Incidental Mutation 'IGL00767:Stk17b'
ID 14268
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk17b
Ensembl Gene ENSMUSG00000026094
Gene Name serine/threonine kinase 17b (apoptosis-inducing)
Synonyms 3110009A03Rik, Drak2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # IGL00767
Quality Score
Status
Chromosome 1
Chromosomal Location 53794671-53824374 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 53803182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139880 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027263] [ENSMUST00000185920]
AlphaFold Q8BG48
Predicted Effect probably benign
Transcript: ENSMUST00000027263
SMART Domains Protein: ENSMUSP00000027263
Gene: ENSMUSG00000026094

DomainStartEndE-ValueType
S_TKc 33 293 5.77e-79 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000185920
SMART Domains Protein: ENSMUSP00000139880
Gene: ENSMUSG00000026094

DomainStartEndE-ValueType
S_TKc 1 93 5.8e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187066
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice display abnormal T cell numbers, increased T cell proliferation, abnormal cytokine physiology, and decreased susceptibility to experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anpep A C 7: 79,490,638 (GRCm39) S293A probably benign Het
Dgkh T A 14: 78,824,701 (GRCm39) probably benign Het
Dlg5 T A 14: 24,215,353 (GRCm39) T657S probably damaging Het
Hpf1 A G 8: 61,349,836 (GRCm39) I155V probably benign Het
Il12rb2 T C 6: 67,280,546 (GRCm39) I554V possibly damaging Het
Mindy2 A G 9: 70,541,285 (GRCm39) probably null Het
Nostrin A G 2: 69,006,119 (GRCm39) T268A probably benign Het
Npy6r A G 18: 44,409,385 (GRCm39) T269A probably benign Het
Nt5dc3 T A 10: 86,656,137 (GRCm39) probably benign Het
Osgin2 G A 4: 16,006,377 (GRCm39) H106Y probably damaging Het
Pdlim3 G A 8: 46,349,827 (GRCm39) G46R probably damaging Het
Pdpk1 T G 17: 24,325,835 (GRCm39) K147N possibly damaging Het
Pfkfb3 T C 2: 11,493,565 (GRCm39) D137G probably damaging Het
Polg G A 7: 79,101,673 (GRCm39) P1048S probably damaging Het
Ptcd3 A T 6: 71,880,432 (GRCm39) I97K probably damaging Het
Resf1 T C 6: 149,236,248 (GRCm39) probably benign Het
Serpinb10 G T 1: 107,463,807 (GRCm39) V30F possibly damaging Het
Tll1 G A 8: 64,524,355 (GRCm39) R444C probably damaging Het
Ttbk2 A G 2: 120,576,226 (GRCm39) V848A probably benign Het
Ttn T C 2: 76,716,017 (GRCm39) probably benign Het
Other mutations in Stk17b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00722:Stk17b APN 1 53,803,299 (GRCm39) missense probably damaging 0.99
IGL01012:Stk17b APN 1 53,800,196 (GRCm39) missense probably benign 0.06
IGL01431:Stk17b APN 1 53,805,074 (GRCm39) splice site probably benign
IGL01914:Stk17b APN 1 53,800,226 (GRCm39) missense probably damaging 0.98
IGL02236:Stk17b APN 1 53,803,247 (GRCm39) missense probably damaging 1.00
IGL02827:Stk17b APN 1 53,815,701 (GRCm39) missense probably benign 0.03
R0013:Stk17b UTSW 1 53,803,291 (GRCm39) missense probably benign 0.36
R0545:Stk17b UTSW 1 53,801,742 (GRCm39) splice site probably benign
R0831:Stk17b UTSW 1 53,796,651 (GRCm39) missense probably damaging 1.00
R1035:Stk17b UTSW 1 53,801,758 (GRCm39) missense probably benign 0.22
R1375:Stk17b UTSW 1 53,805,106 (GRCm39) missense possibly damaging 0.83
R1576:Stk17b UTSW 1 53,796,749 (GRCm39) missense probably damaging 1.00
R1809:Stk17b UTSW 1 53,805,140 (GRCm39) missense possibly damaging 0.80
R1988:Stk17b UTSW 1 53,800,241 (GRCm39) missense probably damaging 1.00
R2033:Stk17b UTSW 1 53,800,235 (GRCm39) missense probably damaging 1.00
R2105:Stk17b UTSW 1 53,815,764 (GRCm39) missense probably benign 0.01
R2255:Stk17b UTSW 1 53,815,731 (GRCm39) missense probably benign 0.00
R4395:Stk17b UTSW 1 53,803,274 (GRCm39) missense probably damaging 0.98
R4521:Stk17b UTSW 1 53,803,197 (GRCm39) missense probably damaging 1.00
R4777:Stk17b UTSW 1 53,810,867 (GRCm39) missense probably damaging 1.00
R4871:Stk17b UTSW 1 53,796,693 (GRCm39) missense probably benign 0.14
R4892:Stk17b UTSW 1 53,810,770 (GRCm39) missense probably damaging 0.99
R4999:Stk17b UTSW 1 53,800,306 (GRCm39) splice site probably null
R5122:Stk17b UTSW 1 53,815,717 (GRCm39) missense probably damaging 1.00
R5621:Stk17b UTSW 1 53,810,943 (GRCm39) nonsense probably null
R6636:Stk17b UTSW 1 53,800,247 (GRCm39) missense probably damaging 1.00
R6924:Stk17b UTSW 1 53,800,218 (GRCm39) missense possibly damaging 0.54
R7283:Stk17b UTSW 1 53,796,674 (GRCm39) missense probably benign
R7322:Stk17b UTSW 1 53,805,104 (GRCm39) missense probably benign 0.16
R7671:Stk17b UTSW 1 53,805,159 (GRCm39) missense probably damaging 0.99
R8984:Stk17b UTSW 1 53,796,784 (GRCm39) missense probably benign 0.05
R9476:Stk17b UTSW 1 53,796,898 (GRCm39) missense probably damaging 1.00
R9510:Stk17b UTSW 1 53,796,898 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-06