Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03256:Vmn1r78'

414635

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r78

Ensembl Gene

ENSMUSG00000061602

Gene Name

vomeronasal 1 receptor 78

Synonyms

V1rg7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL03256

Quality Score

Status

Chromosome

Chromosomal Location

12150257-12159959 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12152798 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 112 (I112N)

Ref Sequence

ENSEMBL: ENSMUSP00000154797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]

Predicted Effect

probably damaging
Transcript: ENSMUST00000078039
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: I112N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209489

Predicted Effect

probably damaging
Transcript: ENSMUST00000228244
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228664
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	C	T	8: 72,445,199	T150I	probably benign	Het
4932438A13Rik	T	C	3: 36,906,683		probably benign	Het
Adam2	T	C	14: 66,053,831	N333D	probably benign	Het
Aifm3	G	A	16: 17,506,310	R578Q	probably benign	Het
Arid2	C	A	15: 96,370,762	Q919K	probably benign	Het
Atp6v1a	T	C	16: 44,111,088		probably benign	Het
Bicd1	A	T	6: 149,513,585	T599S	probably benign	Het
Catsperg2	T	A	7: 29,709,874	R601W	probably damaging	Het
Clca2	A	C	3: 145,086,392	S369R	possibly damaging	Het
Cyfip1	T	G	7: 55,907,434	V795G	possibly damaging	Het
Ddb1	A	G	19: 10,621,861	T544A	probably benign	Het
Defb43	T	C	14: 63,017,880	I54T	probably damaging	Het
Dera	A	G	6: 137,779,645	M89V	probably benign	Het
Fam227b	T	A	2: 125,989,003	K427I	probably damaging	Het
Frk	A	G	10: 34,607,842	I400V	probably benign	Het
Gk5	T	A	9: 96,129,053	L72H	probably damaging	Het
Gprc6a	T	A	10: 51,628,349	Y133F	possibly damaging	Het
Hecw1	G	T	13: 14,280,485	L662M	probably benign	Het
Hecw1	A	G	13: 14,280,484	L662P	probably damaging	Het
Il12b	T	A	11: 44,407,930	S71T	probably benign	Het
Kdm2a	A	T	19: 4,345,510		probably benign	Het
Lhfp	A	G	3: 53,043,553	R83G	possibly damaging	Het
Magel2	C	A	7: 62,380,414	T1022K	unknown	Het
Mycbp2	C	A	14: 103,188,589	V2367F	possibly damaging	Het
Nap1l3	C	T	X: 122,396,208	G271D	probably benign	Het
Nars2	T	A	7: 97,039,910	D346E	possibly damaging	Het
Nek11	T	A	9: 105,244,414	E435D	probably damaging	Het
Nfam1	C	T	15: 83,010,410	G205R	probably benign	Het
Olfr1474	T	A	19: 13,471,267	M99K	probably damaging	Het
Olfr395	A	T	11: 73,906,696	N265K	probably benign	Het
Olfr433	T	C	1: 174,042,208	L86P	probably damaging	Het
Otud3	G	A	4: 138,909,617	R78W	probably damaging	Het
Oxct2a	C	T	4: 123,322,965	A208T	probably damaging	Het
Pcdh11x	A	T	X: 120,400,910	E683D	probably benign	Het
Phtf2	C	A	5: 20,803,252	V144L	probably damaging	Het
Pkn2	T	C	3: 142,803,550		probably null	Het
Puf60	T	A	15: 76,070,596	D459V	possibly damaging	Het
Ralgapa2	A	G	2: 146,460,712		probably null	Het
Rapgef6	A	C	11: 54,657,429	Q813P	probably damaging	Het
Rsf1	A	T	7: 97,679,004	D1071V	possibly damaging	Het
Sctr	T	C	1: 120,031,559		probably benign	Het
Serpini1	A	G	3: 75,619,174	I244M	probably benign	Het
Tada2a	C	A	11: 84,087,192		probably benign	Het
Tada3	A	T	6: 113,375,131	H112Q	possibly damaging	Het
Tnxb	T	A	17: 34,688,720	L1246Q	probably damaging	Het
Txndc16	T	C	14: 45,151,896	N449S	probably damaging	Het
Usp34	T	A	11: 23,420,090	Y1771*	probably null	Het
Vav2	A	T	2: 27,271,900		probably null	Het
Virma	T	C	4: 11,542,207		probably benign	Het
Vnn3	A	T	10: 23,851,800		probably benign	Het

Other mutations in Vmn1r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Vmn1r78	APN	7	12153238	missense	probably benign	0.10
IGL02019:Vmn1r78	APN	7	12152707	missense	probably damaging	0.99
IGL02143:Vmn1r78	APN	7	12152480	missense	probably benign
IGL02154:Vmn1r78	APN	7	12152545	missense	probably benign	0.22
IGL02290:Vmn1r78	APN	7	12153155	missense	probably damaging	1.00
IGL03012:Vmn1r78	APN	7	12153364	missense	probably benign	0.32
IGL03373:Vmn1r78	APN	7	12153343	missense	possibly damaging	0.86
IGL03384:Vmn1r78	APN	7	12153209	missense	possibly damaging	0.94
R0016:Vmn1r78	UTSW	7	12153352	missense	probably benign	0.02
R1445:Vmn1r78	UTSW	7	12152581	missense	possibly damaging	0.64
R1748:Vmn1r78	UTSW	7	12153323	missense	probably damaging	1.00
R2017:Vmn1r78	UTSW	7	12153343	missense	possibly damaging	0.86
R2032:Vmn1r78	UTSW	7	12153283	missense	probably benign	0.00
R2198:Vmn1r78	UTSW	7	12152560	missense	probably benign	0.06
R4330:Vmn1r78	UTSW	7	12152459	splice site	probably null
R4564:Vmn1r78	UTSW	7	12152558	missense	probably damaging	1.00
R4769:Vmn1r78	UTSW	7	12152798	missense	probably damaging	1.00
R4801:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4802:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R5648:Vmn1r78	UTSW	7	12152766	missense	possibly damaging	0.92
R6561:Vmn1r78	UTSW	7	12152899	missense	probably damaging	1.00
R6869:Vmn1r78	UTSW	7	12152749	missense	probably benign	0.01
R6945:Vmn1r78	UTSW	7	12152905	missense	probably benign	0.01
R7793:Vmn1r78	UTSW	7	12153314	missense	probably benign	0.01
R7954:Vmn1r78	UTSW	7	12153300	nonsense	probably null
Z1088:Vmn1r78	UTSW	7	12152714	missense	probably damaging	1.00

Posted On

2016-08-02