|Institutional Source||Beutler Lab|
|Gene Name||CDC42 binding protein kinase beta|
|Is this an essential gene?||Possibly essential (E-score: 0.747)|
|Stock #||R7783 (G1)|
|Chromosomal Location||111292976-111377718 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||C to T at 111336025 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000042565 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041965] [ENSMUST00000222196]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdc42bpb||
(F):5'- GCTCAGGTTGTGATGGGAAAC -3'
(R):5'- GACAGCTTCTAGGGTAGCTAAC -3'
(F):5'- TGTGATGGGAAACACAACTCTG -3'
(R):5'- GAGGTCCGCTGTTAAGAGC -3'