Incidental Mutation 'R8198:Vmn1r81'
ID 635536
Institutional Source Beutler Lab
Gene Symbol Vmn1r81
Ensembl Gene ENSMUSG00000115027
Gene Name vomeronasal 1 receptor 81
Synonyms V1rg9
MMRRC Submission 067621-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.822) question?
Stock # R8198 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 11993686-11994606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11993882 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 242 (V242A)
Ref Sequence ENSEMBL: ENSMUSP00000083409 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086232]
AlphaFold A0A2I3BPG7
Predicted Effect possibly damaging
Transcript: ENSMUST00000086232
AA Change: V242A

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000083409
Gene: ENSMUSG00000115027
AA Change: V242A

DomainStartEndE-ValueType
Pfam:TAS2R 3 301 5.4e-12 PFAM
Pfam:V1R 34 299 6.6e-31 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700024B05Rik T C 14: 41,825,017 (GRCm39) *168R probably null Het
Adgrb1 C A 15: 74,411,094 (GRCm39) T330K probably damaging Het
Ankrd27 T C 7: 35,307,880 (GRCm39) V373A probably benign Het
Aoah C T 13: 21,101,290 (GRCm39) P270L probably damaging Het
AU041133 C G 10: 81,987,249 (GRCm39) P301A probably damaging Het
Aven C T 2: 112,390,120 (GRCm39) R8W probably benign Het
Cd2bp2 A G 7: 126,793,576 (GRCm39) S204P possibly damaging Het
Clca4b C A 3: 144,638,167 (GRCm39) G32C probably damaging Het
Clcn2 A G 16: 20,525,946 (GRCm39) V808A probably damaging Het
Clec4d T C 6: 123,244,965 (GRCm39) C82R probably damaging Het
Dennd1c T C 17: 57,373,460 (GRCm39) D671G possibly damaging Het
Eml5 G A 12: 98,825,145 (GRCm39) R691* probably null Het
Fcnb C T 2: 27,968,330 (GRCm39) S209N possibly damaging Het
Gm4922 T C 10: 18,659,340 (GRCm39) T461A probably benign Het
Gm9964 A G 11: 79,187,405 (GRCm39) V14A unknown Het
Gnb3 T C 6: 124,814,000 (GRCm39) Y196C probably benign Het
H4c2 C G 13: 23,941,283 (GRCm39) Q94E possibly damaging Het
Hps1 C T 19: 42,755,659 (GRCm39) R189Q probably benign Het
Iars2 G A 1: 185,029,703 (GRCm39) T638I probably benign Het
Itpripl2 A G 7: 118,089,819 (GRCm39) S247P probably damaging Het
Leng8 C A 7: 4,147,170 (GRCm39) R523S possibly damaging Het
Lhfpl3 T A 5: 23,478,333 (GRCm39) V72D probably benign Het
Lmntd2 A T 7: 140,791,134 (GRCm39) M426K possibly damaging Het
Lsg1 A T 16: 30,383,594 (GRCm39) V542E probably benign Het
Mphosph6 C T 8: 118,519,449 (GRCm39) V108I probably benign Het
Mta2 A G 19: 8,925,145 (GRCm39) T338A probably benign Het
Ncoa7 T C 10: 30,580,664 (GRCm39) N98S probably benign Het
Or52h7 T A 7: 104,214,140 (GRCm39) D237E probably benign Het
Or7a36 C A 10: 78,820,443 (GRCm39) T273K probably benign Het
Or7a42 T A 10: 78,791,558 (GRCm39) V173E probably damaging Het
Pgr T C 9: 8,958,411 (GRCm39) V806A possibly damaging Het
Rad54b T C 4: 11,612,440 (GRCm39) probably null Het
Sdad1 A T 5: 92,439,811 (GRCm39) C405S probably damaging Het
Semp2l2a T A 8: 13,887,056 (GRCm39) Y345F probably benign Het
Shoc1 T C 4: 59,065,174 (GRCm39) I814V probably benign Het
Smg1 T C 7: 117,744,829 (GRCm39) I3108V probably benign Het
Spink5 A T 18: 44,125,947 (GRCm39) I409F probably benign Het
Syt13 C A 2: 92,783,899 (GRCm39) L390M probably damaging Het
Taf5 T A 19: 47,064,212 (GRCm39) V385E probably damaging Het
Tdrd9 T A 12: 112,006,863 (GRCm39) V909E probably damaging Het
Tex9 G A 9: 72,387,940 (GRCm39) probably benign Het
Timm10b G T 7: 105,327,537 (GRCm39) E61* probably null Het
Tmprss11g A T 5: 86,646,352 (GRCm39) F72I probably benign Het
Trank1 T C 9: 111,219,880 (GRCm39) C2206R probably benign Het
Uba52rt C A 4: 3,973,346 (GRCm39) R72L probably benign Het
Unc45b GC G 11: 82,816,814 (GRCm39) probably null Het
Unc93b1 T C 19: 3,991,910 (GRCm39) S215P possibly damaging Het
Usp48 C T 4: 137,348,470 (GRCm39) probably benign Het
Zgrf1 T A 3: 127,389,673 (GRCm39) probably null Het
Other mutations in Vmn1r81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02026:Vmn1r81 APN 7 11,994,432 (GRCm39) missense probably damaging 1.00
IGL02086:Vmn1r81 APN 7 11,993,792 (GRCm39) missense possibly damaging 0.82
IGL02751:Vmn1r81 APN 7 11,994,374 (GRCm39) missense probably damaging 1.00
IGL02879:Vmn1r81 APN 7 11,994,319 (GRCm39) missense probably benign 0.20
IGL03358:Vmn1r81 APN 7 11,994,232 (GRCm39) missense possibly damaging 0.57
PIT4305001:Vmn1r81 UTSW 7 11,994,590 (GRCm39) missense probably benign 0.01
R0359:Vmn1r81 UTSW 7 11,993,877 (GRCm39) missense probably damaging 1.00
R1615:Vmn1r81 UTSW 7 11,994,441 (GRCm39) missense probably damaging 1.00
R1938:Vmn1r81 UTSW 7 11,994,589 (GRCm39) missense possibly damaging 0.67
R2967:Vmn1r81 UTSW 7 11,993,964 (GRCm39) missense probably damaging 0.99
R2983:Vmn1r81 UTSW 7 11,994,596 (GRCm39) missense probably benign 0.02
R4549:Vmn1r81 UTSW 7 11,993,749 (GRCm39) missense probably damaging 0.99
R5099:Vmn1r81 UTSW 7 11,994,248 (GRCm39) missense possibly damaging 0.86
R5326:Vmn1r81 UTSW 7 11,994,034 (GRCm39) missense probably damaging 1.00
R5542:Vmn1r81 UTSW 7 11,994,034 (GRCm39) missense probably damaging 1.00
R6010:Vmn1r81 UTSW 7 11,994,349 (GRCm39) missense possibly damaging 0.88
R6630:Vmn1r81 UTSW 7 11,994,584 (GRCm39) nonsense probably null
R6724:Vmn1r81 UTSW 7 11,994,599 (GRCm39) missense probably damaging 1.00
R6754:Vmn1r81 UTSW 7 11,993,774 (GRCm39) missense probably damaging 0.98
R9719:Vmn1r81 UTSW 7 11,994,449 (GRCm39) missense probably damaging 1.00
R9790:Vmn1r81 UTSW 7 11,994,113 (GRCm39) missense probably benign 0.15
R9791:Vmn1r81 UTSW 7 11,994,113 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- GGAGCTATCTCTTTCCACAGAAGG -3'
(R):5'- AGCAATCTGGCAACTGCAC -3'

Sequencing Primer
(F):5'- TTCCACAGAAGGGTAAAAATAGTCTG -3'
(R):5'- CTGGCAACTGCACTGTATATG -3'
Posted On 2020-07-13