Incidental Mutation 'R8544:Vmn2r115'
| ID |
659562 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r115
|
| Ensembl Gene |
ENSMUSG00000091076 |
| Gene Name |
vomeronasal 2, receptor 115 |
| Synonyms |
V2Rp4, EG638102 |
| MMRRC Submission |
068509-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.084)
|
| Stock # |
R8544 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
23562951-23579102 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 23564773 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Proline
at position 220
(Q220P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168175]
|
| AlphaFold |
E9Q0E7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168175
AA Change: Q220P
PolyPhen 2
Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: Q220P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
471 |
1.4e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
2.9e-20 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
5e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.1712 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
97% (74/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
C |
A |
15: 37,425,979 (GRCm39) |
|
probably benign |
Het |
| Abcb5 |
A |
T |
12: 118,832,461 (GRCm39) |
L1171H |
probably damaging |
Het |
| Ace |
A |
T |
11: 105,862,116 (GRCm39) |
|
probably null |
Het |
| Adsl |
G |
T |
15: 80,832,734 (GRCm39) |
|
probably benign |
Het |
| Cabin1 |
A |
G |
10: 75,585,890 (GRCm39) |
M215T |
probably benign |
Het |
| Cabp2 |
A |
T |
19: 4,134,892 (GRCm39) |
R77S |
probably damaging |
Het |
| Cast |
A |
T |
13: 74,882,177 (GRCm39) |
H40Q |
possibly damaging |
Het |
| Ccar1 |
A |
T |
10: 62,586,358 (GRCm39) |
Y946N |
unknown |
Het |
| Ccdc9b |
C |
T |
2: 118,587,702 (GRCm39) |
R544K |
unknown |
Het |
| Chst14 |
A |
G |
2: 118,758,010 (GRCm39) |
Y268C |
probably damaging |
Het |
| Dennd1a |
T |
C |
2: 37,872,920 (GRCm39) |
|
probably null |
Het |
| Dnah1 |
A |
G |
14: 30,990,861 (GRCm39) |
Y3153H |
probably damaging |
Het |
| Entpd8 |
T |
C |
2: 24,973,856 (GRCm39) |
V271A |
probably benign |
Het |
| Eppk1 |
C |
T |
15: 75,994,319 (GRCm39) |
R854Q |
probably benign |
Het |
| Fam234b |
A |
G |
6: 135,210,287 (GRCm39) |
Y561C |
probably damaging |
Het |
| Flg |
A |
G |
3: 93,195,448 (GRCm39) |
|
probably benign |
Het |
| Galnt5 |
T |
A |
2: 57,907,160 (GRCm39) |
M541K |
probably damaging |
Het |
| Gjd3 |
C |
A |
11: 98,873,488 (GRCm39) |
E119* |
probably null |
Het |
| Gm266 |
T |
C |
12: 111,451,799 (GRCm39) |
T136A |
possibly damaging |
Het |
| Gng11 |
G |
A |
6: 4,008,045 (GRCm39) |
C36Y |
possibly damaging |
Het |
| Gse1 |
G |
A |
8: 121,280,391 (GRCm39) |
V36I |
probably damaging |
Het |
| Hycc2 |
T |
C |
1: 58,568,981 (GRCm39) |
T477A |
probably benign |
Het |
| Invs |
A |
T |
4: 48,397,598 (GRCm39) |
H335L |
probably damaging |
Het |
| Kcnc2 |
A |
T |
10: 112,292,101 (GRCm39) |
I28F |
probably damaging |
Het |
| Klhl40 |
C |
T |
9: 121,607,892 (GRCm39) |
H351Y |
probably damaging |
Het |
| Kremen2 |
A |
G |
17: 23,961,201 (GRCm39) |
L382P |
probably benign |
Het |
| Lenep |
A |
T |
3: 89,309,784 (GRCm39) |
C55S |
possibly damaging |
Het |
| Lrp12 |
A |
T |
15: 39,741,970 (GRCm39) |
Y248* |
probably null |
Het |
| Man2c1 |
A |
G |
9: 57,038,325 (GRCm39) |
|
probably null |
Het |
| Map2k2 |
T |
C |
10: 80,955,376 (GRCm39) |
M32T |
possibly damaging |
Het |
| Mnt |
A |
G |
11: 74,722,218 (GRCm39) |
R22G |
probably damaging |
Het |
| Mroh1 |
G |
T |
15: 76,327,558 (GRCm39) |
E1127* |
probably null |
Het |
| Mtmr4 |
A |
G |
11: 87,502,735 (GRCm39) |
R930G |
possibly damaging |
Het |
| Nalcn |
A |
G |
14: 123,608,935 (GRCm39) |
V644A |
probably benign |
Het |
| Ngf |
G |
T |
3: 102,427,991 (GRCm39) |
V247F |
probably damaging |
Het |
| Ninj2 |
A |
G |
6: 120,175,018 (GRCm39) |
Y63C |
probably damaging |
Het |
| Or4c121 |
T |
C |
2: 89,024,312 (GRCm39) |
E22G |
possibly damaging |
Het |
| Or51g2 |
A |
T |
7: 102,622,938 (GRCm39) |
I87N |
probably damaging |
Het |
| Phf12 |
A |
C |
11: 77,918,235 (GRCm39) |
I816L |
probably damaging |
Het |
| Pkhd1 |
C |
A |
1: 20,593,199 (GRCm39) |
G1638V |
probably damaging |
Het |
| Plce1 |
T |
A |
19: 38,512,903 (GRCm39) |
S67R |
probably benign |
Het |
| Plekhf1 |
A |
G |
7: 37,920,768 (GRCm39) |
F267L |
probably damaging |
Het |
| Poc1b |
A |
T |
10: 98,960,770 (GRCm39) |
K60* |
probably null |
Het |
| Ppic |
G |
A |
18: 53,544,612 (GRCm39) |
T66M |
probably damaging |
Het |
| Prep |
G |
T |
10: 45,029,223 (GRCm39) |
G541V |
probably damaging |
Het |
| Rasal3 |
C |
T |
17: 32,611,093 (GRCm39) |
V947I |
probably benign |
Het |
| Rbl1 |
T |
C |
2: 157,035,124 (GRCm39) |
R319G |
probably damaging |
Het |
| Rbm34 |
A |
G |
8: 127,696,821 (GRCm39) |
S94P |
probably benign |
Het |
| Repin1 |
G |
T |
6: 48,574,279 (GRCm39) |
E403* |
probably null |
Het |
| Sacm1l |
T |
C |
9: 123,406,123 (GRCm39) |
|
probably null |
Het |
| Scaf8 |
T |
C |
17: 3,213,295 (GRCm39) |
|
probably benign |
Het |
| Scrn1 |
T |
A |
6: 54,499,841 (GRCm39) |
T215S |
probably benign |
Het |
| Sfrp4 |
A |
G |
13: 19,816,336 (GRCm39) |
|
probably null |
Het |
| Slc37a3 |
T |
C |
6: 39,321,297 (GRCm39) |
I406V |
possibly damaging |
Het |
| Sorbs1 |
G |
C |
19: 40,365,244 (GRCm39) |
R180G |
probably benign |
Het |
| Sptbn1 |
C |
A |
11: 30,169,750 (GRCm39) |
|
probably benign |
Het |
| St8sia5 |
T |
C |
18: 77,342,114 (GRCm39) |
Y275H |
probably damaging |
Het |
| Stab1 |
A |
T |
14: 30,885,008 (GRCm39) |
C137* |
probably null |
Het |
| Svep1 |
A |
G |
4: 58,206,025 (GRCm39) |
S118P |
probably benign |
Het |
| Tbx6 |
A |
G |
7: 126,380,656 (GRCm39) |
|
probably null |
Het |
| Tril |
C |
T |
6: 53,796,295 (GRCm39) |
S309N |
possibly damaging |
Het |
| Trmt13 |
A |
G |
3: 116,386,094 (GRCm39) |
|
probably null |
Het |
| Trpm1 |
T |
A |
7: 63,874,356 (GRCm39) |
|
probably null |
Het |
| Tyr |
T |
C |
7: 87,142,000 (GRCm39) |
T110A |
probably benign |
Het |
| Upf1 |
A |
C |
8: 70,789,702 (GRCm39) |
F711C |
probably damaging |
Het |
| Usp5 |
A |
T |
6: 124,800,480 (GRCm39) |
V267D |
probably damaging |
Het |
| Virma |
C |
A |
4: 11,516,949 (GRCm39) |
D714E |
probably benign |
Het |
| Vmn2r40 |
T |
C |
7: 8,911,191 (GRCm39) |
I701V |
|
Het |
| Vwde |
T |
A |
6: 13,187,652 (GRCm39) |
M612L |
probably benign |
Het |
| Wwox |
A |
G |
8: 115,215,646 (GRCm39) |
T140A |
probably benign |
Het |
| Zbtb17 |
CCCCCACCTCCACAGACCCCA |
CCCCCACCTCCACAGACCCCACCTCCACAGACCCCA |
4: 141,194,139 (GRCm39) |
|
probably benign |
Het |
| Zbtb9 |
T |
A |
17: 27,193,448 (GRCm39) |
C284* |
probably null |
Het |
| Zdhhc12 |
C |
A |
2: 29,983,486 (GRCm39) |
A39S |
probably benign |
Het |
| Zfp532 |
T |
A |
18: 65,758,227 (GRCm39) |
I720K |
possibly damaging |
Het |
| Zfp595 |
G |
A |
13: 67,465,244 (GRCm39) |
R340C |
probably damaging |
Het |
|
| Other mutations in Vmn2r115 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Vmn2r115
|
APN |
17 |
23,575,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,345 (GRCm39) |
nonsense |
probably null |
|
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,135 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,252 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,323 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,180 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,567,008 (GRCm39) |
nonsense |
probably null |
|
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,346 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01073:Vmn2r115
|
APN |
17 |
23,564,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01101:Vmn2r115
|
APN |
17 |
23,564,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01300:Vmn2r115
|
APN |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01415:Vmn2r115
|
APN |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Vmn2r115
|
APN |
17 |
23,564,113 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02863:Vmn2r115
|
APN |
17 |
23,578,257 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0023:Vmn2r115
|
UTSW |
17 |
23,565,252 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0197:Vmn2r115
|
UTSW |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0361:Vmn2r115
|
UTSW |
17 |
23,564,196 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0601:Vmn2r115
|
UTSW |
17 |
23,579,074 (GRCm39) |
missense |
probably null |
0.51 |
|
R0676:Vmn2r115
|
UTSW |
17 |
23,565,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0685:Vmn2r115
|
UTSW |
17 |
23,578,249 (GRCm39) |
missense |
probably benign |
|
|
R0865:Vmn2r115
|
UTSW |
17 |
23,565,382 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1124:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1145:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1146:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1207:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1266:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1318:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1367:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1376:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1376:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1420:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1469:Vmn2r115
|
UTSW |
17 |
23,564,992 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Vmn2r115
|
UTSW |
17 |
23,564,992 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1604:Vmn2r115
|
UTSW |
17 |
23,564,245 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1645:Vmn2r115
|
UTSW |
17 |
23,565,192 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1646:Vmn2r115
|
UTSW |
17 |
23,578,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1650:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1678:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1716:Vmn2r115
|
UTSW |
17 |
23,566,795 (GRCm39) |
missense |
probably benign |
|
|
R1846:Vmn2r115
|
UTSW |
17 |
23,578,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1847:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1885:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1887:Vmn2r115
|
UTSW |
17 |
23,565,007 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1937:Vmn2r115
|
UTSW |
17 |
23,578,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2007:Vmn2r115
|
UTSW |
17 |
23,566,927 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2120:Vmn2r115
|
UTSW |
17 |
23,578,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3161:Vmn2r115
|
UTSW |
17 |
23,575,998 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3780:Vmn2r115
|
UTSW |
17 |
23,564,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3806:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R3982:Vmn2r115
|
UTSW |
17 |
23,578,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r115
|
UTSW |
17 |
23,579,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4039:Vmn2r115
|
UTSW |
17 |
23,564,077 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4087:Vmn2r115
|
UTSW |
17 |
23,565,358 (GRCm39) |
missense |
probably benign |
0.35 |
|
R4089:Vmn2r115
|
UTSW |
17 |
23,565,358 (GRCm39) |
missense |
probably benign |
0.35 |
|
R4379:Vmn2r115
|
UTSW |
17 |
23,564,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4417:Vmn2r115
|
UTSW |
17 |
23,564,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4601:Vmn2r115
|
UTSW |
17 |
23,565,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4874:Vmn2r115
|
UTSW |
17 |
23,578,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5466:Vmn2r115
|
UTSW |
17 |
23,579,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5613:Vmn2r115
|
UTSW |
17 |
23,564,307 (GRCm39) |
missense |
probably benign |
|
|
R5821:Vmn2r115
|
UTSW |
17 |
23,566,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6120:Vmn2r115
|
UTSW |
17 |
23,565,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6193:Vmn2r115
|
UTSW |
17 |
23,575,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6213:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R6290:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R6319:Vmn2r115
|
UTSW |
17 |
23,566,877 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6495:Vmn2r115
|
UTSW |
17 |
23,578,572 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6599:Vmn2r115
|
UTSW |
17 |
23,565,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6764:Vmn2r115
|
UTSW |
17 |
23,565,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6970:Vmn2r115
|
UTSW |
17 |
23,564,989 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7023:Vmn2r115
|
UTSW |
17 |
23,578,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7236:Vmn2r115
|
UTSW |
17 |
23,578,576 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7353:Vmn2r115
|
UTSW |
17 |
23,564,887 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7483:Vmn2r115
|
UTSW |
17 |
23,565,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7743:Vmn2r115
|
UTSW |
17 |
23,564,772 (GRCm39) |
nonsense |
probably null |
|
|
R8005:Vmn2r115
|
UTSW |
17 |
23,563,124 (GRCm39) |
nonsense |
probably null |
|
|
R8191:Vmn2r115
|
UTSW |
17 |
23,578,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8890:Vmn2r115
|
UTSW |
17 |
23,578,497 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9098:Vmn2r115
|
UTSW |
17 |
23,564,803 (GRCm39) |
missense |
probably benign |
|
|
R9114:Vmn2r115
|
UTSW |
17 |
23,564,307 (GRCm39) |
missense |
probably benign |
|
|
R9189:Vmn2r115
|
UTSW |
17 |
23,564,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9351:Vmn2r115
|
UTSW |
17 |
23,578,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9397:Vmn2r115
|
UTSW |
17 |
23,564,152 (GRCm39) |
nonsense |
probably null |
|
|
R9410:Vmn2r115
|
UTSW |
17 |
23,578,915 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9593:Vmn2r115
|
UTSW |
17 |
23,578,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
V5622:Vmn2r115
|
UTSW |
17 |
23,578,333 (GRCm39) |
missense |
probably benign |
|
|
V5622:Vmn2r115
|
UTSW |
17 |
23,565,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
X0033:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGAATTCATTGTACCTTGTGCTGG -3'
(R):5'- ACCAGGACTGACATTCCACTG -3'
Sequencing Primer
(F):5'- ACCTTGTGCTGGTTCCTGATTTCTAG -3'
(R):5'- ACTGACATTCCACTGTGAGG -3'
|
| Posted On |
2021-01-18 |
Incidental Mutation