Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02546:Or7g20'

297809

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7g20

Ensembl Gene

ENSMUSG00000045204

Gene Name

olfactory receptor family 7 subfamily G member 20

Synonyms

MOR150-3, GA_x6K02T2PVTD-12771995-12772930, Olfr835

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.127) question?

Stock #

IGL02546

Quality Score

Status

Chromosome

Chromosomal Location

18946421-18947356 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18946650 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 77 (V77D)

Ref Sequence

ENSEMBL: ENSMUSP00000148416 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059315] [ENSMUST00000213018]

AlphaFold

Q7TRG7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000059315
AA Change: V77D

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052610
Gene: ENSMUSG00000045204
AA Change: V77D

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.8e-47	PFAM
Pfam:7TM_GPCR_Srsx	35	206	2.9e-7	PFAM
Pfam:7tm_1	41	303	1.3e-23	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213018
AA Change: V77D

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap6	G	T	12: 52,927,521 (GRCm39)	V144L	probably damaging	Het
Carmil1	A	T	13: 24,299,482 (GRCm39)	N347K	probably damaging	Het
Cyp4a32	A	G	4: 115,468,520 (GRCm39)	Y334C	probably damaging	Het
Dmxl2	C	A	9: 54,273,698 (GRCm39)		probably benign	Het
Eps8	C	T	6: 137,456,064 (GRCm39)	A806T	probably benign	Het
Evl	A	G	12: 108,614,678 (GRCm39)	N24S	possibly damaging	Het
Fbxo15	T	C	18: 84,980,847 (GRCm39)		probably null	Het
Gm14179	A	T	11: 99,634,019 (GRCm39)			Het
Hepacam2	A	G	6: 3,483,568 (GRCm39)	V147A	possibly damaging	Het
Jmjd1c	C	A	10: 67,061,115 (GRCm39)	P1156Q	possibly damaging	Het
Mab21l3	A	T	3: 101,730,624 (GRCm39)	V205E	probably damaging	Het
Mad2l1	T	C	6: 66,512,951 (GRCm39)	I28T	probably damaging	Het
Minar2	T	A	18: 59,205,347 (GRCm39)	M45K	probably damaging	Het
Mroh9	T	A	1: 162,908,145 (GRCm39)	I2F	probably benign	Het
Msr1	A	T	8: 40,068,788 (GRCm39)	I302K	probably benign	Het
Msrb3	C	T	10: 120,685,906 (GRCm39)	V80I	possibly damaging	Het
Ncf4	A	G	15: 78,145,219 (GRCm39)	D269G	probably damaging	Het
Nsl1	T	A	1: 190,803,398 (GRCm39)	H156Q	probably benign	Het
Nutm1	T	C	2: 112,078,669 (GRCm39)	D1082G	probably benign	Het
Or6c216	T	A	10: 129,678,416 (GRCm39)	D165V	probably damaging	Het
Orc4	T	C	2: 48,807,296 (GRCm39)	I212V	probably null	Het
Pde6c	A	G	19: 38,128,488 (GRCm39)	I184V	probably benign	Het
Pfkfb3	A	T	2: 11,493,589 (GRCm39)	F129Y	probably damaging	Het
Ppp3cb	T	C	14: 20,551,622 (GRCm39)	D493G	probably benign	Het
Psg29	A	G	7: 16,942,707 (GRCm39)	Y236C	probably damaging	Het
Pzp	C	T	6: 128,471,662 (GRCm39)		probably benign	Het
Semp2l2b	A	T	10: 21,942,826 (GRCm39)	W385R	probably damaging	Het
Sgf29	T	A	7: 126,271,025 (GRCm39)	V180E	probably damaging	Het
Sh3bp4	A	G	1: 89,071,266 (GRCm39)		probably benign	Het
Slc39a2	A	T	14: 52,132,620 (GRCm39)	T188S	probably benign	Het
Slc6a13	G	T	6: 121,310,323 (GRCm39)	M327I	probably benign	Het
Slitrk6	T	A	14: 110,987,226 (GRCm39)	H827L	probably benign	Het
Thumpd2	T	G	17: 81,361,884 (GRCm39)	K114T	probably benign	Het
Tnfrsf19	A	T	14: 61,210,987 (GRCm39)	C234S	possibly damaging	Het
Tns2	A	G	15: 102,019,375 (GRCm39)	D446G	probably damaging	Het
Tpm4	A	G	8: 72,898,547 (GRCm39)	E137G	probably damaging	Het
Ttn	G	A	2: 76,625,901 (GRCm39)	R13307C	probably damaging	Het
Ubqln3	A	G	7: 103,791,725 (GRCm39)	S122P	probably benign	Het
Ubr5	T	C	15: 38,008,991 (GRCm39)	D1080G	probably benign	Het
Ulk4	A	T	9: 120,981,373 (GRCm39)	L886*	probably null	Het
Unc80	T	C	1: 66,594,112 (GRCm39)	S1164P	possibly damaging	Het
Uspl1	T	C	5: 149,141,114 (GRCm39)	V371A	possibly damaging	Het
Virma	T	C	4: 11,494,804 (GRCm39)	V35A	probably damaging	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zfp787	A	T	7: 6,135,297 (GRCm39)	I318N	probably damaging	Het

Other mutations in Or7g20

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01718:Or7g20	APN	9	18,946,584 (GRCm39)	nonsense	probably null
R0010:Or7g20	UTSW	9	18,946,618 (GRCm39)	missense	probably damaging	1.00
R0107:Or7g20	UTSW	9	18,946,629 (GRCm39)	missense	probably damaging	1.00
R1867:Or7g20	UTSW	9	18,946,562 (GRCm39)	missense	probably benign	0.36
R1891:Or7g20	UTSW	9	18,947,274 (GRCm39)	missense	probably damaging	0.99
R1941:Or7g20	UTSW	9	18,947,162 (GRCm39)	missense	possibly damaging	0.93
R4152:Or7g20	UTSW	9	18,946,816 (GRCm39)	nonsense	probably null
R5451:Or7g20	UTSW	9	18,946,787 (GRCm39)	missense	probably damaging	1.00
R5677:Or7g20	UTSW	9	18,946,854 (GRCm39)	missense	possibly damaging	0.93
R5970:Or7g20	UTSW	9	18,946,443 (GRCm39)	missense	probably benign
R6187:Or7g20	UTSW	9	18,946,689 (GRCm39)	missense	probably benign	0.12
R6805:Or7g20	UTSW	9	18,946,597 (GRCm39)	missense	probably damaging	1.00
R7183:Or7g20	UTSW	9	18,946,628 (GRCm39)	missense	probably damaging	1.00
R8029:Or7g20	UTSW	9	18,947,090 (GRCm39)	missense	probably damaging	1.00
R8139:Or7g20	UTSW	9	18,946,871 (GRCm39)	missense	probably benign	0.07
R8736:Or7g20	UTSW	9	18,946,774 (GRCm39)	missense	probably damaging	1.00
R8868:Or7g20	UTSW	9	18,946,778 (GRCm39)	missense	probably damaging	1.00
R8909:Or7g20	UTSW	9	18,946,888 (GRCm39)	missense	probably benign	0.08
R9116:Or7g20	UTSW	9	18,946,773 (GRCm39)	missense	probably damaging	1.00
R9479:Or7g20	UTSW	9	18,946,730 (GRCm39)	missense	probably benign	0.30
R9786:Or7g20	UTSW	9	18,947,241 (GRCm39)	missense	possibly damaging	0.87

Posted On

2015-04-16