Incidental Mutation 'R1710:Or14c39'
ID 190434
Institutional Source Beutler Lab
Gene Symbol Or14c39
Ensembl Gene ENSMUSG00000060688
Gene Name olfactory receptor family 14 subfamily C member 39
Synonyms Olfr292, MOR220-2, GA_x6K02T2NHDJ-9425121-9424195
MMRRC Submission 039743-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R1710 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 86337549-86344592 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 86344318 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 218 (R218H)
Ref Sequence ENSEMBL: ENSMUSP00000079060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080165]
AlphaFold F8VQ84
Predicted Effect probably benign
Transcript: ENSMUST00000080165
AA Change: R218H

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000079060
Gene: ENSMUSG00000060688
AA Change: R218H

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 2.6e-48 PFAM
Pfam:7tm_1 39 288 2.7e-22 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.5%
Validation Efficiency 98% (117/120)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 114 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503L19Rik A T 18: 70,601,134 (GRCm39) S249R possibly damaging Het
Acadvl T A 11: 69,901,181 (GRCm39) I638F probably damaging Het
Acnat2 T A 4: 49,380,587 (GRCm39) T264S probably benign Het
Acrv1 C T 9: 36,605,551 (GRCm39) Q33* probably null Het
Actrt3 T A 3: 30,653,901 (GRCm39) N33I probably damaging Het
Alyref2 T C 1: 171,331,168 (GRCm39) probably benign Het
Ank2 C A 3: 126,726,709 (GRCm39) E3712* probably null Het
Ano7 C A 1: 93,313,346 (GRCm39) H161Q probably benign Het
Arhgap10 C A 8: 78,085,216 (GRCm39) E451* probably null Het
Arhgap29 T A 3: 121,801,729 (GRCm39) Y748N probably damaging Het
Arhgap45 C T 10: 79,853,932 (GRCm39) Q149* probably null Het
Asap2 C T 12: 21,274,393 (GRCm39) H371Y probably damaging Het
Atp6v1b1 T C 6: 83,735,372 (GRCm39) I480T probably benign Het
BC034090 T C 1: 155,101,610 (GRCm39) D218G possibly damaging Het
Brdt A T 5: 107,491,450 (GRCm39) D74V probably damaging Het
C4b A G 17: 34,962,638 (GRCm39) probably benign Het
Card11 T A 5: 140,888,660 (GRCm39) K233* probably null Het
Catip T G 1: 74,401,929 (GRCm39) F35V possibly damaging Het
Ccdc13 C T 9: 121,648,647 (GRCm39) G247R probably damaging Het
Cep97 T A 16: 55,735,385 (GRCm39) D471V probably damaging Het
Col17a1 A T 19: 47,659,370 (GRCm39) L403Q probably damaging Het
Crbn A G 6: 106,767,906 (GRCm39) S194P possibly damaging Het
Degs1l A G 1: 180,878,884 (GRCm39) M1V probably null Het
Dennd10 A G 19: 60,806,021 (GRCm39) Y102C probably damaging Het
Dhx58 T A 11: 100,594,400 (GRCm39) H97L probably benign Het
Dnah8 T C 17: 31,073,914 (GRCm39) I4528T probably damaging Het
Dpyd A G 3: 118,404,092 (GRCm39) probably null Het
Entpd1 A T 19: 40,714,680 (GRCm39) Q263L probably benign Het
Entrep1 A T 19: 23,957,059 (GRCm39) I317N probably damaging Het
Esyt3 T C 9: 99,218,244 (GRCm39) I130M probably benign Het
Etv1 T C 12: 38,902,261 (GRCm39) F264S probably benign Het
Fat1 T C 8: 45,463,519 (GRCm39) S1354P probably benign Het
Fat4 C A 3: 39,005,304 (GRCm39) T1901N probably damaging Het
Fbxw13 C T 9: 109,010,586 (GRCm39) V351I probably damaging Het
Fmo3 A G 1: 162,795,356 (GRCm39) F160L possibly damaging Het
Fyb2 T A 4: 104,861,113 (GRCm39) D592E probably damaging Het
Gjb4 T C 4: 127,245,663 (GRCm39) M93V possibly damaging Het
Gm5089 C A 14: 122,673,566 (GRCm39) G52* probably null Het
Gm6401 G T 14: 41,788,840 (GRCm39) N76K probably benign Het
Gm6871 A G 7: 41,195,901 (GRCm39) S279P probably damaging Het
Gtf2ird2 T G 5: 134,240,081 (GRCm39) V301G probably benign Het
H2bw2 A C X: 135,828,216 (GRCm39) D35A unknown Het
Hfm1 A G 5: 107,028,380 (GRCm39) F817L probably damaging Het
Hfm1 T C 5: 107,043,869 (GRCm39) E589G probably damaging Het
Hivep2 A T 10: 14,005,249 (GRCm39) K616* probably null Het
Hmcn1 A T 1: 150,551,735 (GRCm39) I2623N probably damaging Het
Igf2bp3 G T 6: 49,082,565 (GRCm39) A339E probably damaging Het
Insyn2b T A 11: 34,354,263 (GRCm39) probably null Het
Irx4 T C 13: 73,415,757 (GRCm39) I182T possibly damaging Het
Jcad T C 18: 4,674,511 (GRCm39) S758P probably damaging Het
Klhdc4 A T 8: 122,526,226 (GRCm39) Y304* probably null Het
Lama1 A G 17: 68,060,786 (GRCm39) I705V probably benign Het
Mbd5 A G 2: 49,147,044 (GRCm39) N418S probably benign Het
Mmp21 C T 7: 133,279,014 (GRCm39) V279I probably damaging Het
Morc4 A C X: 138,755,279 (GRCm39) C272W probably damaging Het
Mrm1 A T 11: 84,709,518 (GRCm39) C180S probably damaging Het
Ncor1 T C 11: 62,313,831 (GRCm39) D103G probably damaging Het
Ndrg4 A G 8: 96,437,314 (GRCm39) D251G probably damaging Het
Ndufaf5 T C 2: 140,035,522 (GRCm39) V246A possibly damaging Het
Noa1 T C 5: 77,457,572 (GRCm39) E111G possibly damaging Het
Nod1 C A 6: 54,921,044 (GRCm39) V425F probably damaging Het
Nos1 A T 5: 118,033,984 (GRCm39) I369F probably damaging Het
Nsun5 C T 5: 135,400,170 (GRCm39) H98Y probably damaging Het
Optn G A 2: 5,057,941 (GRCm39) T76I possibly damaging Het
Or4k15c C G 14: 50,321,827 (GRCm39) V104L probably benign Het
Or5k1b A G 16: 58,581,504 (GRCm39) F12L probably benign Het
Or8d1b A G 9: 38,887,202 (GRCm39) I77V probably damaging Het
Or8g28 T C 9: 39,169,867 (GRCm39) I37V probably benign Het
Or9g19 C T 2: 85,600,199 (GRCm39) T18I probably benign Het
Oscar C T 7: 3,614,855 (GRCm39) W22* probably null Het
Palmd T A 3: 116,717,306 (GRCm39) Y397F probably damaging Het
Plk1 A G 7: 121,768,121 (GRCm39) D447G probably damaging Het
Plscr5 T A 9: 92,087,581 (GRCm39) N183K probably damaging Het
Polk T G 13: 96,625,712 (GRCm39) D364A probably damaging Het
Polr3d T C 14: 70,680,450 (GRCm39) T36A probably benign Het
Ppp1r10 A T 17: 36,237,428 (GRCm39) R199S probably damaging Het
Prkcz C T 4: 155,346,969 (GRCm39) D388N probably damaging Het
Prrc2b T C 2: 32,102,234 (GRCm39) L769P probably damaging Het
Psg26 A G 7: 18,213,966 (GRCm39) V232A probably damaging Het
Pth2r T C 1: 65,375,997 (GRCm39) V85A possibly damaging Het
Rbpms2 T C 9: 65,566,494 (GRCm39) probably benign Het
Reps1 A T 10: 17,994,698 (GRCm39) D514V possibly damaging Het
Riok3 G T 18: 12,276,018 (GRCm39) R238L probably benign Het
Rnf19a T C 15: 36,244,353 (GRCm39) Q569R probably damaging Het
Rorb G A 19: 18,937,865 (GRCm39) T267I probably damaging Het
Rrm2b A T 15: 37,929,340 (GRCm39) M70K probably damaging Het
Rsf1 A T 7: 97,311,556 (GRCm39) E762V possibly damaging Het
S100a2 G A 3: 90,498,699 (GRCm39) V67I probably benign Het
Skp1 T A 11: 52,133,442 (GRCm39) D42E probably benign Het
Slc22a4 A T 11: 53,918,801 (GRCm39) M1K probably null Het
Slc2a9 T A 5: 38,539,387 (GRCm39) Q371L probably damaging Het
Slc4a9 A G 18: 36,665,075 (GRCm39) T475A probably benign Het
Slc8b1 A G 5: 120,657,717 (GRCm39) N60S probably damaging Het
Slx4 A C 16: 3,817,022 (GRCm39) D66E probably benign Het
Smg8 A T 11: 86,977,113 (GRCm39) I156N probably damaging Het
Snx25 A T 8: 46,569,244 (GRCm39) C218S possibly damaging Het
Sulf2 T C 2: 165,920,992 (GRCm39) I784V probably benign Het
Tatdn2 G T 6: 113,674,888 (GRCm39) R72L possibly damaging Het
Tbc1d8 T C 1: 39,445,918 (GRCm39) D91G possibly damaging Het
Tifab C A 13: 56,324,433 (GRCm39) R3S probably benign Het
Tm4sf1 A T 3: 57,200,304 (GRCm39) S104T probably damaging Het
Tmem132e T A 11: 82,334,343 (GRCm39) I618N probably damaging Het
Ttc7b A T 12: 100,369,667 (GRCm39) D367E probably damaging Het
Txlnb A G 10: 17,719,203 (GRCm39) D678G possibly damaging Het
Vgll4 A G 6: 114,934,895 (GRCm39) probably null Het
Vmn2r124 A T 17: 18,282,187 (GRCm39) probably benign Het
Vmn2r2 T C 3: 64,024,820 (GRCm39) D587G probably benign Het
Vmn2r84 G A 10: 130,226,968 (GRCm39) A290V probably benign Het
Vps13c T A 9: 67,818,811 (GRCm39) S1077R probably benign Het
Vsig10 C T 5: 117,489,719 (GRCm39) A495V probably benign Het
Vwa3a A T 7: 120,403,254 (GRCm39) probably null Het
Zfhx2 C A 14: 55,303,455 (GRCm39) A1510S possibly damaging Het
Zfp142 T A 1: 74,611,389 (GRCm39) D601V probably damaging Het
Zfp62 T C 11: 49,108,510 (GRCm39) I867T probably benign Het
Other mutations in Or14c39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Or14c39 APN 7 86,344,501 (GRCm39) missense probably benign 0.10
IGL01751:Or14c39 APN 7 86,343,997 (GRCm39) missense probably benign
IGL02417:Or14c39 APN 7 86,344,027 (GRCm39) missense probably damaging 1.00
IGL02534:Or14c39 APN 7 86,343,939 (GRCm39) missense probably benign 0.17
IGL02830:Or14c39 APN 7 86,344,382 (GRCm39) missense probably damaging 1.00
R0281:Or14c39 UTSW 7 86,344,068 (GRCm39) missense probably benign 0.00
R0423:Or14c39 UTSW 7 86,344,434 (GRCm39) missense possibly damaging 0.95
R0555:Or14c39 UTSW 7 86,344,516 (GRCm39) missense probably damaging 1.00
R0609:Or14c39 UTSW 7 86,344,084 (GRCm39) missense possibly damaging 0.85
R0662:Or14c39 UTSW 7 86,343,838 (GRCm39) missense possibly damaging 0.88
R2144:Or14c39 UTSW 7 86,344,488 (GRCm39) missense probably damaging 0.98
R4400:Or14c39 UTSW 7 86,343,798 (GRCm39) missense probably benign 0.10
R4615:Or14c39 UTSW 7 86,343,936 (GRCm39) missense probably damaging 1.00
R4762:Or14c39 UTSW 7 86,344,329 (GRCm39) missense probably benign 0.01
R4785:Or14c39 UTSW 7 86,343,736 (GRCm39) missense probably damaging 1.00
R4823:Or14c39 UTSW 7 86,343,796 (GRCm39) missense probably damaging 0.99
R4908:Or14c39 UTSW 7 86,344,395 (GRCm39) missense probably benign 0.00
R4983:Or14c39 UTSW 7 86,343,687 (GRCm39) missense probably benign 0.01
R5010:Or14c39 UTSW 7 86,343,793 (GRCm39) missense possibly damaging 0.95
R5024:Or14c39 UTSW 7 86,344,089 (GRCm39) missense probably benign 0.05
R5157:Or14c39 UTSW 7 86,344,440 (GRCm39) missense probably benign 0.19
R5627:Or14c39 UTSW 7 86,344,347 (GRCm39) missense possibly damaging 0.93
R6327:Or14c39 UTSW 7 86,343,760 (GRCm39) missense probably benign 0.09
R6375:Or14c39 UTSW 7 86,344,267 (GRCm39) missense probably benign 0.01
R6775:Or14c39 UTSW 7 86,344,357 (GRCm39) missense probably benign 0.02
R7257:Or14c39 UTSW 7 86,344,012 (GRCm39) missense probably damaging 0.99
R7383:Or14c39 UTSW 7 86,343,960 (GRCm39) missense probably damaging 0.97
R8475:Or14c39 UTSW 7 86,344,361 (GRCm39) missense probably benign 0.21
R9034:Or14c39 UTSW 7 86,343,969 (GRCm39) missense probably benign 0.41
R9134:Or14c39 UTSW 7 86,344,588 (GRCm39) nonsense probably null
R9588:Or14c39 UTSW 7 86,343,948 (GRCm39) missense probably damaging 1.00
R9777:Or14c39 UTSW 7 86,343,988 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- GCCCAATGCTTGTATCAACTCTCTCACT -3'
(R):5'- ACAGCCTCCTTTATCTGTTTGTTTCTAAGAC -3'

Sequencing Primer
(F):5'- CTGGGTGTGCAGCACAAATC -3'
(R):5'- TGGTGGAACAATGGTATAAAATACAG -3'
Posted On 2014-05-14