Incidental Mutation 'R8919:Tle1'
| ID |
679109 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tle1
|
| Ensembl Gene |
ENSMUSG00000008305 |
| Gene Name |
transducin-like enhancer of split 1 |
| Synonyms |
C230057C06Rik, Estm14, Grg1, Tle4l |
| MMRRC Submission |
068706-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.575)
|
| Stock # |
R8919 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
72035379-72119156 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 72076525 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 168
(S168P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072481
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030095]
[ENSMUST00000072695]
[ENSMUST00000074216]
[ENSMUST00000102848]
[ENSMUST00000107337]
[ENSMUST00000137075]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030095
AA Change: S178P
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000030095
Gene: ENSMUSG00000008305
AA Change: S178P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TLE_N
|
1 |
143 |
9.1e-77 |
PFAM |
|
low complexity region
|
155 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
265 |
276 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
314 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
422 |
N/A |
INTRINSIC |
|
WD40
|
484 |
521 |
4.18e-2 |
SMART |
|
WD40
|
527 |
568 |
1.03e-1 |
SMART |
|
WD40
|
573 |
612 |
9.38e-5 |
SMART |
|
WD40
|
615 |
654 |
1.14e-8 |
SMART |
|
WD40
|
657 |
695 |
3.07e1 |
SMART |
|
WD40
|
697 |
736 |
8.96e-2 |
SMART |
|
WD40
|
737 |
777 |
4.14e-1 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072695
AA Change: S168P
PolyPhen 2
Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000072481
Gene: ENSMUSG00000008305
AA Change: S168P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TLE_N
|
1 |
136 |
2.6e-78 |
PFAM |
|
low complexity region
|
145 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
255 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
282 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
412 |
N/A |
INTRINSIC |
|
WD40
|
474 |
511 |
4.18e-2 |
SMART |
|
WD40
|
517 |
558 |
1.03e-1 |
SMART |
|
WD40
|
563 |
602 |
9.38e-5 |
SMART |
|
WD40
|
605 |
644 |
1.14e-8 |
SMART |
|
WD40
|
647 |
685 |
3.07e1 |
SMART |
|
WD40
|
687 |
726 |
8.96e-2 |
SMART |
|
WD40
|
727 |
767 |
4.14e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000074216
AA Change: S168P
PolyPhen 2
Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000073839
Gene: ENSMUSG00000008305
AA Change: S168P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TLE_N
|
1 |
136 |
1.3e-78 |
PFAM |
|
low complexity region
|
145 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
255 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
282 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
412 |
N/A |
INTRINSIC |
|
WD40
|
474 |
511 |
4.18e-2 |
SMART |
|
WD40
|
517 |
558 |
1.03e-1 |
SMART |
|
WD40
|
563 |
602 |
9.38e-5 |
SMART |
|
WD40
|
605 |
644 |
1.14e-8 |
SMART |
|
WD40
|
647 |
685 |
3.07e1 |
SMART |
|
WD40
|
687 |
726 |
8.96e-2 |
SMART |
|
WD40
|
727 |
767 |
4.14e-1 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102848
AA Change: S176P
PolyPhen 2
Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000099912
Gene: ENSMUSG00000008305
AA Change: S176P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TLE_N
|
1 |
144 |
1.3e-76 |
PFAM |
|
low complexity region
|
153 |
181 |
N/A |
INTRINSIC |
|
low complexity region
|
238 |
253 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
274 |
N/A |
INTRINSIC |
|
low complexity region
|
290 |
312 |
N/A |
INTRINSIC |
|
low complexity region
|
408 |
419 |
N/A |
INTRINSIC |
|
WD40
|
481 |
518 |
4.18e-2 |
SMART |
|
WD40
|
524 |
565 |
1.03e-1 |
SMART |
|
WD40
|
570 |
609 |
9.38e-5 |
SMART |
|
WD40
|
612 |
651 |
1.14e-8 |
SMART |
|
WD40
|
654 |
692 |
3.07e1 |
SMART |
|
WD40
|
694 |
733 |
8.96e-2 |
SMART |
|
WD40
|
734 |
774 |
4.14e-1 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107337
AA Change: S168P
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000102960
Gene: ENSMUSG00000008305
AA Change: S168P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TLE_N
|
1 |
136 |
7.2e-80 |
PFAM |
|
low complexity region
|
145 |
173 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000137075
AA Change: S190P
|
| SMART Domains |
Protein: ENSMUSP00000118683
Gene: ENSMUSG00000008305
AA Change: S190P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
17 |
N/A |
INTRINSIC |
|
Pfam:TLE_N
|
22 |
158 |
4.2e-77 |
PFAM |
|
low complexity region
|
167 |
195 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1488 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
99% (81/82) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadat |
C |
T |
8: 60,993,158 (GRCm39) |
T373I |
possibly damaging |
Het |
| Abca13 |
T |
C |
11: 9,241,653 (GRCm39) |
L1172P |
possibly damaging |
Het |
| Abcg2 |
A |
G |
6: 58,661,326 (GRCm39) |
Y459C |
probably benign |
Het |
| AC125199.3 |
T |
C |
16: 88,609,061 (GRCm39) |
N4D |
possibly damaging |
Het |
| Acad8 |
A |
G |
9: 26,910,785 (GRCm39) |
M3T |
probably benign |
Het |
| Acsbg3 |
A |
C |
17: 57,189,218 (GRCm39) |
I209L |
probably benign |
Het |
| Adcyap1r1 |
C |
T |
6: 55,474,080 (GRCm39) |
T472I |
probably damaging |
Het |
| Ank3 |
A |
T |
10: 69,840,671 (GRCm39) |
K1890N |
possibly damaging |
Het |
| Asic1 |
G |
A |
15: 99,569,826 (GRCm39) |
C49Y |
probably benign |
Het |
| Atp1a1 |
T |
C |
3: 101,498,547 (GRCm39) |
N215S |
probably damaging |
Het |
| C87436 |
A |
G |
6: 86,422,774 (GRCm39) |
Y116C |
probably damaging |
Het |
| Car5a |
T |
C |
8: 122,671,519 (GRCm39) |
D5G |
probably benign |
Het |
| Ccdc169 |
T |
C |
3: 55,058,368 (GRCm39) |
|
probably null |
Het |
| Ccdc93 |
A |
G |
1: 121,426,970 (GRCm39) |
R586G |
probably damaging |
Het |
| Cep295 |
A |
G |
9: 15,238,007 (GRCm39) |
V131A |
probably damaging |
Het |
| Cox5a |
A |
G |
9: 57,436,329 (GRCm39) |
D60G |
possibly damaging |
Het |
| Cpne6 |
A |
T |
14: 55,750,104 (GRCm39) |
E78D |
probably benign |
Het |
| Cyp2u1 |
T |
C |
3: 131,089,114 (GRCm39) |
E390G |
probably damaging |
Het |
| Dab2 |
C |
A |
15: 6,465,271 (GRCm39) |
N707K |
|
Het |
| Dock10 |
A |
T |
1: 80,483,147 (GRCm39) |
D2101E |
probably benign |
Het |
| Duoxa2 |
G |
A |
2: 122,132,357 (GRCm39) |
|
probably null |
Het |
| Eif4a3 |
T |
C |
11: 119,190,758 (GRCm39) |
D22G |
probably benign |
Het |
| Fhip1b |
T |
C |
7: 105,037,477 (GRCm39) |
T369A |
possibly damaging |
Het |
| Fubp3 |
A |
G |
2: 31,482,476 (GRCm39) |
|
probably null |
Het |
| Gm10330 |
A |
G |
12: 23,829,887 (GRCm39) |
L98P |
probably benign |
Het |
| Gm5108 |
A |
G |
5: 68,134,299 (GRCm39) |
*102W |
probably null |
Het |
| Gpr149 |
A |
C |
3: 62,438,478 (GRCm39) |
S560A |
probably damaging |
Het |
| Haspin |
T |
C |
11: 73,027,430 (GRCm39) |
D553G |
probably benign |
Het |
| Hsf1 |
C |
T |
15: 76,382,051 (GRCm39) |
H104Y |
probably benign |
Het |
| Ifi203 |
T |
C |
1: 173,756,494 (GRCm39) |
T430A |
unknown |
Het |
| Itih2 |
G |
A |
2: 10,102,822 (GRCm39) |
Q771* |
probably null |
Het |
| Kazald1 |
T |
A |
19: 45,065,395 (GRCm39) |
L92Q |
probably damaging |
Het |
| Krt19 |
T |
C |
11: 100,031,980 (GRCm39) |
E324G |
probably damaging |
Het |
| Lrrc28 |
A |
T |
7: 67,268,833 (GRCm39) |
V79E |
possibly damaging |
Het |
| Ltn1 |
T |
A |
16: 87,178,381 (GRCm39) |
Q1616L |
probably damaging |
Het |
| Mdc1 |
A |
G |
17: 36,158,843 (GRCm39) |
K408E |
probably benign |
Het |
| Nalcn |
A |
T |
14: 123,561,284 (GRCm39) |
M738K |
probably benign |
Het |
| Ncoa4 |
T |
C |
14: 31,894,848 (GRCm39) |
L125P |
probably damaging |
Het |
| Ncor2 |
G |
T |
5: 125,106,253 (GRCm39) |
R810S |
|
Het |
| Neb |
C |
T |
2: 52,127,141 (GRCm39) |
G348D |
|
Het |
| Nfat5 |
T |
A |
8: 108,095,228 (GRCm39) |
F1156L |
probably damaging |
Het |
| Oit3 |
G |
A |
10: 59,277,468 (GRCm39) |
T13I |
unknown |
Het |
| Opa1 |
A |
C |
16: 29,424,340 (GRCm39) |
Q230P |
probably damaging |
Het |
| Or10j3b |
T |
C |
1: 173,044,064 (GRCm39) |
I282T |
probably damaging |
Het |
| Or52k2 |
T |
A |
7: 102,253,711 (GRCm39) |
I50N |
probably damaging |
Het |
| Or5p66 |
A |
G |
7: 107,886,289 (GRCm39) |
F15L |
probably damaging |
Het |
| Or5w12 |
A |
C |
2: 87,502,567 (GRCm39) |
L48W |
probably damaging |
Het |
| Or6c5b |
G |
T |
10: 129,246,082 (GRCm39) |
M282I |
probably benign |
Het |
| Parpbp |
T |
C |
10: 87,946,189 (GRCm39) |
H410R |
probably null |
Het |
| Pex5l |
A |
G |
3: 33,007,333 (GRCm39) |
V481A |
probably damaging |
Het |
| Plekhh3 |
C |
A |
11: 101,057,225 (GRCm39) |
R344L |
probably benign |
Het |
| Prrc2b |
T |
C |
2: 32,104,953 (GRCm39) |
V1477A |
probably benign |
Het |
| Ptp4a2 |
G |
A |
4: 129,738,945 (GRCm39) |
G94S |
possibly damaging |
Het |
| Ptprk |
T |
A |
10: 28,359,203 (GRCm39) |
Y598* |
probably null |
Het |
| Rfx5 |
C |
A |
3: 94,864,475 (GRCm39) |
T207N |
probably damaging |
Het |
| Rnase2b |
A |
G |
14: 51,400,347 (GRCm39) |
T143A |
possibly damaging |
Het |
| Scn1a |
A |
G |
2: 66,168,330 (GRCm39) |
V92A |
probably benign |
Het |
| Shank2 |
C |
A |
7: 143,965,265 (GRCm39) |
P958T |
probably damaging |
Het |
| Slc13a1 |
A |
G |
6: 24,108,194 (GRCm39) |
I294T |
probably damaging |
Het |
| Slc4a8 |
A |
T |
15: 100,712,421 (GRCm39) |
E1084D |
probably benign |
Het |
| Smurf1 |
T |
A |
5: 144,820,422 (GRCm39) |
R549* |
probably null |
Het |
| Spmip10 |
T |
C |
18: 56,725,537 (GRCm39) |
F66L |
probably damaging |
Het |
| Sprr2b |
T |
C |
3: 92,225,032 (GRCm39) |
C93R |
unknown |
Het |
| Tcn2 |
G |
T |
11: 3,873,569 (GRCm39) |
S259Y |
probably damaging |
Het |
| Tent4a |
G |
T |
13: 69,651,828 (GRCm39) |
T531N |
possibly damaging |
Het |
| Tnfrsf1b |
C |
T |
4: 144,950,150 (GRCm39) |
G264D |
probably damaging |
Het |
| Tnks2 |
T |
A |
19: 36,823,088 (GRCm39) |
N118K |
probably damaging |
Het |
| Topaz1 |
G |
T |
9: 122,626,930 (GRCm39) |
|
probably benign |
Het |
| Traf3ip1 |
A |
G |
1: 91,443,796 (GRCm39) |
|
probably benign |
Het |
| Ttk |
A |
G |
9: 83,721,322 (GRCm39) |
E69G |
probably damaging |
Het |
| Tulp3 |
T |
C |
6: 128,310,966 (GRCm39) |
D87G |
probably benign |
Het |
| Usp38 |
C |
T |
8: 81,708,479 (GRCm39) |
G1033D |
probably damaging |
Het |
| Usp44 |
T |
A |
10: 93,693,775 (GRCm39) |
N707K |
probably benign |
Het |
| Vipas39 |
T |
A |
12: 87,305,858 (GRCm39) |
R112* |
probably null |
Het |
| Vmn1r185 |
A |
C |
7: 26,311,206 (GRCm39) |
S100A |
probably damaging |
Het |
| Vmn1r209 |
T |
C |
13: 22,990,223 (GRCm39) |
M156V |
probably benign |
Het |
| Vmn1r3 |
G |
A |
4: 3,184,863 (GRCm39) |
T148I |
probably benign |
Het |
| Wdr41 |
G |
A |
13: 95,151,620 (GRCm39) |
R260H |
probably benign |
Het |
| Wdr90 |
G |
A |
17: 26,076,146 (GRCm39) |
R104C |
|
Het |
| Wnk2 |
A |
T |
13: 49,221,711 (GRCm39) |
H1183Q |
possibly damaging |
Het |
| Zfp667 |
A |
T |
7: 6,308,256 (GRCm39) |
H308L |
possibly damaging |
Het |
| Zfp952 |
A |
G |
17: 33,220,628 (GRCm39) |
N18D |
possibly damaging |
Het |
|
| Other mutations in Tle1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00420:Tle1
|
APN |
4 |
72,087,355 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00972:Tle1
|
APN |
4 |
72,040,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01548:Tle1
|
APN |
4 |
72,088,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01737:Tle1
|
APN |
4 |
72,116,058 (GRCm39) |
splice site |
probably benign |
|
|
IGL01798:Tle1
|
APN |
4 |
72,055,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01943:Tle1
|
APN |
4 |
72,040,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB006:Tle1
|
UTSW |
4 |
72,118,239 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
BB016:Tle1
|
UTSW |
4 |
72,118,239 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
PIT4515001:Tle1
|
UTSW |
4 |
72,117,556 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R0140:Tle1
|
UTSW |
4 |
72,038,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0544:Tle1
|
UTSW |
4 |
72,043,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0603:Tle1
|
UTSW |
4 |
72,036,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0729:Tle1
|
UTSW |
4 |
72,044,679 (GRCm39) |
splice site |
probably benign |
|
|
R0786:Tle1
|
UTSW |
4 |
72,117,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0939:Tle1
|
UTSW |
4 |
72,036,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1297:Tle1
|
UTSW |
4 |
72,043,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1465:Tle1
|
UTSW |
4 |
72,058,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1465:Tle1
|
UTSW |
4 |
72,058,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1512:Tle1
|
UTSW |
4 |
72,059,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Tle1
|
UTSW |
4 |
72,038,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2218:Tle1
|
UTSW |
4 |
72,117,556 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3713:Tle1
|
UTSW |
4 |
72,044,659 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4367:Tle1
|
UTSW |
4 |
72,036,400 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4379:Tle1
|
UTSW |
4 |
72,036,400 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4380:Tle1
|
UTSW |
4 |
72,036,400 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4655:Tle1
|
UTSW |
4 |
72,063,581 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4662:Tle1
|
UTSW |
4 |
72,055,335 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4731:Tle1
|
UTSW |
4 |
72,043,256 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4732:Tle1
|
UTSW |
4 |
72,043,256 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4733:Tle1
|
UTSW |
4 |
72,043,256 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4812:Tle1
|
UTSW |
4 |
72,063,591 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5066:Tle1
|
UTSW |
4 |
72,076,504 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5288:Tle1
|
UTSW |
4 |
72,060,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5386:Tle1
|
UTSW |
4 |
72,060,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5405:Tle1
|
UTSW |
4 |
72,057,208 (GRCm39) |
intron |
probably benign |
|
|
R5579:Tle1
|
UTSW |
4 |
72,058,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5590:Tle1
|
UTSW |
4 |
72,043,208 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5762:Tle1
|
UTSW |
4 |
72,038,372 (GRCm39) |
splice site |
probably null |
|
|
R6617:Tle1
|
UTSW |
4 |
72,059,517 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6750:Tle1
|
UTSW |
4 |
72,040,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7077:Tle1
|
UTSW |
4 |
72,076,612 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7153:Tle1
|
UTSW |
4 |
72,057,298 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7156:Tle1
|
UTSW |
4 |
72,088,953 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7266:Tle1
|
UTSW |
4 |
72,057,924 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7316:Tle1
|
UTSW |
4 |
72,036,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7478:Tle1
|
UTSW |
4 |
72,055,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7523:Tle1
|
UTSW |
4 |
72,063,655 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7736:Tle1
|
UTSW |
4 |
72,117,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7862:Tle1
|
UTSW |
4 |
72,117,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7863:Tle1
|
UTSW |
4 |
72,059,529 (GRCm39) |
missense |
probably null |
0.68 |
|
R7929:Tle1
|
UTSW |
4 |
72,118,239 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8074:Tle1
|
UTSW |
4 |
72,057,216 (GRCm39) |
frame shift |
probably null |
|
|
R8233:Tle1
|
UTSW |
4 |
72,043,181 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8315:Tle1
|
UTSW |
4 |
72,044,428 (GRCm39) |
nonsense |
probably null |
|
|
R8350:Tle1
|
UTSW |
4 |
72,057,203 (GRCm39) |
intron |
probably benign |
|
|
R8494:Tle1
|
UTSW |
4 |
72,043,241 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8512:Tle1
|
UTSW |
4 |
72,040,670 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9171:Tle1
|
UTSW |
4 |
72,043,232 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R9192:Tle1
|
UTSW |
4 |
72,036,753 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9391:Tle1
|
UTSW |
4 |
72,116,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9452:Tle1
|
UTSW |
4 |
72,040,596 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9481:Tle1
|
UTSW |
4 |
72,044,504 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9497:Tle1
|
UTSW |
4 |
72,071,135 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGCGACAGACAGCTCCTG -3'
(R):5'- GGATGGTTTCTCTATCACCACTACTG -3'
Sequencing Primer
(F):5'- GCGACAGACAGCTCCTGTTATC -3'
(R):5'- TCTATCACCACTACTGCCACC -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation