Incidental Mutation 'IGL02832:Ddx1'
| ID |
361490 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ddx1
|
| Ensembl Gene |
ENSMUSG00000037149 |
| Gene Name |
DEAD box helicase 1 |
| Synonyms |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL02832
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
13269308-13299175 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 13277318 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 528
(Q528*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000065987
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071103]
|
| AlphaFold |
Q91VR5 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000071103
AA Change: Q528*
|
| SMART Domains |
Protein: ENSMUSP00000065987
Gene: ENSMUSG00000037149
AA Change: Q528*
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
21 |
444 |
1.95e-47 |
SMART |
|
SPRY
|
130 |
246 |
1.91e-34 |
SMART |
|
HELICc
|
520 |
610 |
8.28e-28 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221028
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 50 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts9 |
G |
A |
6: 92,784,156 (GRCm39) |
T985M |
probably damaging |
Het |
| Alpk1 |
A |
G |
3: 127,473,592 (GRCm39) |
S804P |
possibly damaging |
Het |
| Ap3b1 |
A |
G |
13: 94,664,835 (GRCm39) |
I925V |
unknown |
Het |
| Cep135 |
T |
A |
5: 76,788,796 (GRCm39) |
S1130T |
probably damaging |
Het |
| Cers3 |
A |
T |
7: 66,431,573 (GRCm39) |
M183L |
probably benign |
Het |
| Col5a1 |
A |
G |
2: 27,842,352 (GRCm39) |
E409G |
unknown |
Het |
| Cyp4a32 |
G |
T |
4: 115,471,818 (GRCm39) |
V410F |
probably damaging |
Het |
| Dio2 |
G |
A |
12: 90,696,178 (GRCm39) |
|
probably benign |
Het |
| Dnah9 |
G |
T |
11: 65,931,172 (GRCm39) |
A2008E |
probably damaging |
Het |
| Dnajc2 |
A |
G |
5: 21,965,408 (GRCm39) |
V457A |
probably benign |
Het |
| Dytn |
T |
C |
1: 63,682,532 (GRCm39) |
T372A |
probably benign |
Het |
| Fam135a |
T |
C |
1: 24,067,714 (GRCm39) |
I152V |
probably benign |
Het |
| Fmnl2 |
C |
T |
2: 52,748,261 (GRCm39) |
A36V |
possibly damaging |
Het |
| Galnt7 |
G |
A |
8: 58,005,531 (GRCm39) |
T234I |
probably damaging |
Het |
| Gba1 |
A |
C |
3: 89,110,809 (GRCm39) |
I6L |
probably benign |
Het |
| Gja10 |
A |
G |
4: 32,602,147 (GRCm39) |
V79A |
probably damaging |
Het |
| Gpd2 |
T |
A |
2: 57,228,991 (GRCm39) |
V265E |
probably damaging |
Het |
| Gpld1 |
T |
C |
13: 25,136,861 (GRCm39) |
Y60H |
probably damaging |
Het |
| H2bc27 |
A |
G |
11: 58,839,869 (GRCm39) |
K35R |
probably benign |
Het |
| Heatr9 |
A |
G |
11: 83,409,672 (GRCm39) |
|
probably benign |
Het |
| Krt75 |
T |
A |
15: 101,476,508 (GRCm39) |
D419V |
probably benign |
Het |
| Lrig3 |
A |
T |
10: 125,842,871 (GRCm39) |
I599F |
probably benign |
Het |
| Lrp4 |
A |
G |
2: 91,341,925 (GRCm39) |
D1846G |
probably damaging |
Het |
| Mamdc2 |
C |
T |
19: 23,281,215 (GRCm39) |
A653T |
probably damaging |
Het |
| Myo7a |
A |
T |
7: 97,740,227 (GRCm39) |
|
probably null |
Het |
| Notch2 |
A |
G |
3: 98,044,689 (GRCm39) |
D1537G |
probably benign |
Het |
| Or10k2 |
G |
A |
8: 84,268,100 (GRCm39) |
C109Y |
probably damaging |
Het |
| Or51a25 |
G |
T |
7: 102,372,858 (GRCm39) |
H280N |
probably benign |
Het |
| Or52ae7 |
A |
T |
7: 103,119,905 (GRCm39) |
I220L |
probably benign |
Het |
| Papss1 |
A |
C |
3: 131,288,280 (GRCm39) |
D84A |
probably damaging |
Het |
| Pcdhb16 |
T |
A |
18: 37,611,527 (GRCm39) |
D162E |
probably damaging |
Het |
| Rab11fip1 |
C |
T |
8: 27,642,840 (GRCm39) |
R653Q |
possibly damaging |
Het |
| Rap1gap2 |
A |
T |
11: 74,303,281 (GRCm39) |
|
probably benign |
Het |
| Rasal2 |
T |
C |
1: 156,984,777 (GRCm39) |
D990G |
probably damaging |
Het |
| Rnf32 |
T |
C |
5: 29,410,701 (GRCm39) |
|
probably null |
Het |
| Rp1 |
T |
C |
1: 4,419,936 (GRCm39) |
D392G |
probably benign |
Het |
| Scn9a |
T |
C |
2: 66,398,373 (GRCm39) |
D79G |
probably damaging |
Het |
| Selenon |
A |
T |
4: 134,268,219 (GRCm39) |
V438D |
probably damaging |
Het |
| Slc47a1 |
G |
A |
11: 61,254,239 (GRCm39) |
H158Y |
probably benign |
Het |
| Slc5a12 |
A |
T |
2: 110,471,160 (GRCm39) |
E463D |
probably benign |
Het |
| Taf2 |
C |
T |
15: 54,879,959 (GRCm39) |
V1126M |
probably benign |
Het |
| Tas2r143 |
G |
T |
6: 42,377,259 (GRCm39) |
V30L |
possibly damaging |
Het |
| Tcea3 |
G |
A |
4: 135,995,424 (GRCm39) |
V256M |
probably damaging |
Het |
| Thy1 |
A |
G |
9: 43,958,111 (GRCm39) |
T80A |
probably benign |
Het |
| Tmem9 |
A |
G |
1: 135,947,469 (GRCm39) |
N47S |
probably damaging |
Het |
| Tmprss11g |
T |
C |
5: 86,645,128 (GRCm39) |
Q101R |
probably benign |
Het |
| Trim66 |
C |
T |
7: 109,059,704 (GRCm39) |
C792Y |
probably damaging |
Het |
| Tstd2 |
A |
T |
4: 46,124,949 (GRCm39) |
M226K |
probably damaging |
Het |
| Utrn |
G |
T |
10: 12,613,937 (GRCm39) |
T378K |
possibly damaging |
Het |
| Vmn2r23 |
A |
G |
6: 123,681,355 (GRCm39) |
I88V |
probably benign |
Het |
|
| Other mutations in Ddx1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00725:Ddx1
|
APN |
12 |
13,295,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00725:Ddx1
|
APN |
12 |
13,277,460 (GRCm39) |
splice site |
probably benign |
|
|
IGL00958:Ddx1
|
APN |
12 |
13,290,849 (GRCm39) |
splice site |
probably null |
|
|
IGL01786:Ddx1
|
APN |
12 |
13,279,137 (GRCm39) |
missense |
probably benign |
|
|
IGL02983:Ddx1
|
APN |
12 |
13,273,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Ddx1
|
UTSW |
12 |
13,273,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0931:Ddx1
|
UTSW |
12 |
13,287,818 (GRCm39) |
splice site |
probably benign |
|
|
R1434:Ddx1
|
UTSW |
12 |
13,287,232 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1558:Ddx1
|
UTSW |
12 |
13,289,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1673:Ddx1
|
UTSW |
12 |
13,294,967 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1854:Ddx1
|
UTSW |
12 |
13,279,332 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2910:Ddx1
|
UTSW |
12 |
13,281,441 (GRCm39) |
splice site |
probably null |
|
|
R2911:Ddx1
|
UTSW |
12 |
13,281,441 (GRCm39) |
splice site |
probably null |
|
|
R4181:Ddx1
|
UTSW |
12 |
13,281,504 (GRCm39) |
nonsense |
probably null |
|
|
R4182:Ddx1
|
UTSW |
12 |
13,281,504 (GRCm39) |
nonsense |
probably null |
|
|
R4183:Ddx1
|
UTSW |
12 |
13,281,504 (GRCm39) |
nonsense |
probably null |
|
|
R4231:Ddx1
|
UTSW |
12 |
13,273,858 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4234:Ddx1
|
UTSW |
12 |
13,273,858 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4235:Ddx1
|
UTSW |
12 |
13,273,858 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4243:Ddx1
|
UTSW |
12 |
13,290,910 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Ddx1
|
UTSW |
12 |
13,290,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4821:Ddx1
|
UTSW |
12 |
13,289,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Ddx1
|
UTSW |
12 |
13,273,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5082:Ddx1
|
UTSW |
12 |
13,270,436 (GRCm39) |
nonsense |
probably null |
|
|
R5528:Ddx1
|
UTSW |
12 |
13,279,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5997:Ddx1
|
UTSW |
12 |
13,287,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6398:Ddx1
|
UTSW |
12 |
13,295,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Ddx1
|
UTSW |
12 |
13,286,096 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7085:Ddx1
|
UTSW |
12 |
13,279,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7125:Ddx1
|
UTSW |
12 |
13,293,864 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7307:Ddx1
|
UTSW |
12 |
13,273,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7388:Ddx1
|
UTSW |
12 |
13,275,456 (GRCm39) |
missense |
probably null |
1.00 |
|
R7393:Ddx1
|
UTSW |
12 |
13,280,354 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7460:Ddx1
|
UTSW |
12 |
13,281,440 (GRCm39) |
splice site |
probably null |
|
|
R8310:Ddx1
|
UTSW |
12 |
13,274,280 (GRCm39) |
intron |
probably benign |
|
|
R8479:Ddx1
|
UTSW |
12 |
13,270,749 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8712:Ddx1
|
UTSW |
12 |
13,293,859 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R8790:Ddx1
|
UTSW |
12 |
13,273,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8826:Ddx1
|
UTSW |
12 |
13,277,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Ddx1
|
UTSW |
12 |
13,275,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9214:Ddx1
|
UTSW |
12 |
13,286,119 (GRCm39) |
missense |
probably benign |
|
|
R9400:Ddx1
|
UTSW |
12 |
13,273,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0011:Ddx1
|
UTSW |
12 |
13,279,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Ddx1
|
UTSW |
12 |
13,293,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Ddx1
|
UTSW |
12 |
13,279,260 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Posted On |
2015-12-18 |
Incidental Mutation