Incidental Mutation 'R6888:Olfr1162'
ID 537024
Institutional Source Beutler Lab
Gene Symbol Olfr1162
Ensembl Gene ENSMUSG00000075139
Gene Name olfactory receptor 1162
Synonyms MOR174-14, GA_x6K02T2Q125-49542541-49541597
MMRRC Submission 044982-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6888 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 88045920-88051129 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88050264 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 120 (M120T)
Ref Sequence ENSEMBL: ENSMUSP00000139068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099837] [ENSMUST00000183862]
AlphaFold Q7TR28
Predicted Effect probably damaging
Transcript: ENSMUST00000099837
AA Change: M120T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097425
Gene: ENSMUSG00000075139
AA Change: M120T

Pfam:7tm_4 33 310 2.9e-46 PFAM
Pfam:7tm_1 43 292 1.5e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000183862
AA Change: M120T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139068
Gene: ENSMUSG00000075139
AA Change: M120T

Pfam:7tm_1 43 292 4.2e-27 PFAM
Pfam:7tm_4 141 285 3.1e-37 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110051M20Rik A G 2: 91,421,894 (GRCm38) Y41H probably damaging Het
Actg1 T C 11: 120,347,315 (GRCm38) Y190C probably damaging Het
Adgrv1 A G 13: 81,508,669 (GRCm38) I2902T probably damaging Het
AI429214 G A 8: 36,993,833 (GRCm38) G45D possibly damaging Het
Ambra1 A G 2: 91,769,027 (GRCm38) D164G probably damaging Het
Ap3b1 A T 13: 94,408,791 (GRCm38) Q184L probably benign Het
Arhgef17 T C 7: 100,930,820 (GRCm38) D307G possibly damaging Het
AY761185 A T 8: 20,944,555 (GRCm38) Y52* probably null Het
Bfsp1 A G 2: 143,826,719 (GRCm38) S647P probably benign Het
C130073F10Rik A G 4: 101,890,256 (GRCm38) V192A probably benign Het
Cacna1g T A 11: 94,459,207 (GRCm38) D604V probably benign Het
Ccdc170 T C 10: 4,546,854 (GRCm38) V458A possibly damaging Het
Ccdc187 G A 2: 26,289,734 (GRCm38) R238W probably damaging Het
Cdh1 A G 8: 106,658,314 (GRCm38) S380G probably benign Het
Cdk5rap3 T C 11: 96,916,192 (GRCm38) H4R probably benign Het
Cftr G A 6: 18,313,730 (GRCm38) probably null Het
Dnajc16 A G 4: 141,776,992 (GRCm38) V219A probably benign Het
Drd3 A T 16: 43,817,139 (GRCm38) I266F probably benign Het
Dut A G 2: 125,257,124 (GRCm38) D177G probably benign Het
Esr1 A G 10: 4,857,076 (GRCm38) I331V probably benign Het
Fam129c G T 8: 71,603,739 (GRCm38) R361L probably benign Het
Gm11110 A G 17: 57,102,143 (GRCm38) probably benign Het
Grm7 G T 6: 111,358,353 (GRCm38) G575V possibly damaging Het
Heatr3 A G 8: 88,170,884 (GRCm38) Y531C probably damaging Het
Igfn1 A G 1: 135,982,480 (GRCm38) V122A probably benign Het
Igsf21 T C 4: 140,034,743 (GRCm38) D208G probably benign Het
Kntc1 T C 5: 123,811,310 (GRCm38) Y1915H probably damaging Het
Lamc1 A T 1: 153,262,492 (GRCm38) D205E probably damaging Het
Limch1 C T 5: 67,021,926 (GRCm38) T713I probably benign Het
Lrp1b A G 2: 41,471,126 (GRCm38) I555T probably benign Het
Lrp2 A T 2: 69,524,141 (GRCm38) F448I probably damaging Het
March6 T C 15: 31,459,233 (GRCm38) K896E probably benign Het
Mpp6 T G 6: 50,180,277 (GRCm38) probably null Het
Mroh4 T C 15: 74,613,249 (GRCm38) Y469C possibly damaging Het
Nos3 T C 5: 24,383,335 (GRCm38) V1060A possibly damaging Het
Nr1h4 A G 10: 89,456,542 (GRCm38) I406T probably damaging Het
Odf2l T C 3: 145,148,618 (GRCm38) probably null Het
Olfr1387 A T 11: 49,460,260 (GRCm38) T194S probably damaging Het
Pbx2 A G 17: 34,594,107 (GRCm38) Y119C possibly damaging Het
Pdcd6ip C A 9: 113,671,837 (GRCm38) A526S probably benign Het
Prx G A 7: 27,519,634 (GRCm38) D1187N possibly damaging Het
Ptpro G A 6: 137,380,200 (GRCm38) V230I probably benign Het
Rtn3 C T 19: 7,457,249 (GRCm38) M440I probably benign Het
Sar1b T C 11: 51,788,192 (GRCm38) I96T probably damaging Het
Sds T C 5: 120,480,900 (GRCm38) probably null Het
Secisbp2 A G 13: 51,679,941 (GRCm38) T706A probably benign Het
Sorcs3 A T 19: 48,693,824 (GRCm38) M433L possibly damaging Het
Sppl2a A G 2: 126,904,992 (GRCm38) V472A probably damaging Het
Tbc1d9 A G 8: 83,271,588 (GRCm38) E1258G possibly damaging Het
Tbxas1 C A 6: 38,952,074 (GRCm38) probably benign Het
Tg T C 15: 66,696,246 (GRCm38) I1333T probably damaging Het
Tmem108 C T 9: 103,499,716 (GRCm38) G178D probably damaging Het
Tmem174 A G 13: 98,637,061 (GRCm38) L87P probably damaging Het
Tmppe T A 9: 114,404,701 (GRCm38) S23T probably damaging Het
Ttn G A 2: 76,761,103 (GRCm38) T21074I probably benign Het
Tub A G 7: 109,029,298 (GRCm38) M338V probably null Het
Vmn1r160 A T 7: 22,872,106 (GRCm38) R295* probably null Het
Vps52 T C 17: 33,963,206 (GRCm38) V518A probably benign Het
Wdr59 A G 8: 111,451,043 (GRCm38) V909A probably benign Het
Wnk1 T C 6: 119,948,781 (GRCm38) T1241A probably benign Het
Zfp882 G A 8: 71,914,286 (GRCm38) C319Y probably benign Het
Znfx1 A T 2: 167,038,940 (GRCm38) I308N possibly damaging Het
Other mutations in Olfr1162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01669:Olfr1162 APN 2 88,049,784 (GRCm38) missense possibly damaging 0.63
IGL01965:Olfr1162 APN 2 88,050,436 (GRCm38) missense probably benign 0.14
IGL02183:Olfr1162 APN 2 88,049,989 (GRCm38) missense possibly damaging 0.96
R0281:Olfr1162 UTSW 2 88,050,412 (GRCm38) missense possibly damaging 0.96
R0501:Olfr1162 UTSW 2 88,050,471 (GRCm38) missense probably damaging 1.00
R4254:Olfr1162 UTSW 2 88,049,779 (GRCm38) missense possibly damaging 0.62
R4589:Olfr1162 UTSW 2 88,050,479 (GRCm38) missense probably benign 0.12
R4824:Olfr1162 UTSW 2 88,050,088 (GRCm38) missense probably damaging 1.00
R5148:Olfr1162 UTSW 2 88,050,393 (GRCm38) missense probably benign 0.08
R5580:Olfr1162 UTSW 2 88,050,324 (GRCm38) missense possibly damaging 0.79
R6174:Olfr1162 UTSW 2 88,050,302 (GRCm38) nonsense probably null
R7935:Olfr1162 UTSW 2 88,049,946 (GRCm38) missense probably damaging 1.00
R7951:Olfr1162 UTSW 2 88,050,257 (GRCm38) nonsense probably null
R9123:Olfr1162 UTSW 2 88,049,950 (GRCm38) missense probably damaging 0.99
R9125:Olfr1162 UTSW 2 88,049,950 (GRCm38) missense probably damaging 0.99
R9133:Olfr1162 UTSW 2 88,050,438 (GRCm38) missense probably damaging 1.00
R9280:Olfr1162 UTSW 2 88,050,114 (GRCm38) missense probably damaging 1.00
R9374:Olfr1162 UTSW 2 88,050,165 (GRCm38) nonsense probably null
R9552:Olfr1162 UTSW 2 88,050,165 (GRCm38) nonsense probably null
Z1177:Olfr1162 UTSW 2 88,050,304 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-10-18