|Institutional Source||Beutler Lab|
|Gene Name||insulin-like growth factor 2 mRNA binding protein 3|
|Synonyms||IMP3, 2610101N11Rik, Koc13|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6959 (G1)|
|Chromosomal Location||49085223-49214957 bp(-) (GRCm38)|
|Type of Mutation||splice site (4 bp from exon)|
|DNA Base Change (assembly)||T to C at 49117148 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000031838 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031838]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||94% (61/65)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Igf2bp3||
(F):5'- TCATGTGAGACCAACAACGC -3'
(R):5'- TTGCCTACATCCCAGATGAAAC -3'
(F):5'- CATGATCAGGTGACAAGGCTTCC -3'
(R):5'- TCCCAGATGAAACTGCTGC -3'