Mutagenetix > Incidental Mutation

Incidental Mutation 'R9509:Fat2'

718024

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

mKIAA0811, LOC245827, Fath2, EMI2

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9509 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

55250609-55336564 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 55309887 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 787 (V787A)

Ref Sequence

ENSEMBL: ENSMUSP00000067556 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000068853
AA Change: V787A

PolyPhen 2 Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: V787A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000108864
AA Change: V787A

PolyPhen 2 Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: V787A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	TTCCTCCTCCTCCTCCTCCTCC	TTCCTCCTCCTCCTCCTCC	3: 138,065,834		probably benign	Het
2310035C23Rik	A	G	1: 105,686,979	E216G	probably damaging	Het
4932415D10Rik	A	T	10: 82,296,395	N260K	probably benign	Het
5830411N06Rik	T	A	7: 140,299,731	Y1093*	probably null	Het
Acan	C	T	7: 79,091,020	P378L	probably damaging	Het
Akap6	A	G	12: 53,142,238	D2145G	probably damaging	Het
Akap9	A	T	5: 4,046,349	D2408V	probably benign	Het
Apol10a	C	A	15: 77,488,768	Y201*	probably null	Het
Arhgef4	T	C	1: 34,723,691	I676T	unknown	Het
Capn13	T	C	17: 73,337,451	H361R	probably benign	Het
Ccdc88a	G	A	11: 29,464,143	V894I	probably benign	Het
Chd4	T	A	6: 125,122,522	L1655Q	possibly damaging	Het
Chil1	G	A	1: 134,188,675	E307K	probably damaging	Het
Dhfr	T	A	13: 92,368,231	I139N	probably damaging	Het
Dock8	A	G	19: 25,095,621	S422G	probably benign	Het
Dspp	C	A	5: 104,177,791	D673E	unknown	Het
Dst	G	T	1: 33,908,384	W38L	possibly damaging	Het
Dynlt1b	A	T	17: 6,435,016	E26D	probably benign	Het
Dysf	A	T	6: 84,210,797	Y2059F	probably damaging	Het
Efcab5	G	A	11: 77,104,151	S1198F	possibly damaging	Het
Erp44	T	C	4: 48,208,750	I237V	probably benign	Het
Exosc2	G	A	2: 31,674,743	V107I	probably benign	Het
Fbn2	C	G	18: 58,114,478	G448A	probably benign	Het
Fbxw21	A	G	9: 109,148,149	V164A	possibly damaging	Het
Gabpa	G	A	16: 84,852,507	V201I	possibly damaging	Het
Gm12253	G	A	11: 58,439,945	V177M	probably benign	Het
Il2rb	C	A	15: 78,490,216	W84L	probably damaging	Het
Kank4	T	A	4: 98,774,867	T695S	possibly damaging	Het
Klhl29	T	C	12: 5,140,629	Q122R	probably damaging	Het
L3mbtl1	A	G	2: 162,967,383	E670G	probably damaging	Het
Lifr	A	G	15: 7,159,474	Y112C	probably damaging	Het
Lins1	C	T	7: 66,708,371	Q85*	probably null	Het
Lpcat1	T	A	13: 73,494,832	V175E	probably damaging	Het
Mdm1	T	C	10: 118,146,825	S122P	probably damaging	Het
Mtfmt	C	T	9: 65,435,865	R18C	probably benign	Het
Mylk4	T	C	13: 32,720,560	N197S	probably benign	Het
Neurl4	T	A	11: 69,902,145	L83*	probably null	Het
Nlrc3	T	C	16: 3,964,816	D259G	probably damaging	Het
Nsf	A	T	11: 103,863,248	D487E	probably benign	Het
Olfr138	A	G	17: 38,275,390	I206M	probably benign	Het
Olfr1385	A	G	11: 49,494,649	I39V	probably benign	Het
Olfr469	T	A	7: 107,823,233	T79S	probably benign	Het
Palb2	T	A	7: 122,128,176	K157M	probably damaging	Het
Pbrm1	T	C	14: 31,084,957	S1114P	probably damaging	Het
Pdia6	T	A	12: 17,280,988	M364K	probably damaging	Het
Pf4	G	T	5: 90,773,189	G83W	probably damaging	Het
Pibf1	T	C	14: 99,101,285	M79T	probably benign	Het
Polr3b	T	G	10: 84,631,786	Y77D	probably damaging	Het
Pomt2	T	A	12: 87,138,028	H208L	possibly damaging	Het
Pprc1	A	T	19: 46,063,399	K456M	unknown	Het
Rasgef1a	A	T	6: 118,084,430	K119*	probably null	Het
Rbbp6	T	A	7: 122,998,568	Y701N	unknown	Het
Reln	A	T	5: 22,344,200	V70E	possibly damaging	Het
Rgs17	T	C	10: 5,862,576	N41S	probably benign	Het
Rhbdf1	A	T	11: 32,215,055	I106N	possibly damaging	Het
Robo1	T	A	16: 72,962,279	N393K	probably damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,579,920		probably benign	Het
Scnn1a	A	T	6: 125,342,641	D495V	probably damaging	Het
Serpinf2	G	A	11: 75,438,069	P45L	probably benign	Het
Setdb1	A	C	3: 95,354,589	I122S	possibly damaging	Het
Slc4a9	A	T	18: 36,535,390	M701L	probably damaging	Het
Supv3l1	T	C	10: 62,429,632	T710A	probably benign	Het
Syne1	A	T	10: 5,348,927		probably null	Het
Tenm3	A	T	8: 48,313,257	Y743*	probably null	Het
Tgm2	A	T	2: 158,127,290	Y388*	probably null	Het
Tmem55a	T	A	4: 14,892,485	C116*	probably null	Het
Tor3a	A	G	1: 156,655,929	S308P	possibly damaging	Het
Trim12a	T	C	7: 104,304,344	K187E	probably benign	Het
Trpc1	C	T	9: 95,743,196		probably null	Het
Uaca	C	T	9: 60,872,216	T1295M	possibly damaging	Het
Ush2a	T	A	1: 188,916,243	Y4682N	probably damaging	Het
Vldlr	A	G	19: 27,244,287	N684S	probably benign	Het
Vmn2r72	T	A	7: 85,754,867	I39L	probably benign	Het
Vps13b	A	T	15: 35,841,311	M2496L	possibly damaging	Het
Zbtb5	C	T	4: 44,994,332	V351M	probably damaging	Het
Zeb2	T	A	2: 44,997,864	T394S	possibly damaging	Het
Zfp352	A	G	4: 90,224,706	E361G	probably damaging	Het
Zfp54	C	A	17: 21,434,367	Y374*	probably null	Het
Zfp869	C	A	8: 69,706,946	G326W	probably damaging	Het
Zfyve28	C	T	5: 34,197,548	A806T	probably benign	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55311244	missense	probably benign
IGL00897:Fat2	APN	11	55289252	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55284191	missense	probably benign
IGL01306:Fat2	APN	11	55310872	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55269309	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55282156	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55283387	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55278930	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55296209	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55262568	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55283980	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55312005	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55311823	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55270146	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55296195	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55312245	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55282840	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55289296	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55309042	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55262419	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55273129	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55281092	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55270259	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55311124	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55281793	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55311283	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55282828	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55311096	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55282385	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55256618	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55256653	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55270194	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55283246	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55311901	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55253920	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55286043	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55310995	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55284029	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55256219	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55262595	missense	probably benign
IGL03325:Fat2	APN	11	55282342	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55282361	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55311164	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55310872	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55262787	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55262787	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55282213	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55256110	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55311249	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55311249	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55262871	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55262871	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55310039	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55310039	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55298605	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55283678	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55289286	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55252118	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55273211	missense	probably benign
R0158:Fat2	UTSW	11	55296185	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55296288	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55292093	splice site	probably benign
R0384:Fat2	UTSW	11	55269465	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55310777	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55270349	missense	probably benign	0.42
R0416:Fat2	UTSW	11	55284134	missense	possibly damaging	0.94
R0437:Fat2	UTSW	11	55282799	missense	probably benign	0.02
R0463:Fat2	UTSW	11	55262829	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55283402	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55311843	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55283128	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55309209	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55253633	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55253633	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55311775	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55311775	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55256225	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55268179	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55310773	missense	probably benign
R1428:Fat2	UTSW	11	55296087	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55287811	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55262673	missense	probably benign
R1506:Fat2	UTSW	11	55284264	missense	probably benign
R1547:Fat2	UTSW	11	55252255	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55253664	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55309974	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55283404	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55291870	splice site	probably null
R1601:Fat2	UTSW	11	55282010	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55278924	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55267684	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55284719	missense	probably benign
R1644:Fat2	UTSW	11	55287783	missense	possibly damaging	0.91
R1644:Fat2	UTSW	11	55296181	missense	possibly damaging	0.94
R1691:Fat2	UTSW	11	55311852	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55281371	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55256647	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55310865	missense	probably benign	0.01
R1800:Fat2	UTSW	11	55283892	missense	probably damaging	1.00
R1807:Fat2	UTSW	11	55289259	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55256780	missense	probably benign	0.29
R1848:Fat2	UTSW	11	55311558	missense	probably damaging	1.00
R1866:Fat2	UTSW	11	55292014	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55262178	missense	probably benign
R1954:Fat2	UTSW	11	55311084	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55253827	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55282757	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55281860	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55309677	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55256564	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55303716	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55267575	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55282360	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55311901	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55270096	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55310812	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55281973	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55283773	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55311305	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55284709	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55252171	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55311796	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55278998	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55260516	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55281685	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55312069	missense	probably benign
R3620:Fat2	UTSW	11	55256695	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55281101	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55309650	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55256186	missense	probably benign
R3889:Fat2	UTSW	11	55281763	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55296382	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55283984	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55284301	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55262268	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55309640	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55296198	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55270097	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55265951	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55284752	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55296213	nonsense	probably null
R4669:Fat2	UTSW	11	55311615	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55285015	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55311468	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55311468	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55281187	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55285060	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55283979	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55311318	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55279018	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55310637	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55279033	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55283092	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55310704	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55278988	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55296333	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55253832	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55281175	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55287878	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55267656	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55282166	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55262820	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55303941	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55252226	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55303688	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55310086	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55253681	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55269361	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55262337	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55253889	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55282277	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55281130	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55282481	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55310316	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55310681	nonsense	probably null
R5660:Fat2	UTSW	11	55284176	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55289237	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55252346	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55262325	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55270382	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55284051	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55310303	nonsense	probably null
R6030:Fat2	UTSW	11	55310303	nonsense	probably null
R6032:Fat2	UTSW	11	55253934	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55253934	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55296072	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55296271	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55262581	missense	probably benign
R6307:Fat2	UTSW	11	55281280	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55289310	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55282216	missense	probably benign	0.29
R6455:Fat2	UTSW	11	55270457	missense	probably damaging	0.96
R6483:Fat2	UTSW	11	55296345	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55262397	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55284988	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55283800	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55296105	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55252262	missense	probably benign
R6679:Fat2	UTSW	11	55309305	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55310858	nonsense	probably null
R6762:Fat2	UTSW	11	55253482	splice site	probably null
R6810:Fat2	UTSW	11	55282241	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55309341	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55282771	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55252474	nonsense	probably null
R6941:Fat2	UTSW	11	55262088	missense	probably benign
R7023:Fat2	UTSW	11	55310502	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55269433	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55281851	nonsense	probably null
R7095:Fat2	UTSW	11	55311331	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55283434	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55282336	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55281262	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55285001	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55281045	nonsense	probably null
R7246:Fat2	UTSW	11	55296382	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55311262	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55285030	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55286067	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55282304	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55256551	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55309101	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55303919	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55278963	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55310432	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55303653	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55282330	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55309840	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55284347	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55310763	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55284796	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55310706	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55281131	nonsense	probably null
R7757:Fat2	UTSW	11	55311421	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55311220	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55253364	splice site	probably null
R7924:Fat2	UTSW	11	55262787	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55310167	missense	probably benign
R7936:Fat2	UTSW	11	55311160	nonsense	probably null
R7938:Fat2	UTSW	11	55273096	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55287734	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55312066	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55296139	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55252084	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55270455	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55287812	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55284397	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55273171	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55284610	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55312209	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55270275	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55284136	missense	probably benign
R8269:Fat2	UTSW	11	55282709	missense	possibly damaging	0.48
R8443:Fat2	UTSW	11	55311709	missense	probably damaging	1.00
R8465:Fat2	UTSW	11	55256704	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55282968	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55309237	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55253866	missense	probably benign
R8704:Fat2	UTSW	11	55281311	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55268303	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55282960	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55281103	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55282924	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55310070	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55256810	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55282903	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55303721	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55262521	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55298610	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55278937	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55256740	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55310571	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55310697	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55281301	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55310688	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55253522	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55252012	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55309926	missense	probably damaging	0.99
R9514:Fat2	UTSW	11	55284982	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55289267	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55256779	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55268311	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55303925	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55252260	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55310431	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55296210	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55309414	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55283234	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55282795	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55284991	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55303700	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55310121	missense	probably damaging	0.96
Z1177:Fat2	UTSW	11	55278966	nonsense	probably null
Z1186:Fat2	UTSW	11	55308970	frame shift	probably null
Z1186:Fat2	UTSW	11	55309799	missense	probably benign
Z1187:Fat2	UTSW	11	55308970	frame shift	probably null
Z1187:Fat2	UTSW	11	55309799	missense	probably benign
Z1188:Fat2	UTSW	11	55308970	frame shift	probably null
Z1188:Fat2	UTSW	11	55309799	missense	probably benign
Z1189:Fat2	UTSW	11	55308970	frame shift	probably null
Z1189:Fat2	UTSW	11	55309799	missense	probably benign
Z1190:Fat2	UTSW	11	55308970	frame shift	probably null
Z1190:Fat2	UTSW	11	55309799	missense	probably benign
Z1191:Fat2	UTSW	11	55308970	frame shift	probably null
Z1191:Fat2	UTSW	11	55309799	missense	probably benign
Z1192:Fat2	UTSW	11	55308970	frame shift	probably null
Z1192:Fat2	UTSW	11	55309799	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TCAGTAGGGTGTAGCGAACC -3'
(R):5'- ACATTCTGGAGCAGGTTCC -3'

Sequencing Primer
(F):5'- TGTAGCGAACCCTCCCGTTG -3'
(R):5'- GAGCAGGTTCCCGTCAACAC -3'

Posted On

2022-07-18