Incidental Mutation 'R4820:Cic'
| ID |
370130 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cic
|
| Ensembl Gene |
ENSMUSG00000005442 |
| Gene Name |
capicua transcriptional repressor |
| Synonyms |
1200010B10Rik |
| MMRRC Submission |
042436-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.949)
|
| Stock # |
R4820 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
24967129-24993584 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 24971157 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 296
(V296A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132351
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169266]
[ENSMUST00000169392]
|
| AlphaFold |
Q924A2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169266
AA Change: V296A
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000132351
Gene: ENSMUSG00000005442
AA Change: V296A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
|
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
|
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
|
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
|
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
|
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
|
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
|
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
|
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
|
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
|
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
|
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
|
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
|
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
|
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
|
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
|
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
|
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
|
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
|
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
|
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169392
|
| SMART Domains |
Protein: ENSMUSP00000131680
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0805 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.3%
- 10x: 96.5%
- 20x: 92.9%
|
| Validation Efficiency |
96% (104/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(61) : Targeted, other(4) Gene trapped(57)
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930488N24Rik |
T |
C |
17: 14,326,481 (GRCm39) |
|
noncoding transcript |
Het |
| 5730455P16Rik |
A |
T |
11: 80,266,346 (GRCm39) |
S132T |
possibly damaging |
Het |
| Aadacl3 |
T |
A |
4: 144,184,527 (GRCm39) |
H77L |
probably damaging |
Het |
| Actr5 |
T |
A |
2: 158,467,426 (GRCm39) |
V122D |
probably damaging |
Het |
| Adamts7 |
A |
G |
9: 90,071,739 (GRCm39) |
D678G |
possibly damaging |
Het |
| Alpk1 |
T |
A |
3: 127,464,708 (GRCm39) |
D1190V |
probably benign |
Het |
| Apbb1ip |
A |
T |
2: 22,765,265 (GRCm39) |
N649Y |
unknown |
Het |
| Atp6v0a1 |
A |
G |
11: 100,933,776 (GRCm39) |
I522V |
probably benign |
Het |
| Brd10 |
T |
C |
19: 29,695,809 (GRCm39) |
N1228S |
possibly damaging |
Het |
| Cars1 |
T |
C |
7: 143,124,301 (GRCm39) |
D375G |
probably damaging |
Het |
| Catspere1 |
A |
T |
1: 177,687,441 (GRCm39) |
|
noncoding transcript |
Het |
| Ccdc87 |
A |
G |
19: 4,890,579 (GRCm39) |
D357G |
probably damaging |
Het |
| Cd101 |
A |
T |
3: 100,929,471 (GRCm39) |
S8T |
probably benign |
Het |
| Cfap65 |
C |
T |
1: 74,966,791 (GRCm39) |
A299T |
probably benign |
Het |
| Col7a1 |
T |
A |
9: 108,797,675 (GRCm39) |
S1686T |
possibly damaging |
Het |
| Ctbp2 |
A |
C |
7: 132,615,423 (GRCm39) |
L504R |
probably damaging |
Het |
| Cttnbp2nl |
T |
C |
3: 104,918,640 (GRCm39) |
K67E |
probably benign |
Het |
| Cyp2c50 |
C |
T |
19: 40,102,024 (GRCm39) |
P480S |
probably damaging |
Het |
| Dcdc5 |
A |
C |
2: 106,166,420 (GRCm39) |
|
noncoding transcript |
Het |
| Defb2 |
G |
T |
8: 22,333,317 (GRCm39) |
E31* |
probably null |
Het |
| Dhrs1 |
T |
A |
14: 55,977,083 (GRCm39) |
N244I |
possibly damaging |
Het |
| Dop1b |
A |
G |
16: 93,589,978 (GRCm39) |
I134V |
probably benign |
Het |
| Eif1ad11 |
A |
T |
12: 87,994,158 (GRCm39) |
I129F |
unknown |
Het |
| Etl4 |
A |
G |
2: 20,811,496 (GRCm39) |
D1193G |
possibly damaging |
Het |
| Ezh1 |
A |
C |
11: 101,094,594 (GRCm39) |
S399R |
probably damaging |
Het |
| Fam161a |
T |
C |
11: 22,970,076 (GRCm39) |
S26P |
probably damaging |
Het |
| Fcgbp |
C |
A |
7: 27,813,383 (GRCm39) |
S2306Y |
probably damaging |
Het |
| Fras1 |
T |
C |
5: 96,876,512 (GRCm39) |
I2415T |
probably benign |
Het |
| Gas2l3 |
A |
G |
10: 89,252,907 (GRCm39) |
L246P |
probably damaging |
Het |
| Gdf15 |
C |
T |
8: 71,082,246 (GRCm39) |
V287M |
probably damaging |
Het |
| Gm7742 |
T |
C |
17: 21,420,235 (GRCm39) |
|
noncoding transcript |
Het |
| Grin2d |
T |
C |
7: 45,507,363 (GRCm39) |
D446G |
probably damaging |
Het |
| Hemk1 |
A |
G |
9: 107,205,385 (GRCm39) |
F107L |
probably benign |
Het |
| Hmgcr |
C |
T |
13: 96,796,700 (GRCm39) |
G197S |
probably damaging |
Het |
| Ift52 |
G |
A |
2: 162,873,108 (GRCm39) |
G207D |
probably benign |
Het |
| Il17re |
A |
G |
6: 113,442,816 (GRCm39) |
T275A |
probably benign |
Het |
| Iqcf3 |
T |
C |
9: 106,430,788 (GRCm39) |
|
probably benign |
Het |
| Kcna1 |
A |
G |
6: 126,619,099 (GRCm39) |
I407T |
probably damaging |
Het |
| Kcnrg |
T |
A |
14: 61,845,386 (GRCm39) |
M142K |
probably benign |
Het |
| Lhx9 |
C |
A |
1: 138,766,105 (GRCm39) |
V237L |
probably benign |
Het |
| Lipo3 |
A |
C |
19: 33,560,497 (GRCm39) |
I56S |
probably damaging |
Het |
| Loxhd1 |
C |
G |
18: 77,472,663 (GRCm39) |
P1060R |
probably damaging |
Het |
| Map2k4 |
A |
C |
11: 65,587,201 (GRCm39) |
|
probably benign |
Het |
| Methig1 |
A |
G |
15: 100,251,416 (GRCm39) |
K109R |
possibly damaging |
Het |
| Mmrn1 |
G |
A |
6: 60,950,027 (GRCm39) |
V326I |
probably benign |
Het |
| Myo15a |
G |
A |
11: 60,367,741 (GRCm39) |
R167H |
probably damaging |
Het |
| Ncoa7 |
G |
A |
10: 30,524,472 (GRCm39) |
T142M |
probably damaging |
Het |
| Nfkb2 |
C |
A |
19: 46,296,493 (GRCm39) |
Q254K |
probably damaging |
Het |
| Nherf1 |
A |
G |
11: 115,070,918 (GRCm39) |
E290G |
probably benign |
Het |
| Nol6 |
G |
T |
4: 41,121,508 (GRCm39) |
P278Q |
probably damaging |
Het |
| Nptxr |
T |
A |
15: 79,677,027 (GRCm39) |
D285V |
probably damaging |
Het |
| Oosp3 |
T |
C |
19: 11,688,997 (GRCm39) |
W82R |
probably damaging |
Het |
| Or6b3 |
A |
T |
1: 92,438,812 (GRCm39) |
*313K |
probably null |
Het |
| Or6n1 |
A |
G |
1: 173,916,742 (GRCm39) |
I45M |
possibly damaging |
Het |
| Pa2g4 |
G |
T |
10: 128,395,199 (GRCm39) |
T322K |
probably damaging |
Het |
| Parp16 |
C |
A |
9: 65,145,175 (GRCm39) |
F291L |
probably damaging |
Het |
| Pdzd9 |
A |
T |
7: 120,267,619 (GRCm39) |
D65E |
probably damaging |
Het |
| Pgap3 |
A |
G |
11: 98,281,300 (GRCm39) |
W238R |
probably damaging |
Het |
| Pgf |
G |
A |
12: 85,218,538 (GRCm39) |
H67Y |
probably benign |
Het |
| Pik3cb |
T |
C |
9: 98,955,679 (GRCm39) |
T413A |
probably benign |
Het |
| Plcxd2 |
A |
T |
16: 45,800,700 (GRCm39) |
C175S |
probably benign |
Het |
| Pou2f1 |
A |
T |
1: 165,719,517 (GRCm39) |
|
probably benign |
Het |
| Ppfia1 |
T |
G |
7: 144,052,106 (GRCm39) |
N846T |
probably benign |
Het |
| Ppid |
T |
A |
3: 79,502,504 (GRCm39) |
|
probably null |
Het |
| Prkcq |
G |
A |
2: 11,231,797 (GRCm39) |
|
probably null |
Het |
| Ptgds |
T |
C |
2: 25,359,058 (GRCm39) |
K66E |
probably benign |
Het |
| Ptpmt1 |
A |
G |
2: 90,748,283 (GRCm39) |
|
noncoding transcript |
Het |
| Rab3il1 |
G |
A |
19: 10,004,034 (GRCm39) |
G51D |
probably benign |
Het |
| Rdx |
T |
C |
9: 51,974,891 (GRCm39) |
V9A |
probably damaging |
Het |
| Rpl7l1 |
T |
C |
17: 47,089,014 (GRCm39) |
N239S |
probably benign |
Het |
| Rrbp1 |
C |
A |
2: 143,806,685 (GRCm39) |
A978S |
possibly damaging |
Het |
| Rsf1 |
GCGGCGGCG |
GCGGCGGCGCCGGCGGCG |
7: 97,229,126 (GRCm39) |
|
probably benign |
Het |
| Scn3a |
A |
T |
2: 65,291,622 (GRCm39) |
I1708N |
probably damaging |
Het |
| Serinc1 |
A |
G |
10: 57,401,466 (GRCm39) |
I109T |
possibly damaging |
Het |
| Shroom1 |
G |
A |
11: 53,355,966 (GRCm39) |
V339I |
probably benign |
Het |
| Slc30a8 |
T |
A |
15: 52,169,880 (GRCm39) |
C36S |
probably benign |
Het |
| Slco1b2 |
A |
G |
6: 141,631,158 (GRCm39) |
I597M |
probably benign |
Het |
| Snx27 |
A |
G |
3: 94,427,518 (GRCm39) |
F228S |
probably damaging |
Het |
| Spata31f1a |
T |
A |
4: 42,851,815 (GRCm39) |
I114F |
probably damaging |
Het |
| Speer4e2 |
G |
T |
5: 15,026,225 (GRCm39) |
T144K |
probably benign |
Het |
| Stim1 |
T |
A |
7: 102,064,571 (GRCm39) |
F214I |
probably damaging |
Het |
| Svep1 |
T |
C |
4: 58,082,664 (GRCm39) |
T1987A |
probably benign |
Het |
| Tamm41 |
A |
G |
6: 115,002,378 (GRCm39) |
I18T |
possibly damaging |
Het |
| Tmem150b |
T |
A |
7: 4,726,871 (GRCm39) |
D79V |
probably damaging |
Het |
| Tmem167 |
T |
A |
13: 90,252,548 (GRCm39) |
I68N |
probably benign |
Het |
| Traf3 |
A |
G |
12: 111,227,204 (GRCm39) |
E339G |
possibly damaging |
Het |
| Tspan12 |
G |
A |
6: 21,795,660 (GRCm39) |
P177S |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,783,562 (GRCm39) |
I810T |
probably benign |
Het |
| Ulk1 |
T |
C |
5: 110,939,996 (GRCm39) |
T407A |
probably benign |
Het |
| Uroc1 |
G |
A |
6: 90,334,600 (GRCm39) |
|
probably null |
Het |
| Vmn2r-ps69 |
T |
C |
7: 84,959,584 (GRCm39) |
|
noncoding transcript |
Het |
| Wdr59 |
T |
C |
8: 112,207,446 (GRCm39) |
N476S |
probably benign |
Het |
| Zfp472 |
A |
G |
17: 33,196,416 (GRCm39) |
M164V |
probably benign |
Het |
| Zfp608 |
T |
C |
18: 55,120,756 (GRCm39) |
N277S |
probably benign |
Het |
| Zfp831 |
T |
C |
2: 174,547,097 (GRCm39) |
C1427R |
possibly damaging |
Het |
|
| Other mutations in Cic |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cic
|
APN |
7 |
24,991,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01668:Cic
|
APN |
7 |
24,990,629 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02229:Cic
|
APN |
7 |
24,990,375 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02506:Cic
|
APN |
7 |
24,990,282 (GRCm39) |
missense |
probably benign |
|
|
IGL02794:Cic
|
APN |
7 |
24,985,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Cic
|
APN |
7 |
24,985,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL03304:Cic
|
APN |
7 |
24,984,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Capuccino
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Cassock
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
Monkey
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850_Cic_466
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
1mM(1):Cic
|
UTSW |
7 |
24,990,214 (GRCm39) |
splice site |
probably benign |
|
|
IGL03046:Cic
|
UTSW |
7 |
24,990,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0027:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0027:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0038:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0063:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0064:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0064:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0118:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0241:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0377:Cic
|
UTSW |
7 |
24,985,224 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Cic
|
UTSW |
7 |
24,984,662 (GRCm39) |
missense |
probably benign |
|
|
R1253:Cic
|
UTSW |
7 |
24,990,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Cic
|
UTSW |
7 |
24,979,162 (GRCm39) |
intron |
probably benign |
|
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1519:Cic
|
UTSW |
7 |
24,993,235 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1586:Cic
|
UTSW |
7 |
24,985,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Cic
|
UTSW |
7 |
24,987,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Cic
|
UTSW |
7 |
24,986,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cic
|
UTSW |
7 |
24,970,961 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2063:Cic
|
UTSW |
7 |
24,972,876 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2161:Cic
|
UTSW |
7 |
24,987,559 (GRCm39) |
splice site |
probably null |
|
|
R2495:Cic
|
UTSW |
7 |
24,991,201 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Cic
|
UTSW |
7 |
24,972,646 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3692:Cic
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
R3709:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3710:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3872:Cic
|
UTSW |
7 |
24,971,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3946:Cic
|
UTSW |
7 |
24,971,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4199:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4426:Cic
|
UTSW |
7 |
24,993,433 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4502:Cic
|
UTSW |
7 |
24,987,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4586:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4614:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4664:Cic
|
UTSW |
7 |
24,990,099 (GRCm39) |
small deletion |
probably benign |
|
|
R4688:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4695:Cic
|
UTSW |
7 |
24,973,013 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4696:Cic
|
UTSW |
7 |
24,987,908 (GRCm39) |
missense |
probably benign |
|
|
R4746:Cic
|
UTSW |
7 |
24,987,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Cic
|
UTSW |
7 |
24,991,636 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4767:Cic
|
UTSW |
7 |
24,971,025 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4776:Cic
|
UTSW |
7 |
24,982,308 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4850:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4851:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4922:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R4989:Cic
|
UTSW |
7 |
24,986,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5131:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R5718:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5801:Cic
|
UTSW |
7 |
24,970,863 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5949:Cic
|
UTSW |
7 |
24,971,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6000:Cic
|
UTSW |
7 |
24,971,423 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6246:Cic
|
UTSW |
7 |
24,971,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6283:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Cic
|
UTSW |
7 |
24,972,248 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6481:Cic
|
UTSW |
7 |
24,987,706 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6919:Cic
|
UTSW |
7 |
24,971,202 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6920:Cic
|
UTSW |
7 |
24,990,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6995:Cic
|
UTSW |
7 |
24,970,736 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7002:Cic
|
UTSW |
7 |
24,971,621 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7113:Cic
|
UTSW |
7 |
24,972,869 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7560:Cic
|
UTSW |
7 |
24,972,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7680:Cic
|
UTSW |
7 |
24,991,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7698:Cic
|
UTSW |
7 |
24,972,597 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7746:Cic
|
UTSW |
7 |
24,988,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7841:Cic
|
UTSW |
7 |
24,985,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Cic
|
UTSW |
7 |
24,984,551 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7916:Cic
|
UTSW |
7 |
24,987,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7920:Cic
|
UTSW |
7 |
24,971,384 (GRCm39) |
missense |
probably benign |
|
|
R8056:Cic
|
UTSW |
7 |
24,990,366 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8226:Cic
|
UTSW |
7 |
24,987,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8281:Cic
|
UTSW |
7 |
24,971,249 (GRCm39) |
missense |
probably benign |
|
|
R8847:Cic
|
UTSW |
7 |
24,970,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8991:Cic
|
UTSW |
7 |
24,988,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9083:Cic
|
UTSW |
7 |
24,985,470 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9140:Cic
|
UTSW |
7 |
24,985,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9200:Cic
|
UTSW |
7 |
24,971,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9208:Cic
|
UTSW |
7 |
24,987,502 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9301:Cic
|
UTSW |
7 |
24,991,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9408:Cic
|
UTSW |
7 |
24,971,414 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9569:Cic
|
UTSW |
7 |
24,972,120 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9752:Cic
|
UTSW |
7 |
24,971,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
V7732:Cic
|
UTSW |
7 |
24,991,670 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Cic
|
UTSW |
7 |
24,970,444 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTATGAAGGAGTACCCGGTGG -3'
(R):5'- ACCTCAGCATCCTCAGGTTG -3'
Sequencing Primer
(F):5'- CCCGGTGGTGGTGTGGAC -3'
(R):5'- CTTGGGCTCCACGGAAGAAG -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation