Mutagenetix > Incidental Mutation

Incidental Mutation 'R4279:Vmn1r119'

322797

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r119

Ensembl Gene

ENSMUSG00000094010

Gene Name

vomeronasal 1 receptor 119

Synonyms

Gm1447, LOC384696

MMRRC Submission

041079-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R4279 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20745457-20746380 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20745786 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 199 (M199L)

Ref Sequence

ENSEMBL: ENSMUSP00000127126 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164683]

AlphaFold

E9Q4H3

Predicted Effect

probably benign
Transcript: ENSMUST00000164683
AA Change: M199L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000127126
Gene: ENSMUSG00000094010
AA Change: M199L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	7.4e-17	PFAM
Pfam:7tm_1	31	290	2.1e-7	PFAM
Pfam:V1R	41	298	2e-18	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.6%
20x: 96.0%

Validation Efficiency

98% (40/41)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arid2	T	A	15: 96,269,637 (GRCm39)	L1250Q	probably damaging	Het
Ccdc73	A	T	2: 104,815,355 (GRCm39)	N364Y	possibly damaging	Het
Ccl25	T	A	8: 4,399,829 (GRCm39)	L56Q	probably damaging	Het
Ctnnd2	C	A	15: 30,905,966 (GRCm39)	A871E	probably damaging	Het
Cyp2b23	C	T	7: 26,365,452 (GRCm39)	S461N	possibly damaging	Het
Dgat2	C	A	7: 98,813,912 (GRCm39)	G120V	probably damaging	Het
Dsp	A	T	13: 38,369,207 (GRCm39)	I768F	probably damaging	Het
Dzank1	T	C	2: 144,333,765 (GRCm39)	E356G	probably benign	Het
Fam120a	A	T	13: 49,042,734 (GRCm39)	V889D	probably benign	Het
Fxyd5	C	A	7: 30,734,811 (GRCm39)	D139Y	probably null	Het
Gcnt2	T	C	13: 41,041,666 (GRCm39)	V275A	probably benign	Het
Gimap4	A	G	6: 48,667,511 (GRCm39)	I89V	probably benign	Het
Gm6578	G	A	6: 12,100,187 (GRCm39)		noncoding transcript	Het
Jmjd8	A	G	17: 26,048,787 (GRCm39)		probably benign	Het
Jmy	G	C	13: 93,635,390 (GRCm39)	P142R	probably damaging	Het
Jmy	C	A	13: 93,635,781 (GRCm39)	D12Y	probably damaging	Het
Kif13b	G	T	14: 65,016,805 (GRCm39)	A1324S	probably damaging	Het
Klhl31	T	C	9: 77,563,121 (GRCm39)	S629P	unknown	Het
Lpar1	A	G	4: 58,487,115 (GRCm39)	V52A	possibly damaging	Het
Lrp5	A	G	19: 3,641,778 (GRCm39)	S1395P	possibly damaging	Het
Mogs	T	C	6: 83,093,048 (GRCm39)	L132P	probably damaging	Het
Ncam1	C	A	9: 49,418,259 (GRCm39)		probably benign	Het
Ndufs8	A	T	19: 3,961,014 (GRCm39)	F88I	probably damaging	Het
Nos2	T	A	11: 78,820,602 (GRCm39)	L69Q	probably benign	Het
Or51a6	T	A	7: 102,604,292 (GRCm39)	Q179L	probably benign	Het
Pls3	A	T	X: 74,846,138 (GRCm39)	I192N	probably benign	Het
Psmd6	T	C	14: 14,112,297 (GRCm38)	N388S	possibly damaging	Het
Rrbp1	T	C	2: 143,805,028 (GRCm39)	T1046A	probably benign	Het
Scn11a	T	C	9: 119,583,428 (GRCm39)	E1729G	probably benign	Het
Slc6a3	A	G	13: 73,692,953 (GRCm39)	D191G	possibly damaging	Het
Slc9a1	T	C	4: 133,139,400 (GRCm39)	F206S	probably benign	Het
Tmc5	A	G	7: 118,273,886 (GRCm39)	*968W	probably null	Het
Ttn	T	A	2: 76,585,168 (GRCm39)	I22042F	probably damaging	Het
Unc13a	T	C	8: 72,119,311 (GRCm39)	K9R	probably damaging	Het
Vegfa	A	G	17: 46,342,392 (GRCm39)	V142A	probably benign	Het
Vnn1	A	T	10: 23,774,410 (GRCm39)	D151V	possibly damaging	Het
Zfp365	A	T	10: 67,733,431 (GRCm39)	F254I	probably benign	Het

Other mutations in Vmn1r119

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01363:Vmn1r119	APN	7	20,746,056 (GRCm39)	missense	probably benign	0.41
IGL02218:Vmn1r119	APN	7	20,745,561 (GRCm39)	missense	probably benign	0.11
R0639:Vmn1r119	UTSW	7	20,745,593 (GRCm39)	missense	possibly damaging	0.70
R1844:Vmn1r119	UTSW	7	20,746,121 (GRCm39)	missense	probably damaging	1.00
R2250:Vmn1r119	UTSW	7	20,746,184 (GRCm39)	missense	probably damaging	1.00
R2927:Vmn1r119	UTSW	7	20,746,056 (GRCm39)	missense	probably benign	0.41
R5022:Vmn1r119	UTSW	7	20,746,245 (GRCm39)	missense	probably benign	0.08
R6160:Vmn1r119	UTSW	7	20,745,740 (GRCm39)	missense	possibly damaging	0.47
R6523:Vmn1r119	UTSW	7	20,745,777 (GRCm39)	missense	possibly damaging	0.75
R7013:Vmn1r119	UTSW	7	20,745,714 (GRCm39)	missense	probably damaging	1.00
R7218:Vmn1r119	UTSW	7	20,745,572 (GRCm39)	missense	probably benign	0.00
R7320:Vmn1r119	UTSW	7	20,746,271 (GRCm39)	missense	probably damaging	0.99
R8233:Vmn1r119	UTSW	7	20,745,932 (GRCm39)	missense	probably damaging	0.99
R8550:Vmn1r119	UTSW	7	20,745,980 (GRCm39)	missense	probably benign	0.00
R9151:Vmn1r119	UTSW	7	20,745,593 (GRCm39)	missense	possibly damaging	0.70
R9300:Vmn1r119	UTSW	7	20,745,638 (GRCm39)	missense	probably damaging	1.00
R9343:Vmn1r119	UTSW	7	20,746,358 (GRCm39)	missense	probably benign	0.03
R9345:Vmn1r119	UTSW	7	20,746,034 (GRCm39)	missense	probably damaging	0.99
R9661:Vmn1r119	UTSW	7	20,746,224 (GRCm39)	missense	possibly damaging	0.87
X0060:Vmn1r119	UTSW	7	20,746,208 (GRCm39)	missense	possibly damaging	0.79
Z1177:Vmn1r119	UTSW	7	20,745,705 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- CTGACAAGCCTTACGAAGAAATGAG -3'
(R):5'- CAAGTGTCACAAACATGGCAAG -3'

Sequencing Primer
(F):5'- GCCTTACGAAGAAATGAGAATGC -3'
(R):5'- GTGTCACAAACATGGCAAGTTATTC -3'

Posted On

2015-06-20