Mutagenetix > Incidental Mutation

Incidental Mutation 'R6351:Olfr1502'

514298

Institutional Source

Beutler Lab

Gene Symbol

Olfr1502

Ensembl Gene

ENSMUSG00000056858

Gene Name

olfactory receptor 1502

Synonyms

GA_x6K02T2RE5P-4193992-4194942, MOR211-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R6351 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

13861795-13862745 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 13861822 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 10 (T10A)

Ref Sequence

ENSEMBL: ENSMUSP00000073843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074221]

AlphaFold

Q8VG66

Predicted Effect

probably benign
Transcript: ENSMUST00000074221
AA Change: T10A

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: T10A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	7.1e-43	PFAM
Pfam:7tm_1	41	290	1.6e-17	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.9%

Validation Efficiency

99% (95/96)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700025F22Rik	C	T	19: 11,142,401	G14D	probably damaging	Het
4932438A13Rik	G	A	3: 36,908,228	A493T	probably damaging	Het
Acaa1a	C	A	9: 119,341,564	S17*	probably null	Het
Adamts16	T	A	13: 70,836,203	S114C	probably damaging	Het
Agpat5	T	C	8: 18,846,708	V50A	probably benign	Het
Agrn	T	C	4: 156,179,434	N124S	probably benign	Het
AI481877	T	C	4: 59,069,317	D703G	probably benign	Het
Ak8	T	C	2: 28,735,626	I227T	probably benign	Het
Akap6	A	G	12: 53,142,025	E2074G	probably damaging	Het
Apc	T	A	18: 34,312,212	S702R	probably damaging	Het
Ascc3	T	C	10: 50,720,673	I1233T	probably damaging	Het
Asphd2	A	T	5: 112,385,832	F318I	probably damaging	Het
Bnc2	T	C	4: 84,293,143	T397A	probably benign	Het
Bpifb4	C	T	2: 153,957,134	T528I	probably damaging	Het
Brinp3	A	G	1: 146,901,585	E590G	probably damaging	Het
Ccdc149	A	G	5: 52,385,135	S372P	probably benign	Het
Cdhr2	A	G	13: 54,726,776	H887R	probably benign	Het
Clcn6	C	T	4: 148,017,500	V376I	probably benign	Het
Cntln	T	G	4: 85,115,354	C1305W	probably damaging	Het
Cspg4	A	G	9: 56,892,644	D1564G	probably benign	Het
Cux1	A	T	5: 136,309,792	S582T	probably damaging	Het
Cwh43	G	A	5: 73,411,905	A97T	possibly damaging	Het
Dsc1	A	T	18: 20,086,769	F781L	probably damaging	Het
Dsc3	G	T	18: 19,966,291	H723N	probably benign	Het
Ear10	A	T	14: 43,923,055	V105D	probably damaging	Het
Ecel1	A	G	1: 87,149,509	V659A	possibly damaging	Het
Eogt	A	T	6: 97,120,194	F316I	probably damaging	Het
Etaa1	T	C	11: 17,947,188	N310D	possibly damaging	Het
Exoc3l2	G	A	7: 19,469,708	R75Q	possibly damaging	Het
Fam186a	A	C	15: 99,941,742	L2207R	probably damaging	Het
Fam187b	T	C	7: 30,977,599	Y178H	probably damaging	Het
Fat1	A	T	8: 45,033,495	Q3362L	probably damaging	Het
Fat3	A	T	9: 15,938,398	S3903T	probably damaging	Het
Fsip2	G	A	2: 82,992,684	V6254I	possibly damaging	Het
Gabra5	T	C	7: 57,413,780	T299A	probably damaging	Het
Gbp11	T	C	5: 105,327,598	T295A	probably benign	Het
Glcci1	C	T	6: 8,573,203	Q44*	probably null	Het
Gpc5	A	T	14: 115,399,200	T432S	probably benign	Het
Grhl1	G	A	12: 24,584,858	E228K	probably damaging	Het
Hyal5	T	C	6: 24,891,709		probably null	Het
Idh2	TCCCAGG	T	7: 80,098,331		probably benign	Het
Ints9	A	G	14: 64,993,007	I128V	probably damaging	Het
Kcnt2	A	T	1: 140,375,112	N130I	probably damaging	Het
Krba1	T	C	6: 48,414,128	V717A	probably benign	Het
Lrp12	T	A	15: 39,878,188	D377V	probably damaging	Het
Magi1	G	T	6: 93,943,229	D135E	possibly damaging	Het
Map10	T	A	8: 125,671,245	L459Q	probably damaging	Het
Mitf	A	G	6: 98,003,912	D238G	possibly damaging	Het
Mylk	G	T	16: 34,921,971	R951L	probably benign	Het
Nacad	T	A	11: 6,599,235	D1272V	probably damaging	Het
Nacad	T	A	11: 6,600,165	K1009*	probably null	Het
Ncor1	T	C	11: 62,373,298	D786G	probably benign	Het
Oas2	G	A	5: 120,748,538	R188C	probably benign	Het
Odf2l	A	G	3: 145,135,718	I300V	probably benign	Het
Olfr338	T	A	2: 36,377,196	V140D	possibly damaging	Het
Olfr484	A	G	7: 108,124,430	S278P	probably damaging	Het
Olfr624	A	G	7: 103,670,956	I25T	possibly damaging	Het
Olfr64	A	T	7: 103,893,135	L200*	probably null	Het
Pes1	T	A	11: 3,978,865	D574E	probably benign	Het
Phf20	C	T	2: 156,294,210	R650C	possibly damaging	Het
Pias4	G	A	10: 81,157,264	T248I	probably damaging	Het
Pkhd1	T	C	1: 20,211,951	T2889A	probably benign	Het
Plcxd1	C	A	5: 110,102,167		probably null	Het
Plekha7	A	G	7: 116,176,898	F194L	probably damaging	Het
Plxnb2	T	C	15: 89,157,770	N1642S	possibly damaging	Het
Pnpla7	A	T	2: 25,011,564	D534V	probably damaging	Het
Ppp2r5c	A	T	12: 110,554,879	S279C	probably damaging	Het
Ptprq	T	A	10: 107,708,668	T334S	probably damaging	Het
Rab39	T	C	9: 53,686,521	D148G	probably benign	Het
Reep3	A	T	10: 67,034,653	F121L	probably benign	Het
Reln	G	T	5: 21,901,663	C3236*	probably null	Het
Rrp8	C	T	7: 105,734,809	C162Y	probably damaging	Het
Scrib	C	A	15: 76,064,986	Q399H	possibly damaging	Het
Sertad1	T	A	7: 27,489,799	Y182N	possibly damaging	Het
Sfrp5	A	G	19: 42,201,824	V63A	possibly damaging	Het
Slc46a1	T	C	11: 78,467,159	M346T	probably benign	Het
Sycp2	A	G	2: 178,363,416	L886S	probably damaging	Het
Teddm1b	A	T	1: 153,874,759	I105F	probably benign	Het
Thumpd1	A	T	7: 119,720,605	I46N	possibly damaging	Het
Tmod4	A	G	3: 95,127,853	N223S	probably damaging	Het
Tnfrsf10b	G	C	14: 69,773,401	C85S	probably damaging	Het
Tox	T	C	4: 6,697,439	T455A	probably benign	Het
Tox	T	C	4: 6,741,536	Q148R	probably benign	Het
Trp53bp1	A	C	2: 121,269,945	S109R	probably damaging	Het
Tshz2	A	T	2: 169,884,968	T26S	probably benign	Het
Tubb4a	T	A	17: 57,081,016	N337Y	probably damaging	Het
Tubb6	T	A	18: 67,401,388	V119E	probably damaging	Het
Unk	C	T	11: 116,054,946	T481I	probably benign	Het
Vmn2r112	C	T	17: 22,601,278	T44I	probably benign	Het
Vstm5	G	A	9: 15,257,533	G131D	probably damaging	Het
Wscd1	T	C	11: 71,759,883	L12P	probably damaging	Het
Zfp369	T	A	13: 65,296,230	S396T	possibly damaging	Het
Zfp932	T	A	5: 110,009,343	C302*	probably null	Het
Zfp972	A	T	2: 177,906,935		probably null	Het
Zfyve21	C	A	12: 111,827,594	A212E	probably benign	Het

Other mutations in Olfr1502

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Olfr1502	APN	19	13861786	unclassified	probably benign
IGL01061:Olfr1502	APN	19	13862705	missense	possibly damaging	0.94
IGL01534:Olfr1502	APN	19	13861919	missense	probably damaging	1.00
IGL02017:Olfr1502	APN	19	13862231	missense	possibly damaging	0.58
IGL02039:Olfr1502	APN	19	13862719	nonsense	probably null
IGL02173:Olfr1502	APN	19	13862014	missense	probably benign	0.00
IGL02219:Olfr1502	APN	19	13861823	missense	probably damaging	1.00
IGL02475:Olfr1502	APN	19	13862299	missense	probably damaging	1.00
IGL02604:Olfr1502	APN	19	13861806	missense	probably benign	0.01
R0012:Olfr1502	UTSW	19	13861823	missense	probably damaging	0.98
R0594:Olfr1502	UTSW	19	13862279	missense	probably benign	0.04
R2184:Olfr1502	UTSW	19	13862035	missense	probably benign	0.02
R2518:Olfr1502	UTSW	19	13862309	missense	probably damaging	1.00
R5541:Olfr1502	UTSW	19	13861964	missense	probably benign
R5587:Olfr1502	UTSW	19	13862576	missense	probably damaging	1.00
R6211:Olfr1502	UTSW	19	13862574	missense	probably benign	0.01
R7575:Olfr1502	UTSW	19	13862017	missense	probably damaging	1.00
R8425:Olfr1502	UTSW	19	13862485	missense	probably benign	0.00
R9545:Olfr1502	UTSW	19	13861853	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- ACCTGAAGAGTATGTGCCTCTTATC -3'
(R):5'- CCAACACAGAGAGATGGCTCAG -3'

Sequencing Primer
(F):5'- AGAGTATGTGCCTCTTATCTTTTCAG -3'
(R):5'- TGGCTCAGAAAGAAGTACATTGG -3'

Posted On

2018-04-27