Incidental Mutation 'R2104:Casp8ap2'
ID |
230764 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Casp8ap2
|
Ensembl Gene |
ENSMUSG00000028282 |
Gene Name |
caspase 8 associated protein 2 |
Synonyms |
FLASH, D4Ertd659e |
MMRRC Submission |
040108-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R2104 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
32615462-32653271 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 32644727 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 1267
(S1267P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136016
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029950]
[ENSMUST00000108178]
[ENSMUST00000178925]
|
AlphaFold |
Q9WUF3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000029950
AA Change: S1267P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000029950 Gene: ENSMUSG00000028282 AA Change: S1267P
Domain | Start | End | E-Value | Type |
coiled coil region
|
68 |
142 |
N/A |
INTRINSIC |
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
low complexity region
|
458 |
477 |
N/A |
INTRINSIC |
low complexity region
|
1124 |
1135 |
N/A |
INTRINSIC |
low complexity region
|
1250 |
1268 |
N/A |
INTRINSIC |
low complexity region
|
1360 |
1377 |
N/A |
INTRINSIC |
low complexity region
|
1458 |
1470 |
N/A |
INTRINSIC |
low complexity region
|
1477 |
1498 |
N/A |
INTRINSIC |
low complexity region
|
1882 |
1895 |
N/A |
INTRINSIC |
PDB:2LR8|A
|
1896 |
1962 |
1e-31 |
PDB |
Blast:SANT
|
1905 |
1955 |
2e-21 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108178
|
SMART Domains |
Protein: ENSMUSP00000103813 Gene: ENSMUSG00000028282
Domain | Start | End | E-Value | Type |
PDB:2LR8|A
|
126 |
190 |
4e-26 |
PDB |
Blast:SANT
|
139 |
183 |
4e-19 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000178925
AA Change: S1267P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000136016 Gene: ENSMUSG00000028282 AA Change: S1267P
Domain | Start | End | E-Value | Type |
coiled coil region
|
68 |
142 |
N/A |
INTRINSIC |
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
low complexity region
|
458 |
477 |
N/A |
INTRINSIC |
low complexity region
|
1124 |
1135 |
N/A |
INTRINSIC |
low complexity region
|
1250 |
1268 |
N/A |
INTRINSIC |
low complexity region
|
1360 |
1377 |
N/A |
INTRINSIC |
low complexity region
|
1458 |
1470 |
N/A |
INTRINSIC |
low complexity region
|
1477 |
1498 |
N/A |
INTRINSIC |
low complexity region
|
1882 |
1895 |
N/A |
INTRINSIC |
PDB:2LR8|A
|
1896 |
1962 |
1e-31 |
PDB |
Blast:SANT
|
1905 |
1955 |
2e-21 |
BLAST |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.3%
|
Validation Efficiency |
100% (80/80) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008] PHENOTYPE: Mice homozygous for disruption of this gene die before implantation. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 81 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acsm3 |
G |
A |
7: 119,383,527 (GRCm39) |
V563I |
probably benign |
Het |
Amer3 |
T |
C |
1: 34,627,759 (GRCm39) |
V666A |
probably benign |
Het |
Ankrd16 |
A |
G |
2: 11,784,711 (GRCm39) |
|
probably benign |
Het |
Ankub1 |
G |
T |
3: 57,580,296 (GRCm39) |
C120* |
probably null |
Het |
Arhgap31 |
T |
C |
16: 38,445,941 (GRCm39) |
I135V |
probably benign |
Het |
Atp2c2 |
G |
A |
8: 120,476,584 (GRCm39) |
G633D |
probably benign |
Het |
Camta1 |
T |
A |
4: 151,537,751 (GRCm39) |
Q143L |
probably damaging |
Het |
Ccn4 |
A |
G |
15: 66,791,176 (GRCm39) |
E326G |
probably benign |
Het |
Cdh1 |
T |
A |
8: 107,380,391 (GRCm39) |
|
probably benign |
Het |
Cdhr4 |
C |
A |
9: 107,873,460 (GRCm39) |
D397E |
probably damaging |
Het |
Cdk6 |
T |
G |
5: 3,394,387 (GRCm39) |
S7R |
probably benign |
Het |
Cert1 |
T |
A |
13: 96,771,394 (GRCm39) |
N550K |
probably damaging |
Het |
Cilp2 |
C |
A |
8: 70,335,442 (GRCm39) |
E519* |
probably null |
Het |
Clybl |
A |
G |
14: 122,548,718 (GRCm39) |
Y40C |
probably damaging |
Het |
Ctnnal1 |
T |
C |
4: 56,812,329 (GRCm39) |
*732W |
probably null |
Het |
Ctns |
A |
T |
11: 73,083,907 (GRCm39) |
S38R |
probably benign |
Het |
Cwh43 |
A |
T |
5: 73,578,873 (GRCm39) |
K293N |
possibly damaging |
Het |
Dcaf5 |
G |
T |
12: 80,385,635 (GRCm39) |
D830E |
probably benign |
Het |
Dmxl2 |
A |
G |
9: 54,322,848 (GRCm39) |
V1512A |
probably damaging |
Het |
Dnah9 |
A |
T |
11: 65,951,950 (GRCm39) |
C1850S |
probably damaging |
Het |
Dpp8 |
C |
T |
9: 64,981,849 (GRCm39) |
|
probably null |
Het |
Enam |
A |
T |
5: 88,649,646 (GRCm39) |
Q385L |
probably damaging |
Het |
Etv3 |
A |
G |
3: 87,443,369 (GRCm39) |
T318A |
possibly damaging |
Het |
Exd2 |
T |
G |
12: 80,543,575 (GRCm39) |
I586S |
probably benign |
Het |
Fat3 |
A |
G |
9: 15,909,813 (GRCm39) |
V2063A |
possibly damaging |
Het |
Fezf1 |
A |
G |
6: 23,247,331 (GRCm39) |
F248S |
possibly damaging |
Het |
Flnc |
T |
C |
6: 29,450,734 (GRCm39) |
|
probably null |
Het |
Foxc2 |
A |
G |
8: 121,844,819 (GRCm39) |
Y489C |
probably damaging |
Het |
Gfm2 |
A |
G |
13: 97,308,028 (GRCm39) |
E540G |
probably damaging |
Het |
Hrg |
T |
C |
16: 22,774,949 (GRCm39) |
I193T |
probably benign |
Het |
Ifih1 |
G |
A |
2: 62,440,889 (GRCm39) |
Q426* |
probably null |
Het |
Ifit1bl2 |
T |
A |
19: 34,596,920 (GRCm39) |
D232V |
probably benign |
Het |
Igf2bp1 |
A |
G |
11: 95,866,122 (GRCm39) |
V122A |
probably damaging |
Het |
Inpp1 |
T |
G |
1: 52,838,577 (GRCm39) |
Q24P |
probably damaging |
Het |
Kifc2 |
A |
G |
15: 76,545,454 (GRCm39) |
D67G |
probably damaging |
Het |
Lrrc43 |
G |
A |
5: 123,639,177 (GRCm39) |
G402D |
probably benign |
Het |
Lrrc8c |
C |
T |
5: 105,755,224 (GRCm39) |
T333M |
possibly damaging |
Het |
Mab21l3 |
G |
T |
3: 101,730,744 (GRCm39) |
A165D |
probably benign |
Het |
Mcub |
T |
A |
3: 129,712,337 (GRCm39) |
R179S |
probably benign |
Het |
Mdfi |
G |
C |
17: 48,135,562 (GRCm39) |
A56G |
possibly damaging |
Het |
Mdn1 |
A |
T |
4: 32,743,843 (GRCm39) |
|
probably null |
Het |
Meox2 |
A |
G |
12: 37,217,476 (GRCm39) |
T226A |
probably damaging |
Het |
Mipol1 |
A |
G |
12: 57,352,842 (GRCm39) |
|
probably null |
Het |
Mms22l |
T |
G |
4: 24,591,084 (GRCm39) |
N1018K |
probably benign |
Het |
Mn1 |
T |
C |
5: 111,602,617 (GRCm39) |
I1285T |
possibly damaging |
Het |
Muc20 |
T |
G |
16: 32,614,547 (GRCm39) |
S277R |
probably damaging |
Het |
Muc6 |
C |
A |
7: 141,213,991 (GRCm39) |
V2845L |
probably benign |
Het |
Mup5 |
C |
A |
4: 61,751,962 (GRCm39) |
G96C |
probably damaging |
Het |
Neb |
T |
A |
2: 52,146,826 (GRCm39) |
M2813L |
probably benign |
Het |
Neb |
C |
A |
2: 52,161,570 (GRCm39) |
R2074L |
probably damaging |
Het |
Oasl2 |
A |
T |
5: 115,049,063 (GRCm39) |
K168* |
probably null |
Het |
Or6c5 |
T |
C |
10: 129,074,368 (GRCm39) |
S117P |
probably damaging |
Het |
P2rx2 |
C |
T |
5: 110,489,007 (GRCm39) |
D203N |
probably damaging |
Het |
Ptprg |
T |
C |
14: 11,952,897 (GRCm38) |
|
probably null |
Het |
Rims4 |
C |
T |
2: 163,706,785 (GRCm39) |
|
probably null |
Het |
Rtn4ip1 |
T |
A |
10: 43,808,402 (GRCm39) |
W60R |
probably benign |
Het |
Sccpdh |
T |
C |
1: 179,498,162 (GRCm39) |
S69P |
probably benign |
Het |
Serpina3b |
T |
A |
12: 104,105,069 (GRCm39) |
I415N |
probably benign |
Het |
Slc22a4 |
T |
C |
11: 53,874,436 (GRCm39) |
|
probably benign |
Het |
Slc4a5 |
G |
A |
6: 83,274,360 (GRCm39) |
A1076T |
probably benign |
Het |
Slit1 |
T |
C |
19: 41,590,686 (GRCm39) |
K1329E |
possibly damaging |
Het |
Synj2bp |
A |
C |
12: 81,548,826 (GRCm39) |
F138V |
probably benign |
Het |
Taar7a |
T |
C |
10: 23,868,959 (GRCm39) |
I141V |
probably damaging |
Het |
Tas1r3 |
T |
C |
4: 155,946,588 (GRCm39) |
E339G |
probably benign |
Het |
Tep1 |
A |
G |
14: 51,088,037 (GRCm39) |
|
probably benign |
Het |
Tgds |
A |
T |
14: 118,359,149 (GRCm39) |
Y146* |
probably null |
Het |
Tgm3 |
G |
A |
2: 129,879,403 (GRCm39) |
V332I |
probably benign |
Het |
Tnnt2 |
A |
G |
1: 135,771,547 (GRCm39) |
|
probably benign |
Het |
Top1 |
T |
A |
2: 160,546,739 (GRCm39) |
Y340N |
probably damaging |
Het |
Topbp1 |
T |
C |
9: 103,195,181 (GRCm39) |
|
probably benign |
Het |
Tpst1 |
A |
G |
5: 130,131,202 (GRCm39) |
N224S |
probably benign |
Het |
Traf4 |
A |
G |
11: 78,050,840 (GRCm39) |
F439L |
probably damaging |
Het |
Trim58 |
A |
G |
11: 58,533,964 (GRCm39) |
|
probably benign |
Het |
Tspan31 |
T |
C |
10: 126,904,004 (GRCm39) |
N205S |
probably damaging |
Het |
Ube3a |
T |
A |
7: 58,926,225 (GRCm39) |
N334K |
possibly damaging |
Het |
Ugt2a3 |
A |
T |
5: 87,477,541 (GRCm39) |
|
probably null |
Het |
Vwf |
G |
A |
6: 125,623,293 (GRCm39) |
V1797I |
probably benign |
Het |
Wdr81 |
G |
T |
11: 75,343,809 (GRCm39) |
P486Q |
probably damaging |
Het |
Whamm |
C |
T |
7: 81,241,519 (GRCm39) |
R277* |
probably null |
Het |
Yipf7 |
T |
A |
5: 69,678,462 (GRCm39) |
N56I |
possibly damaging |
Het |
Zfp523 |
A |
T |
17: 28,414,190 (GRCm39) |
T75S |
probably benign |
Het |
|
Other mutations in Casp8ap2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00686:Casp8ap2
|
APN |
4 |
32,641,433 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00714:Casp8ap2
|
APN |
4 |
32,649,192 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00754:Casp8ap2
|
APN |
4 |
32,641,036 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00954:Casp8ap2
|
APN |
4 |
32,645,403 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00970:Casp8ap2
|
APN |
4 |
32,646,182 (GRCm39) |
missense |
probably benign |
|
IGL01534:Casp8ap2
|
APN |
4 |
32,648,134 (GRCm39) |
splice site |
probably benign |
|
IGL01596:Casp8ap2
|
APN |
4 |
32,646,365 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01686:Casp8ap2
|
APN |
4 |
32,641,294 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02002:Casp8ap2
|
APN |
4 |
32,639,391 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02273:Casp8ap2
|
APN |
4 |
32,643,974 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02510:Casp8ap2
|
APN |
4 |
32,639,704 (GRCm39) |
missense |
probably benign |
0.05 |
IGL02600:Casp8ap2
|
APN |
4 |
32,630,246 (GRCm39) |
missense |
probably null |
1.00 |
IGL02929:Casp8ap2
|
APN |
4 |
32,624,105 (GRCm39) |
utr 5 prime |
probably benign |
|
F5770:Casp8ap2
|
UTSW |
4 |
32,639,944 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02988:Casp8ap2
|
UTSW |
4 |
32,644,590 (GRCm39) |
missense |
probably benign |
0.14 |
R0023:Casp8ap2
|
UTSW |
4 |
32,640,185 (GRCm39) |
missense |
probably damaging |
0.99 |
R0027:Casp8ap2
|
UTSW |
4 |
32,643,810 (GRCm39) |
missense |
probably benign |
0.01 |
R0090:Casp8ap2
|
UTSW |
4 |
32,640,327 (GRCm39) |
missense |
probably damaging |
1.00 |
R0117:Casp8ap2
|
UTSW |
4 |
32,640,817 (GRCm39) |
missense |
probably benign |
0.00 |
R0144:Casp8ap2
|
UTSW |
4 |
32,643,797 (GRCm39) |
missense |
possibly damaging |
0.50 |
R0268:Casp8ap2
|
UTSW |
4 |
32,644,079 (GRCm39) |
missense |
probably damaging |
0.99 |
R0344:Casp8ap2
|
UTSW |
4 |
32,644,079 (GRCm39) |
missense |
probably damaging |
0.99 |
R0555:Casp8ap2
|
UTSW |
4 |
32,640,381 (GRCm39) |
missense |
probably damaging |
1.00 |
R1051:Casp8ap2
|
UTSW |
4 |
32,640,790 (GRCm39) |
missense |
probably benign |
0.28 |
R1165:Casp8ap2
|
UTSW |
4 |
32,640,563 (GRCm39) |
missense |
probably benign |
0.01 |
R1243:Casp8ap2
|
UTSW |
4 |
32,645,687 (GRCm39) |
missense |
probably benign |
0.03 |
R1311:Casp8ap2
|
UTSW |
4 |
32,648,111 (GRCm39) |
missense |
probably damaging |
0.98 |
R1337:Casp8ap2
|
UTSW |
4 |
32,645,721 (GRCm39) |
missense |
possibly damaging |
0.64 |
R1471:Casp8ap2
|
UTSW |
4 |
32,639,386 (GRCm39) |
nonsense |
probably null |
|
R1497:Casp8ap2
|
UTSW |
4 |
32,639,938 (GRCm39) |
missense |
probably benign |
0.00 |
R1521:Casp8ap2
|
UTSW |
4 |
32,631,867 (GRCm39) |
missense |
probably damaging |
1.00 |
R1588:Casp8ap2
|
UTSW |
4 |
32,640,541 (GRCm39) |
missense |
probably benign |
0.00 |
R1625:Casp8ap2
|
UTSW |
4 |
32,648,068 (GRCm39) |
missense |
probably benign |
0.04 |
R1731:Casp8ap2
|
UTSW |
4 |
32,641,442 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1899:Casp8ap2
|
UTSW |
4 |
32,643,647 (GRCm39) |
missense |
probably damaging |
0.98 |
R2000:Casp8ap2
|
UTSW |
4 |
32,634,874 (GRCm39) |
missense |
probably damaging |
1.00 |
R2021:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
R2022:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
R2023:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
R2088:Casp8ap2
|
UTSW |
4 |
32,631,126 (GRCm39) |
missense |
probably damaging |
1.00 |
R2128:Casp8ap2
|
UTSW |
4 |
32,640,142 (GRCm39) |
missense |
probably benign |
0.06 |
R2129:Casp8ap2
|
UTSW |
4 |
32,640,142 (GRCm39) |
missense |
probably benign |
0.06 |
R2305:Casp8ap2
|
UTSW |
4 |
32,646,411 (GRCm39) |
missense |
probably damaging |
1.00 |
R2316:Casp8ap2
|
UTSW |
4 |
32,643,781 (GRCm39) |
missense |
probably benign |
0.31 |
R2919:Casp8ap2
|
UTSW |
4 |
32,645,343 (GRCm39) |
missense |
probably damaging |
1.00 |
R4091:Casp8ap2
|
UTSW |
4 |
32,643,611 (GRCm39) |
missense |
probably damaging |
1.00 |
R4357:Casp8ap2
|
UTSW |
4 |
32,646,150 (GRCm39) |
missense |
probably benign |
0.00 |
R4807:Casp8ap2
|
UTSW |
4 |
32,644,505 (GRCm39) |
missense |
possibly damaging |
0.89 |
R4828:Casp8ap2
|
UTSW |
4 |
32,639,807 (GRCm39) |
missense |
probably benign |
|
R4908:Casp8ap2
|
UTSW |
4 |
32,639,905 (GRCm39) |
missense |
possibly damaging |
0.90 |
R4945:Casp8ap2
|
UTSW |
4 |
32,631,163 (GRCm39) |
missense |
possibly damaging |
0.57 |
R4962:Casp8ap2
|
UTSW |
4 |
32,640,554 (GRCm39) |
missense |
probably damaging |
0.99 |
R6014:Casp8ap2
|
UTSW |
4 |
32,641,400 (GRCm39) |
missense |
probably damaging |
0.97 |
R6092:Casp8ap2
|
UTSW |
4 |
32,639,380 (GRCm39) |
missense |
probably damaging |
1.00 |
R6257:Casp8ap2
|
UTSW |
4 |
32,641,364 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6289:Casp8ap2
|
UTSW |
4 |
32,639,590 (GRCm39) |
missense |
probably damaging |
1.00 |
R6482:Casp8ap2
|
UTSW |
4 |
32,634,813 (GRCm39) |
missense |
probably damaging |
1.00 |
R6496:Casp8ap2
|
UTSW |
4 |
32,641,553 (GRCm39) |
missense |
probably benign |
0.05 |
R6515:Casp8ap2
|
UTSW |
4 |
32,646,423 (GRCm39) |
missense |
possibly damaging |
0.64 |
R7015:Casp8ap2
|
UTSW |
4 |
32,644,278 (GRCm39) |
missense |
probably damaging |
1.00 |
R7033:Casp8ap2
|
UTSW |
4 |
32,639,392 (GRCm39) |
missense |
probably damaging |
1.00 |
R7072:Casp8ap2
|
UTSW |
4 |
32,644,766 (GRCm39) |
missense |
probably damaging |
1.00 |
R7448:Casp8ap2
|
UTSW |
4 |
32,643,974 (GRCm39) |
missense |
possibly damaging |
0.84 |
R7944:Casp8ap2
|
UTSW |
4 |
32,645,909 (GRCm39) |
missense |
probably benign |
0.12 |
R7945:Casp8ap2
|
UTSW |
4 |
32,645,909 (GRCm39) |
missense |
probably benign |
0.12 |
R8170:Casp8ap2
|
UTSW |
4 |
32,615,490 (GRCm39) |
splice site |
probably benign |
|
R8179:Casp8ap2
|
UTSW |
4 |
32,643,939 (GRCm39) |
nonsense |
probably null |
|
R8207:Casp8ap2
|
UTSW |
4 |
32,646,446 (GRCm39) |
missense |
possibly damaging |
0.63 |
R8263:Casp8ap2
|
UTSW |
4 |
32,644,072 (GRCm39) |
missense |
probably damaging |
1.00 |
R8298:Casp8ap2
|
UTSW |
4 |
32,640,429 (GRCm39) |
missense |
probably benign |
0.30 |
R9441:Casp8ap2
|
UTSW |
4 |
32,645,873 (GRCm39) |
missense |
probably benign |
0.00 |
R9455:Casp8ap2
|
UTSW |
4 |
32,643,924 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9729:Casp8ap2
|
UTSW |
4 |
32,643,807 (GRCm39) |
missense |
possibly damaging |
0.71 |
V7580:Casp8ap2
|
UTSW |
4 |
32,639,944 (GRCm39) |
missense |
probably benign |
0.00 |
X0018:Casp8ap2
|
UTSW |
4 |
32,643,738 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- GAGAGAACCCAACATTCAAATTGTC -3'
(R):5'- CAGCAGCTGTTTCTCTGGAG -3'
Sequencing Primer
(F):5'- TCACTGGGATGTGAAAAATCTGAAG -3'
(R):5'- GGAGTCTTTAATTCCCACTCTGC -3'
|
Posted On |
2014-09-18 |