Mutagenetix > Incidental Mutation

Incidental Mutation 'R6495:Vmn2r115'

520475

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r115

Ensembl Gene

ENSMUSG00000091076

Gene Name

vomeronasal 2, receptor 115

Synonyms

V2Rp4, EG638102

MMRRC Submission

044627-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R6495 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23562951-23579102 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23578572 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 682 (I682F)

Ref Sequence

ENSEMBL: ENSMUSP00000131447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168175]

AlphaFold

E9Q0E7

Predicted Effect

probably benign
Transcript: ENSMUST00000168175
AA Change: I682F

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: I682F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	1.4e-28	PFAM
Pfam:NCD3G	512	565	2.9e-20	PFAM
Pfam:7tm_3	598	833	5e-55	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.8%

Validation Efficiency

100% (50/50)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak2	T	A	12: 112,740,148 (GRCm39)	E502V	probably damaging	Het
Apbb1ip	T	A	2: 22,743,132 (GRCm39)	Y321*	probably null	Het
Apob	A	G	12: 8,040,394 (GRCm39)	K577R	probably null	Het
Arfgef3	A	G	10: 18,486,950 (GRCm39)		probably null	Het
Asap3	T	A	4: 135,955,790 (GRCm39)		probably null	Het
Atp13a5	C	T	16: 29,140,440 (GRCm39)		probably null	Het
Bcan	C	A	3: 87,903,904 (GRCm39)	A194S	possibly damaging	Het
Cacybp	T	C	1: 160,036,093 (GRCm39)	T32A	probably benign	Het
Cd82	A	G	2: 93,260,357 (GRCm39)	V90A	probably benign	Het
Chd5	C	T	4: 152,451,829 (GRCm39)	R714C	probably damaging	Het
Cpb2	T	C	14: 75,512,519 (GRCm39)	Y311H	probably damaging	Het
Cyp39a1	T	C	17: 44,002,585 (GRCm39)	Y267H	probably benign	Het
Dnajc6	C	T	4: 101,492,262 (GRCm39)	Q766*	probably null	Het
Dusp3	T	C	11: 101,872,653 (GRCm39)	I48V	probably benign	Het
Eif3c	A	T	7: 126,146,672 (GRCm39)	F809I	probably damaging	Het
Exosc10	C	T	4: 148,647,329 (GRCm39)	P213S	probably benign	Het
Galns	C	T	8: 123,327,349 (GRCm39)	G141D	probably damaging	Het
Gm3233	A	T	10: 77,594,886 (GRCm39)		probably benign	Het
Hadha	A	T	5: 30,325,048 (GRCm39)	L714H	probably benign	Het
Map3k20	T	C	2: 72,198,763 (GRCm39)	M123T	probably damaging	Het
Nt5dc1	A	G	10: 34,200,365 (GRCm39)	L217P	probably damaging	Het
Nubp2	A	T	17: 25,104,577 (GRCm39)	D54E	probably damaging	Het
Onecut1	C	T	9: 74,770,497 (GRCm39)	R307C	probably damaging	Het
Or5b116	T	A	19: 13,422,989 (GRCm39)	D204E	probably benign	Het
Pcdhb17	A	G	18: 37,618,720 (GRCm39)	Y170C	probably damaging	Het
Pkd2	T	A	5: 104,637,159 (GRCm39)	C591S	probably damaging	Het
Pramel15	T	C	4: 144,103,409 (GRCm39)	N239S	probably benign	Het
Pwp2	A	T	10: 78,012,961 (GRCm39)	V549E	probably damaging	Het
Rapsn	A	T	2: 90,866,973 (GRCm39)	S92C	probably damaging	Het
Rbm19	A	G	5: 120,257,745 (GRCm39)	S90G	probably damaging	Het
Rfc1	G	A	5: 65,431,158 (GRCm39)		probably null	Het
Rims2	T	A	15: 39,381,208 (GRCm39)	F1046L	probably benign	Het
S100a16	C	T	3: 90,449,735 (GRCm39)	R73C	probably benign	Het
Shroom3	T	C	5: 93,089,928 (GRCm39)	Y893H	possibly damaging	Het
Stt3b	T	A	9: 115,096,388 (GRCm39)	Y253F	possibly damaging	Het
Taar8b	A	G	10: 23,967,160 (GRCm39)	*345Q	probably null	Het
Tas2r119	G	A	15: 32,177,676 (GRCm39)	V81I	probably benign	Het
Tas2r129	A	G	6: 132,928,128 (GRCm39)	I22V	probably benign	Het
Tbc1d19	T	G	5: 54,046,555 (GRCm39)		probably null	Het
Tnip3	A	T	6: 65,582,846 (GRCm39)	I218F	probably benign	Het
Tnks	A	T	8: 35,307,120 (GRCm39)		probably null	Het
Ttc29	T	C	8: 79,008,963 (GRCm39)	Y278H	possibly damaging	Het
Tut7	T	C	13: 59,947,753 (GRCm39)	E454G	possibly damaging	Het
Uba7	T	A	9: 107,854,213 (GRCm39)	C214*	probably null	Het
Vmn2r75	A	T	7: 85,813,287 (GRCm39)	M505K	probably benign	Het
Wdr19	A	T	5: 65,415,466 (GRCm39)	T1313S	probably benign	Het
Zbtb22	A	G	17: 34,136,224 (GRCm39)	D123G	probably damaging	Het
Zdhhc7	A	G	8: 120,813,395 (GRCm39)	I138T	probably benign	Het
Zfp706	T	C	15: 37,004,045 (GRCm39)	K7R	unknown	Het
Zkscan3	G	A	13: 21,572,075 (GRCm39)	P519L	probably damaging	Het

Other mutations in Vmn2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r115	APN	17	23,575,934 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,345 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,371 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,135 (GRCm39)	missense	probably benign	0.03
IGL00990:Vmn2r115	APN	17	23,565,252 (GRCm39)	missense	probably benign	0.14
IGL00990:Vmn2r115	APN	17	23,565,313 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,323 (GRCm39)	missense	probably benign	0.22
IGL00990:Vmn2r115	APN	17	23,565,150 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,180 (GRCm39)	missense	possibly damaging	0.90
IGL00990:Vmn2r115	APN	17	23,567,008 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,798 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,753 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,238 (GRCm39)	missense	probably benign	0.19
IGL00990:Vmn2r115	APN	17	23,565,346 (GRCm39)	missense	probably benign	0.30
IGL01073:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01101:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01300:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL01415:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL02309:Vmn2r115	APN	17	23,564,113 (GRCm39)	missense	probably benign	0.01
IGL02863:Vmn2r115	APN	17	23,578,257 (GRCm39)	missense	probably damaging	0.97
R0023:Vmn2r115	UTSW	17	23,565,252 (GRCm39)	missense	probably benign	0.14
R0197:Vmn2r115	UTSW	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r115	UTSW	17	23,564,196 (GRCm39)	missense	probably benign	0.11
R0601:Vmn2r115	UTSW	17	23,579,074 (GRCm39)	missense	probably null	0.51
R0676:Vmn2r115	UTSW	17	23,565,238 (GRCm39)	missense	probably benign	0.19
R0685:Vmn2r115	UTSW	17	23,578,249 (GRCm39)	missense	probably benign
R0865:Vmn2r115	UTSW	17	23,565,382 (GRCm39)	missense	possibly damaging	0.65
R1124:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1145:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1146:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1207:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1266:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1318:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1367:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1420:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1604:Vmn2r115	UTSW	17	23,564,245 (GRCm39)	missense	probably benign	0.12
R1645:Vmn2r115	UTSW	17	23,565,192 (GRCm39)	missense	possibly damaging	0.69
R1646:Vmn2r115	UTSW	17	23,578,513 (GRCm39)	missense	probably damaging	1.00
R1650:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1678:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1716:Vmn2r115	UTSW	17	23,566,795 (GRCm39)	missense	probably benign
R1846:Vmn2r115	UTSW	17	23,578,357 (GRCm39)	missense	probably damaging	1.00
R1847:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1885:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1887:Vmn2r115	UTSW	17	23,565,007 (GRCm39)	missense	possibly damaging	0.91
R1937:Vmn2r115	UTSW	17	23,578,388 (GRCm39)	missense	probably damaging	1.00
R2007:Vmn2r115	UTSW	17	23,566,927 (GRCm39)	missense	possibly damaging	0.94
R2120:Vmn2r115	UTSW	17	23,578,297 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r115	UTSW	17	23,575,998 (GRCm39)	missense	possibly damaging	0.82
R3780:Vmn2r115	UTSW	17	23,564,146 (GRCm39)	missense	probably damaging	1.00
R3806:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R3982:Vmn2r115	UTSW	17	23,578,948 (GRCm39)	missense	probably damaging	1.00
R4019:Vmn2r115	UTSW	17	23,579,017 (GRCm39)	missense	probably damaging	1.00
R4039:Vmn2r115	UTSW	17	23,564,077 (GRCm39)	missense	probably benign	0.26
R4087:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4089:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4379:Vmn2r115	UTSW	17	23,564,197 (GRCm39)	missense	possibly damaging	0.95
R4417:Vmn2r115	UTSW	17	23,564,854 (GRCm39)	missense	probably benign	0.02
R4601:Vmn2r115	UTSW	17	23,565,373 (GRCm39)	missense	probably benign	0.01
R4874:Vmn2r115	UTSW	17	23,578,825 (GRCm39)	missense	probably damaging	1.00
R5466:Vmn2r115	UTSW	17	23,579,030 (GRCm39)	missense	probably damaging	1.00
R5613:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R5821:Vmn2r115	UTSW	17	23,566,937 (GRCm39)	missense	probably damaging	0.99
R6120:Vmn2r115	UTSW	17	23,565,003 (GRCm39)	missense	probably damaging	1.00
R6193:Vmn2r115	UTSW	17	23,575,983 (GRCm39)	missense	probably benign	0.01
R6213:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6290:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6319:Vmn2r115	UTSW	17	23,566,877 (GRCm39)	missense	possibly damaging	0.70
R6599:Vmn2r115	UTSW	17	23,565,006 (GRCm39)	missense	probably benign	0.00
R6764:Vmn2r115	UTSW	17	23,565,046 (GRCm39)	missense	probably damaging	1.00
R6970:Vmn2r115	UTSW	17	23,564,989 (GRCm39)	missense	probably benign	0.23
R7023:Vmn2r115	UTSW	17	23,578,785 (GRCm39)	missense	probably damaging	1.00
R7236:Vmn2r115	UTSW	17	23,578,576 (GRCm39)	missense	probably benign	0.01
R7353:Vmn2r115	UTSW	17	23,564,887 (GRCm39)	missense	possibly damaging	0.65
R7483:Vmn2r115	UTSW	17	23,565,371 (GRCm39)	missense	possibly damaging	0.95
R7743:Vmn2r115	UTSW	17	23,564,772 (GRCm39)	nonsense	probably null
R8005:Vmn2r115	UTSW	17	23,563,124 (GRCm39)	nonsense	probably null
R8191:Vmn2r115	UTSW	17	23,578,530 (GRCm39)	missense	probably damaging	1.00
R8544:Vmn2r115	UTSW	17	23,564,773 (GRCm39)	missense	possibly damaging	0.88
R8890:Vmn2r115	UTSW	17	23,578,497 (GRCm39)	missense	probably damaging	0.98
R9098:Vmn2r115	UTSW	17	23,564,803 (GRCm39)	missense	probably benign
R9114:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R9189:Vmn2r115	UTSW	17	23,564,784 (GRCm39)	missense	probably damaging	1.00
R9351:Vmn2r115	UTSW	17	23,578,482 (GRCm39)	missense	probably benign	0.05
R9397:Vmn2r115	UTSW	17	23,564,152 (GRCm39)	nonsense	probably null
R9410:Vmn2r115	UTSW	17	23,578,915 (GRCm39)	missense	possibly damaging	0.67
R9593:Vmn2r115	UTSW	17	23,578,184 (GRCm39)	missense	probably damaging	0.99
V5622:Vmn2r115	UTSW	17	23,578,333 (GRCm39)	missense	probably benign
V5622:Vmn2r115	UTSW	17	23,565,201 (GRCm39)	missense	probably damaging	1.00
X0023:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
X0033:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- CTTGGGGTCATTGTGAAGCAC -3'
(R):5'- CAATGATGATCTGTCCATGCTC -3'

Sequencing Primer
(F):5'- ACAGTACTCCAGTTGTTAAGGCC -3'
(R):5'- ATGATCTGTCCATGCTCAGATTG -3'

Posted On

2018-06-06