Incidental Mutation 'R3900:Gm10608'
| ID |
308942 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gm10608
|
| Ensembl Gene |
ENSMUSG00000074029 |
| Gene Name |
predicted gene 10608 |
| Synonyms |
EG546165 |
| MMRRC Submission |
041607-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.082)
|
| Stock # |
R3900 (G1)
|
| Quality Score |
142 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
118991798-118992473 bp(+) (GRCm39) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA to CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA
at 118989784 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091246
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000010795]
[ENSMUST00000093527]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000010795
|
| SMART Domains |
Protein: ENSMUSP00000010795
Gene: ENSMUSG00000010651
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Thiolase_N
|
38 |
291 |
6.7e-90 |
PFAM |
|
Pfam:Thiolase_C
|
298 |
421 |
3e-53 |
PFAM |
|
Pfam:ACP_syn_III_C
|
329 |
420 |
1.8e-7 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000093527
|
| SMART Domains |
Protein: ENSMUSP00000091246
Gene: ENSMUSG00000074029
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3915
|
11 |
80 |
3.1e-10 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000213924
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
98% (45/46) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833439L19Rik |
A |
T |
13: 54,700,781 (GRCm39) |
S212R |
probably damaging |
Het |
| AI182371 |
T |
C |
2: 34,975,228 (GRCm39) |
I334V |
probably benign |
Het |
| Anpep |
A |
G |
7: 79,488,973 (GRCm39) |
S372P |
probably benign |
Het |
| Apc2 |
C |
A |
10: 80,131,806 (GRCm39) |
|
probably null |
Het |
| Bcl6 |
T |
G |
16: 23,796,304 (GRCm39) |
E41A |
possibly damaging |
Het |
| Brpf1 |
A |
G |
6: 113,295,394 (GRCm39) |
I674V |
probably benign |
Het |
| Cherp |
A |
G |
8: 73,223,780 (GRCm39) |
I201T |
possibly damaging |
Het |
| Cluh |
A |
G |
11: 74,557,930 (GRCm39) |
H1056R |
probably benign |
Het |
| Csgalnact2 |
A |
T |
6: 118,097,975 (GRCm39) |
F122I |
probably damaging |
Het |
| Cubn |
C |
A |
2: 13,291,791 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
A |
T |
11: 117,985,634 (GRCm39) |
I1481N |
possibly damaging |
Het |
| Eif2ak4 |
A |
G |
2: 118,305,510 (GRCm39) |
Y1561C |
probably damaging |
Het |
| Elfn1 |
G |
A |
5: 139,957,719 (GRCm39) |
R241H |
probably damaging |
Het |
| Eml5 |
G |
A |
12: 98,791,782 (GRCm39) |
R1245C |
probably damaging |
Het |
| Fchsd2 |
A |
G |
7: 100,841,006 (GRCm39) |
K172E |
possibly damaging |
Het |
| Gm6133 |
A |
G |
18: 78,393,365 (GRCm39) |
N120D |
probably benign |
Het |
| Hivep2 |
C |
A |
10: 14,004,713 (GRCm39) |
T437K |
probably benign |
Het |
| Igsf9 |
T |
C |
1: 172,317,125 (GRCm39) |
L35P |
probably damaging |
Het |
| Khdc3 |
T |
C |
9: 73,011,628 (GRCm39) |
|
probably benign |
Het |
| Mmrn2 |
G |
T |
14: 34,121,517 (GRCm39) |
|
probably null |
Het |
| Mrgpra1 |
G |
T |
7: 46,985,275 (GRCm39) |
R135S |
possibly damaging |
Het |
| Or4c11b |
A |
T |
2: 88,625,273 (GRCm39) |
L182F |
possibly damaging |
Het |
| Or8g2b |
A |
G |
9: 39,750,698 (GRCm39) |
|
probably null |
Het |
| Otud3 |
T |
C |
4: 138,624,196 (GRCm39) |
N282S |
probably benign |
Het |
| Prkar1a |
A |
G |
11: 109,551,901 (GRCm39) |
K130R |
probably benign |
Het |
| Rd3 |
T |
C |
1: 191,717,217 (GRCm39) |
V114A |
probably damaging |
Het |
| Rictor |
T |
G |
15: 6,818,954 (GRCm39) |
D1392E |
probably benign |
Het |
| Setd2 |
C |
T |
9: 110,421,586 (GRCm39) |
R273W |
probably damaging |
Het |
| Slc22a18 |
C |
A |
7: 143,033,507 (GRCm39) |
A86E |
probably damaging |
Het |
| Slc24a1 |
A |
T |
9: 64,835,426 (GRCm39) |
S900R |
probably damaging |
Het |
| Smarcc1 |
T |
C |
9: 109,947,586 (GRCm39) |
|
probably benign |
Het |
| Smoc1 |
T |
C |
12: 81,214,287 (GRCm39) |
V234A |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,544,030 (GRCm39) |
T4443A |
possibly damaging |
Het |
| Timp2 |
C |
T |
11: 118,194,542 (GRCm39) |
D139N |
probably damaging |
Het |
| Trim69 |
A |
G |
2: 122,009,322 (GRCm39) |
T461A |
probably benign |
Het |
| Ubash3b |
C |
T |
9: 40,942,860 (GRCm39) |
D211N |
probably benign |
Het |
| Ubr4 |
T |
C |
4: 139,206,373 (GRCm39) |
|
probably null |
Het |
| Ubr5 |
T |
C |
15: 38,019,486 (GRCm39) |
D752G |
probably damaging |
Het |
| Urb1 |
A |
T |
16: 90,580,264 (GRCm39) |
I633N |
possibly damaging |
Het |
| Usp36 |
T |
A |
11: 118,170,650 (GRCm39) |
D28V |
possibly damaging |
Het |
| Wdr6 |
G |
A |
9: 108,452,968 (GRCm39) |
A305V |
probably damaging |
Het |
| Zfp248 |
T |
C |
6: 118,406,527 (GRCm39) |
N253S |
probably damaging |
Het |
|
| Other mutations in Gm10608 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
3-1:Gm10608
|
UTSW |
9 |
118,990,156 (GRCm39) |
unclassified |
probably benign |
|
|
R1023:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R1053:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1148:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1148:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1167:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1172:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1211:Gm10608
|
UTSW |
9 |
118,989,780 (GRCm39) |
frame shift |
probably null |
|
|
R1601:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R1766:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1939:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2016:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R2127:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R2217:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2270:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2372:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R2844:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2959:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2968:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R3084:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3607:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R3702:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3779:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R3839:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3947:Gm10608
|
UTSW |
9 |
118,989,730 (GRCm39) |
small deletion |
probably benign |
|
|
R4015:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R4024:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R5346:Gm10608
|
UTSW |
9 |
118,989,792 (GRCm39) |
frame shift |
probably null |
|
|
R8225:Gm10608
|
UTSW |
9 |
118,989,776 (GRCm39) |
frame shift |
probably null |
|
|
X0065:Gm10608
|
UTSW |
9 |
118,989,931 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AATGTGACAGGTGCCACAAC -3'
(R):5'- GCCTCTTCATAGGTCACATGCC -3'
Sequencing Primer
(F):5'- AGGTGCCACAACAGGGC -3'
(R):5'- TCAGATGGCAAAGCTTCCTG -3'
|
| Posted On |
2015-04-17 |
Incidental Mutation