Mutagenetix > Incidental Mutation

Incidental Mutation 'R0416:Fat2'

40330

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

mKIAA0811, LOC245827, Fath2, EMI2

MMRRC Submission

038618-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0416 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

55250609-55336564 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 55284134 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 1918 (I1918F)

Ref Sequence

ENSEMBL: ENSMUSP00000104492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000068853
AA Change: I1918F

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: I1918F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000108864
AA Change: I1918F

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: I1918F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Meta Mutation Damage Score

0.2214

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 96.2%
20x: 91.8%

Validation Efficiency

99% (74/75)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm2	A	G	7: 119,563,556 (GRCm38)	I18V	probably benign	Het
Adamdec1	T	G	14: 68,568,712 (GRCm38)	E438A	possibly damaging	Het
Adamts17	A	G	7: 66,915,898 (GRCm38)		probably null	Het
Ankrd44	T	G	1: 54,743,339 (GRCm38)	I359L	possibly damaging	Het
Ap2s1	C	A	7: 16,747,365 (GRCm38)	N86K	probably damaging	Het
Arih1	T	A	9: 59,426,710 (GRCm38)		probably benign	Het
Astn1	T	A	1: 158,509,891 (GRCm38)	I389N	probably damaging	Het
Brca2	T	C	5: 150,569,392 (GRCm38)	S3291P	possibly damaging	Het
Cacna1d	T	C	14: 30,100,688 (GRCm38)		probably benign	Het
Ccl7	C	A	11: 82,045,866 (GRCm38)		probably benign	Het
Cd74	A	T	18: 60,811,414 (GRCm38)	Y232F	possibly damaging	Het
Cep128	A	G	12: 91,230,867 (GRCm38)		probably benign	Het
Cep89	T	A	7: 35,416,402 (GRCm38)		probably benign	Het
Cmya5	T	G	13: 93,089,856 (GRCm38)	N2908T	probably benign	Het
Coil	T	C	11: 88,981,986 (GRCm38)	L391S	possibly damaging	Het
Cpd	C	T	11: 76,785,204 (GRCm38)	V1208I	probably benign	Het
Ddx19a	T	C	8: 110,979,057 (GRCm38)	D254G	probably damaging	Het
Desi2	T	A	1: 178,256,321 (GRCm38)		probably benign	Het
Dnah11	A	T	12: 117,911,058 (GRCm38)	M4024K	probably damaging	Het
Ergic2	A	T	6: 148,183,144 (GRCm38)	L53H	probably damaging	Het
Etv2	T	C	7: 30,634,633 (GRCm38)	Y225C	probably benign	Het
F10	G	A	8: 13,055,448 (GRCm38)	A338T	probably damaging	Het
Fam228b	T	A	12: 4,762,382 (GRCm38)	D132V	probably damaging	Het
Fbxw5	C	T	2: 25,503,239 (GRCm38)	S214F	probably damaging	Het
Glyat	G	A	19: 12,651,453 (GRCm38)	R204Q	possibly damaging	Het
Gm4825	T	C	15: 85,510,981 (GRCm38)		noncoding transcript	Het
Ino80d	G	T	1: 63,086,276 (GRCm38)	T9K	possibly damaging	Het
Lifr	A	T	15: 7,166,914 (GRCm38)	D193V	probably damaging	Het
Lrp12	G	T	15: 39,878,911 (GRCm38)		probably benign	Het
Lrp3	A	G	7: 35,202,353 (GRCm38)	V701A	probably benign	Het
Mfsd11	T	A	11: 116,865,882 (GRCm38)		probably benign	Het
Mrto4	A	T	4: 139,349,732 (GRCm38)		probably null	Het
Msi1	T	C	5: 115,430,649 (GRCm38)	F43L	possibly damaging	Het
Mthfsd	T	C	8: 121,101,237 (GRCm38)	D168G	probably damaging	Het
Myo15	T	A	11: 60,511,174 (GRCm38)	V3099E	probably damaging	Het
Myrf	T	C	19: 10,215,812 (GRCm38)		probably null	Het
Nadk	C	A	4: 155,587,799 (GRCm38)		probably benign	Het
Nav1	T	C	1: 135,471,126 (GRCm38)	K573E	possibly damaging	Het
Ndufs3	A	G	2: 90,898,388 (GRCm38)	V207A	probably damaging	Het
Nlrp3	T	C	11: 59,555,924 (GRCm38)		probably benign	Het
Nlrx1	T	G	9: 44,262,914 (GRCm38)	D330A	probably benign	Het
Olfr331	T	C	11: 58,502,396 (GRCm38)	I53M	unknown	Het
Olfr444	G	A	6: 42,955,570 (GRCm38)	C24Y	probably benign	Het
Osbpl3	C	T	6: 50,348,018 (GRCm38)	V167I	probably benign	Het
Pcnx	A	T	12: 81,974,466 (GRCm38)	I1410F	probably benign	Het
Piezo2	G	A	18: 63,024,491 (GRCm38)	R2383C	probably damaging	Het
Pip5kl1	A	T	2: 32,583,424 (GRCm38)	K358*	probably null	Het
Polg	T	C	7: 79,452,240 (GRCm38)		probably benign	Het
Prr14l	T	A	5: 32,828,717 (GRCm38)	I1145F	probably benign	Het
Psmb1	C	T	17: 15,494,519 (GRCm38)	V39I	probably benign	Het
Ptk6	T	C	2: 181,202,308 (GRCm38)	Y66C	possibly damaging	Het
Robo4	T	C	9: 37,404,766 (GRCm38)		probably benign	Het
Sdk2	A	G	11: 113,803,203 (GRCm38)	Y1801H	probably damaging	Het
Serpinb3a	C	A	1: 107,049,386 (GRCm38)	A95S	probably benign	Het
Setd1a	CTGGTGGTGGTGGTGGTGGTAGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGG	CTGGTGGTGGTGGTGGTAGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGG	7: 127,785,297 (GRCm38)		probably benign	Het
Sik2	A	T	9: 50,995,632 (GRCm38)	Y98N	probably damaging	Het
Slc30a1	C	T	1: 191,909,726 (GRCm38)	P495S	probably benign	Het
Smg1	A	T	7: 118,184,461 (GRCm38)		probably benign	Het
Stk3	T	A	15: 35,114,632 (GRCm38)	I45L	probably benign	Het
Tapbp	A	G	17: 33,925,418 (GRCm38)	T163A	probably damaging	Het
Tdrd5	T	C	1: 156,285,481 (GRCm38)	K410E	probably damaging	Het
Trim30b	A	T	7: 104,363,766 (GRCm38)	M152K	probably benign	Het
Trpm6	G	T	19: 18,783,025 (GRCm38)		probably benign	Het
Tsc22d1	T	C	14: 76,505,303 (GRCm38)		probably benign	Het
U2surp	A	T	9: 95,485,607 (GRCm38)	F444I	probably damaging	Het
Vmn2r95	C	T	17: 18,441,402 (GRCm38)	P470L	probably damaging	Het
Zc3h4	T	G	7: 16,420,275 (GRCm38)	Y163D	probably damaging	Het
Zfp62	A	T	11: 49,215,676 (GRCm38)	H198L	probably damaging	Het
Zmym1	A	G	4: 127,058,820 (GRCm38)	L56P	probably benign	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55,311,244 (GRCm38)	missense	probably benign
IGL00897:Fat2	APN	11	55,289,252 (GRCm38)	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55,284,191 (GRCm38)	missense	probably benign
IGL01306:Fat2	APN	11	55,310,872 (GRCm38)	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55,269,309 (GRCm38)	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55,282,156 (GRCm38)	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55,283,387 (GRCm38)	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55,278,930 (GRCm38)	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55,296,209 (GRCm38)	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55,262,568 (GRCm38)	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55,283,980 (GRCm38)	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55,312,005 (GRCm38)	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55,311,823 (GRCm38)	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55,270,146 (GRCm38)	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55,296,195 (GRCm38)	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55,312,245 (GRCm38)	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55,282,840 (GRCm38)	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55,289,296 (GRCm38)	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55,309,042 (GRCm38)	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55,262,419 (GRCm38)	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55,273,129 (GRCm38)	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55,281,092 (GRCm38)	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55,270,259 (GRCm38)	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55,311,124 (GRCm38)	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55,281,793 (GRCm38)	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55,311,283 (GRCm38)	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55,282,828 (GRCm38)	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55,311,096 (GRCm38)	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55,282,385 (GRCm38)	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55,256,618 (GRCm38)	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55,256,653 (GRCm38)	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55,270,194 (GRCm38)	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55,283,246 (GRCm38)	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55,311,901 (GRCm38)	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55,253,920 (GRCm38)	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55,286,043 (GRCm38)	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55,310,995 (GRCm38)	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55,284,029 (GRCm38)	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55,256,219 (GRCm38)	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55,262,595 (GRCm38)	missense	probably benign
IGL03325:Fat2	APN	11	55,282,342 (GRCm38)	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55,282,361 (GRCm38)	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55,311,164 (GRCm38)	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55,310,872 (GRCm38)	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55,282,213 (GRCm38)	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55,256,110 (GRCm38)	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55,311,249 (GRCm38)	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55,311,249 (GRCm38)	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55,262,871 (GRCm38)	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55,262,871 (GRCm38)	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55,310,039 (GRCm38)	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55,310,039 (GRCm38)	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55,298,605 (GRCm38)	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55,283,678 (GRCm38)	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55,289,286 (GRCm38)	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55,252,118 (GRCm38)	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55,273,211 (GRCm38)	missense	probably benign
R0158:Fat2	UTSW	11	55,296,185 (GRCm38)	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55,296,288 (GRCm38)	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55,292,093 (GRCm38)	splice site	probably benign
R0384:Fat2	UTSW	11	55,269,465 (GRCm38)	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55,310,777 (GRCm38)	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55,270,349 (GRCm38)	missense	probably benign	0.42
R0437:Fat2	UTSW	11	55,282,799 (GRCm38)	missense	probably benign	0.02
R0463:Fat2	UTSW	11	55,262,829 (GRCm38)	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55,283,402 (GRCm38)	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55,311,843 (GRCm38)	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55,283,128 (GRCm38)	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55,309,209 (GRCm38)	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55,253,633 (GRCm38)	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55,253,633 (GRCm38)	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55,311,775 (GRCm38)	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55,311,775 (GRCm38)	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55,256,225 (GRCm38)	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55,268,179 (GRCm38)	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55,310,773 (GRCm38)	missense	probably benign
R1428:Fat2	UTSW	11	55,296,087 (GRCm38)	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55,287,811 (GRCm38)	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55,262,673 (GRCm38)	missense	probably benign
R1506:Fat2	UTSW	11	55,284,264 (GRCm38)	missense	probably benign
R1547:Fat2	UTSW	11	55,252,255 (GRCm38)	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55,253,664 (GRCm38)	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55,309,974 (GRCm38)	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55,283,404 (GRCm38)	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55,291,870 (GRCm38)	splice site	probably null
R1601:Fat2	UTSW	11	55,282,010 (GRCm38)	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55,278,924 (GRCm38)	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55,284,719 (GRCm38)	missense	probably benign
R1634:Fat2	UTSW	11	55,267,684 (GRCm38)	missense	probably damaging	1.00
R1644:Fat2	UTSW	11	55,296,181 (GRCm38)	missense	possibly damaging	0.94
R1644:Fat2	UTSW	11	55,287,783 (GRCm38)	missense	possibly damaging	0.91
R1691:Fat2	UTSW	11	55,311,852 (GRCm38)	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55,281,371 (GRCm38)	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55,256,647 (GRCm38)	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55,310,865 (GRCm38)	missense	probably benign	0.01
R1800:Fat2	UTSW	11	55,283,892 (GRCm38)	missense	probably damaging	1.00
R1807:Fat2	UTSW	11	55,289,259 (GRCm38)	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55,256,780 (GRCm38)	missense	probably benign	0.29
R1848:Fat2	UTSW	11	55,311,558 (GRCm38)	missense	probably damaging	1.00
R1866:Fat2	UTSW	11	55,292,014 (GRCm38)	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55,262,178 (GRCm38)	missense	probably benign
R1954:Fat2	UTSW	11	55,311,084 (GRCm38)	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55,253,827 (GRCm38)	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55,282,757 (GRCm38)	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55,281,860 (GRCm38)	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55,309,677 (GRCm38)	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55,256,564 (GRCm38)	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55,303,716 (GRCm38)	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55,267,575 (GRCm38)	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55,282,360 (GRCm38)	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55,311,901 (GRCm38)	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55,270,096 (GRCm38)	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55,310,812 (GRCm38)	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55,281,973 (GRCm38)	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55,283,773 (GRCm38)	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55,311,305 (GRCm38)	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55,284,709 (GRCm38)	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55,252,171 (GRCm38)	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55,311,796 (GRCm38)	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55,278,998 (GRCm38)	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55,260,516 (GRCm38)	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55,281,685 (GRCm38)	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55,312,069 (GRCm38)	missense	probably benign
R3620:Fat2	UTSW	11	55,256,695 (GRCm38)	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55,281,101 (GRCm38)	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55,309,650 (GRCm38)	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55,256,186 (GRCm38)	missense	probably benign
R3889:Fat2	UTSW	11	55,281,763 (GRCm38)	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55,296,382 (GRCm38)	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55,283,984 (GRCm38)	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55,284,301 (GRCm38)	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55,262,268 (GRCm38)	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55,309,640 (GRCm38)	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55,296,198 (GRCm38)	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55,270,097 (GRCm38)	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55,265,951 (GRCm38)	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55,284,752 (GRCm38)	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55,296,213 (GRCm38)	nonsense	probably null
R4669:Fat2	UTSW	11	55,311,615 (GRCm38)	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55,285,015 (GRCm38)	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55,311,468 (GRCm38)	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55,311,468 (GRCm38)	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55,281,187 (GRCm38)	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55,285,060 (GRCm38)	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55,283,979 (GRCm38)	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55,311,318 (GRCm38)	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55,279,018 (GRCm38)	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55,310,637 (GRCm38)	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55,279,033 (GRCm38)	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55,283,092 (GRCm38)	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55,310,704 (GRCm38)	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55,278,988 (GRCm38)	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55,296,333 (GRCm38)	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55,253,832 (GRCm38)	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55,281,175 (GRCm38)	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55,287,878 (GRCm38)	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55,267,656 (GRCm38)	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55,282,166 (GRCm38)	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55,262,820 (GRCm38)	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55,303,941 (GRCm38)	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55,252,226 (GRCm38)	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55,303,688 (GRCm38)	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55,310,086 (GRCm38)	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55,253,681 (GRCm38)	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55,269,361 (GRCm38)	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55,262,337 (GRCm38)	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55,253,889 (GRCm38)	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55,282,277 (GRCm38)	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55,281,130 (GRCm38)	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55,282,481 (GRCm38)	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55,310,316 (GRCm38)	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55,310,681 (GRCm38)	nonsense	probably null
R5660:Fat2	UTSW	11	55,284,176 (GRCm38)	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55,289,237 (GRCm38)	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55,252,346 (GRCm38)	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55,262,325 (GRCm38)	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55,270,382 (GRCm38)	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55,284,051 (GRCm38)	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55,310,303 (GRCm38)	nonsense	probably null
R6030:Fat2	UTSW	11	55,310,303 (GRCm38)	nonsense	probably null
R6032:Fat2	UTSW	11	55,253,934 (GRCm38)	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55,253,934 (GRCm38)	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55,296,072 (GRCm38)	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55,296,271 (GRCm38)	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55,262,581 (GRCm38)	missense	probably benign
R6307:Fat2	UTSW	11	55,281,280 (GRCm38)	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55,289,310 (GRCm38)	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55,282,216 (GRCm38)	missense	probably benign	0.29
R6455:Fat2	UTSW	11	55,270,457 (GRCm38)	missense	probably damaging	0.96
R6483:Fat2	UTSW	11	55,296,345 (GRCm38)	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55,262,397 (GRCm38)	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55,284,988 (GRCm38)	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55,283,800 (GRCm38)	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55,296,105 (GRCm38)	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55,252,262 (GRCm38)	missense	probably benign
R6679:Fat2	UTSW	11	55,309,305 (GRCm38)	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55,310,858 (GRCm38)	nonsense	probably null
R6762:Fat2	UTSW	11	55,253,482 (GRCm38)	splice site	probably null
R6810:Fat2	UTSW	11	55,282,241 (GRCm38)	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55,309,341 (GRCm38)	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55,282,771 (GRCm38)	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55,252,474 (GRCm38)	nonsense	probably null
R6941:Fat2	UTSW	11	55,262,088 (GRCm38)	missense	probably benign
R7023:Fat2	UTSW	11	55,310,502 (GRCm38)	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55,269,433 (GRCm38)	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55,281,851 (GRCm38)	nonsense	probably null
R7095:Fat2	UTSW	11	55,311,331 (GRCm38)	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55,283,434 (GRCm38)	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55,282,336 (GRCm38)	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55,281,262 (GRCm38)	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55,285,001 (GRCm38)	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55,281,045 (GRCm38)	nonsense	probably null
R7246:Fat2	UTSW	11	55,296,382 (GRCm38)	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55,311,262 (GRCm38)	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55,285,030 (GRCm38)	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55,286,067 (GRCm38)	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55,282,304 (GRCm38)	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55,256,551 (GRCm38)	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55,309,101 (GRCm38)	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55,303,919 (GRCm38)	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55,278,963 (GRCm38)	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55,310,432 (GRCm38)	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55,303,653 (GRCm38)	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55,282,330 (GRCm38)	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55,309,840 (GRCm38)	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55,284,347 (GRCm38)	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55,310,763 (GRCm38)	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55,284,796 (GRCm38)	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55,310,706 (GRCm38)	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55,281,131 (GRCm38)	nonsense	probably null
R7757:Fat2	UTSW	11	55,311,421 (GRCm38)	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55,311,220 (GRCm38)	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55,253,364 (GRCm38)	splice site	probably null
R7924:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55,310,167 (GRCm38)	missense	probably benign
R7936:Fat2	UTSW	11	55,311,160 (GRCm38)	nonsense	probably null
R7938:Fat2	UTSW	11	55,273,096 (GRCm38)	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55,287,734 (GRCm38)	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55,312,066 (GRCm38)	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55,296,139 (GRCm38)	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55,252,084 (GRCm38)	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55,270,455 (GRCm38)	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55,287,812 (GRCm38)	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55,284,397 (GRCm38)	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55,273,171 (GRCm38)	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55,284,610 (GRCm38)	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55,312,209 (GRCm38)	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55,270,275 (GRCm38)	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55,284,136 (GRCm38)	missense	probably benign
R8269:Fat2	UTSW	11	55,282,709 (GRCm38)	missense	possibly damaging	0.48
R8443:Fat2	UTSW	11	55,311,709 (GRCm38)	missense	probably damaging	1.00
R8465:Fat2	UTSW	11	55,256,704 (GRCm38)	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55,282,968 (GRCm38)	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55,309,237 (GRCm38)	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55,253,866 (GRCm38)	missense	probably benign
R8704:Fat2	UTSW	11	55,281,311 (GRCm38)	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55,268,303 (GRCm38)	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55,282,960 (GRCm38)	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55,281,103 (GRCm38)	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55,282,924 (GRCm38)	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55,310,070 (GRCm38)	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55,256,810 (GRCm38)	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55,282,903 (GRCm38)	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55,303,721 (GRCm38)	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55,262,521 (GRCm38)	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55,298,610 (GRCm38)	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55,278,937 (GRCm38)	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55,256,740 (GRCm38)	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55,310,571 (GRCm38)	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55,310,697 (GRCm38)	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55,281,301 (GRCm38)	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55,310,688 (GRCm38)	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55,253,522 (GRCm38)	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55,252,012 (GRCm38)	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55,309,926 (GRCm38)	missense	probably damaging	0.99
R9509:Fat2	UTSW	11	55,309,887 (GRCm38)	missense	possibly damaging	0.51
R9514:Fat2	UTSW	11	55,284,982 (GRCm38)	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55,289,267 (GRCm38)	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55,256,779 (GRCm38)	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55,268,311 (GRCm38)	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55,303,925 (GRCm38)	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55,252,260 (GRCm38)	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55,310,431 (GRCm38)	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55,296,210 (GRCm38)	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55,309,414 (GRCm38)	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55,283,234 (GRCm38)	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55,284,991 (GRCm38)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,282,795 (GRCm38)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,310,121 (GRCm38)	missense	probably damaging	0.96
Z1176:Fat2	UTSW	11	55,303,700 (GRCm38)	missense	probably damaging	1.00
Z1177:Fat2	UTSW	11	55,278,966 (GRCm38)	nonsense	probably null
Z1186:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1186:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1187:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1187:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1188:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1188:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1189:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1189:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1190:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1190:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1191:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1191:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1192:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1192:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- TCCTGCTGCTCCCGATCAAATG -3'
(R):5'- TCCGAGATGTGAATGACTCTCCTCC -3'

Sequencing Primer
(F):5'- GACCATGTGAAATAAGTCTGTGCC -3'
(R):5'- CCAGGTTCTCAGAGCAGATATACG -3'

Posted On

2013-05-23