Incidental Mutation 'IGL02971:Or8b3b'
ID 365794
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b3b
Ensembl Gene ENSMUSG00000046150
Gene Name olfactory receptor family 8 subfamily B member 3B
Synonyms GA_x6K02T2PVTD-32375756-32374818, MOR164-3, Olfr918
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.259) question?
Stock # IGL02971
Quality Score
Chromosome 9
Chromosomal Location 38583800-38584777 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38584564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 72 (M72L)
Ref Sequence ENSEMBL: ENSMUSP00000057210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055099] [ENSMUST00000215461]
AlphaFold E9PVZ7
Predicted Effect probably damaging
Transcript: ENSMUST00000055099
AA Change: M72L

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000057210
Gene: ENSMUSG00000046150
AA Change: M72L

transmembrane domain 9 31 N/A INTRINSIC
Pfam:7tm_4 44 319 6.5e-48 PFAM
Pfam:7tm_1 54 301 3.9e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213750
Predicted Effect possibly damaging
Transcript: ENSMUST00000215461
AA Change: M59L

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216579
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik C T 2: 103,953,564 (GRCm39) T130I probably benign Het
Ahi1 T C 10: 20,876,450 (GRCm39) L787P possibly damaging Het
Atf3 A G 1: 190,909,640 (GRCm39) S10P probably benign Het
Cdr2l A G 11: 115,281,726 (GRCm39) N77S probably damaging Het
Cnp A G 11: 100,467,525 (GRCm39) D156G probably benign Het
Cntn3 A T 6: 102,145,894 (GRCm39) D982E probably damaging Het
Col22a1 A G 15: 71,878,587 (GRCm39) L190S probably damaging Het
Csmd3 C T 15: 47,777,325 (GRCm39) probably benign Het
Dnah5 A G 15: 28,384,607 (GRCm39) D3117G probably damaging Het
Dock5 T C 14: 67,994,558 (GRCm39) E1834G probably null Het
Eea1 A G 10: 95,877,389 (GRCm39) T1368A probably benign Het
Fam83f T C 15: 80,556,350 (GRCm39) V78A probably benign Het
Fcgbp G A 7: 27,800,898 (GRCm39) V1315I probably damaging Het
Fsd2 A T 7: 81,198,671 (GRCm39) Y364* probably null Het
Gm21976 G A 13: 98,439,057 (GRCm39) G16R probably null Het
Guca2b A G 4: 119,514,885 (GRCm39) S59P probably damaging Het
Hars2 A G 18: 36,919,231 (GRCm39) E123G probably damaging Het
Hdac2 A T 10: 36,876,370 (GRCm39) K462* probably null Het
Huwe1 T A X: 150,710,622 (GRCm39) probably benign Het
Iqgap3 T A 3: 87,997,611 (GRCm39) N262K probably benign Het
Kat6b A G 14: 21,719,826 (GRCm39) S1502G probably damaging Het
Mapkapk3 A T 9: 107,134,279 (GRCm39) D328E probably benign Het
Naca C T 10: 127,877,437 (GRCm39) probably benign Het
Npffr1 T C 10: 61,449,918 (GRCm39) V64A probably damaging Het
Oga A G 19: 45,750,682 (GRCm39) F671S probably damaging Het
Or2t49 A G 11: 58,393,211 (GRCm39) L57P probably damaging Het
Pcca A G 14: 123,126,945 (GRCm39) D718G probably damaging Het
Pde6a A C 18: 61,397,326 (GRCm39) D670A probably damaging Het
Pramel7 T A 2: 87,320,417 (GRCm39) E292V probably benign Het
Prmt9 A C 8: 78,291,698 (GRCm39) M357L probably benign Het
Ptgfr A T 3: 151,540,963 (GRCm39) S182T probably benign Het
Rtraf A T 14: 19,866,260 (GRCm39) M152K possibly damaging Het
Satb1 T C 17: 52,049,717 (GRCm39) D579G possibly damaging Het
Serpinb6a A G 13: 34,115,453 (GRCm39) probably null Het
Slc5a9 T C 4: 111,747,497 (GRCm39) I297V possibly damaging Het
Slf1 T A 13: 77,195,223 (GRCm39) probably benign Het
St8sia2 C T 7: 73,616,559 (GRCm39) V139M probably damaging Het
Tas2r114 T C 6: 131,666,243 (GRCm39) M262V probably benign Het
Tmem147 A G 7: 30,428,847 (GRCm39) probably benign Het
Tmem220 A G 11: 66,924,933 (GRCm39) probably null Het
Uspl1 A G 5: 149,125,156 (GRCm39) N35S possibly damaging Het
Vmn1r170 A T 7: 23,305,759 (GRCm39) I54F possibly damaging Het
Vmn2r121 T G X: 123,037,591 (GRCm39) I810L probably damaging Het
Wbp2nl A T 15: 82,189,945 (GRCm39) T46S possibly damaging Het
Zfp955b T A 17: 33,519,940 (GRCm39) M57K probably benign Het
Other mutations in Or8b3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or8b3b APN 9 38,584,320 (GRCm39) missense probably benign 0.01
IGL01388:Or8b3b APN 9 38,584,379 (GRCm39) nonsense probably null
IGL01516:Or8b3b APN 9 38,584,159 (GRCm39) missense probably benign 0.09
IGL02121:Or8b3b APN 9 38,584,711 (GRCm39) missense probably damaging 0.98
IGL02209:Or8b3b APN 9 38,584,342 (GRCm39) missense possibly damaging 0.84
IGL02256:Or8b3b APN 9 38,584,776 (GRCm39) start codon destroyed probably null
IGL02517:Or8b3b APN 9 38,584,209 (GRCm39) missense probably damaging 1.00
IGL02648:Or8b3b APN 9 38,584,312 (GRCm39) missense probably benign
IGL02747:Or8b3b APN 9 38,584,380 (GRCm39) missense probably benign 0.11
E0370:Or8b3b UTSW 9 38,583,857 (GRCm39) missense probably damaging 0.99
R0616:Or8b3b UTSW 9 38,584,776 (GRCm39) start codon destroyed probably null
R2173:Or8b3b UTSW 9 38,584,240 (GRCm39) missense probably benign 0.03
R2989:Or8b3b UTSW 9 38,583,831 (GRCm39) missense probably benign
R3430:Or8b3b UTSW 9 38,584,435 (GRCm39) missense probably damaging 1.00
R3809:Or8b3b UTSW 9 38,584,159 (GRCm39) missense probably benign 0.09
R4688:Or8b3b UTSW 9 38,584,659 (GRCm39) missense probably damaging 1.00
R4702:Or8b3b UTSW 9 38,584,776 (GRCm39) start codon destroyed probably null
R5548:Or8b3b UTSW 9 38,584,600 (GRCm39) missense probably benign 0.00
R5590:Or8b3b UTSW 9 38,584,261 (GRCm39) missense probably damaging 1.00
R6082:Or8b3b UTSW 9 38,583,866 (GRCm39) missense probably damaging 1.00
R6214:Or8b3b UTSW 9 38,584,510 (GRCm39) missense probably benign 0.13
R6215:Or8b3b UTSW 9 38,584,510 (GRCm39) missense probably benign 0.13
R6893:Or8b3b UTSW 9 38,584,355 (GRCm39) missense possibly damaging 0.95
R7215:Or8b3b UTSW 9 38,584,743 (GRCm39) missense probably benign 0.05
R7624:Or8b3b UTSW 9 38,583,919 (GRCm39) missense probably benign 0.18
R7862:Or8b3b UTSW 9 38,584,624 (GRCm39) missense probably benign 0.01
R8116:Or8b3b UTSW 9 38,584,464 (GRCm39) missense possibly damaging 0.93
R8897:Or8b3b UTSW 9 38,584,147 (GRCm39) missense probably damaging 1.00
R8899:Or8b3b UTSW 9 38,584,147 (GRCm39) missense probably damaging 1.00
R9114:Or8b3b UTSW 9 38,583,892 (GRCm39) missense probably benign
R9293:Or8b3b UTSW 9 38,584,414 (GRCm39) missense probably damaging 1.00
R9311:Or8b3b UTSW 9 38,583,925 (GRCm39) missense probably damaging 1.00
R9690:Or8b3b UTSW 9 38,584,477 (GRCm39) nonsense probably null
R9734:Or8b3b UTSW 9 38,584,239 (GRCm39) missense probably benign
Posted On 2015-12-18