Incidental Mutation 'R7197:Nynrin'
ID 560039
Institutional Source Beutler Lab
Gene Symbol Nynrin
Ensembl Gene ENSMUSG00000075592
Gene Name NYN domain and retroviral integrase containing
Synonyms
MMRRC Submission 045276-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7197 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 56091572-56112193 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 56109380 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 1496 (I1496F)
Ref Sequence ENSEMBL: ENSMUSP00000098098 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479]
AlphaFold Q5DTZ0
Predicted Effect probably benign
Transcript: ENSMUST00000100529
AA Change: I1496F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: I1496F

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 1.6e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168479
AA Change: I1496F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: I1496F

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 5.5e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (77/79)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik AGCTTCCCTGCTT AGCTT 9: 57,165,505 (GRCm39) probably null Het
Aars2 T C 17: 45,819,885 (GRCm39) Y221H probably damaging Het
Abca8b G A 11: 109,836,648 (GRCm39) R1216* probably null Het
Acad8 A T 9: 26,888,967 (GRCm39) probably null Het
Acer2 A G 4: 86,805,287 (GRCm39) T84A probably null Het
Adgrb2 A G 4: 129,903,315 (GRCm39) N613S probably damaging Het
Arap2 T C 5: 62,798,729 (GRCm39) D1300G possibly damaging Het
Castor1 T C 11: 4,168,949 (GRCm39) C39R probably damaging Het
Ccl11 A T 11: 81,948,665 (GRCm39) probably benign Het
Cfh A T 1: 140,016,505 (GRCm39) Y1151* probably null Het
Cobll1 A G 2: 64,928,882 (GRCm39) S815P probably benign Het
Cryz T C 3: 154,327,205 (GRCm39) S240P probably damaging Het
Csmd2 A G 4: 128,404,826 (GRCm39) Y2404C Het
F13a1 T C 13: 37,100,860 (GRCm39) D428G probably damaging Het
Fbxo42 A G 4: 140,927,396 (GRCm39) S559G probably benign Het
Fry A G 5: 150,393,232 (GRCm39) S263G Het
Fshr C T 17: 89,292,897 (GRCm39) A594T probably damaging Het
Gm1527 A G 3: 28,980,690 (GRCm39) M597V probably null Het
Gpr158 A T 2: 21,815,412 (GRCm39) T602S probably damaging Het
Hmgxb4 C A 8: 75,756,624 (GRCm39) T583K probably damaging Het
Igkv8-30 C T 6: 70,094,069 (GRCm39) C114Y probably damaging Het
Igsf5 T A 16: 96,204,546 (GRCm39) N366K probably damaging Het
Kif15 T C 9: 122,838,991 (GRCm39) probably null Het
Klk1b26 T A 7: 43,665,821 (GRCm39) probably null Het
Lama1 G T 17: 68,044,700 (GRCm39) E200* probably null Het
Lpar5 C T 6: 125,059,347 (GRCm39) T356I probably benign Het
Lrch3 A T 16: 32,810,665 (GRCm39) T538S probably damaging Het
Mansc4 A G 6: 146,977,203 (GRCm39) S138P probably damaging Het
Mief1 T C 15: 80,134,061 (GRCm39) S373P possibly damaging Het
Nbas G T 12: 13,570,751 (GRCm39) V2053F possibly damaging Het
Nek11 T C 9: 105,121,614 (GRCm39) E435G probably damaging Het
Odf1 A T 15: 38,219,794 (GRCm39) M41L probably benign Het
Or10a5 A G 7: 106,635,364 (GRCm39) M8V probably benign Het
Or4c115 A G 2: 88,927,626 (GRCm39) V215A probably benign Het
Or4c29 A T 2: 88,740,708 (GRCm39) F10I probably benign Het
Or7h8 T G 9: 20,123,851 (GRCm39) S69A probably benign Het
Oxnad1 T C 14: 31,818,473 (GRCm39) V106A possibly damaging Het
Padi4 C A 4: 140,488,969 (GRCm39) E157* probably null Het
Parp10 A T 15: 76,126,616 (GRCm39) F217L probably damaging Het
Pcdhb18 T A 18: 37,623,436 (GRCm39) S255R probably benign Het
Pde4c G T 8: 71,197,978 (GRCm39) G102W probably damaging Het
Pde6a T C 18: 61,391,295 (GRCm39) Y547H probably damaging Het
Phf11b A T 14: 59,563,507 (GRCm39) L137I probably benign Het
Pigh A C 12: 79,130,463 (GRCm39) I134S probably damaging Het
Pigt G A 2: 164,344,436 (GRCm39) V362M probably damaging Het
Pld1 A G 3: 28,078,401 (GRCm39) D20G probably damaging Het
Pou3f2 T C 4: 22,487,288 (GRCm39) R282G probably damaging Het
Ppp2r5d A G 17: 46,996,527 (GRCm39) V382A probably damaging Het
Prdm16 T C 4: 154,425,967 (GRCm39) E606G probably damaging Het
Psg28 A G 7: 18,164,509 (GRCm39) Y68H probably damaging Het
Qpctl C A 7: 18,882,944 (GRCm39) W56L probably damaging Het
Rab11fip5 G A 6: 85,319,137 (GRCm39) P584L probably damaging Het
Sde2 C T 1: 180,678,843 (GRCm39) H36Y probably benign Het
Sema4d T C 13: 51,856,872 (GRCm39) S787G probably benign Het
Sgca C T 11: 94,864,014 (GRCm39) probably null Het
Shroom3 A G 5: 93,090,463 (GRCm39) E1071G probably damaging Het
Skint5 A G 4: 113,437,679 (GRCm39) probably null Het
Slc44a3 T A 3: 121,319,411 (GRCm39) D110V probably benign Het
Slc4a4 A C 5: 89,082,433 (GRCm39) probably benign Het
Slc4a8 A G 15: 100,688,857 (GRCm39) D389G probably damaging Het
Sp3 C G 2: 72,809,953 (GRCm39) E11Q probably benign Het
Srrm2 A G 17: 24,037,198 (GRCm39) S1281G unknown Het
Tat A T 8: 110,723,459 (GRCm39) I316F probably benign Het
Thoc5 A G 11: 4,865,563 (GRCm39) T381A probably benign Het
Tiam1 T C 16: 89,681,826 (GRCm39) Y384C probably damaging Het
Tmem45a A T 16: 56,632,026 (GRCm39) F197L probably damaging Het
Trav8d-1 A G 14: 53,016,435 (GRCm39) Y107C probably damaging Het
Trim10 T A 17: 37,187,846 (GRCm39) V354D probably damaging Het
Unc45b A T 11: 82,831,013 (GRCm39) probably null Het
Unc79 A G 12: 103,078,765 (GRCm39) I1643M probably benign Het
Unc80 G T 1: 66,560,725 (GRCm39) G818* probably null Het
Usp15 A T 10: 122,966,910 (GRCm39) M470K possibly damaging Het
Vldlr T C 19: 27,212,241 (GRCm39) V85A probably benign Het
Vma21-ps A G 4: 52,496,994 (GRCm39) V84A probably benign Het
Vmn2r67 C T 7: 84,785,774 (GRCm39) V744I possibly damaging Het
Wdr73 A G 7: 80,542,946 (GRCm39) C221R probably benign Het
Zxdc C T 6: 90,355,819 (GRCm39) H443Y probably damaging Het
Other mutations in Nynrin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Nynrin APN 14 56,105,905 (GRCm39) missense probably benign 0.38
IGL01131:Nynrin APN 14 56,110,142 (GRCm39) missense probably damaging 1.00
IGL01357:Nynrin APN 14 56,107,874 (GRCm39) missense probably benign
IGL01537:Nynrin APN 14 56,109,502 (GRCm39) missense possibly damaging 0.87
IGL01583:Nynrin APN 14 56,107,968 (GRCm39) missense probably damaging 1.00
IGL01726:Nynrin APN 14 56,101,611 (GRCm39) missense probably benign
IGL02161:Nynrin APN 14 56,101,441 (GRCm39) missense probably damaging 1.00
IGL02167:Nynrin APN 14 56,100,792 (GRCm39) missense probably damaging 1.00
IGL02247:Nynrin APN 14 56,109,167 (GRCm39) nonsense probably null
IGL02302:Nynrin APN 14 56,105,962 (GRCm39) missense probably benign 0.43
IGL02524:Nynrin APN 14 56,108,931 (GRCm39) missense possibly damaging 0.73
IGL02600:Nynrin APN 14 56,101,449 (GRCm39) missense probably benign 0.38
IGL02639:Nynrin APN 14 56,108,112 (GRCm39) missense probably damaging 1.00
IGL02654:Nynrin APN 14 56,100,716 (GRCm39) missense possibly damaging 0.95
IGL02659:Nynrin APN 14 56,103,554 (GRCm39) unclassified probably benign
IGL02736:Nynrin APN 14 56,108,366 (GRCm39) missense probably damaging 1.00
IGL02949:Nynrin APN 14 56,109,837 (GRCm39) missense probably damaging 0.99
PIT4458001:Nynrin UTSW 14 56,101,425 (GRCm39) missense probably benign 0.39
R0017:Nynrin UTSW 14 56,109,852 (GRCm39) missense probably damaging 1.00
R0078:Nynrin UTSW 14 56,100,789 (GRCm39) missense probably damaging 1.00
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0413:Nynrin UTSW 14 56,109,648 (GRCm39) missense possibly damaging 0.90
R0609:Nynrin UTSW 14 56,110,218 (GRCm39) missense probably damaging 1.00
R0626:Nynrin UTSW 14 56,105,492 (GRCm39) missense probably damaging 1.00
R1205:Nynrin UTSW 14 56,091,646 (GRCm39) intron probably benign
R1222:Nynrin UTSW 14 56,100,998 (GRCm39) missense probably benign 0.02
R1385:Nynrin UTSW 14 56,102,356 (GRCm39) missense probably benign 0.00
R1820:Nynrin UTSW 14 56,107,835 (GRCm39) missense possibly damaging 0.95
R1829:Nynrin UTSW 14 56,110,404 (GRCm39) missense possibly damaging 0.50
R1874:Nynrin UTSW 14 56,100,950 (GRCm39) missense probably benign 0.04
R1927:Nynrin UTSW 14 56,101,049 (GRCm39) missense probably benign 0.00
R2233:Nynrin UTSW 14 56,109,524 (GRCm39) missense possibly damaging 0.83
R3018:Nynrin UTSW 14 56,100,867 (GRCm39) missense probably benign 0.00
R3154:Nynrin UTSW 14 56,101,044 (GRCm39) missense possibly damaging 0.46
R3853:Nynrin UTSW 14 56,101,562 (GRCm39) missense probably benign 0.24
R4648:Nynrin UTSW 14 56,110,351 (GRCm39) nonsense probably null
R4722:Nynrin UTSW 14 56,091,852 (GRCm39) missense probably damaging 0.97
R4735:Nynrin UTSW 14 56,107,625 (GRCm39) missense probably benign 0.03
R4736:Nynrin UTSW 14 56,101,454 (GRCm39) missense probably damaging 1.00
R4780:Nynrin UTSW 14 56,100,720 (GRCm39) missense probably damaging 1.00
R4804:Nynrin UTSW 14 56,102,326 (GRCm39) missense probably benign
R4816:Nynrin UTSW 14 56,109,458 (GRCm39) missense probably damaging 1.00
R5307:Nynrin UTSW 14 56,101,263 (GRCm39) missense probably damaging 1.00
R5372:Nynrin UTSW 14 56,105,948 (GRCm39) missense probably benign 0.01
R5432:Nynrin UTSW 14 56,101,923 (GRCm39) missense possibly damaging 0.80
R5800:Nynrin UTSW 14 56,108,088 (GRCm39) missense probably damaging 1.00
R5825:Nynrin UTSW 14 56,101,683 (GRCm39) missense probably benign 0.00
R6149:Nynrin UTSW 14 56,091,780 (GRCm39) missense possibly damaging 0.83
R6244:Nynrin UTSW 14 56,105,485 (GRCm39) missense probably damaging 1.00
R6350:Nynrin UTSW 14 56,105,533 (GRCm39) missense probably benign 0.19
R6379:Nynrin UTSW 14 56,107,848 (GRCm39) missense probably damaging 1.00
R6437:Nynrin UTSW 14 56,109,227 (GRCm39) missense probably benign 0.00
R6501:Nynrin UTSW 14 56,100,989 (GRCm39) missense probably benign
R6702:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6703:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6907:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6908:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6928:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6934:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6935:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R7204:Nynrin UTSW 14 56,110,190 (GRCm39) missense probably damaging 1.00
R7272:Nynrin UTSW 14 56,107,872 (GRCm39) missense probably damaging 1.00
R7335:Nynrin UTSW 14 56,101,371 (GRCm39) missense probably benign
R7361:Nynrin UTSW 14 56,107,857 (GRCm39) missense possibly damaging 0.71
R7368:Nynrin UTSW 14 56,107,968 (GRCm39) missense probably damaging 1.00
R7443:Nynrin UTSW 14 56,108,873 (GRCm39) missense probably benign 0.18
R7584:Nynrin UTSW 14 56,109,041 (GRCm39) missense probably damaging 1.00
R7677:Nynrin UTSW 14 56,107,693 (GRCm39) missense probably benign
R7723:Nynrin UTSW 14 56,109,502 (GRCm39) missense possibly damaging 0.87
R7776:Nynrin UTSW 14 56,103,420 (GRCm39) missense probably damaging 1.00
R7787:Nynrin UTSW 14 56,107,980 (GRCm39) missense probably benign
R7842:Nynrin UTSW 14 56,102,553 (GRCm39) missense probably damaging 1.00
R7852:Nynrin UTSW 14 56,108,886 (GRCm39) missense probably damaging 0.96
R8040:Nynrin UTSW 14 56,108,982 (GRCm39) missense probably benign 0.01
R8159:Nynrin UTSW 14 56,102,517 (GRCm39) missense probably benign
R8159:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R8258:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8259:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8343:Nynrin UTSW 14 56,101,248 (GRCm39) missense probably benign
R8504:Nynrin UTSW 14 56,107,703 (GRCm39) missense probably benign 0.01
R8671:Nynrin UTSW 14 56,107,899 (GRCm39) missense possibly damaging 0.52
R8691:Nynrin UTSW 14 56,110,106 (GRCm39) missense probably damaging 1.00
R8777:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R8777-TAIL:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R9041:Nynrin UTSW 14 56,108,753 (GRCm39) missense possibly damaging 0.83
R9346:Nynrin UTSW 14 56,100,495 (GRCm39) missense probably benign 0.01
R9366:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R9690:Nynrin UTSW 14 56,108,204 (GRCm39) missense probably benign 0.00
RF007:Nynrin UTSW 14 56,103,658 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- CACCCTGGCCGATATCATTG -3'
(R):5'- AATCTGCAGACTGGACCAAG -3'

Sequencing Primer
(F):5'- ATCATTGCCAAGTTGCAGGC -3'
(R):5'- AAGGGGCTGTCGACCTGAG -3'
Posted On 2019-06-26