Incidental Mutation 'R9257:Zfp831'
| ID |
701924 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp831
|
| Ensembl Gene |
ENSMUSG00000050600 |
| Gene Name |
zinc finger protein 831 |
| Synonyms |
ENSMUSG00000050600, OTTMUSG00000017459 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9257 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
174485327-174552625 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 174488156 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 944
(C944S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000060255
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059452]
|
| AlphaFold |
A2ADM8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000059452
AA Change: C944S
PolyPhen 2
Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000060255
Gene: ENSMUSG00000050600
AA Change: C944S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
120 |
135 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
143 |
165 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
171 |
195 |
7.78e-3 |
SMART |
|
low complexity region
|
201 |
216 |
N/A |
INTRINSIC |
|
low complexity region
|
237 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
345 |
371 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
392 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
717 |
736 |
N/A |
INTRINSIC |
|
low complexity region
|
856 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
1520 |
1529 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 97.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921509C19Rik |
T |
A |
2: 151,315,627 (GRCm39) |
D17V |
probably benign |
Het |
| 9130401M01Rik |
A |
C |
15: 57,892,414 (GRCm39) |
H128Q |
possibly damaging |
Het |
| Abcd2 |
T |
C |
15: 91,075,315 (GRCm39) |
Y166C |
possibly damaging |
Het |
| Adamtsl4 |
C |
A |
3: 95,588,575 (GRCm39) |
V546F |
probably damaging |
Het |
| Als2cl |
T |
A |
9: 110,723,755 (GRCm39) |
V717E |
probably damaging |
Het |
| Atm |
A |
G |
9: 53,407,150 (GRCm39) |
|
probably null |
Het |
| Atp2c1 |
C |
A |
9: 105,291,851 (GRCm39) |
E904* |
probably null |
Het |
| Ccdc88c |
G |
A |
12: 100,889,474 (GRCm39) |
S1523F |
possibly damaging |
Het |
| Cds1 |
A |
T |
5: 101,963,751 (GRCm39) |
I357F |
probably benign |
Het |
| Cilp |
T |
A |
9: 65,174,451 (GRCm39) |
V13D |
possibly damaging |
Het |
| Copz2 |
A |
G |
11: 96,748,386 (GRCm39) |
D180G |
possibly damaging |
Het |
| Cpsf1 |
C |
T |
15: 76,484,992 (GRCm39) |
E546K |
probably benign |
Het |
| Ctsm |
T |
C |
13: 61,684,413 (GRCm39) |
N320D |
probably damaging |
Het |
| Fat3 |
G |
A |
9: 15,907,863 (GRCm39) |
T2713I |
probably benign |
Het |
| Fcrl5 |
T |
A |
3: 87,343,195 (GRCm39) |
S2T |
probably benign |
Het |
| Fgfr4 |
T |
C |
13: 55,315,974 (GRCm39) |
S796P |
unknown |
Het |
| Flrt3 |
A |
G |
2: 140,502,159 (GRCm39) |
F490L |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,910,359 (GRCm39) |
I3263F |
probably damaging |
Het |
| Hydin |
A |
T |
8: 111,301,648 (GRCm39) |
D3793V |
probably damaging |
Het |
| Kif5c |
T |
A |
2: 49,590,604 (GRCm39) |
L269* |
probably null |
Het |
| Klhl32 |
A |
G |
4: 24,649,608 (GRCm39) |
V396A |
probably benign |
Het |
| Krt1c |
C |
T |
15: 101,724,926 (GRCm39) |
R228Q |
probably benign |
Het |
| Lcn9 |
T |
C |
2: 25,714,784 (GRCm39) |
|
probably null |
Het |
| Lingo4 |
A |
C |
3: 94,310,676 (GRCm39) |
D538A |
probably benign |
Het |
| Lonp1 |
G |
T |
17: 56,927,516 (GRCm39) |
Y299* |
probably null |
Het |
| Mettl16 |
T |
A |
11: 74,708,127 (GRCm39) |
V442D |
possibly damaging |
Het |
| Mettl25b |
G |
T |
3: 87,831,768 (GRCm39) |
Q397K |
probably benign |
Het |
| Mis18bp1 |
A |
G |
12: 65,180,631 (GRCm39) |
V950A |
probably benign |
Het |
| Mndal |
A |
T |
1: 173,690,274 (GRCm39) |
V352E |
probably damaging |
Het |
| Mrpl55 |
T |
C |
11: 59,096,578 (GRCm39) |
V117A |
probably benign |
Het |
| Muc6 |
T |
A |
7: 141,226,738 (GRCm39) |
S1430C |
unknown |
Het |
| Myh11 |
C |
A |
16: 14,087,120 (GRCm39) |
G119C |
|
Het |
| Myorg |
T |
C |
4: 41,499,030 (GRCm39) |
D200G |
probably benign |
Het |
| Neu1 |
A |
G |
17: 35,150,396 (GRCm39) |
D5G |
probably benign |
Het |
| Nrcam |
T |
A |
12: 44,610,837 (GRCm39) |
D512E |
probably benign |
Het |
| Nup214 |
T |
G |
2: 31,923,347 (GRCm39) |
V1292G |
possibly damaging |
Het |
| Nwd1 |
T |
A |
8: 73,397,566 (GRCm39) |
L602M |
probably damaging |
Het |
| Or6c3b |
C |
A |
10: 129,527,003 (GRCm39) |
L302F |
probably benign |
Het |
| Pck2 |
G |
T |
14: 55,782,702 (GRCm39) |
G379W |
probably damaging |
Het |
| Per2 |
C |
T |
1: 91,376,445 (GRCm39) |
V143M |
probably damaging |
Het |
| Pfkl |
A |
T |
10: 77,825,489 (GRCm39) |
Y634N |
probably damaging |
Het |
| Phlpp1 |
A |
G |
1: 106,100,281 (GRCm39) |
D183G |
possibly damaging |
Het |
| Pkdrej |
T |
A |
15: 85,700,098 (GRCm39) |
Y1946F |
probably damaging |
Het |
| Plxna4 |
C |
T |
6: 32,139,018 (GRCm39) |
D1717N |
probably damaging |
Het |
| Ppp1r14bl |
G |
T |
1: 23,141,275 (GRCm39) |
T13N |
probably benign |
Het |
| Pramel23 |
T |
A |
4: 143,425,685 (GRCm39) |
D86V |
probably damaging |
Het |
| Prdm16 |
A |
T |
4: 154,422,155 (GRCm39) |
V879E |
probably damaging |
Het |
| Prr23a3 |
T |
C |
9: 98,747,298 (GRCm39) |
V84A |
probably benign |
Het |
| Ptp4a1 |
A |
G |
1: 30,985,346 (GRCm39) |
|
probably benign |
Het |
| Rhbdf1 |
T |
C |
11: 32,160,754 (GRCm39) |
H634R |
probably benign |
Het |
| Rmi2 |
T |
C |
16: 10,653,089 (GRCm39) |
S46P |
probably benign |
Het |
| Rsf1 |
A |
T |
7: 97,334,918 (GRCm39) |
E1350D |
|
Het |
| Slc6a6 |
T |
A |
6: 91,716,952 (GRCm39) |
F276Y |
possibly damaging |
Het |
| Sppl3 |
A |
G |
5: 115,221,532 (GRCm39) |
Y120C |
probably benign |
Het |
| Stard13 |
G |
T |
5: 150,985,956 (GRCm39) |
A518E |
probably benign |
Het |
| Taf2 |
A |
T |
15: 54,929,409 (GRCm39) |
V49E |
possibly damaging |
Het |
| Tas2r140 |
T |
A |
6: 40,468,592 (GRCm39) |
W141R |
probably damaging |
Het |
| Tlx2 |
T |
A |
6: 83,047,035 (GRCm39) |
H9L |
unknown |
Het |
| Tmco1 |
C |
T |
1: 167,136,132 (GRCm39) |
|
probably benign |
Het |
| Tmem132d |
G |
A |
5: 127,861,491 (GRCm39) |
Q877* |
probably null |
Het |
| Unc5d |
A |
T |
8: 29,215,174 (GRCm39) |
|
probably null |
Het |
| Upp1 |
A |
T |
11: 9,075,661 (GRCm39) |
T4S |
probably benign |
Het |
| Uros |
A |
T |
7: 133,292,853 (GRCm39) |
I146N |
probably damaging |
Het |
| Vsig10 |
A |
T |
5: 117,463,131 (GRCm39) |
D119V |
probably benign |
Het |
| Washc2 |
C |
A |
6: 116,193,069 (GRCm39) |
Y138* |
probably null |
Het |
| Ywhah |
T |
A |
5: 33,184,095 (GRCm39) |
D99E |
probably benign |
Het |
| Zdbf2 |
G |
A |
1: 63,345,400 (GRCm39) |
G1260R |
probably damaging |
Het |
| Zfp663 |
T |
C |
2: 165,195,974 (GRCm39) |
T82A |
probably benign |
Het |
|
| Other mutations in Zfp831 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Zfp831
|
APN |
2 |
174,488,078 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00091:Zfp831
|
APN |
2 |
174,487,451 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL00764:Zfp831
|
APN |
2 |
174,487,701 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01538:Zfp831
|
APN |
2 |
174,486,399 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01700:Zfp831
|
APN |
2 |
174,486,711 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01718:Zfp831
|
APN |
2 |
174,485,631 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02221:Zfp831
|
APN |
2 |
174,485,519 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02250:Zfp831
|
APN |
2 |
174,489,994 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL03209:Zfp831
|
APN |
2 |
174,487,059 (GRCm39) |
missense |
probably benign |
0.40 |
|
D4043:Zfp831
|
UTSW |
2 |
174,487,059 (GRCm39) |
missense |
probably benign |
0.40 |
|
FR4304:Zfp831
|
UTSW |
2 |
174,487,274 (GRCm39) |
small insertion |
probably benign |
|
|
FR4340:Zfp831
|
UTSW |
2 |
174,487,273 (GRCm39) |
small insertion |
probably benign |
|
|
FR4449:Zfp831
|
UTSW |
2 |
174,487,275 (GRCm39) |
small insertion |
probably benign |
|
|
FR4449:Zfp831
|
UTSW |
2 |
174,487,264 (GRCm39) |
small insertion |
probably benign |
|
|
FR4589:Zfp831
|
UTSW |
2 |
174,487,261 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfp831
|
UTSW |
2 |
174,487,276 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfp831
|
UTSW |
2 |
174,487,269 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfp831
|
UTSW |
2 |
174,487,264 (GRCm39) |
small insertion |
probably benign |
|
|
IGL02802:Zfp831
|
UTSW |
2 |
174,486,945 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
P0028:Zfp831
|
UTSW |
2 |
174,487,139 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
PIT4531001:Zfp831
|
UTSW |
2 |
174,488,516 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0631:Zfp831
|
UTSW |
2 |
174,487,083 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0644:Zfp831
|
UTSW |
2 |
174,487,656 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0782:Zfp831
|
UTSW |
2 |
174,488,423 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1156:Zfp831
|
UTSW |
2 |
174,488,710 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1280:Zfp831
|
UTSW |
2 |
174,545,852 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Zfp831
|
UTSW |
2 |
174,487,683 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1883:Zfp831
|
UTSW |
2 |
174,545,870 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1884:Zfp831
|
UTSW |
2 |
174,545,870 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2127:Zfp831
|
UTSW |
2 |
174,489,917 (GRCm39) |
missense |
probably benign |
0.33 |
|
R2137:Zfp831
|
UTSW |
2 |
174,547,539 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2268:Zfp831
|
UTSW |
2 |
174,486,034 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2330:Zfp831
|
UTSW |
2 |
174,489,882 (GRCm39) |
nonsense |
probably null |
|
|
R3547:Zfp831
|
UTSW |
2 |
174,499,476 (GRCm39) |
missense |
probably benign |
|
|
R3821:Zfp831
|
UTSW |
2 |
174,485,816 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4163:Zfp831
|
UTSW |
2 |
174,485,822 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4232:Zfp831
|
UTSW |
2 |
174,547,447 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4778:Zfp831
|
UTSW |
2 |
174,488,600 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4820:Zfp831
|
UTSW |
2 |
174,547,097 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4912:Zfp831
|
UTSW |
2 |
174,486,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5119:Zfp831
|
UTSW |
2 |
174,547,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5152:Zfp831
|
UTSW |
2 |
174,486,357 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5723:Zfp831
|
UTSW |
2 |
174,487,200 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5741:Zfp831
|
UTSW |
2 |
174,486,945 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5888:Zfp831
|
UTSW |
2 |
174,485,420 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5975:Zfp831
|
UTSW |
2 |
174,485,885 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6092:Zfp831
|
UTSW |
2 |
174,547,299 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6158:Zfp831
|
UTSW |
2 |
174,485,651 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6212:Zfp831
|
UTSW |
2 |
174,487,661 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6233:Zfp831
|
UTSW |
2 |
174,488,490 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6248:Zfp831
|
UTSW |
2 |
174,486,308 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6255:Zfp831
|
UTSW |
2 |
174,488,214 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6460:Zfp831
|
UTSW |
2 |
174,488,360 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6477:Zfp831
|
UTSW |
2 |
174,545,960 (GRCm39) |
missense |
probably benign |
|
|
R6864:Zfp831
|
UTSW |
2 |
174,488,533 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7396:Zfp831
|
UTSW |
2 |
174,487,002 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7447:Zfp831
|
UTSW |
2 |
174,487,896 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7499:Zfp831
|
UTSW |
2 |
174,485,816 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7662:Zfp831
|
UTSW |
2 |
174,487,934 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7857:Zfp831
|
UTSW |
2 |
174,547,035 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7889:Zfp831
|
UTSW |
2 |
174,487,097 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7896:Zfp831
|
UTSW |
2 |
174,488,921 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8074:Zfp831
|
UTSW |
2 |
174,486,528 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8089:Zfp831
|
UTSW |
2 |
174,486,717 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8438:Zfp831
|
UTSW |
2 |
174,486,796 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8716:Zfp831
|
UTSW |
2 |
174,547,049 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8757:Zfp831
|
UTSW |
2 |
174,487,874 (GRCm39) |
missense |
probably benign |
|
|
R8759:Zfp831
|
UTSW |
2 |
174,487,874 (GRCm39) |
missense |
probably benign |
|
|
R8899:Zfp831
|
UTSW |
2 |
174,485,978 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8976:Zfp831
|
UTSW |
2 |
174,487,079 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9146:Zfp831
|
UTSW |
2 |
174,487,461 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9324:Zfp831
|
UTSW |
2 |
174,547,113 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9467:Zfp831
|
UTSW |
2 |
174,486,789 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9729:Zfp831
|
UTSW |
2 |
174,487,938 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Zfp831
|
UTSW |
2 |
174,547,662 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1177:Zfp831
|
UTSW |
2 |
174,485,981 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGATTCCCCATTGCCTTC -3'
(R):5'- TGCCCAACCACTAGGATGTTG -3'
Sequencing Primer
(F):5'- ATTGCCTTCTGTACCCAGGAC -3'
(R):5'- GGATGTTGTCCTTGGTCCTATCTC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation