Incidental Mutation 'R6211:Olfr1502'
ID503482
Institutional Source Beutler Lab
Gene Symbol Olfr1502
Ensembl Gene ENSMUSG00000056858
Gene Nameolfactory receptor 1502
SynonymsGA_x6K02T2RE5P-4193992-4194942, MOR211-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.120) question?
Stock #R6211 (G1)
Quality Score225.009
Status Validated
Chromosome19
Chromosomal Location13861795-13862745 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 13862574 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Methionine at position 260 (I260M)
Ref Sequence ENSEMBL: ENSMUSP00000073843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074221]
Predicted Effect probably benign
Transcript: ENSMUST00000074221
AA Change: I260M

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: I260M

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.1e-43 PFAM
Pfam:7tm_1 41 290 1.6e-17 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.6%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406P16Rik A T 7: 34,239,004 H1035Q possibly damaging Het
Acin1 A T 14: 54,644,046 W391R probably damaging Het
Arl6ip1 A T 7: 118,127,250 S18R probably benign Het
Armc3 G A 2: 19,296,803 probably null Het
Casc1 C T 6: 145,200,491 R95Q probably damaging Het
Ccdc162 G T 10: 41,630,145 S883* probably null Het
Cd300lg A G 11: 102,054,169 M358V possibly damaging Het
Cdh23 A G 10: 60,410,821 V949A possibly damaging Het
Cenpo C T 12: 4,216,733 S126N probably benign Het
Chd3 A T 11: 69,352,677 D1366E probably damaging Het
Chd4 A G 6: 125,101,285 E169G possibly damaging Het
Clec1b A G 6: 129,401,477 T24A possibly damaging Het
Clhc1 A G 11: 29,578,145 I558V probably damaging Het
Col5a2 T A 1: 45,376,666 R1440S probably damaging Het
Cops3 A G 11: 59,817,901 probably benign Het
Cxcr4 A G 1: 128,589,450 V158A probably damaging Het
Dnah7a A G 1: 53,419,636 M3781T probably damaging Het
Elovl5 C A 9: 77,981,502 T217K probably damaging Het
Fbln7 G T 2: 128,895,340 M358I probably damaging Het
Fbxl13 C T 5: 21,484,021 R763Q possibly damaging Het
Gabrr3 C A 16: 59,448,108 N361K probably benign Het
Gbp7 A G 3: 142,545,993 M534V probably benign Het
Hcar2 G A 5: 123,864,954 T162I probably benign Het
Hdc A T 2: 126,593,977 L658Q probably damaging Het
Hivep3 A G 4: 120,098,405 Y1306C probably damaging Het
Homer3 C T 8: 70,285,524 R49C probably damaging Het
Hspa4 C T 11: 53,262,939 E702K probably benign Het
Iqgap3 A G 3: 88,091,515 N308D probably benign Het
Itga8 G A 2: 12,193,509 T555M probably damaging Het
Lrfn5 G T 12: 61,839,470 V15L probably benign Het
Lrrk1 T C 7: 66,302,710 K493E possibly damaging Het
Lyzl6 A G 11: 103,635,063 I77T probably damaging Het
Mavs G T 2: 131,240,391 R65L probably damaging Het
Mdn1 T G 4: 32,696,269 D1217E probably benign Het
Olfr103 A T 17: 37,336,708 F175I possibly damaging Het
Olfr648 A T 7: 104,179,747 Y220* probably null Het
Otof C A 5: 30,371,900 V1762L probably damaging Het
Pcdha12 T C 18: 37,020,321 L31P probably damaging Het
Pxk C A 14: 8,163,952 P515T probably damaging Het
Qrich2 A T 11: 116,453,542 D1759E probably benign Het
Rps6ka1 A T 4: 133,869,306 F33Y probably damaging Het
Rxfp2 G A 5: 150,044,126 probably null Het
Slc23a4 A T 6: 34,956,961 I202N probably damaging Het
Slc24a5 A T 2: 125,088,251 I491F probably benign Het
Slco1a1 T A 6: 141,909,049 K625N probably benign Het
Snx31 A G 15: 36,546,885 V51A probably damaging Het
Sox6 G T 7: 115,801,462 H48Q probably damaging Het
Tas2r109 A T 6: 132,980,624 Y114* probably null Het
Tbc1d2 C T 4: 46,629,912 G252R probably benign Het
Timm13 A C 10: 80,900,480 probably null Het
Tpsb2 G A 17: 25,367,763 A250T possibly damaging Het
Trpm6 T C 19: 18,783,128 I131T probably damaging Het
Vars2 A T 17: 35,665,662 probably null Het
Vmn2r35 T A 7: 7,786,528 I737F probably damaging Het
Wdr46 C A 17: 33,944,485 T339K probably damaging Het
Other mutations in Olfr1502
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Olfr1502 APN 19 13861786 unclassified probably benign
IGL01061:Olfr1502 APN 19 13862705 missense possibly damaging 0.94
IGL01534:Olfr1502 APN 19 13861919 missense probably damaging 1.00
IGL02017:Olfr1502 APN 19 13862231 missense possibly damaging 0.58
IGL02039:Olfr1502 APN 19 13862719 nonsense probably null
IGL02173:Olfr1502 APN 19 13862014 missense probably benign 0.00
IGL02219:Olfr1502 APN 19 13861823 missense probably damaging 1.00
IGL02475:Olfr1502 APN 19 13862299 missense probably damaging 1.00
IGL02604:Olfr1502 APN 19 13861806 missense probably benign 0.01
R0012:Olfr1502 UTSW 19 13861823 missense probably damaging 0.98
R0594:Olfr1502 UTSW 19 13862279 missense probably benign 0.04
R2184:Olfr1502 UTSW 19 13862035 missense probably benign 0.02
R2518:Olfr1502 UTSW 19 13862309 missense probably damaging 1.00
R5541:Olfr1502 UTSW 19 13861964 missense probably benign
R5587:Olfr1502 UTSW 19 13862576 missense probably damaging 1.00
R6351:Olfr1502 UTSW 19 13861822 missense probably benign 0.04
R7575:Olfr1502 UTSW 19 13862017 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCTGGCCTGTAGTGACAC -3'
(R):5'- CCTCACTCAGTGTTGTGTGC -3'

Sequencing Primer
(F):5'- GGCCTGTAGTGACACAACAAATATTG -3'
(R):5'- CAGTGTTGTGTGCATTGGGAAAC -3'
Posted On2018-02-27