 124,449,500 T576A probably damaging Het
Col1a2 G A 6: 4,516,003 V165I unknown Het
Copg2 A T 6: 30,861,469 probably null Het
Cps1 A G 1: 67,139,770 H47R probably benign Het
Cytip T C 2: 58,134,190 D206G possibly damaging Het
Dnmt1 C T 9: 20,918,193 E824K probably damaging Het
Dock7 A C 4: 98,989,233 V442G probably benign Het
Dsc1 T G 18: 20,114,516 K14T probably damaging Het
Dync1h1 C T 12: 110,616,496 P371L probably damaging Het
Enah A G 1: 181,906,448 probably benign Het
Fam189a1 C T 7: 64,761,801 V395M probably benign Het
Fastkd1 T C 2: 69,712,383 T27A probably benign Het
Fcho1 A G 8: 71,715,524 L248P probably damaging Het
Fezf1 A T 6: 23,247,029 V268D probably damaging Het
Fgd2 T A 17: 29,378,347 V547E probably benign Het
Flnb T A 14: 7,887,682 probably benign Het
Gabrg3 A G 7: 56,729,706 M316T probably damaging Het
Gigyf2 T C 1: 87,449,080 F1265L probably damaging Het
Git2 A G 5: 114,752,281 S271P probably damaging Het
Gm13103 G T 4: 143,852,088 probably benign Het
Gm14085 T C 2: 122,521,698 M339T probably damaging Het
Gorab T C 1: 163,397,169 D21G possibly damaging Het
Gpr179 T A 11: 97,338,438 T964S possibly damaging Het
Hdac5 A G 11: 102,196,252 V1042A possibly damaging Het
Hoxa2 T A 6: 52,163,560 T149S probably damaging Het
Igsf8 G T 1: 172,319,407 *108L probably null Het
Il1rap C T 16: 26,701,105 T307M possibly damaging Het
Itih2 T C 2: 10,117,394 D232G probably benign Het
Jak3 A G 8: 71,683,377 Y607C probably damaging Het
Kcnh1 C T 1: 192,277,053 P305L probably damaging Het
Lrrc7 T A 3: 158,164,353 I644F probably damaging Het
Lrrn2 T C 1: 132,937,728 L177P probably damaging Het
Map4k3 C A 17: 80,602,193 K712N probably damaging Het
Med11 A G 11: 70,452,084 T36A probably benign Het
Mmp14 A G 14: 54,440,434 D504G probably damaging Het
Mob1a A G 6: 83,334,158 T120A probably benign Het
Mr1 T A 1: 155,137,690 D47V probably damaging Het
Nacad G T 11: 6,601,382 A603E possibly damaging Het
Nwd1 T A 8: 72,667,680 W524R probably damaging Het
Olfr1508 T C 14: 52,463,551 T153A probably benign Het
Olfr525 T A 7: 140,323,188 M163K possibly damaging Het
Olfr742 A T 14: 50,515,482 T93S probably benign Het
Parp14 G A 16: 35,856,760 A946V probably benign Het
Pde6c T A 19: 38,133,246 C101S probably benign Het
Pdia3 G A 2: 121,432,377 G275S probably damaging Het
Pdlim4 G A 11: 54,068,887 R16C probably damaging Het
Pet2 G A X: 89,405,366 R386* probably null Het
Pfkp A G 13: 6,605,634 probably null Het
Plcg2 T A 8: 117,573,365 S225T probably benign Het
Pramel1 T C 4: 143,397,531 S259P probably damaging Het
Rc3h2 T C 2: 37,411,215 N92D possibly damaging Het
Ric8b C A 10: 85,001,881 N517K probably damaging Het
Rnf34 G A 5: 122,864,174 R65H probably damaging Het
Rraga C T 4: 86,576,327 R137C probably damaging Het
Scube2 C T 7: 109,804,764 probably benign Het
Spata31d1d T C 13: 59,727,973 I583V probably benign Het
Suox T C 10: 128,670,656 E501G probably benign Het
Susd1 A G 4: 59,390,561 probably benign Het
Tac1 T C 6: 7,555,653 S14P probably damaging Het
Tbc1d8 T C 1: 39,372,515 E1080G possibly damaging Het
Tll1 A C 8: 64,071,310 S447R possibly damaging Het
Tmem132e G A 11: 82,443,372 V662M probably damaging Het
Upf2 G T 2: 6,034,098 probably benign Het
Uspl1 A G 5: 149,214,957 E989G probably damaging Het
Vmn2r25 A T 6: 123,839,522 C367S probably damaging Het
Vps13b A T 15: 35,623,657 Q1240L probably benign Het
Xrcc1 C T 7: 24,570,319 probably benign Het
Yeats2 T G 16: 20,186,425 V385G probably benign Het
Other mutations in Vmn1r58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn1r58 APN 7 5411055 missense probably benign 0.19
IGL02792:Vmn1r58 APN 7 5411229 start codon destroyed probably null 0.04
IGL03215:Vmn1r58 APN 7 5410836 missense probably benign 0.00
IGL03259:Vmn1r58 APN 7 5411087 nonsense probably null
K7894:Vmn1r58 UTSW 7 5410703 missense probably benign 0.01
R0033:Vmn1r58 UTSW 7 5410388 missense probably damaging 1.00
R0225:Vmn1r58 UTSW 7 5410866 missense probably benign 0.02
R0304:Vmn1r58 UTSW 7 5410496 missense probably damaging 1.00
R0360:Vmn1r58 UTSW 7 5410330 missense probably benign 0.25
R0363:Vmn1r58 UTSW 7 5410637 missense probably damaging 1.00
R0454:Vmn1r58 UTSW 7 5410998 missense possibly damaging 0.69
R0565:Vmn1r58 UTSW 7 5411166 missense probably benign 0.06
R0646:Vmn1r58 UTSW 7 5410677 missense probably benign 0.00
R0853:Vmn1r58 UTSW 7 5410325 missense probably damaging 1.00
R0920:Vmn1r58 UTSW 7 5410789 missense probably benign 0.00
R1696:Vmn1r58 UTSW 7 5410728 missense possibly damaging 0.67
R1823:Vmn1r58 UTSW 7 5410406 missense possibly damaging 0.95
R2326:Vmn1r58 UTSW 7 5410940 missense probably damaging 1.00
R4088:Vmn1r58 UTSW 7 5410655 missense probably damaging 1.00
R5065:Vmn1r58 UTSW 7 5410835 missense probably benign 0.00
R5087:Vmn1r58 UTSW 7 5410667 missense probably benign 0.04
R5407:Vmn1r58 UTSW 7 5410873 missense probably benign 0.01
R6855:Vmn1r58 UTSW 7 5410452 missense possibly damaging 0.56
R7052:Vmn1r58 UTSW 7 5411135 missense probably benign 0.04
R7334:Vmn1r58 UTSW 7 5411067 missense probably benign 0.04
R7763:Vmn1r58 UTSW 7 5410913 missense probably damaging 1.00
R7840:Vmn1r58 UTSW 7 5411243 start gained probably benign
R7875:Vmn1r58 UTSW 7 5410754 missense probably damaging 0.98
R7923:Vmn1r58 UTSW 7 5411243 start gained probably benign
R7958:Vmn1r58 UTSW 7 5410754 missense probably damaging 0.98
R8004:Vmn1r58 UTSW 7 5410507 nonsense probably null
R8115:Vmn1r58 UTSW 7 5410342 missense probably benign 0.00
X0058:Vmn1r58 UTSW 7 5410395 missense possibly damaging 0.89
Z1176:Vmn1r58 UTSW 7 5410904 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTGCAGAGAACAATGACCCTTACG -3'
(R):5'- CCCAATGAATGTCAGTGGTCCACAG -3'

Sequencing Primer
(F):5'- TTTGTGGCATACCTCAACCAGAG -3'
(R):5'- TGTCAGTGGTCCACAGAAATC -3'
Posted On2013-07-11