Incidental Mutation 'R9045:Vmn2r58'
| ID |
687986 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r58
|
| Ensembl Gene |
ENSMUSG00000090383 |
| Gene Name |
vomeronasal 2, receptor 58 |
| Synonyms |
EG628422 |
| MMRRC Submission |
068872-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.377)
|
| Stock # |
R9045 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41486305-41522094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 41487087 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 603
(I603V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171671]
|
| AlphaFold |
K7N6V2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171671
AA Change: I603V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: I603V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.8e-23 |
PFAM |
|
Pfam:7tm_3
|
597 |
835 |
2.9e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.6%
|
| Validation Efficiency |
100% (66/66) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5930422O12Rik |
A |
C |
8: 33,919,362 (GRCm39) |
M61L |
|
Het |
| 9130401M01Rik |
G |
T |
15: 57,892,130 (GRCm39) |
A223E |
possibly damaging |
Het |
| Adgra1 |
T |
G |
7: 139,432,566 (GRCm39) |
L135V |
possibly damaging |
Het |
| Aida |
A |
G |
1: 183,094,940 (GRCm39) |
E127G |
possibly damaging |
Het |
| Ankrd31 |
T |
A |
13: 96,968,034 (GRCm39) |
L557* |
probably null |
Het |
| Atxn7l3 |
T |
A |
11: 102,183,272 (GRCm39) |
T221S |
probably damaging |
Het |
| Bbs7 |
A |
G |
3: 36,666,184 (GRCm39) |
S27P |
probably benign |
Het |
| Cela3b |
A |
T |
4: 137,152,110 (GRCm39) |
C116S |
possibly damaging |
Het |
| Clstn3 |
A |
C |
6: 124,408,921 (GRCm39) |
M909R |
probably damaging |
Het |
| Cnot2 |
T |
C |
10: 116,322,160 (GRCm39) |
E523G |
probably benign |
Het |
| Col12a1 |
T |
A |
9: 79,582,034 (GRCm39) |
T1406S |
probably benign |
Het |
| Cr2 |
A |
T |
1: 194,837,680 (GRCm39) |
N763K |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,284,088 (GRCm39) |
F557L |
probably damaging |
Het |
| Cyth1 |
T |
C |
11: 118,073,090 (GRCm39) |
H270R |
possibly damaging |
Het |
| Epg5 |
T |
C |
18: 77,992,014 (GRCm39) |
L237P |
probably damaging |
Het |
| Fbxo36 |
G |
A |
1: 84,874,300 (GRCm39) |
D99N |
probably damaging |
Het |
| Fcgbpl1 |
T |
A |
7: 27,853,856 (GRCm39) |
C1607S |
probably damaging |
Het |
| Flot2 |
A |
G |
11: 77,950,023 (GRCm39) |
I417M |
probably benign |
Het |
| Fryl |
A |
G |
5: 73,182,118 (GRCm39) |
L143P |
|
Het |
| Gckr |
A |
G |
5: 31,457,353 (GRCm39) |
N122S |
possibly damaging |
Het |
| Gm3250 |
T |
A |
10: 77,617,932 (GRCm39) |
T149S |
unknown |
Het |
| Golga3 |
G |
A |
5: 110,340,963 (GRCm39) |
M552I |
probably benign |
Het |
| Grip1 |
T |
A |
10: 119,871,356 (GRCm39) |
D694E |
probably damaging |
Het |
| Heatr1 |
T |
C |
13: 12,428,233 (GRCm39) |
V790A |
probably benign |
Het |
| Ighv1-54 |
G |
A |
12: 115,157,500 (GRCm39) |
T49I |
probably benign |
Het |
| Iglv1 |
A |
G |
16: 18,904,053 (GRCm39) |
V22A |
probably benign |
Het |
| Lama1 |
A |
T |
17: 68,060,838 (GRCm39) |
Y722F |
|
Het |
| Laptm5 |
A |
T |
4: 130,655,955 (GRCm39) |
E91V |
|
Het |
| Lrig1 |
A |
G |
6: 94,585,688 (GRCm39) |
|
probably null |
Het |
| Mcph1 |
T |
G |
8: 18,682,443 (GRCm39) |
S527A |
probably benign |
Het |
| Med13l |
G |
T |
5: 118,880,816 (GRCm39) |
V1303L |
probably benign |
Het |
| Mindy4 |
A |
G |
6: 55,295,283 (GRCm39) |
D741G |
probably benign |
Het |
| Myo15b |
T |
A |
11: 115,783,178 (GRCm39) |
*3034R |
probably null |
Het |
| Nfkbie |
A |
T |
17: 45,872,959 (GRCm39) |
K354I |
probably damaging |
Het |
| Npat |
A |
G |
9: 53,474,776 (GRCm39) |
N856S |
possibly damaging |
Het |
| Nr2c2ap |
A |
G |
8: 70,585,808 (GRCm39) |
D122G |
probably damaging |
Het |
| Nr4a3 |
C |
A |
4: 48,067,694 (GRCm39) |
T430K |
possibly damaging |
Het |
| Or12e10 |
C |
A |
2: 87,640,416 (GRCm39) |
S84Y |
probably damaging |
Het |
| Or52ab4 |
T |
G |
7: 102,987,903 (GRCm39) |
I214R |
probably damaging |
Het |
| Or5h25 |
A |
G |
16: 58,930,365 (GRCm39) |
S203P |
probably benign |
Het |
| Otud7b |
A |
G |
3: 96,059,895 (GRCm39) |
K397E |
probably benign |
Het |
| Pafah1b3 |
G |
T |
7: 24,996,898 (GRCm39) |
|
probably benign |
Het |
| Pcdhgc3 |
G |
T |
18: 37,940,669 (GRCm39) |
V357L |
probably damaging |
Het |
| Pde2a |
A |
G |
7: 101,152,498 (GRCm39) |
T354A |
unknown |
Het |
| Pira12 |
A |
G |
7: 3,897,547 (GRCm39) |
I516T |
possibly damaging |
Het |
| Rbfa |
T |
C |
18: 80,236,026 (GRCm39) |
H241R |
probably damaging |
Het |
| Rhox3c |
C |
T |
X: 36,651,303 (GRCm39) |
|
probably benign |
Het |
| Rps6ka1 |
C |
T |
4: 133,600,150 (GRCm39) |
|
probably benign |
Het |
| S1pr2 |
T |
C |
9: 20,878,890 (GRCm39) |
T313A |
probably benign |
Het |
| Sbno1 |
A |
G |
5: 124,543,720 (GRCm39) |
V273A |
probably benign |
Het |
| Scg3 |
T |
C |
9: 75,570,522 (GRCm39) |
N344S |
probably damaging |
Het |
| Serpinb1c |
C |
G |
13: 33,066,027 (GRCm39) |
G306A |
probably benign |
Het |
| Sh2d6 |
C |
T |
6: 72,492,604 (GRCm39) |
G206D |
probably benign |
Het |
| Slamf9 |
G |
A |
1: 172,304,938 (GRCm39) |
S184N |
probably damaging |
Het |
| Slc50a1 |
T |
C |
3: 89,176,042 (GRCm39) |
T168A |
probably damaging |
Het |
| Tas2r124 |
G |
C |
6: 132,732,034 (GRCm39) |
W114C |
probably damaging |
Het |
| Tgm4 |
C |
T |
9: 122,877,616 (GRCm39) |
T206I |
possibly damaging |
Het |
| Tmem52 |
A |
G |
4: 155,553,899 (GRCm39) |
|
probably null |
Het |
| Vmn2r102 |
A |
G |
17: 19,880,841 (GRCm39) |
K61E |
probably benign |
Het |
| Vstm2l |
G |
T |
2: 157,756,795 (GRCm39) |
G22V |
unknown |
Het |
| Vwa5b1 |
T |
A |
4: 138,315,990 (GRCm39) |
Y584F |
probably damaging |
Het |
| Wdfy3 |
A |
T |
5: 101,995,040 (GRCm39) |
V3233D |
probably damaging |
Het |
| Wdhd1 |
A |
G |
14: 47,511,409 (GRCm39) |
V101A |
probably benign |
Het |
| Zfc3h1 |
C |
A |
10: 115,263,319 (GRCm39) |
Q1761K |
possibly damaging |
Het |
| Zfp180 |
G |
A |
7: 23,804,315 (GRCm39) |
V245I |
probably benign |
Het |
| Zfp846 |
A |
T |
9: 20,505,189 (GRCm39) |
I350L |
probably benign |
Het |
|
| Other mutations in Vmn2r58 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Vmn2r58
|
APN |
7 |
41,513,854 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL00924:Vmn2r58
|
APN |
7 |
41,486,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01291:Vmn2r58
|
APN |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01480:Vmn2r58
|
APN |
7 |
41,514,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01551:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01591:Vmn2r58
|
APN |
7 |
41,514,753 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01940:Vmn2r58
|
APN |
7 |
41,487,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01994:Vmn2r58
|
APN |
7 |
41,486,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02041:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02222:Vmn2r58
|
APN |
7 |
41,513,449 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02317:Vmn2r58
|
APN |
7 |
41,486,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02614:Vmn2r58
|
APN |
7 |
41,486,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02673:Vmn2r58
|
APN |
7 |
41,514,082 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03323:Vmn2r58
|
APN |
7 |
41,511,295 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03337:Vmn2r58
|
APN |
7 |
41,513,810 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03380:Vmn2r58
|
APN |
7 |
41,513,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
ANU05:Vmn2r58
|
UTSW |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0138:Vmn2r58
|
UTSW |
7 |
41,487,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0141:Vmn2r58
|
UTSW |
7 |
41,511,309 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0421:Vmn2r58
|
UTSW |
7 |
41,514,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0604:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0854:Vmn2r58
|
UTSW |
7 |
41,486,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Vmn2r58
|
UTSW |
7 |
41,513,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1441:Vmn2r58
|
UTSW |
7 |
41,486,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1678:Vmn2r58
|
UTSW |
7 |
41,513,480 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1691:Vmn2r58
|
UTSW |
7 |
41,486,913 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1699:Vmn2r58
|
UTSW |
7 |
41,509,951 (GRCm39) |
missense |
probably benign |
|
|
R1865:Vmn2r58
|
UTSW |
7 |
41,486,682 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2008:Vmn2r58
|
UTSW |
7 |
41,509,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Vmn2r58
|
UTSW |
7 |
41,513,417 (GRCm39) |
missense |
probably benign |
|
|
R2202:Vmn2r58
|
UTSW |
7 |
41,513,594 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3787:Vmn2r58
|
UTSW |
7 |
41,513,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3883:Vmn2r58
|
UTSW |
7 |
41,513,914 (GRCm39) |
nonsense |
probably null |
|
|
R3944:Vmn2r58
|
UTSW |
7 |
41,513,885 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3949:Vmn2r58
|
UTSW |
7 |
41,513,348 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4232:Vmn2r58
|
UTSW |
7 |
41,487,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4409:Vmn2r58
|
UTSW |
7 |
41,522,051 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4411:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4413:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4600:Vmn2r58
|
UTSW |
7 |
41,522,046 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4610:Vmn2r58
|
UTSW |
7 |
41,487,117 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r58
|
UTSW |
7 |
41,509,935 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4793:Vmn2r58
|
UTSW |
7 |
41,514,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4870:Vmn2r58
|
UTSW |
7 |
41,486,639 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4981:Vmn2r58
|
UTSW |
7 |
41,486,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r58
|
UTSW |
7 |
41,487,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5024:Vmn2r58
|
UTSW |
7 |
41,513,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5064:Vmn2r58
|
UTSW |
7 |
41,486,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5330:Vmn2r58
|
UTSW |
7 |
41,513,384 (GRCm39) |
nonsense |
probably null |
|
|
R5526:Vmn2r58
|
UTSW |
7 |
41,522,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5980:Vmn2r58
|
UTSW |
7 |
41,514,480 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6163:Vmn2r58
|
UTSW |
7 |
41,486,825 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6365:Vmn2r58
|
UTSW |
7 |
41,513,607 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6567:Vmn2r58
|
UTSW |
7 |
41,514,673 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6594:Vmn2r58
|
UTSW |
7 |
41,486,535 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6980:Vmn2r58
|
UTSW |
7 |
41,513,662 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7373:Vmn2r58
|
UTSW |
7 |
41,487,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Vmn2r58
|
UTSW |
7 |
41,487,123 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7630:Vmn2r58
|
UTSW |
7 |
41,513,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7807:Vmn2r58
|
UTSW |
7 |
41,521,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8114:Vmn2r58
|
UTSW |
7 |
41,511,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Vmn2r58
|
UTSW |
7 |
41,514,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8313:Vmn2r58
|
UTSW |
7 |
41,521,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8412:Vmn2r58
|
UTSW |
7 |
41,513,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8530:Vmn2r58
|
UTSW |
7 |
41,513,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Vmn2r58
|
UTSW |
7 |
41,487,219 (GRCm39) |
missense |
probably benign |
|
|
R8881:Vmn2r58
|
UTSW |
7 |
41,486,609 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8936:Vmn2r58
|
UTSW |
7 |
41,513,981 (GRCm39) |
missense |
|
|
|
R9166:Vmn2r58
|
UTSW |
7 |
41,513,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9706:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF006:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
RF027:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn2r58
|
UTSW |
7 |
41,513,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGGCCAACACTGTGGAGAG -3'
(R):5'- AGCAGAGGATTGATTCATAGTCC -3'
Sequencing Primer
(F):5'- CAAAATTCCAAATGCTGTCTGCTGC -3'
(R):5'- TCATAGTCCCTTTAATTTCTGAACAG -3'
|
| Posted On |
2021-11-19 |
Incidental Mutation