Incidental Mutation 'R9481:Vsig10l'
| ID |
716245 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vsig10l
|
| Ensembl Gene |
ENSMUSG00000070604 |
| Gene Name |
V-set and immunoglobulin domain containing 10 like |
| Synonyms |
2210412E05Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.204)
|
| Stock # |
R9481 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
43112575-43121443 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to T
at 43112795 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Stop codon
at position 18
(E18*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103611
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000107977]
[ENSMUST00000203042]
[ENSMUST00000203633]
[ENSMUST00000203769]
[ENSMUST00000204680]
|
| AlphaFold |
D3YZF7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000107977
AA Change: E18*
|
| SMART Domains |
Protein: ENSMUSP00000103611
Gene: ENSMUSG00000070604
AA Change: E18*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
28 |
52 |
N/A |
INTRINSIC |
|
IG
|
183 |
285 |
1.92e0 |
SMART |
|
IG
|
298 |
383 |
2.15e-3 |
SMART |
|
IGc2
|
406 |
465 |
4.19e-6 |
SMART |
|
Blast:IG_like
|
582 |
649 |
1e-13 |
BLAST |
|
transmembrane domain
|
764 |
786 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203042
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203633
|
| SMART Domains |
Protein: ENSMUSP00000145061
Gene: ENSMUSG00000107482
| Domain | Start | End | E-Value | Type |
|---|
|
ETF
|
26 |
216 |
2.7e-65 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203769
|
| SMART Domains |
Protein: ENSMUSP00000144692
Gene: ENSMUSG00000070604
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
81 |
183 |
8.1e-3 |
SMART |
|
IG
|
196 |
281 |
9.2e-6 |
SMART |
|
IGc2
|
304 |
363 |
1.8e-8 |
SMART |
|
Blast:IG_like
|
480 |
547 |
9e-14 |
BLAST |
|
transmembrane domain
|
662 |
684 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204680
|
| SMART Domains |
Protein: ENSMUSP00000145493
Gene: ENSMUSG00000107482
| Domain | Start | End | E-Value | Type |
|---|
|
ETF
|
26 |
168 |
2.4e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb9 |
T |
C |
5: 124,228,176 (GRCm39) |
T22A |
possibly damaging |
Het |
| Acsf2 |
C |
T |
11: 94,464,044 (GRCm39) |
V47M |
probably benign |
Het |
| Ahcyl1 |
A |
T |
3: 107,579,388 (GRCm39) |
C215* |
probably null |
Het |
| Ambn |
G |
T |
5: 88,613,050 (GRCm39) |
|
probably null |
Het |
| Apol9b |
G |
T |
15: 77,619,656 (GRCm39) |
V151L |
probably benign |
Het |
| Arid1b |
A |
G |
17: 5,369,007 (GRCm39) |
Y1070C |
probably damaging |
Het |
| Arnt |
T |
C |
3: 95,391,092 (GRCm39) |
L322P |
possibly damaging |
Het |
| Bdnf |
A |
G |
2: 109,553,935 (GRCm39) |
D103G |
possibly damaging |
Het |
| Ccdc9 |
A |
T |
7: 16,016,761 (GRCm39) |
D42E |
probably damaging |
Het |
| Cdh13 |
A |
G |
8: 119,963,676 (GRCm39) |
T419A |
|
Het |
| Chst13 |
G |
A |
6: 90,286,506 (GRCm39) |
P152L |
probably damaging |
Het |
| Clasp2 |
A |
T |
9: 113,670,669 (GRCm39) |
R329W |
probably damaging |
Het |
| Csmd3 |
A |
G |
15: 47,470,459 (GRCm39) |
C2495R |
|
Het |
| Cyba |
A |
T |
8: 123,154,394 (GRCm39) |
I43N |
possibly damaging |
Het |
| Cyp2a5 |
A |
C |
7: 26,540,511 (GRCm39) |
T375P |
possibly damaging |
Het |
| Cyp2r1 |
A |
G |
7: 114,152,369 (GRCm39) |
F196S |
probably damaging |
Het |
| Efcab2 |
T |
C |
1: 178,308,887 (GRCm39) |
F130S |
probably damaging |
Het |
| Eml6 |
T |
G |
11: 29,788,641 (GRCm39) |
|
probably null |
Het |
| Fbln5 |
A |
T |
12: 101,734,728 (GRCm39) |
C181* |
probably null |
Het |
| Glyatl3 |
A |
G |
17: 41,221,016 (GRCm39) |
V117A |
probably benign |
Het |
| Gpc6 |
A |
G |
14: 117,163,432 (GRCm39) |
S29G |
probably benign |
Het |
| Hadhb |
T |
G |
5: 30,368,711 (GRCm39) |
S13A |
probably benign |
Het |
| Hook1 |
C |
T |
4: 95,901,505 (GRCm39) |
R488C |
probably damaging |
Het |
| Icam5 |
A |
G |
9: 20,948,877 (GRCm39) |
Y743C |
probably damaging |
Het |
| Il15ra |
T |
C |
2: 11,724,854 (GRCm39) |
V108A |
probably benign |
Het |
| Itga1 |
T |
C |
13: 115,152,753 (GRCm39) |
N223S |
probably benign |
Het |
| Kat6b |
AGAGGAGGAGGAGGAGGAGGA |
AGAGGAGGAGGAGGAGGA |
14: 21,712,417 (GRCm39) |
|
probably benign |
Het |
| Kcnk1 |
T |
C |
8: 126,756,281 (GRCm39) |
C268R |
probably damaging |
Het |
| Kctd19 |
A |
T |
8: 106,120,249 (GRCm39) |
L264M |
probably benign |
Het |
| Kmt2c |
A |
T |
5: 25,554,860 (GRCm39) |
I1258K |
probably benign |
Het |
| Kmt2c |
A |
T |
5: 25,497,907 (GRCm39) |
D3949E |
probably damaging |
Het |
| Lyst |
G |
A |
13: 13,857,653 (GRCm39) |
E2481K |
possibly damaging |
Het |
| Megf10 |
T |
A |
18: 57,395,090 (GRCm39) |
I484N |
probably benign |
Het |
| Mettl21e |
T |
C |
1: 44,245,857 (GRCm39) |
I130V |
probably benign |
Het |
| Nmnat2 |
C |
A |
1: 152,962,181 (GRCm39) |
N140K |
possibly damaging |
Het |
| Nsmaf |
T |
C |
4: 6,414,976 (GRCm39) |
K630R |
probably benign |
Het |
| Or2t1 |
C |
T |
14: 14,328,756 (GRCm38) |
S215L |
probably benign |
Het |
| Or5w15 |
A |
T |
2: 87,568,576 (GRCm39) |
F31I |
probably benign |
Het |
| Or8b38 |
G |
T |
9: 37,972,707 (GRCm39) |
L30F |
probably benign |
Het |
| Or8g26 |
T |
C |
9: 39,096,172 (GRCm39) |
S230P |
possibly damaging |
Het |
| Pafah1b2 |
G |
A |
9: 45,884,284 (GRCm39) |
Q123* |
probably null |
Het |
| Ptprb |
T |
A |
10: 116,155,353 (GRCm39) |
N415K |
probably benign |
Het |
| Rev3l |
T |
A |
10: 39,701,033 (GRCm39) |
D1843E |
probably benign |
Het |
| Rps6ka4 |
T |
A |
19: 6,809,372 (GRCm39) |
R427S |
possibly damaging |
Het |
| Scgb2b24 |
A |
T |
7: 33,436,795 (GRCm39) |
L106I |
probably benign |
Het |
| Skint9 |
A |
T |
4: 112,248,915 (GRCm39) |
M171K |
probably benign |
Het |
| Spata17 |
A |
G |
1: 186,844,756 (GRCm39) |
V281A |
possibly damaging |
Het |
| Spef1 |
A |
T |
2: 131,014,625 (GRCm39) |
V99E |
probably damaging |
Het |
| Srpra |
C |
T |
9: 35,126,015 (GRCm39) |
T431I |
probably damaging |
Het |
| Stk32c |
G |
A |
7: 138,768,173 (GRCm39) |
P36L |
unknown |
Het |
| Taar7d |
T |
C |
10: 23,903,739 (GRCm39) |
I207T |
probably benign |
Het |
| Tle1 |
G |
A |
4: 72,044,504 (GRCm39) |
T501I |
probably damaging |
Het |
| Tmem88b |
A |
T |
4: 155,868,733 (GRCm39) |
W172R |
probably damaging |
Het |
| Usp48 |
G |
A |
4: 137,340,996 (GRCm39) |
G332E |
probably benign |
Het |
| Vcl |
G |
T |
14: 21,070,726 (GRCm39) |
V771L |
probably benign |
Het |
| Vmn1r200 |
T |
A |
13: 22,579,911 (GRCm39) |
M238K |
probably damaging |
Het |
| Vmn2r96 |
A |
G |
17: 18,793,621 (GRCm39) |
|
probably benign |
Het |
| Wdfy3 |
A |
G |
5: 102,000,478 (GRCm39) |
L2964P |
probably benign |
Het |
| Zfp334 |
G |
A |
2: 165,222,271 (GRCm39) |
R591W |
probably damaging |
Het |
| Zpld2 |
G |
A |
4: 133,929,312 (GRCm39) |
P331L |
probably benign |
Het |
|
| Other mutations in Vsig10l |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01319:Vsig10l
|
APN |
7 |
43,114,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01390:Vsig10l
|
APN |
7 |
43,115,889 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02401:Vsig10l
|
APN |
7 |
43,113,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02404:Vsig10l
|
APN |
7 |
43,113,171 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02514:Vsig10l
|
APN |
7 |
43,113,338 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02636:Vsig10l
|
APN |
7 |
43,113,002 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02805:Vsig10l
|
APN |
7 |
43,114,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02823:Vsig10l
|
APN |
7 |
43,115,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02827:Vsig10l
|
APN |
7 |
43,114,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0111:Vsig10l
|
UTSW |
7 |
43,117,525 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0394:Vsig10l
|
UTSW |
7 |
43,114,879 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0465:Vsig10l
|
UTSW |
7 |
43,116,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Vsig10l
|
UTSW |
7 |
43,113,561 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1689:Vsig10l
|
UTSW |
7 |
43,114,792 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1991:Vsig10l
|
UTSW |
7 |
43,116,892 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2103:Vsig10l
|
UTSW |
7 |
43,116,892 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2358:Vsig10l
|
UTSW |
7 |
43,118,185 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3015:Vsig10l
|
UTSW |
7 |
43,116,881 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4024:Vsig10l
|
UTSW |
7 |
43,117,510 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4031:Vsig10l
|
UTSW |
7 |
43,114,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4807:Vsig10l
|
UTSW |
7 |
43,113,173 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5020:Vsig10l
|
UTSW |
7 |
43,114,741 (GRCm39) |
nonsense |
probably null |
|
|
R5261:Vsig10l
|
UTSW |
7 |
43,120,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5317:Vsig10l
|
UTSW |
7 |
43,114,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Vsig10l
|
UTSW |
7 |
43,114,247 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5656:Vsig10l
|
UTSW |
7 |
43,113,575 (GRCm39) |
nonsense |
probably null |
|
|
R5842:Vsig10l
|
UTSW |
7 |
43,118,396 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6012:Vsig10l
|
UTSW |
7 |
43,117,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6235:Vsig10l
|
UTSW |
7 |
43,118,396 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6309:Vsig10l
|
UTSW |
7 |
43,120,397 (GRCm39) |
splice site |
probably null |
|
|
R6994:Vsig10l
|
UTSW |
7 |
43,114,491 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7250:Vsig10l
|
UTSW |
7 |
43,113,099 (GRCm39) |
missense |
probably benign |
|
|
R7397:Vsig10l
|
UTSW |
7 |
43,117,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7767:Vsig10l
|
UTSW |
7 |
43,113,141 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7956:Vsig10l
|
UTSW |
7 |
43,117,494 (GRCm39) |
missense |
probably benign |
|
|
R8086:Vsig10l
|
UTSW |
7 |
43,114,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8139:Vsig10l
|
UTSW |
7 |
43,113,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8297:Vsig10l
|
UTSW |
7 |
43,113,531 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8341:Vsig10l
|
UTSW |
7 |
43,113,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Vsig10l
|
UTSW |
7 |
43,114,326 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8925:Vsig10l
|
UTSW |
7 |
43,116,020 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8927:Vsig10l
|
UTSW |
7 |
43,116,020 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8948:Vsig10l
|
UTSW |
7 |
43,117,623 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9157:Vsig10l
|
UTSW |
7 |
43,112,948 (GRCm39) |
missense |
|
|
|
R9203:Vsig10l
|
UTSW |
7 |
43,112,657 (GRCm39) |
start codon destroyed |
probably null |
|
|
X0028:Vsig10l
|
UTSW |
7 |
43,112,788 (GRCm39) |
utr 3 prime |
probably benign |
|
|
X0067:Vsig10l
|
UTSW |
7 |
43,116,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCATTCCTGCTGGACTTGTCAG -3'
(R):5'- ATTCAGCCCCTGAGGAAACC -3'
Sequencing Primer
(F):5'- CAATGCAAGCTGTGGATCTC -3'
(R):5'- ACCGGTTGGAATCAGGGATTC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation