Incidental Mutation 'R9372:Vmn2r15'
| ID |
709366 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r15
|
| Ensembl Gene |
ENSMUSG00000091375 |
| Gene Name |
vomeronasal 2, receptor 15 |
| Synonyms |
EG211223 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.090)
|
| Stock # |
R9372 (G1)
|
| Quality Score |
217.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109434135-109445422 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 109441953 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Leucine
at position 160
(P160L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128333
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167133]
|
| AlphaFold |
L7N2A0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167133
AA Change: P160L
PolyPhen 2
Score 0.599 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: P160L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
472 |
1e-29 |
PFAM |
|
Pfam:NCD3G
|
514 |
568 |
5.8e-18 |
PFAM |
|
Pfam:7tm_3
|
601 |
836 |
9.1e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2200002D01Rik |
CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
7: 28,947,048 (GRCm39) |
|
probably benign |
Het |
| Aass |
T |
C |
6: 23,078,856 (GRCm39) |
T719A |
probably damaging |
Het |
| Abcb8 |
A |
G |
5: 24,605,114 (GRCm39) |
E100G |
probably benign |
Het |
| Actr1b |
C |
T |
1: 36,741,561 (GRCm39) |
E104K |
probably damaging |
Het |
| Atad5 |
T |
A |
11: 79,985,094 (GRCm39) |
S60R |
possibly damaging |
Het |
| Bcan |
G |
T |
3: 87,895,610 (GRCm39) |
A842D |
probably benign |
Het |
| Cacna2d2 |
G |
A |
9: 107,394,802 (GRCm39) |
E623K |
probably benign |
Het |
| Cdk15 |
T |
C |
1: 59,370,142 (GRCm39) |
Y393H |
probably benign |
Het |
| Ceacam12 |
C |
T |
7: 17,803,229 (GRCm39) |
R212C |
probably benign |
Het |
| Ceacam5 |
T |
C |
7: 17,481,267 (GRCm39) |
I338T |
possibly damaging |
Het |
| Crcp |
A |
G |
5: 130,088,664 (GRCm39) |
D139G |
possibly damaging |
Het |
| Crls1 |
T |
A |
2: 132,707,802 (GRCm39) |
Y290* |
probably null |
Het |
| Dcun1d5 |
A |
G |
9: 7,206,780 (GRCm39) |
N206D |
probably damaging |
Het |
| Dmtf1 |
A |
T |
5: 9,190,399 (GRCm39) |
V105E |
possibly damaging |
Het |
| Dnah7a |
T |
C |
1: 53,543,474 (GRCm39) |
Y2232C |
probably benign |
Het |
| Dnajc25 |
T |
A |
4: 59,003,394 (GRCm39) |
V55E |
probably damaging |
Het |
| Dpy19l4 |
T |
C |
4: 11,303,343 (GRCm39) |
M193V |
possibly damaging |
Het |
| Dsc1 |
A |
T |
18: 20,221,489 (GRCm39) |
V662E |
probably damaging |
Het |
| Enpp6 |
G |
A |
8: 47,506,627 (GRCm39) |
V144I |
possibly damaging |
Het |
| Fip1l1 |
A |
G |
5: 74,707,463 (GRCm39) |
T204A |
possibly damaging |
Het |
| Flvcr2 |
T |
C |
12: 85,793,795 (GRCm39) |
V57A |
probably benign |
Het |
| Fsip2 |
T |
G |
2: 82,822,756 (GRCm39) |
I6163S |
possibly damaging |
Het |
| Gipr |
T |
A |
7: 18,896,863 (GRCm39) |
M136L |
probably benign |
Het |
| Gm7298 |
A |
G |
6: 121,748,746 (GRCm39) |
I674V |
probably benign |
Het |
| Gtf2a1 |
C |
T |
12: 91,534,592 (GRCm39) |
V221I |
probably damaging |
Het |
| Haus3 |
A |
T |
5: 34,321,002 (GRCm39) |
D481E |
probably benign |
Het |
| Hinfp |
A |
C |
9: 44,209,083 (GRCm39) |
V345G |
probably damaging |
Het |
| Hs3st5 |
A |
T |
10: 36,708,698 (GRCm39) |
K78* |
probably null |
Het |
| Ighv1-31 |
T |
C |
12: 114,792,894 (GRCm39) |
Y114C |
probably damaging |
Het |
| Ighv5-15 |
T |
A |
12: 113,790,357 (GRCm39) |
T88S |
probably damaging |
Het |
| Ildr1 |
G |
A |
16: 36,542,721 (GRCm39) |
D418N |
probably damaging |
Het |
| Ints10 |
C |
T |
8: 69,271,967 (GRCm39) |
T556I |
probably damaging |
Het |
| Isoc1 |
G |
T |
18: 58,792,757 (GRCm39) |
R65L |
possibly damaging |
Het |
| Itm2c |
C |
T |
1: 85,833,055 (GRCm39) |
R130C |
probably damaging |
Het |
| Jup |
C |
T |
11: 100,270,391 (GRCm39) |
C372Y |
probably damaging |
Het |
| Kif11 |
T |
C |
19: 37,399,892 (GRCm39) |
V793A |
probably benign |
Het |
| Klrg1 |
A |
C |
6: 122,256,699 (GRCm39) |
V29G |
probably benign |
Het |
| Lrch4 |
A |
G |
5: 137,631,953 (GRCm39) |
T114A |
possibly damaging |
Het |
| Map3k3 |
C |
T |
11: 106,033,335 (GRCm39) |
T196M |
probably damaging |
Het |
| Marchf1 |
C |
A |
8: 66,921,145 (GRCm39) |
T274N |
probably benign |
Het |
| Nxpe5 |
A |
T |
5: 138,249,445 (GRCm39) |
T412S |
probably benign |
Het |
| Or10q1 |
C |
T |
19: 13,727,069 (GRCm39) |
H200Y |
probably benign |
Het |
| Pcnt |
A |
G |
10: 76,258,960 (GRCm39) |
W502R |
probably damaging |
Het |
| Pfdn5 |
T |
C |
15: 102,235,286 (GRCm39) |
|
probably null |
Het |
| Pkn2 |
A |
T |
3: 142,535,018 (GRCm39) |
V232E |
probably damaging |
Het |
| Ppfibp1 |
T |
C |
6: 146,898,307 (GRCm39) |
S88P |
probably damaging |
Het |
| Prr23a4 |
A |
G |
9: 98,785,478 (GRCm39) |
I48V |
probably benign |
Het |
| Ptprz1 |
G |
A |
6: 23,045,706 (GRCm39) |
E2159K |
probably damaging |
Het |
| Smyd3 |
T |
C |
1: 178,871,470 (GRCm39) |
E303G |
possibly damaging |
Het |
| Snx13 |
T |
A |
12: 35,151,048 (GRCm39) |
N336K |
possibly damaging |
Het |
| Src |
A |
G |
2: 157,311,808 (GRCm39) |
E512G |
possibly damaging |
Het |
| Stard9 |
T |
A |
2: 120,495,420 (GRCm39) |
C98* |
probably null |
Het |
| Tapbpl |
A |
G |
6: 125,203,672 (GRCm39) |
V336A |
probably benign |
Het |
| Tbrg1 |
G |
A |
9: 37,563,945 (GRCm39) |
T230I |
probably damaging |
Het |
| Tm7sf3 |
C |
T |
6: 146,525,179 (GRCm39) |
D89N |
possibly damaging |
Het |
| Tmem132c |
G |
A |
5: 127,640,145 (GRCm39) |
G772D |
probably damaging |
Het |
| Tmem219 |
C |
T |
7: 126,496,017 (GRCm39) |
G119S |
possibly damaging |
Het |
| Ttbk2 |
T |
A |
2: 120,603,766 (GRCm39) |
S325C |
probably benign |
Het |
| Ttc28 |
A |
T |
5: 111,331,073 (GRCm39) |
Y431F |
probably benign |
Het |
| Vmn1r27 |
A |
T |
6: 58,192,746 (GRCm39) |
M86K |
possibly damaging |
Het |
| Zfc3h1 |
A |
T |
10: 115,221,223 (GRCm39) |
S41C |
unknown |
Het |
| Zfp260 |
C |
A |
7: 29,804,232 (GRCm39) |
T44K |
probably benign |
Het |
| Zfp7 |
TGCGGGAAAGGTTTCCACCTGAGCG |
TGCG |
15: 76,774,800 (GRCm39) |
|
probably benign |
Het |
| Zfp760 |
A |
G |
17: 21,941,035 (GRCm39) |
N70S |
probably benign |
Het |
| Zfp788 |
T |
A |
7: 41,299,708 (GRCm39) |
Y781* |
probably null |
Het |
| Zfp800 |
A |
T |
6: 28,256,433 (GRCm39) |
S52T |
possibly damaging |
Het |
|
| Other mutations in Vmn2r15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01335:Vmn2r15
|
APN |
5 |
109,434,602 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01367:Vmn2r15
|
APN |
5 |
109,441,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01844:Vmn2r15
|
APN |
5 |
109,434,135 (GRCm39) |
makesense |
probably null |
|
|
IGL02190:Vmn2r15
|
APN |
5 |
109,441,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02754:Vmn2r15
|
APN |
5 |
109,441,134 (GRCm39) |
nonsense |
probably null |
|
|
IGL02797:Vmn2r15
|
APN |
5 |
109,445,250 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03301:Vmn2r15
|
APN |
5 |
109,445,221 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03407:Vmn2r15
|
APN |
5 |
109,434,185 (GRCm39) |
nonsense |
probably null |
|
|
BB001:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r15
|
UTSW |
5 |
109,435,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4520001:Vmn2r15
|
UTSW |
5 |
109,434,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Vmn2r15
|
UTSW |
5 |
109,441,010 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0111:Vmn2r15
|
UTSW |
5 |
109,435,022 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0379:Vmn2r15
|
UTSW |
5 |
109,434,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Vmn2r15
|
UTSW |
5 |
109,434,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Vmn2r15
|
UTSW |
5 |
109,440,881 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0964:Vmn2r15
|
UTSW |
5 |
109,445,401 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1232:Vmn2r15
|
UTSW |
5 |
109,441,168 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1241:Vmn2r15
|
UTSW |
5 |
109,440,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R1394:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1395:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1423:Vmn2r15
|
UTSW |
5 |
109,441,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1439:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Vmn2r15
|
UTSW |
5 |
109,441,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1777:Vmn2r15
|
UTSW |
5 |
109,442,136 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1844:Vmn2r15
|
UTSW |
5 |
109,434,860 (GRCm39) |
nonsense |
probably null |
|
|
R2072:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2074:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2122:Vmn2r15
|
UTSW |
5 |
109,434,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Vmn2r15
|
UTSW |
5 |
109,445,309 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2268:Vmn2r15
|
UTSW |
5 |
109,441,073 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2831:Vmn2r15
|
UTSW |
5 |
109,434,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Vmn2r15
|
UTSW |
5 |
109,445,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4058:Vmn2r15
|
UTSW |
5 |
109,441,312 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4615:Vmn2r15
|
UTSW |
5 |
109,441,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4663:Vmn2r15
|
UTSW |
5 |
109,441,940 (GRCm39) |
missense |
probably benign |
|
|
R4681:Vmn2r15
|
UTSW |
5 |
109,434,488 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4751:Vmn2r15
|
UTSW |
5 |
109,434,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5095:Vmn2r15
|
UTSW |
5 |
109,436,317 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5300:Vmn2r15
|
UTSW |
5 |
109,441,974 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5309:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5335:Vmn2r15
|
UTSW |
5 |
109,434,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5421:Vmn2r15
|
UTSW |
5 |
109,434,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5805:Vmn2r15
|
UTSW |
5 |
109,434,806 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6280:Vmn2r15
|
UTSW |
5 |
109,441,291 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6324:Vmn2r15
|
UTSW |
5 |
109,434,137 (GRCm39) |
makesense |
probably null |
|
|
R6383:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Vmn2r15
|
UTSW |
5 |
109,434,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r15
|
UTSW |
5 |
109,441,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Vmn2r15
|
UTSW |
5 |
109,440,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,445,388 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,441,105 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7423:Vmn2r15
|
UTSW |
5 |
109,445,394 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7552:Vmn2r15
|
UTSW |
5 |
109,440,774 (GRCm39) |
nonsense |
probably null |
|
|
R7619:Vmn2r15
|
UTSW |
5 |
109,436,190 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7892:Vmn2r15
|
UTSW |
5 |
109,434,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8099:Vmn2r15
|
UTSW |
5 |
109,441,185 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8189:Vmn2r15
|
UTSW |
5 |
109,434,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8275:Vmn2r15
|
UTSW |
5 |
109,434,150 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,441,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,440,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8465:Vmn2r15
|
UTSW |
5 |
109,445,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8679:Vmn2r15
|
UTSW |
5 |
109,434,779 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8682:Vmn2r15
|
UTSW |
5 |
109,441,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8809:Vmn2r15
|
UTSW |
5 |
109,434,874 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9016:Vmn2r15
|
UTSW |
5 |
109,442,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9596:Vmn2r15
|
UTSW |
5 |
109,440,791 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9619:Vmn2r15
|
UTSW |
5 |
109,440,622 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9685:Vmn2r15
|
UTSW |
5 |
109,440,598 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9716:Vmn2r15
|
UTSW |
5 |
109,445,224 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9772:Vmn2r15
|
UTSW |
5 |
109,434,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0065:Vmn2r15
|
UTSW |
5 |
109,441,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1187:Vmn2r15
|
UTSW |
5 |
109,434,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCCAAGTTTTCATGTAGGCAC -3'
(R):5'- CCGTTGATCATGGTCAATGTGAAG -3'
Sequencing Primer
(F):5'- GCTAATTGGTTAAGAGCACTGCC -3'
(R):5'- GAAACATTGGGACTTCTCGATG -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation