|Institutional Source||Beutler Lab|
|Gene Name||fucosyltransferase 9|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4722 (G1)|
|Chromosomal Location||25609332-25800244 bp(-) (GRCm38)|
|Type of Mutation||utr 5 prime|
|DNA Base Change (assembly)||T to C at 25799734 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000103834 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000084770] [ENSMUST00000108199]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (68/69)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased number of neuronal stem cells with increased self-renewal capacity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fut9||
(F):5'- TCTAACGATGTACGGTGGGC -3'
(R):5'- CCCACAGGCTCATTTTGGAG -3'
(F):5'- GCTCAGTCCTGTGCCTGAC -3'
(R):5'- AACCTGTACCCGGCTGCTATG -3'