Incidental Mutation 'R1491:Rasgrp1'
| ID |
163708 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rasgrp1
|
| Ensembl Gene |
ENSMUSG00000027347 |
| Gene Name |
RAS guanyl releasing protein 1 |
| Synonyms |
|
| MMRRC Submission |
039543-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.264)
|
| Stock # |
R1491 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
117110464-117173358 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 117113100 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 771
(Q771*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136423
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102534]
[ENSMUST00000172901]
[ENSMUST00000173252]
[ENSMUST00000173541]
[ENSMUST00000174770]
[ENSMUST00000178884]
|
| AlphaFold |
Q9Z1S3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000102534
AA Change: Q771*
|
| SMART Domains |
Protein: ENSMUSP00000099593
Gene: ENSMUSG00000027347
AA Change: Q771*
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
Pfam:EF-hand_6
|
474 |
502 |
5e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172901
|
| SMART Domains |
Protein: ENSMUSP00000133449
Gene: ENSMUSG00000027347
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.2e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173252
|
| SMART Domains |
Protein: ENSMUSP00000134592
Gene: ENSMUSG00000027347
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.1e-5 |
PFAM |
|
Pfam:C1_1
|
507 |
539 |
3.4e-8 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000173541
AA Change: Q736*
|
| SMART Domains |
Protein: ENSMUSP00000134027
Gene: ENSMUSG00000027347
AA Change: Q736*
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
441 |
464 |
1.6e-5 |
PFAM |
|
Pfam:EF-hand_6
|
442 |
467 |
1.6e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
705 |
756 |
2e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174770
|
| SMART Domains |
Protein: ENSMUSP00000134167
Gene: ENSMUSG00000027347
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000178884
AA Change: Q771*
|
| SMART Domains |
Protein: ENSMUSP00000136423
Gene: ENSMUSG00000027347
AA Change: Q771*
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.5%
- 20x: 90.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A730018C14Rik |
T |
A |
12: 112,381,489 (GRCm39) |
|
noncoding transcript |
Het |
| Acss3 |
A |
G |
10: 106,773,169 (GRCm39) |
S606P |
probably benign |
Het |
| Adamts13 |
C |
T |
2: 26,868,327 (GRCm39) |
T146M |
probably damaging |
Het |
| Adora2b |
G |
A |
11: 62,156,363 (GRCm39) |
V271M |
probably benign |
Het |
| Agpat5 |
A |
G |
8: 18,896,739 (GRCm39) |
Y55C |
probably damaging |
Het |
| AI987944 |
A |
C |
7: 41,023,772 (GRCm39) |
Y402* |
probably null |
Het |
| Angptl4 |
C |
T |
17: 34,000,165 (GRCm39) |
A68T |
possibly damaging |
Het |
| Ankmy1 |
T |
C |
1: 92,814,531 (GRCm39) |
I325M |
probably benign |
Het |
| Arfgap2 |
A |
G |
2: 91,105,204 (GRCm39) |
K423E |
probably damaging |
Het |
| Arfgef3 |
A |
T |
10: 18,522,302 (GRCm39) |
S575T |
probably damaging |
Het |
| Arhgap24 |
A |
G |
5: 103,008,198 (GRCm39) |
I40V |
possibly damaging |
Het |
| Arhgef7 |
T |
C |
8: 11,869,733 (GRCm39) |
|
probably null |
Het |
| Arid1a |
C |
A |
4: 133,448,237 (GRCm39) |
S477I |
unknown |
Het |
| Armc7 |
T |
C |
11: 115,367,029 (GRCm39) |
V58A |
probably damaging |
Het |
| Arrdc5 |
A |
T |
17: 56,601,222 (GRCm39) |
I301N |
probably damaging |
Het |
| Capn15 |
G |
A |
17: 26,183,453 (GRCm39) |
P343S |
probably damaging |
Het |
| Catspere2 |
C |
T |
1: 177,843,495 (GRCm39) |
T69I |
possibly damaging |
Het |
| Ccdc39 |
T |
C |
3: 33,880,629 (GRCm39) |
K446R |
probably damaging |
Het |
| Cgn |
C |
T |
3: 94,670,535 (GRCm39) |
R1002Q |
probably damaging |
Het |
| Clstn3 |
A |
T |
6: 124,414,449 (GRCm39) |
I759N |
possibly damaging |
Het |
| Cops5 |
A |
G |
1: 10,104,243 (GRCm39) |
V166A |
possibly damaging |
Het |
| Cramp1 |
G |
T |
17: 25,191,323 (GRCm39) |
T1046K |
probably benign |
Het |
| Cthrc1 |
T |
G |
15: 38,950,072 (GRCm39) |
V143G |
probably damaging |
Het |
| Cul9 |
G |
A |
17: 46,849,490 (GRCm39) |
Q552* |
probably null |
Het |
| Cyp27b1 |
A |
T |
10: 126,886,957 (GRCm39) |
D391V |
probably damaging |
Het |
| Dcun1d2 |
A |
G |
8: 13,331,040 (GRCm39) |
L30S |
probably damaging |
Het |
| Dsc3 |
T |
C |
18: 20,120,091 (GRCm39) |
E189G |
probably damaging |
Het |
| Dst |
T |
G |
1: 34,193,675 (GRCm39) |
S295A |
probably damaging |
Het |
| Dusp22 |
A |
G |
13: 30,892,798 (GRCm39) |
T192A |
probably benign |
Het |
| Esp24 |
A |
T |
17: 39,349,176 (GRCm39) |
M1L |
probably null |
Het |
| Evc2 |
G |
A |
5: 37,550,541 (GRCm39) |
|
probably null |
Het |
| Fgd6 |
A |
G |
10: 93,880,694 (GRCm39) |
N516S |
probably benign |
Het |
| Fmn1 |
T |
C |
2: 113,426,714 (GRCm39) |
Y1144H |
probably damaging |
Het |
| Fut8 |
T |
A |
12: 77,495,448 (GRCm39) |
I346K |
possibly damaging |
Het |
| Gata3 |
A |
C |
2: 9,882,201 (GRCm39) |
V32G |
probably damaging |
Het |
| Glrb |
A |
T |
3: 80,819,282 (GRCm39) |
C39S |
possibly damaging |
Het |
| Gpr171 |
A |
G |
3: 59,005,016 (GRCm39) |
V253A |
probably benign |
Het |
| Hdac5 |
A |
G |
11: 102,092,079 (GRCm39) |
V670A |
probably benign |
Het |
| Hmgxb3 |
T |
C |
18: 61,266,980 (GRCm39) |
S1085G |
probably benign |
Het |
| Hspa4l |
A |
G |
3: 40,741,226 (GRCm39) |
N746S |
probably benign |
Het |
| Hyal5 |
A |
G |
6: 24,877,902 (GRCm39) |
T333A |
probably benign |
Het |
| Ippk |
T |
C |
13: 49,615,069 (GRCm39) |
V484A |
probably benign |
Het |
| Jmjd8 |
A |
T |
17: 26,048,266 (GRCm39) |
T33S |
possibly damaging |
Het |
| Kctd19 |
T |
A |
8: 106,113,694 (GRCm39) |
I660L |
possibly damaging |
Het |
| Lrat |
A |
G |
3: 82,810,649 (GRCm39) |
V124A |
probably benign |
Het |
| Madcam1 |
A |
G |
10: 79,502,358 (GRCm39) |
I281V |
probably benign |
Het |
| Mast2 |
T |
A |
4: 116,173,688 (GRCm39) |
I455F |
possibly damaging |
Het |
| Mroh7 |
A |
G |
4: 106,560,255 (GRCm39) |
L683P |
probably benign |
Het |
| Myo15b |
C |
A |
11: 115,777,683 (GRCm39) |
|
probably null |
Het |
| Ncam1 |
T |
C |
9: 49,416,849 (GRCm39) |
E814G |
probably benign |
Het |
| Ncoa3 |
A |
G |
2: 165,897,182 (GRCm39) |
T658A |
probably benign |
Het |
| Or13a20 |
T |
G |
7: 140,232,650 (GRCm39) |
Y253D |
probably damaging |
Het |
| Or9a2 |
T |
C |
6: 41,748,456 (GRCm39) |
Y259C |
possibly damaging |
Het |
| P2ry13 |
T |
C |
3: 59,116,939 (GRCm39) |
K280E |
probably damaging |
Het |
| Paqr8 |
C |
A |
1: 21,005,048 (GRCm39) |
F67L |
probably benign |
Het |
| Pfkfb3 |
G |
T |
2: 11,498,747 (GRCm39) |
R37S |
probably damaging |
Het |
| Phf14 |
A |
G |
6: 11,941,478 (GRCm39) |
D310G |
possibly damaging |
Het |
| Phkb |
A |
G |
8: 86,602,286 (GRCm39) |
S26G |
possibly damaging |
Het |
| Pkd1l2 |
T |
A |
8: 117,755,147 (GRCm39) |
I1684F |
probably damaging |
Het |
| Plod2 |
T |
C |
9: 92,488,637 (GRCm39) |
V621A |
probably benign |
Het |
| Plvap |
T |
C |
8: 71,964,116 (GRCm39) |
N82S |
probably damaging |
Het |
| Pomgnt2 |
A |
G |
9: 121,811,326 (GRCm39) |
V485A |
probably damaging |
Het |
| Psmd9 |
A |
G |
5: 123,366,410 (GRCm39) |
E14G |
probably benign |
Het |
| Pwwp2b |
A |
G |
7: 138,835,879 (GRCm39) |
E440G |
probably damaging |
Het |
| Rft1 |
C |
T |
14: 30,388,744 (GRCm39) |
Q223* |
probably null |
Het |
| Rgs22 |
C |
A |
15: 36,093,047 (GRCm39) |
V409F |
probably damaging |
Het |
| Rgsl1 |
G |
A |
1: 153,701,672 (GRCm39) |
P261S |
possibly damaging |
Het |
| Rpl7a |
A |
G |
2: 26,801,127 (GRCm39) |
N38S |
probably damaging |
Het |
| Sh3rf2 |
T |
A |
18: 42,187,004 (GRCm39) |
F41Y |
probably damaging |
Het |
| Spata6 |
T |
A |
4: 111,603,388 (GRCm39) |
S34R |
probably damaging |
Het |
| Sult2a3 |
A |
T |
7: 13,856,867 (GRCm39) |
Y18N |
probably benign |
Het |
| Tapt1 |
A |
G |
5: 44,375,444 (GRCm39) |
|
probably null |
Het |
| Tex2 |
A |
T |
11: 106,394,466 (GRCm39) |
C615S |
possibly damaging |
Het |
| Trim43b |
T |
C |
9: 88,969,665 (GRCm39) |
K261R |
possibly damaging |
Het |
| Unc5c |
T |
A |
3: 141,495,583 (GRCm39) |
M484K |
probably damaging |
Het |
| Vezf1 |
T |
A |
11: 87,964,573 (GRCm39) |
S242T |
probably damaging |
Het |
| Vmn2r1 |
A |
G |
3: 63,997,034 (GRCm39) |
Y230C |
probably damaging |
Het |
| Vmn2r94 |
A |
G |
17: 18,477,965 (GRCm39) |
S149P |
probably damaging |
Het |
| Wfdc1 |
T |
A |
8: 120,393,405 (GRCm39) |
|
probably null |
Het |
| Zfp975 |
T |
C |
7: 42,312,236 (GRCm39) |
T126A |
probably benign |
Het |
| Zmym4 |
T |
C |
4: 126,776,105 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Rasgrp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00504:Rasgrp1
|
APN |
2 |
117,136,272 (GRCm39) |
nonsense |
probably null |
|
|
IGL00901:Rasgrp1
|
APN |
2 |
117,115,611 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01083:Rasgrp1
|
APN |
2 |
117,115,549 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01325:Rasgrp1
|
APN |
2 |
117,129,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Rasgrp1
|
APN |
2 |
117,119,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01776:Rasgrp1
|
APN |
2 |
117,117,321 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01780:Rasgrp1
|
APN |
2 |
117,115,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01859:Rasgrp1
|
APN |
2 |
117,119,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01892:Rasgrp1
|
APN |
2 |
117,124,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02068:Rasgrp1
|
APN |
2 |
117,131,059 (GRCm39) |
splice site |
probably benign |
|
|
IGL02684:Rasgrp1
|
APN |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
bukhansan
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Commendatore
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
dragged
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
grouper
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
Gyeryandsan
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Haddock
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
jovial
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
mercurial
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
naejangsan
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
sea_bass
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
venutian
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Rasgrp1
|
UTSW |
2 |
117,115,428 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0786:Rasgrp1
|
UTSW |
2 |
117,130,980 (GRCm39) |
missense |
probably benign |
|
|
R1068:Rasgrp1
|
UTSW |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1165:Rasgrp1
|
UTSW |
2 |
117,115,420 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1707:Rasgrp1
|
UTSW |
2 |
117,129,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Rasgrp1
|
UTSW |
2 |
117,120,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2214:Rasgrp1
|
UTSW |
2 |
117,115,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2425:Rasgrp1
|
UTSW |
2 |
117,119,931 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3236:Rasgrp1
|
UTSW |
2 |
117,122,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3915:Rasgrp1
|
UTSW |
2 |
117,119,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Rasgrp1
|
UTSW |
2 |
117,115,510 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4163:Rasgrp1
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4781:Rasgrp1
|
UTSW |
2 |
117,122,190 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4782:Rasgrp1
|
UTSW |
2 |
117,115,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5028:Rasgrp1
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
R6019:Rasgrp1
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6220:Rasgrp1
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R6294:Rasgrp1
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
R6335:Rasgrp1
|
UTSW |
2 |
117,124,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6948:Rasgrp1
|
UTSW |
2 |
117,129,085 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7165:Rasgrp1
|
UTSW |
2 |
117,168,885 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7246:Rasgrp1
|
UTSW |
2 |
117,168,835 (GRCm39) |
nonsense |
probably null |
|
|
R7372:Rasgrp1
|
UTSW |
2 |
117,115,635 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7400:Rasgrp1
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7449:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7475:Rasgrp1
|
UTSW |
2 |
117,116,589 (GRCm39) |
missense |
probably benign |
|
|
R7487:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7573:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7672:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8016:Rasgrp1
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
R8199:Rasgrp1
|
UTSW |
2 |
117,124,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8527:Rasgrp1
|
UTSW |
2 |
117,168,785 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8692:Rasgrp1
|
UTSW |
2 |
117,115,353 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8725:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8727:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8880:Rasgrp1
|
UTSW |
2 |
117,115,425 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9280:Rasgrp1
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9675:Rasgrp1
|
UTSW |
2 |
117,173,190 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R9792:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9793:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9795:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1176:Rasgrp1
|
UTSW |
2 |
117,132,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTGCTGAACGTCTGCAATGAG -3'
(R):5'- TTACGATGCCTGCGTCACACTAC -3'
Sequencing Primer
(F):5'- GCAATGAGTTTTGAAGTGAGATCCC -3'
(R):5'- CCCAAGAATGGATTGTTCTGTC -3'
|
| Posted On |
2014-03-28 |
Incidental Mutation