Incidental Mutation 'R9364:Olfr169'
ID 708869
Institutional Source Beutler Lab
Gene Symbol Olfr169
Ensembl Gene ENSMUSG00000068535
Gene Name olfactory receptor 169
Synonyms GA_x54KRFPKG5P-16014972-16014031, MOR273-3P
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R9364 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 19564889-19571809 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19565972 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 304 (I304F)
Ref Sequence ENSEMBL: ENSMUSP00000149087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090062] [ENSMUST00000215040] [ENSMUST00000215476] [ENSMUST00000216070]
AlphaFold Q7TS53
Predicted Effect possibly damaging
Transcript: ENSMUST00000090062
AA Change: I304F

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000087516
Gene: ENSMUSG00000068535
AA Change: I304F

DomainStartEndE-ValueType
Pfam:7tm_4 28 308 1.3e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 303 2e-6 PFAM
Pfam:7tm_1 41 290 7.4e-29 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215040
AA Change: I304F

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215476
AA Change: I304F

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216070
AA Change: I304F

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 29,247,623 probably benign Het
Ankrd17 C T 5: 90,268,649 R1108Q probably damaging Het
Ccdc136 C T 6: 29,405,961 A102V probably damaging Het
Ccnyl1 A G 1: 64,714,591 Y187C probably damaging Het
Copa G A 1: 172,117,264 V882I probably benign Het
Cyp17a1 C T 19: 46,668,726 R361H probably damaging Het
Ddx49 T C 8: 70,293,576 T459A probably benign Het
Depdc5 A G 5: 32,964,732 N1133S probably benign Het
Dnajc18 T C 18: 35,675,207 D329G probably damaging Het
Dusp16 G A 6: 134,719,019 P283L probably damaging Het
Efcab12 A G 6: 115,838,014 V40A probably benign Het
Emb G T 13: 117,220,560 probably benign Het
Fam120b G A 17: 15,405,758 A458T possibly damaging Het
Fgd4 G A 16: 16,490,489 T9I probably benign Het
Hivep1 G A 13: 42,154,775 D164N possibly damaging Het
Klf13 T A 7: 63,924,861 probably benign Het
Lrrc47 T C 4: 154,015,941 S325P possibly damaging Het
Mast3 C T 8: 70,786,182 V493M probably damaging Het
Med22 T C 2: 26,905,809 T200A probably benign Het
Mettl15 T A 2: 109,131,615 Q216H probably benign Het
Mmel1 A G 4: 154,892,510 D561G probably null Het
Ms4a4a G A 19: 11,390,344 M191I probably benign Het
Myh11 T A 16: 14,200,716 N1922I Het
Myo7b T C 18: 32,000,360 I371V probably benign Het
Myo9b T C 8: 71,355,839 S1697P probably damaging Het
Neurod4 T C 10: 130,270,971 T145A probably benign Het
Nfx1 T C 4: 41,023,756 V1055A probably benign Het
Ntng1 C T 3: 110,135,364 A49T probably damaging Het
Oc90 G A 15: 65,889,588 P194S probably benign Het
Olfr1087 A T 2: 86,690,231 V248D possibly damaging Het
Olfr1375 T A 11: 51,048,396 Y96* probably null Het
Olfr446 T A 6: 42,927,600 I123N probably damaging Het
Opcml A C 9: 28,903,328 N292T probably damaging Het
Oplah A G 15: 76,309,587 S57P probably benign Het
Pdzd8 A T 19: 59,345,142 L149Q probably damaging Het
Pid1 A G 1: 84,159,311 V33A probably benign Het
Prpsap1 A G 11: 116,494,189 probably benign Het
R3hdml T C 2: 163,492,615 W42R probably benign Het
Rnase6 A T 14: 51,130,405 N85Y possibly damaging Het
Scn3a T A 2: 65,461,252 M1717L possibly damaging Het
Setbp1 C T 18: 78,783,384 S1338N probably benign Het
Sh2b2 T C 5: 136,224,152 T389A probably benign Het
Sh2d4a G A 8: 68,294,366 G82D probably damaging Het
Skint9 A T 4: 112,391,718 M171K probably benign Het
Slc5a11 C T 7: 123,269,101 R505W probably damaging Het
Slx4 C A 16: 3,987,956 M577I probably benign Het
Soga3 G A 10: 29,196,779 R689Q probably damaging Het
Tarbp1 C T 8: 126,450,723 V737I probably benign Het
Tm7sf3 C T 6: 146,623,681 D89N possibly damaging Het
Tmem100 A T 11: 90,035,707 E120V probably damaging Het
Trim72 C T 7: 128,010,001 T325M possibly damaging Het
Trpc2 G A 7: 102,090,612 G581D possibly damaging Het
Tyw1 G A 5: 130,269,224 R202Q probably damaging Het
Ubn1 T C 16: 5,070,628 S154P unknown Het
Uchl1 T A 5: 66,676,306 M6K probably damaging Het
Vmn1r193 A T 13: 22,219,819 M1K probably null Het
Wisp1 G A 15: 66,913,051 R191K probably benign Het
Zfp429 T A 13: 67,390,412 K304N probably benign Het
Zfp618 A G 4: 63,118,587 N375D probably damaging Het
Zfp7 TGCGGGAAAGGTTTCCACCTGAGCG TGCG 15: 76,890,600 probably benign Het
Zfp78 A T 7: 6,379,355 D468V probably benign Het
Zfp809 A C 9: 22,239,098 Y297S probably damaging Het
Other mutations in Olfr169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01080:Olfr169 APN 16 19566208 missense probably damaging 1.00
IGL01862:Olfr169 APN 16 19566676 missense probably damaging 1.00
IGL02064:Olfr169 APN 16 19566548 missense probably damaging 1.00
IGL03061:Olfr169 APN 16 19566713 missense possibly damaging 0.87
IGL03136:Olfr169 APN 16 19566353 missense probably damaging 1.00
R0066:Olfr169 UTSW 16 19566049 missense probably damaging 1.00
R0243:Olfr169 UTSW 16 19566294 missense probably damaging 0.97
R0629:Olfr169 UTSW 16 19565980 missense possibly damaging 0.88
R1644:Olfr169 UTSW 16 19566406 missense probably benign 0.11
R1943:Olfr169 UTSW 16 19566437 missense probably benign 0.19
R3016:Olfr169 UTSW 16 19566391 missense probably damaging 1.00
R4290:Olfr169 UTSW 16 19566244 missense possibly damaging 0.88
R4689:Olfr169 UTSW 16 19566513 nonsense probably null
R4791:Olfr169 UTSW 16 19566663 missense possibly damaging 0.50
R5497:Olfr169 UTSW 16 19566330 missense probably benign 0.10
R5843:Olfr169 UTSW 16 19566583 missense probably damaging 1.00
R6106:Olfr169 UTSW 16 19566259 missense probably damaging 0.99
R6249:Olfr169 UTSW 16 19565975 missense probably damaging 0.99
R7895:Olfr169 UTSW 16 19566722 nonsense probably null
R9284:Olfr169 UTSW 16 19566607 missense probably damaging 1.00
R9335:Olfr169 UTSW 16 19566763 missense probably benign 0.32
R9404:Olfr169 UTSW 16 19565981 missense probably benign 0.01
R9475:Olfr169 UTSW 16 19566520 missense probably benign 0.09
R9554:Olfr169 UTSW 16 19565972 missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- ATTGCCTTACTACAGCATAGCAAG -3'
(R):5'- CCCGGCAAAAGTCCTTTTCC -3'

Sequencing Primer
(F):5'- GCAAGACTTTACCATGGGCATCTG -3'
(R):5'- GGCAAAAGTCCTTTTCCACCTG -3'
Posted On 2022-04-18