Incidental Mutation 'R7627:H2ac15'
ID 589512
Institutional Source Beutler Lab
Gene Symbol H2ac15
Ensembl Gene ENSMUSG00000063021
Gene Name H2A clustered histone 15
Synonyms Hist1h2ak
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # R7627 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 21937605-21937997 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 21937916 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 28 (V28L)
Ref Sequence ENSEMBL: ENSMUSP00000074310 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074752] [ENSMUST00000091709] [ENSMUST00000102983]
AlphaFold Q8CGP7
Predicted Effect probably benign
Transcript: ENSMUST00000074752
AA Change: V28L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000074310
Gene: ENSMUSG00000063021
AA Change: V28L

DomainStartEndE-ValueType
H2A 3 123 1.22e-80 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091709
SMART Domains Protein: ENSMUSP00000089301
Gene: ENSMUSG00000095217

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 4.64e-72 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102983
SMART Domains Protein: ENSMUSP00000100048
Gene: ENSMUSG00000064288

DomainStartEndE-ValueType
H4 16 90 2.59e-29 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230112D13Rik T A 14: 34,234,055 (GRCm39) I79L unknown Het
Acta2 G A 19: 34,229,931 (GRCm39) T8I probably benign Het
Acvrl1 G A 15: 101,033,747 (GRCm39) R143Q probably benign Het
Adam22 A G 5: 8,417,933 (GRCm39) S8P probably benign Het
Ankrd11 A G 8: 123,617,690 (GRCm39) I2054T possibly damaging Het
Cactin CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG 10: 81,157,152 (GRCm39) probably benign Het
Cad T A 5: 31,217,508 (GRCm39) L354Q probably damaging Het
Ccdc15 A T 9: 37,253,698 (GRCm39) C184S unknown Het
Ccl8 A G 11: 82,006,865 (GRCm39) D26G probably benign Het
Ccsap T C 8: 124,569,097 (GRCm39) Y248C probably damaging Het
Col5a1 T G 2: 27,840,665 (GRCm39) Y271* probably null Het
Dnmt3b A G 2: 153,519,500 (GRCm39) N695S probably benign Het
Dync1li2 A G 8: 105,156,140 (GRCm39) C234R probably benign Het
Dync2h1 A T 9: 7,101,111 (GRCm39) D2758E probably benign Het
Eif2ak3 A T 6: 70,869,919 (GRCm39) T869S probably benign Het
Foxn4 G T 5: 114,398,495 (GRCm39) P175H possibly damaging Het
Gbp5 T G 3: 142,206,319 (GRCm39) M1R probably null Het
Glp2r G T 11: 67,637,589 (GRCm39) L30I unknown Het
Gls A T 1: 52,205,425 (GRCm39) D639E probably benign Het
Gm5145 G T 17: 20,790,654 (GRCm39) E11* probably null Het
Gm9772 T A 17: 22,226,160 (GRCm39) K41N probably damaging Het
Gnat3 A T 5: 18,204,746 (GRCm39) D133V Het
Gse1 C A 8: 121,299,516 (GRCm39) P849T unknown Het
Hoxb9 A G 11: 96,165,521 (GRCm39) T197A probably damaging Het
Krt39 A G 11: 99,405,575 (GRCm39) S442P possibly damaging Het
Leng9 A G 7: 4,151,617 (GRCm39) L353P probably damaging Het
Mamdc2 A T 19: 23,288,355 (GRCm39) M561K probably damaging Het
Mamdc4 A G 2: 25,458,225 (GRCm39) V395A probably damaging Het
Mrpl32 G A 13: 14,787,498 (GRCm39) R36C probably benign Het
Or6b2b A T 1: 92,419,107 (GRCm39) Y123* probably null Het
Or7e168 A G 9: 19,719,947 (GRCm39) D111G probably damaging Het
Papss1 T A 3: 131,290,873 (GRCm39) D205E probably benign Het
Pdlim2 T C 14: 70,408,924 (GRCm39) D151G probably benign Het
Pdxp T C 15: 78,798,339 (GRCm39) V57A probably damaging Het
Plec T A 15: 76,061,594 (GRCm39) E2781V probably damaging Het
Prr7 GCGCCGCCGCACGCGCACCCGCACCCACACCATCACGCACTGCCGCACCCACCGCCGCCGCAC GCGCCGCCGCAC 13: 55,620,147 (GRCm39) probably benign Het
Rnf32 G A 5: 29,402,948 (GRCm39) probably benign Het
Ryr2 A G 13: 11,776,213 (GRCm39) V1108A possibly damaging Het
Slc4a8 A G 15: 100,686,104 (GRCm39) H276R probably benign Het
Slco1a7 C T 6: 141,690,271 (GRCm39) V161I probably damaging Het
Spta1 T A 1: 174,032,944 (GRCm39) D1000E probably damaging Het
Sva C A 6: 42,019,598 (GRCm39) Q153K unknown Het
Tmprss11d T C 5: 86,457,365 (GRCm39) Y236C possibly damaging Het
Zfp160 T C 17: 21,247,270 (GRCm39) S607P probably damaging Het
Zfp82 C A 7: 29,756,147 (GRCm39) G312W probably damaging Het
Other mutations in H2ac15
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4576001:H2ac15 UTSW 13 21,937,781 (GRCm39) missense probably damaging 1.00
R4585:H2ac15 UTSW 13 21,937,882 (GRCm39) missense possibly damaging 0.92
R4586:H2ac15 UTSW 13 21,937,882 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TATCAAGGGCCTCACTTCCC -3'
(R):5'- ATTGGTCTAGGTGCAATGCTTC -3'

Sequencing Primer
(F):5'- TCTTCTTGGGCAGCAGC -3'
(R):5'- GGTGCAATGCTTCTATGTAACC -3'
Posted On 2019-10-24