Incidental Mutation 'R9098:Vmn2r115'
ID 691513
Institutional Source Beutler Lab
Gene Symbol Vmn2r115
Ensembl Gene ENSMUSG00000091076
Gene Name vomeronasal 2, receptor 115
Synonyms V2Rp4, EG638102
MMRRC Submission 068913-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R9098 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 23562951-23579102 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 23564803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 230 (T230K)
Ref Sequence ENSEMBL: ENSMUSP00000131447 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168175]
AlphaFold E9Q0E7
Predicted Effect probably benign
Transcript: ENSMUST00000168175
AA Change: T230K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: T230K

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 471 1.4e-28 PFAM
Pfam:NCD3G 512 565 2.9e-20 PFAM
Pfam:7tm_3 598 833 5e-55 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 97% (72/74)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 11,633,211 (GRCm39) D168V probably damaging Het
Abcb4 A T 5: 9,008,441 (GRCm39) D1203V probably damaging Het
Acat2 G A 17: 13,178,979 (GRCm39) probably benign Het
Adam3 C T 8: 25,179,484 (GRCm39) C611Y probably damaging Het
Adgrb1 A G 15: 74,415,189 (GRCm39) D638G probably damaging Het
Adra1b T C 11: 43,667,218 (GRCm39) N340D probably damaging Het
Ankrd31 A G 13: 96,916,879 (GRCm39) H131R probably damaging Het
Aoc2 T C 11: 101,217,164 (GRCm39) S416P possibly damaging Het
Armc8 G A 9: 99,387,362 (GRCm39) R419* probably null Het
Atp6v1h T G 1: 5,163,638 (GRCm39) V90G probably damaging Het
Avl9 T C 6: 56,707,628 (GRCm39) V191A probably benign Het
Bsn G A 9: 107,990,173 (GRCm39) P1860S possibly damaging Het
Btd A G 14: 31,384,233 (GRCm39) K73R probably benign Het
Cd22 T C 7: 30,567,391 (GRCm39) K731R probably benign Het
Chmp7 C A 14: 69,956,911 (GRCm39) L332F probably damaging Het
Cirop T G 14: 54,932,686 (GRCm39) S393R probably damaging Het
Cldn11 A G 3: 31,217,276 (GRCm39) E148G probably damaging Het
Cmtm1 TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG 8: 105,036,334 (GRCm39) probably null Het
Cnbd1 A T 4: 18,886,061 (GRCm39) Y319* probably null Het
Cnnm4 A G 1: 36,511,170 (GRCm39) T133A probably benign Het
Cpeb4 A T 11: 31,822,679 (GRCm39) E131V probably benign Het
Ctns A G 11: 73,078,561 (GRCm39) probably null Het
Dhx36 C A 3: 62,414,142 (GRCm39) Q73H probably benign Het
Dhx36 C A 3: 62,414,141 (GRCm39) E74* probably null Het
Dnah5 A G 15: 28,420,107 (GRCm39) T3802A Het
Fbxo31 G A 8: 122,281,136 (GRCm39) R337C probably damaging Het
Flnc C T 6: 29,455,518 (GRCm39) Q2056* probably null Het
Fmo9 T C 1: 166,492,199 (GRCm39) D408G possibly damaging Het
Gipr C T 7: 18,897,495 (GRCm39) S117N unknown Het
Gm14412 T A 2: 177,006,356 (GRCm39) H513L probably damaging Het
Gm21663 G C 5: 26,147,167 (GRCm39) C46W probably benign Het
Gucy1a2 A T 9: 3,634,489 (GRCm39) I178L probably benign Het
Htr1b A T 9: 81,514,481 (GRCm39) L42Q Het
Htr2b T C 1: 86,027,481 (GRCm39) T342A probably damaging Het
Jkampl T C 6: 73,446,517 (GRCm39) T11A probably benign Het
Jph2 C T 2: 163,181,473 (GRCm39) V564M probably damaging Het
Kcnmb1 A G 11: 33,914,806 (GRCm39) T36A probably damaging Het
Krit1 A C 5: 3,863,135 (GRCm39) K310N probably benign Het
Lama1 C T 17: 68,111,508 (GRCm39) T2253M Het
Lpar6 C T 14: 73,476,233 (GRCm39) L65F probably damaging Het
Megf6 G A 4: 154,354,160 (GRCm39) G1355R probably damaging Het
Mmp3 T A 9: 7,446,936 (GRCm39) Y39N probably damaging Het
Mrtfb A G 16: 13,221,053 (GRCm39) H743R probably benign Het
Ms4a18 C A 19: 10,990,741 (GRCm39) V118F Het
Mthfr G A 4: 148,126,082 (GRCm39) S51N probably benign Het
Muc16 T A 9: 18,554,975 (GRCm39) T3773S unknown Het
Mus81 T A 19: 5,534,032 (GRCm39) K400* probably null Het
Naaladl2 A T 3: 24,487,344 (GRCm39) D192E probably benign Het
Naip5 T C 13: 100,366,127 (GRCm39) D329G possibly damaging Het
Nek11 T A 9: 105,170,856 (GRCm39) H393L probably benign Het
Nmt2 T A 2: 3,306,315 (GRCm39) probably benign Het
Nmur2 T C 11: 55,920,408 (GRCm39) D279G possibly damaging Het
Nol4l C A 2: 153,312,630 (GRCm39) R226L probably damaging Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or10d4c A G 9: 39,558,379 (GRCm39) D119G probably damaging Het
Or1o2 T C 17: 37,542,961 (GRCm39) Y100C probably benign Het
Or5ak22 T C 2: 85,229,995 (GRCm39) N294S probably damaging Het
Palm A G 10: 79,654,988 (GRCm39) T249A probably benign Het
Pramel22 A T 4: 143,381,097 (GRCm39) Y309N probably benign Het
Rhobtb3 A G 13: 76,087,702 (GRCm39) I95T probably damaging Het
Rnpep A T 1: 135,206,559 (GRCm39) F178L possibly damaging Het
Rsl1d1 A G 16: 11,019,227 (GRCm39) S105P probably damaging Het
Rxra C T 2: 27,638,756 (GRCm39) T253I possibly damaging Het
Schip1 A G 3: 67,972,318 (GRCm39) D15G Het
Sis T A 3: 72,844,578 (GRCm39) I719F possibly damaging Het
Snx18 A G 13: 113,754,310 (GRCm39) S208P probably benign Het
Srcap T C 7: 127,151,816 (GRCm39) V2125A probably damaging Het
Stx7 C T 10: 24,058,724 (GRCm39) Q199* probably null Het
Syt6 T C 3: 103,492,895 (GRCm39) I134T probably damaging Het
Tlr12 A G 4: 128,510,870 (GRCm39) M460T probably benign Het
Tnni3k T C 3: 154,647,314 (GRCm39) T398A possibly damaging Het
Tspan4 T C 7: 141,071,816 (GRCm39) S188P probably benign Het
Ubap2l A G 3: 89,909,756 (GRCm39) S1025P unknown Het
Ubl7 A G 9: 57,829,035 (GRCm39) D219G probably benign Het
Vmn2r95 T A 17: 18,660,167 (GRCm39) M193K possibly damaging Het
Zfp639 A G 3: 32,573,885 (GRCm39) E170G probably damaging Het
Zfy1 A G Y: 725,987 (GRCm39) S593P possibly damaging Het
Zscan4-ps1 T A 7: 10,799,495 (GRCm39) T465S probably damaging Het
Other mutations in Vmn2r115
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r115 APN 17 23,575,934 (GRCm39) missense probably benign 0.00
IGL00990:Vmn2r115 APN 17 23,565,345 (GRCm39) nonsense probably null
IGL00990:Vmn2r115 APN 17 23,578,371 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,565,135 (GRCm39) missense probably benign 0.03
IGL00990:Vmn2r115 APN 17 23,565,252 (GRCm39) missense probably benign 0.14
IGL00990:Vmn2r115 APN 17 23,565,313 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,578,323 (GRCm39) missense probably benign 0.22
IGL00990:Vmn2r115 APN 17 23,565,150 (GRCm39) missense probably benign 0.00
IGL00990:Vmn2r115 APN 17 23,565,180 (GRCm39) missense possibly damaging 0.90
IGL00990:Vmn2r115 APN 17 23,567,008 (GRCm39) nonsense probably null
IGL00990:Vmn2r115 APN 17 23,578,798 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,578,753 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,565,238 (GRCm39) missense probably benign 0.19
IGL00990:Vmn2r115 APN 17 23,565,346 (GRCm39) missense probably benign 0.30
IGL01073:Vmn2r115 APN 17 23,564,971 (GRCm39) missense probably benign 0.12
IGL01101:Vmn2r115 APN 17 23,564,971 (GRCm39) missense probably benign 0.12
IGL01300:Vmn2r115 APN 17 23,578,755 (GRCm39) missense probably damaging 1.00
IGL01415:Vmn2r115 APN 17 23,578,755 (GRCm39) missense probably damaging 1.00
IGL02309:Vmn2r115 APN 17 23,564,113 (GRCm39) missense probably benign 0.01
IGL02863:Vmn2r115 APN 17 23,578,257 (GRCm39) missense probably damaging 0.97
R0023:Vmn2r115 UTSW 17 23,565,252 (GRCm39) missense probably benign 0.14
R0197:Vmn2r115 UTSW 17 23,578,755 (GRCm39) missense probably damaging 1.00
R0361:Vmn2r115 UTSW 17 23,564,196 (GRCm39) missense probably benign 0.11
R0601:Vmn2r115 UTSW 17 23,579,074 (GRCm39) missense probably null 0.51
R0676:Vmn2r115 UTSW 17 23,565,238 (GRCm39) missense probably benign 0.19
R0685:Vmn2r115 UTSW 17 23,578,249 (GRCm39) missense probably benign
R0865:Vmn2r115 UTSW 17 23,565,382 (GRCm39) missense possibly damaging 0.65
R1124:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1145:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1146:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1207:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1266:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1318:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1367:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1376:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1376:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1420:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1469:Vmn2r115 UTSW 17 23,564,992 (GRCm39) missense probably damaging 0.99
R1469:Vmn2r115 UTSW 17 23,564,992 (GRCm39) missense probably damaging 0.99
R1604:Vmn2r115 UTSW 17 23,564,245 (GRCm39) missense probably benign 0.12
R1645:Vmn2r115 UTSW 17 23,565,192 (GRCm39) missense possibly damaging 0.69
R1646:Vmn2r115 UTSW 17 23,578,513 (GRCm39) missense probably damaging 1.00
R1650:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1678:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1716:Vmn2r115 UTSW 17 23,566,795 (GRCm39) missense probably benign
R1846:Vmn2r115 UTSW 17 23,578,357 (GRCm39) missense probably damaging 1.00
R1847:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1885:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1887:Vmn2r115 UTSW 17 23,565,007 (GRCm39) missense possibly damaging 0.91
R1937:Vmn2r115 UTSW 17 23,578,388 (GRCm39) missense probably damaging 1.00
R2007:Vmn2r115 UTSW 17 23,566,927 (GRCm39) missense possibly damaging 0.94
R2120:Vmn2r115 UTSW 17 23,578,297 (GRCm39) missense probably damaging 1.00
R3161:Vmn2r115 UTSW 17 23,575,998 (GRCm39) missense possibly damaging 0.82
R3780:Vmn2r115 UTSW 17 23,564,146 (GRCm39) missense probably damaging 1.00
R3806:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R3982:Vmn2r115 UTSW 17 23,578,948 (GRCm39) missense probably damaging 1.00
R4019:Vmn2r115 UTSW 17 23,579,017 (GRCm39) missense probably damaging 1.00
R4039:Vmn2r115 UTSW 17 23,564,077 (GRCm39) missense probably benign 0.26
R4087:Vmn2r115 UTSW 17 23,565,358 (GRCm39) missense probably benign 0.35
R4089:Vmn2r115 UTSW 17 23,565,358 (GRCm39) missense probably benign 0.35
R4379:Vmn2r115 UTSW 17 23,564,197 (GRCm39) missense possibly damaging 0.95
R4417:Vmn2r115 UTSW 17 23,564,854 (GRCm39) missense probably benign 0.02
R4601:Vmn2r115 UTSW 17 23,565,373 (GRCm39) missense probably benign 0.01
R4874:Vmn2r115 UTSW 17 23,578,825 (GRCm39) missense probably damaging 1.00
R5466:Vmn2r115 UTSW 17 23,579,030 (GRCm39) missense probably damaging 1.00
R5613:Vmn2r115 UTSW 17 23,564,307 (GRCm39) missense probably benign
R5821:Vmn2r115 UTSW 17 23,566,937 (GRCm39) missense probably damaging 0.99
R6120:Vmn2r115 UTSW 17 23,565,003 (GRCm39) missense probably damaging 1.00
R6193:Vmn2r115 UTSW 17 23,575,983 (GRCm39) missense probably benign 0.01
R6213:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R6290:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R6319:Vmn2r115 UTSW 17 23,566,877 (GRCm39) missense possibly damaging 0.70
R6495:Vmn2r115 UTSW 17 23,578,572 (GRCm39) missense probably benign 0.02
R6599:Vmn2r115 UTSW 17 23,565,006 (GRCm39) missense probably benign 0.00
R6764:Vmn2r115 UTSW 17 23,565,046 (GRCm39) missense probably damaging 1.00
R6970:Vmn2r115 UTSW 17 23,564,989 (GRCm39) missense probably benign 0.23
R7023:Vmn2r115 UTSW 17 23,578,785 (GRCm39) missense probably damaging 1.00
R7236:Vmn2r115 UTSW 17 23,578,576 (GRCm39) missense probably benign 0.01
R7353:Vmn2r115 UTSW 17 23,564,887 (GRCm39) missense possibly damaging 0.65
R7483:Vmn2r115 UTSW 17 23,565,371 (GRCm39) missense possibly damaging 0.95
R7743:Vmn2r115 UTSW 17 23,564,772 (GRCm39) nonsense probably null
R8005:Vmn2r115 UTSW 17 23,563,124 (GRCm39) nonsense probably null
R8191:Vmn2r115 UTSW 17 23,578,530 (GRCm39) missense probably damaging 1.00
R8544:Vmn2r115 UTSW 17 23,564,773 (GRCm39) missense possibly damaging 0.88
R8890:Vmn2r115 UTSW 17 23,578,497 (GRCm39) missense probably damaging 0.98
R9114:Vmn2r115 UTSW 17 23,564,307 (GRCm39) missense probably benign
R9189:Vmn2r115 UTSW 17 23,564,784 (GRCm39) missense probably damaging 1.00
R9351:Vmn2r115 UTSW 17 23,578,482 (GRCm39) missense probably benign 0.05
R9397:Vmn2r115 UTSW 17 23,564,152 (GRCm39) nonsense probably null
R9410:Vmn2r115 UTSW 17 23,578,915 (GRCm39) missense possibly damaging 0.67
R9593:Vmn2r115 UTSW 17 23,578,184 (GRCm39) missense probably damaging 0.99
V5622:Vmn2r115 UTSW 17 23,578,333 (GRCm39) missense probably benign
V5622:Vmn2r115 UTSW 17 23,565,201 (GRCm39) missense probably damaging 1.00
X0023:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
X0033:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- TCATCCTGTCCTGAGTGATCATG -3'
(R):5'- ACTGACATTCCACTGTGAGG -3'

Sequencing Primer
(F):5'- CCTGAGTGATCATGAAAAATTTCCC -3'
(R):5'- ACATTCCACTGTGAGGTAGTGATCC -3'
Posted On 2021-12-30