Incidental Mutation 'R7190:Gpr150'
ID559563
Institutional Source Beutler Lab
Gene Symbol Gpr150
Ensembl Gene ENSMUSG00000045509
Gene NameG protein-coupled receptor 150
SynonymsC030001A19Rik, PGR11
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #R7190 (G1)
Quality Score225.009
Status Validated
Chromosome13
Chromosomal Location76054851-76056996 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 76055873 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 318 (A318T)
Ref Sequence ENSEMBL: ENSMUSP00000049592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056130] [ENSMUST00000120573]
Predicted Effect probably benign
Transcript: ENSMUST00000056130
AA Change: A318T

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000049592
Gene: ENSMUSG00000045509
AA Change: A318T

DomainStartEndE-ValueType
low complexity region 37 50 N/A INTRINSIC
Pfam:7tm_1 66 345 2.7e-22 PFAM
low complexity region 353 370 N/A INTRINSIC
low complexity region 387 401 N/A INTRINSIC
low complexity region 410 420 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000120573
SMART Domains Protein: ENSMUSP00000113274
Gene: ENSMUSG00000021592

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Sulfatase 35 371 6e-49 PFAM
low complexity region 381 392 N/A INTRINSIC
low complexity region 537 555 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add3 C T 19: 53,216,899 R27* probably null Het
Armc3 T A 2: 19,293,136 Y573N probably damaging Het
BC024978 G A 7: 27,201,123 A176T probably damaging Het
Bod1l A C 5: 41,819,938 N1344K probably benign Het
Camta1 T G 4: 151,148,523 N231T possibly damaging Het
Capza2 T A 6: 17,654,121 Y57* probably null Het
Ccdc186 T A 19: 56,792,000 I871F probably damaging Het
Cntnap5b A G 1: 100,431,849 probably null Het
Dnah2 G T 11: 69,549,097 probably null Het
Fhod3 T C 18: 25,090,755 F1053L probably damaging Het
Foxj1 A G 11: 116,332,375 Y201H possibly damaging Het
Gatad2b T A 3: 90,350,415 I210N probably benign Het
Gba T A 3: 89,204,362 I112N probably damaging Het
Gbp2 T C 3: 142,633,447 V420A probably benign Het
Gm3106 T G 5: 94,218,237 N71K probably benign Het
Gm8251 A C 1: 44,061,615 S108A probably benign Het
Golga3 T A 5: 110,209,855 H1072Q probably damaging Het
Gpr6 T C 10: 41,070,960 N209D probably damaging Het
Grin2b T C 6: 135,732,948 N1200S possibly damaging Het
Ifi207 G A 1: 173,730,252 H307Y unknown Het
Il20ra A T 10: 19,742,941 I46F probably damaging Het
Lvrn A G 18: 46,900,503 D927G probably benign Het
Nlrc4 G T 17: 74,445,203 D728E probably damaging Het
Nup107 T C 10: 117,762,135 D630G probably benign Het
Olfr378 A T 11: 73,425,164 I273N probably benign Het
Olfr787 T C 10: 129,462,757 I27T probably benign Het
Pclo C A 5: 14,679,729 A2867D unknown Het
Perm1 A G 4: 156,219,815 T754A possibly damaging Het
Plpbp G T 8: 27,051,297 V162L probably benign Het
Plscr4 A T 9: 92,488,641 E220D probably benign Het
Ppp2r3a A T 9: 101,212,527 M199K probably benign Het
Rassf6 T C 5: 90,606,807 E204G probably damaging Het
Reln A C 5: 22,047,947 D667E probably damaging Het
Rere A G 4: 150,610,953 I462V unknown Het
Rpain A G 11: 70,971,909 E76G possibly damaging Het
Strc T G 2: 121,369,026 I1311L probably benign Het
Svil A G 18: 5,092,937 M1385V probably benign Het
Syne2 T A 12: 76,066,587 D1083E probably benign Het
Szt2 T A 4: 118,389,006 H986L probably damaging Het
Tcl1b2 G T 12: 105,147,234 probably null Het
Thy1 T A 9: 44,046,925 S117T possibly damaging Het
Tmem183a A T 1: 134,354,758 I203N probably damaging Het
Tmprss11g T C 5: 86,496,632 I118V probably benign Het
Tsen34 T C 7: 3,694,807 V69A possibly damaging Het
Ttn T C 2: 76,886,799 Q7506R unknown Het
Vmn1r184 T C 7: 26,267,680 S284P probably damaging Het
Wdr19 A G 5: 65,240,862 D810G probably benign Het
Zer1 T C 2: 30,103,432 D554G probably damaging Het
Zfp626 A T 7: 27,818,343 T250S probably benign Het
Other mutations in Gpr150
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Gpr150 APN 13 76056423 missense probably benign
IGL01759:Gpr150 APN 13 76055665 missense possibly damaging 0.94
IGL03162:Gpr150 APN 13 76056831 unclassified probably benign
R1103:Gpr150 UTSW 13 76055593 missense probably damaging 1.00
R3885:Gpr150 UTSW 13 76056538 missense probably damaging 0.98
R4472:Gpr150 UTSW 13 76056154 missense probably benign 0.15
R5838:Gpr150 UTSW 13 76055926 missense probably benign 0.01
R5861:Gpr150 UTSW 13 76056073 missense possibly damaging 0.48
R6170:Gpr150 UTSW 13 76056557 missense probably damaging 0.97
R7248:Gpr150 UTSW 13 76056007 missense probably benign 0.01
R7257:Gpr150 UTSW 13 76056466 missense probably benign 0.00
R7665:Gpr150 UTSW 13 76055974 missense probably damaging 1.00
R7821:Gpr150 UTSW 13 76056392 missense probably benign 0.19
Z1177:Gpr150 UTSW 13 76056150 nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCCCATTCGCTGATATCGG -3'
(R):5'- GCTCTATGAAGCTATCGTGGGC -3'

Sequencing Primer
(F):5'- ATTCGCTGATATCGGCTTCTTC -3'
(R):5'- AAGCTATCGTGGGCTTCGC -3'
Posted On2019-06-26