Mutagenetix > Incidental Mutation

Incidental Mutation 'R1253:Vmn2r92'

151860

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r92

Ensembl Gene

ENSMUSG00000091350

Gene Name

vomeronasal 2, receptor 92

Synonyms

EG627111

MMRRC Submission

039320-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

R1253 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18372192-18405440 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18387028 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 122 (N122K)

Ref Sequence

ENSEMBL: ENSMUSP00000128685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169686]

AlphaFold

L7N2A4

Predicted Effect

probably benign
Transcript: ENSMUST00000169686
AA Change: N122K

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000128685
Gene: ENSMUSG00000091350
AA Change: N122K

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	463	4.7e-38	PFAM
Pfam:NCD3G	510	564	2.5e-19	PFAM
Pfam:7tm_3	597	832	1.1e-52	PFAM
low complexity region	843	855	N/A	INTRINSIC

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.8%
20x: 91.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actg2	G	A	6: 83,499,869 (GRCm39)	T127I	probably damaging	Het
Aph1b	T	A	9: 66,697,931 (GRCm39)	K102*	probably null	Het
Caskin1	A	G	17: 24,724,047 (GRCm39)	K945R	probably damaging	Het
Ccdc137	C	A	11: 120,349,005 (GRCm39)	A12E	probably benign	Het
Cdhr1	A	G	14: 36,801,582 (GRCm39)	M787T	probably benign	Het
Cic	T	A	7: 24,990,373 (GRCm39)	V1958E	probably damaging	Het
Col6a6	T	A	9: 105,651,502 (GRCm39)	I1170F	probably null	Het
Cyp2c54	T	A	19: 40,034,629 (GRCm39)	Y347F	probably damaging	Het
Kntc1	AGTGT	AGT	5: 123,948,925 (GRCm39)		probably null	Het
Large1	T	C	8: 73,775,050 (GRCm39)	Y220C	probably damaging	Het
Macf1	A	T	4: 123,351,760 (GRCm39)	D1592E	probably damaging	Het
Mtus2	C	T	5: 148,240,380 (GRCm39)	Q76*	probably null	Het
Olfm3	A	T	3: 114,916,418 (GRCm39)	D450V	probably damaging	Het
Or1l4b	T	A	2: 37,036,884 (GRCm39)	V220D	possibly damaging	Het
Or4k6	A	G	14: 50,475,581 (GRCm39)	C254R	probably damaging	Het
Or5ae1	T	A	7: 84,565,917 (GRCm39)	I310K	probably benign	Het
Ormdl1	G	A	1: 53,344,681 (GRCm39)	R81K	possibly damaging	Het
Pcdhb12	G	A	18: 37,568,874 (GRCm39)	V7I	possibly damaging	Het
Ptprt	A	G	2: 162,120,146 (GRCm39)	I107T	probably damaging	Het
Rbm27	A	C	18: 42,434,839 (GRCm39)	D301A	probably damaging	Het
Rexo2	A	T	9: 48,380,232 (GRCm39)	I200N	probably damaging	Het
Rtn4ip1	A	T	10: 43,786,867 (GRCm39)	I192L	probably benign	Het
Serpinb9e	T	C	13: 33,439,102 (GRCm39)	F176S	possibly damaging	Het
Sorcs3	C	A	19: 48,195,175 (GRCm39)	A186E	possibly damaging	Het
Spata31	A	G	13: 65,069,838 (GRCm39)	Y662C	probably benign	Het
Sphkap	G	A	1: 83,256,619 (GRCm39)	P377S	possibly damaging	Het
Srrt	T	C	5: 137,298,598 (GRCm39)	K222R	probably benign	Het
Tas2r129	T	C	6: 132,928,999 (GRCm39)	I312T	probably benign	Het
Thbs4	G	T	13: 92,913,413 (GRCm39)	P169Q	probably benign	Het
Tmtc3	T	C	10: 100,287,252 (GRCm39)	M515V	probably benign	Het
Ugcg	C	T	4: 59,207,798 (GRCm39)	P46S	probably benign	Het

Other mutations in Vmn2r92

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01591:Vmn2r92	APN	17	18,405,423 (GRCm39)	missense	unknown
IGL01758:Vmn2r92	APN	17	18,372,275 (GRCm39)	nonsense	probably null
IGL02614:Vmn2r92	APN	17	18,387,503 (GRCm39)	splice site	probably benign
IGL03095:Vmn2r92	APN	17	18,386,972 (GRCm39)	missense	possibly damaging	0.55
IGL03403:Vmn2r92	APN	17	18,387,114 (GRCm39)	missense	probably damaging	0.98
R0133:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0225:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0227:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0265:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0266:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0267:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0420:Vmn2r92	UTSW	17	18,389,183 (GRCm39)	missense	probably benign	0.01
R0426:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R0494:Vmn2r92	UTSW	17	18,388,219 (GRCm39)	missense	probably damaging	1.00
R1497:Vmn2r92	UTSW	17	18,387,625 (GRCm39)	missense	probably benign	0.02
R1571:Vmn2r92	UTSW	17	18,372,352 (GRCm39)	missense	probably damaging	0.96
R1656:Vmn2r92	UTSW	17	18,372,198 (GRCm39)	missense	probably benign
R1816:Vmn2r92	UTSW	17	18,386,939 (GRCm39)	missense	probably damaging	0.98
R2229:Vmn2r92	UTSW	17	18,387,654 (GRCm39)	missense	probably benign	0.01
R2909:Vmn2r92	UTSW	17	18,405,377 (GRCm39)	missense	possibly damaging	0.89
R3694:Vmn2r92	UTSW	17	18,372,205 (GRCm39)	nonsense	probably null
R4207:Vmn2r92	UTSW	17	18,404,523 (GRCm39)	missense	possibly damaging	0.62
R4548:Vmn2r92	UTSW	17	18,391,578 (GRCm39)	missense	probably benign
R4612:Vmn2r92	UTSW	17	18,387,132 (GRCm39)	missense	probably benign	0.25
R4742:Vmn2r92	UTSW	17	18,387,119 (GRCm39)	missense	probably benign	0.06
R4824:Vmn2r92	UTSW	17	18,372,183 (GRCm39)	utr 5 prime	probably benign
R4865:Vmn2r92	UTSW	17	18,387,634 (GRCm39)	missense	probably benign	0.16
R4900:Vmn2r92	UTSW	17	18,404,605 (GRCm39)	missense	probably benign	0.27
R5084:Vmn2r92	UTSW	17	18,405,439 (GRCm39)	makesense	probably null
R5140:Vmn2r92	UTSW	17	18,372,312 (GRCm39)	missense	probably benign	0.07
R5995:Vmn2r92	UTSW	17	18,389,213 (GRCm39)	critical splice donor site	probably null
R6045:Vmn2r92	UTSW	17	18,388,305 (GRCm39)	critical splice donor site	probably null
R6269:Vmn2r92	UTSW	17	18,387,036 (GRCm39)	missense	probably benign	0.01
R6877:Vmn2r92	UTSW	17	18,389,084 (GRCm39)	missense	probably damaging	1.00
R7151:Vmn2r92	UTSW	17	18,387,005 (GRCm39)	missense	probably benign	0.01
R7260:Vmn2r92	UTSW	17	18,387,138 (GRCm39)	missense	probably damaging	1.00
R7344:Vmn2r92	UTSW	17	18,387,513 (GRCm39)	missense	probably benign	0.01
R7514:Vmn2r92	UTSW	17	18,391,533 (GRCm39)	missense	probably damaging	1.00
R7576:Vmn2r92	UTSW	17	18,387,621 (GRCm39)	missense	probably benign	0.01
R7584:Vmn2r92	UTSW	17	18,387,028 (GRCm39)	missense	probably benign	0.08
R7912:Vmn2r92	UTSW	17	18,404,970 (GRCm39)	missense	possibly damaging	0.91
R7941:Vmn2r92	UTSW	17	18,405,099 (GRCm39)	missense	possibly damaging	0.89
R8178:Vmn2r92	UTSW	17	18,386,988 (GRCm39)	missense	possibly damaging	0.69
R8238:Vmn2r92	UTSW	17	18,405,278 (GRCm39)	missense	probably benign	0.00
R8239:Vmn2r92	UTSW	17	18,405,278 (GRCm39)	missense	probably benign	0.00
R8252:Vmn2r92	UTSW	17	18,387,134 (GRCm39)	missense	probably damaging	1.00
R8322:Vmn2r92	UTSW	17	18,386,886 (GRCm39)	missense	probably damaging	0.99
R8355:Vmn2r92	UTSW	17	18,405,061 (GRCm39)	missense	probably damaging	0.99
R9399:Vmn2r92	UTSW	17	18,389,137 (GRCm39)	missense	probably benign	0.29
R9639:Vmn2r92	UTSW	17	18,372,352 (GRCm39)	missense	probably damaging	0.96
R9747:Vmn2r92	UTSW	17	18,405,201 (GRCm39)	missense	possibly damaging	0.66
R9773:Vmn2r92	UTSW	17	18,386,949 (GRCm39)	missense	probably damaging	1.00
X0066:Vmn2r92	UTSW	17	18,405,157 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r92	UTSW	17	18,404,795 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TGTGCTTGCCTAAACCTAACGTATTCA -3'
(R):5'- CTTACCTGGCTCATTGACTACACCAAC -3'

Sequencing Primer
(F):5'- AACGTATTCATCTAATCTAGTTCAGC -3'
(R):5'- TCTCTTACAACCAAGAGAAATCTGG -3'

Posted On

2014-01-29