Mutagenetix > Incidental Mutation

Incidental Mutation 'R8294:Or11g26'

638865

Institutional Source

Beutler Lab

Gene Symbol

Or11g26

Ensembl Gene

ENSMUSG00000068431

Gene Name

olfactory receptor family 11 subfamily G member 26

Synonyms

Olfr742, MOR106-6, GA_x6K02T2PMLR-6224293-6225228

MMRRC Submission

067784-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R8294 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

50752578-50753697 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50753083 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 141 (T141A)

Ref Sequence

ENSEMBL: ENSMUSP00000087273 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089836]

AlphaFold

A2RTP5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000089836
AA Change: T141A

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000087273
Gene: ENSMUSG00000068431
AA Change: T141A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.9e-55	PFAM
Pfam:7tm_1	45	294	1.5e-20	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

98% (42/43)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	C	3: 121,897,217 (GRCm39)	V632A	possibly damaging	Het
Abcf2	CAT	CATAAT	5: 24,781,589 (GRCm39)		probably benign	Het
Acat2	T	C	17: 13,175,243 (GRCm39)	I79V	probably benign	Het
Arid3a	A	T	10: 79,786,535 (GRCm39)		silent	Het
Cecr2	C	T	6: 120,710,747 (GRCm39)	A154V	probably damaging	Het
Cog3	A	C	14: 75,954,619 (GRCm39)	L650R	probably damaging	Het
Col12a1	A	T	9: 79,606,594 (GRCm39)	F610I	possibly damaging	Het
Col24a1	A	G	3: 145,186,844 (GRCm39)	D1215G	probably null	Het
Ctsh	C	G	9: 89,950,489 (GRCm39)	A219G	possibly damaging	Het
Dnah10	C	T	5: 124,859,410 (GRCm39)	L2126F	probably damaging	Het
Dock10	A	G	1: 80,488,079 (GRCm39)	V2028A	possibly damaging	Het
Ece1	T	C	4: 137,675,931 (GRCm39)	V435A	possibly damaging	Het
Epha8	G	T	4: 136,665,897 (GRCm39)	L420M	probably damaging	Het
H4c1	A	G	13: 23,944,957 (GRCm39)	F62L	probably damaging	Het
Hk1	T	G	10: 62,131,624 (GRCm39)	I245L	probably benign	Het
Hyal6	A	C	6: 24,734,378 (GRCm39)	K104Q	possibly damaging	Het
Kalrn	T	C	16: 33,853,954 (GRCm39)	I2017V	probably benign	Het
Khdc4	C	T	3: 88,603,915 (GRCm39)	A244V	probably damaging	Het
Krt72	A	T	15: 101,694,472 (GRCm39)	L141Q	probably damaging	Het
Map3k4	C	A	17: 12,537,500 (GRCm39)	A6S	unknown	Het
Muc6	T	C	7: 141,217,263 (GRCm39)	Y2470C	possibly damaging	Het
Nrip1	A	G	16: 76,089,418 (GRCm39)	V713A	probably damaging	Het
Or10q1b	A	G	19: 13,683,010 (GRCm39)	D273G	probably benign	Het
Or2ah1	T	A	2: 85,653,531 (GRCm39)	I72N	probably damaging	Het
Or6aa1	T	C	7: 86,044,487 (GRCm39)	Y73C	probably damaging	Het
Paip1	C	T	13: 119,587,300 (GRCm39)	T304I	possibly damaging	Het
Pde4dip	A	G	3: 97,674,694 (GRCm39)	L74P	probably damaging	Het
Prkch	T	A	12: 73,806,484 (GRCm39)	L577H	probably damaging	Het
Rp1	A	G	1: 4,416,220 (GRCm39)	S1631P	probably benign	Het
Rph3a	A	G	5: 121,099,429 (GRCm39)	F154S	probably damaging	Het
S1pr5	A	G	9: 21,156,300 (GRCm39)	V42A	possibly damaging	Het
Scaper	G	A	9: 55,517,280 (GRCm39)	L1052F	possibly damaging	Het
Slc44a2	G	T	9: 21,259,643 (GRCm39)	V597F	probably damaging	Het
Srsf1	T	A	11: 87,939,467 (GRCm39)	S116T	probably benign	Het
Ssh2	A	G	11: 77,345,027 (GRCm39)	D1004G	probably benign	Het
St3gal5	T	A	6: 72,074,816 (GRCm39)	D25E		Het
Syt17	A	T	7: 118,009,228 (GRCm39)	Y327N	probably damaging	Het
T	T	A	17: 8,653,364 (GRCm39)	M1K	probably null	Het
Tmem201	A	T	4: 149,815,554 (GRCm39)	I132N	possibly damaging	Het
Tmprss15	A	T	16: 78,868,176 (GRCm39)	C211S	probably benign	Het
Trim36	T	C	18: 46,331,588 (GRCm39)	D7G	probably benign	Het
Trip11	T	A	12: 101,811,160 (GRCm39)	K1863N	possibly damaging	Het
Vmn2r13	A	T	5: 109,322,978 (GRCm39)	S104T	probably benign	Het
Zfp977	T	C	7: 42,229,689 (GRCm39)	T279A	probably benign	Het

Other mutations in Or11g26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02385:Or11g26	APN	14	50,752,900 (GRCm39)	missense	probably damaging	0.97
R0046:Or11g26	UTSW	14	50,753,596 (GRCm39)	makesense	probably null
R0369:Or11g26	UTSW	14	50,753,282 (GRCm39)	missense	probably benign	0.00
R0612:Or11g26	UTSW	14	50,752,939 (GRCm39)	missense	probably benign
R1588:Or11g26	UTSW	14	50,753,584 (GRCm39)	missense	probably benign
R1726:Or11g26	UTSW	14	50,753,636 (GRCm39)	splice site	probably null
R1998:Or11g26	UTSW	14	50,752,813 (GRCm39)	missense	probably benign	0.00
R2875:Or11g26	UTSW	14	50,753,269 (GRCm39)	missense	probably benign	0.06
R4009:Or11g26	UTSW	14	50,753,419 (GRCm39)	missense	possibly damaging	0.77
R5119:Or11g26	UTSW	14	50,752,966 (GRCm39)	missense	probably benign	0.00
R5232:Or11g26	UTSW	14	50,753,495 (GRCm39)	missense	probably damaging	0.99
R5627:Or11g26	UTSW	14	50,753,257 (GRCm39)	missense	probably benign
R5930:Or11g26	UTSW	14	50,753,249 (GRCm39)	missense	probably benign
R6597:Or11g26	UTSW	14	50,753,008 (GRCm39)	missense	probably benign	0.11
R7441:Or11g26	UTSW	14	50,752,853 (GRCm39)	missense	probably damaging	1.00
R7596:Or11g26	UTSW	14	50,753,002 (GRCm39)	missense	probably benign	0.14
R8051:Or11g26	UTSW	14	50,753,100 (GRCm39)	missense	probably benign	0.00
R8329:Or11g26	UTSW	14	50,753,015 (GRCm39)	missense	probably damaging	0.99
R8380:Or11g26	UTSW	14	50,753,297 (GRCm39)	missense	probably benign	0.00
R9517:Or11g26	UTSW	14	50,752,770 (GRCm39)	missense	probably benign
R9647:Or11g26	UTSW	14	50,753,552 (GRCm39)	missense	probably damaging	1.00
R9694:Or11g26	UTSW	14	50,752,669 (GRCm39)	missense	probably benign
R9796:Or11g26	UTSW	14	50,753,229 (GRCm39)	missense	probably damaging	1.00
Z1088:Or11g26	UTSW	14	50,752,984 (GRCm39)	missense	possibly damaging	0.90
Z1176:Or11g26	UTSW	14	50,753,522 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTTCCTGGAGATCTGGTATGTC -3'
(R):5'- ATTGTCCAGAAAACCTCCATCAATG -3'

Sequencing Primer
(F):5'- GGTATGTCACCTCCACAGTC -3'
(R):5'- CATCAATGGGGCTCTGGAAC -3'

Posted On

2020-07-28