Incidental Mutation 'R9509:Robo1'
| ID |
718044 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo1
|
| Ensembl Gene |
ENSMUSG00000022883 |
| Gene Name |
roundabout guidance receptor 1 |
| Synonyms |
DUTT1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9509 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
72105194-72842983 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 72759167 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 393
(N393K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023600
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023600
AA Change: N393K
PolyPhen 2
Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000023600
Gene: ENSMUSG00000022883
AA Change: N393K
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
41 |
115 |
3.15e-10 |
SMART |
|
IGc2
|
143 |
208 |
2.52e-9 |
SMART |
|
IGc2
|
235 |
298 |
3.85e-14 |
SMART |
|
IGv
|
328 |
391 |
3.71e-7 |
SMART |
|
IGc2
|
428 |
493 |
2.46e-12 |
SMART |
|
FN3
|
522 |
604 |
3.17e-13 |
SMART |
|
FN3
|
634 |
721 |
1.66e0 |
SMART |
|
FN3
|
736 |
822 |
4.28e-10 |
SMART |
|
low complexity region
|
1108 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1157 |
N/A |
INTRINSIC |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1298 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1442 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1563 |
1576 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1611 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
TTCCTCCTCCTCCTCCTCCTCC |
TTCCTCCTCCTCCTCCTCC |
3: 137,771,595 (GRCm39) |
|
probably benign |
Het |
| Acan |
C |
T |
7: 78,740,768 (GRCm39) |
P378L |
probably damaging |
Het |
| Akap6 |
A |
G |
12: 53,189,021 (GRCm39) |
D2145G |
probably damaging |
Het |
| Akap9 |
A |
T |
5: 4,096,349 (GRCm39) |
D2408V |
probably benign |
Het |
| Apol10a |
C |
A |
15: 77,372,968 (GRCm39) |
Y201* |
probably null |
Het |
| Arhgef4 |
T |
C |
1: 34,762,772 (GRCm39) |
I676T |
unknown |
Het |
| Capn13 |
T |
C |
17: 73,644,446 (GRCm39) |
H361R |
probably benign |
Het |
| Ccdc88a |
G |
A |
11: 29,414,143 (GRCm39) |
V894I |
probably benign |
Het |
| Chd4 |
T |
A |
6: 125,099,485 (GRCm39) |
L1655Q |
possibly damaging |
Het |
| Chi3l1 |
G |
A |
1: 134,116,413 (GRCm39) |
E307K |
probably damaging |
Het |
| Dhfr |
T |
A |
13: 92,504,739 (GRCm39) |
I139N |
probably damaging |
Het |
| Dock8 |
A |
G |
19: 25,072,985 (GRCm39) |
S422G |
probably benign |
Het |
| Dspp |
C |
A |
5: 104,325,657 (GRCm39) |
D673E |
unknown |
Het |
| Dst |
G |
T |
1: 33,947,465 (GRCm39) |
W38L |
possibly damaging |
Het |
| Dynlt1b |
A |
T |
17: 6,702,415 (GRCm39) |
E26D |
probably benign |
Het |
| Dysf |
A |
T |
6: 84,187,779 (GRCm39) |
Y2059F |
probably damaging |
Het |
| Efcab5 |
G |
A |
11: 76,994,977 (GRCm39) |
S1198F |
possibly damaging |
Het |
| Erp44 |
T |
C |
4: 48,208,750 (GRCm39) |
I237V |
probably benign |
Het |
| Exosc2 |
G |
A |
2: 31,564,755 (GRCm39) |
V107I |
probably benign |
Het |
| Fat2 |
A |
G |
11: 55,200,713 (GRCm39) |
V787A |
possibly damaging |
Het |
| Fbn2 |
C |
G |
18: 58,247,550 (GRCm39) |
G448A |
probably benign |
Het |
| Fbxw21 |
A |
G |
9: 108,977,217 (GRCm39) |
V164A |
possibly damaging |
Het |
| Gabpa |
G |
A |
16: 84,649,395 (GRCm39) |
V201I |
possibly damaging |
Het |
| Gm12253 |
G |
A |
11: 58,330,771 (GRCm39) |
V177M |
probably benign |
Het |
| Il2rb |
C |
A |
15: 78,374,416 (GRCm39) |
W84L |
probably damaging |
Het |
| Kank4 |
T |
A |
4: 98,663,104 (GRCm39) |
T695S |
possibly damaging |
Het |
| Klhl29 |
T |
C |
12: 5,190,629 (GRCm39) |
Q122R |
probably damaging |
Het |
| L3mbtl1 |
A |
G |
2: 162,809,303 (GRCm39) |
E670G |
probably damaging |
Het |
| Lifr |
A |
G |
15: 7,188,955 (GRCm39) |
Y112C |
probably damaging |
Het |
| Lins1 |
C |
T |
7: 66,358,119 (GRCm39) |
Q85* |
probably null |
Het |
| Lpcat1 |
T |
A |
13: 73,642,951 (GRCm39) |
V175E |
probably damaging |
Het |
| Mdm1 |
T |
C |
10: 117,982,730 (GRCm39) |
S122P |
probably damaging |
Het |
| Mtfmt |
C |
T |
9: 65,343,147 (GRCm39) |
R18C |
probably benign |
Het |
| Mylk4 |
T |
C |
13: 32,904,543 (GRCm39) |
N197S |
probably benign |
Het |
| Neurl4 |
T |
A |
11: 69,792,971 (GRCm39) |
L83* |
probably null |
Het |
| Nlrc3 |
T |
C |
16: 3,782,680 (GRCm39) |
D259G |
probably damaging |
Het |
| Nsf |
A |
T |
11: 103,754,074 (GRCm39) |
D487E |
probably benign |
Het |
| Or2n1e |
A |
G |
17: 38,586,281 (GRCm39) |
I206M |
probably benign |
Het |
| Or2y1 |
A |
G |
11: 49,385,476 (GRCm39) |
I39V |
probably benign |
Het |
| Or5p50 |
T |
A |
7: 107,422,440 (GRCm39) |
T79S |
probably benign |
Het |
| Palb2 |
T |
A |
7: 121,727,399 (GRCm39) |
K157M |
probably damaging |
Het |
| Pbrm1 |
T |
C |
14: 30,806,914 (GRCm39) |
S1114P |
probably damaging |
Het |
| Pdia6 |
T |
A |
12: 17,330,989 (GRCm39) |
M364K |
probably damaging |
Het |
| Pf4 |
G |
T |
5: 90,921,048 (GRCm39) |
G83W |
probably damaging |
Het |
| Pibf1 |
T |
C |
14: 99,338,721 (GRCm39) |
M79T |
probably benign |
Het |
| Pip4p2 |
T |
A |
4: 14,892,485 (GRCm39) |
C116* |
probably null |
Het |
| Polr3b |
T |
G |
10: 84,467,650 (GRCm39) |
Y77D |
probably damaging |
Het |
| Pomt2 |
T |
A |
12: 87,184,802 (GRCm39) |
H208L |
possibly damaging |
Het |
| Pprc1 |
A |
T |
19: 46,051,838 (GRCm39) |
K456M |
unknown |
Het |
| Rasgef1a |
A |
T |
6: 118,061,391 (GRCm39) |
K119* |
probably null |
Het |
| Rbbp6 |
T |
A |
7: 122,597,791 (GRCm39) |
Y701N |
unknown |
Het |
| Relch |
A |
G |
1: 105,614,704 (GRCm39) |
E216G |
probably damaging |
Het |
| Reln |
A |
T |
5: 22,549,198 (GRCm39) |
V70E |
possibly damaging |
Het |
| Rgs17 |
T |
C |
10: 5,812,576 (GRCm39) |
N41S |
probably benign |
Het |
| Rhbdf1 |
A |
T |
11: 32,165,055 (GRCm39) |
I106N |
possibly damaging |
Het |
| Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,127 (GRCm39) |
|
probably benign |
Het |
| Scart2 |
T |
A |
7: 139,879,644 (GRCm39) |
Y1093* |
probably null |
Het |
| Scnn1a |
A |
T |
6: 125,319,604 (GRCm39) |
D495V |
probably damaging |
Het |
| Serpinf2 |
G |
A |
11: 75,328,895 (GRCm39) |
P45L |
probably benign |
Het |
| Setdb1 |
A |
C |
3: 95,261,900 (GRCm39) |
I122S |
possibly damaging |
Het |
| Slc4a9 |
A |
T |
18: 36,668,443 (GRCm39) |
M701L |
probably damaging |
Het |
| Spata31h1 |
A |
T |
10: 82,132,229 (GRCm39) |
N260K |
probably benign |
Het |
| Supv3l1 |
T |
C |
10: 62,265,411 (GRCm39) |
T710A |
probably benign |
Het |
| Syne1 |
A |
T |
10: 5,298,927 (GRCm39) |
|
probably null |
Het |
| Tenm3 |
A |
T |
8: 48,766,292 (GRCm39) |
Y743* |
probably null |
Het |
| Tgm2 |
A |
T |
2: 157,969,210 (GRCm39) |
Y388* |
probably null |
Het |
| Tor3a |
A |
G |
1: 156,483,499 (GRCm39) |
S308P |
possibly damaging |
Het |
| Trim12a |
T |
C |
7: 103,953,551 (GRCm39) |
K187E |
probably benign |
Het |
| Trpc1 |
C |
T |
9: 95,625,249 (GRCm39) |
|
probably null |
Het |
| Uaca |
C |
T |
9: 60,779,498 (GRCm39) |
T1295M |
possibly damaging |
Het |
| Ush2a |
T |
A |
1: 188,648,440 (GRCm39) |
Y4682N |
probably damaging |
Het |
| Vldlr |
A |
G |
19: 27,221,687 (GRCm39) |
N684S |
probably benign |
Het |
| Vmn2r72 |
T |
A |
7: 85,404,075 (GRCm39) |
I39L |
probably benign |
Het |
| Vps13b |
A |
T |
15: 35,841,457 (GRCm39) |
M2496L |
possibly damaging |
Het |
| Zbtb5 |
C |
T |
4: 44,994,332 (GRCm39) |
V351M |
probably damaging |
Het |
| Zeb2 |
T |
A |
2: 44,887,876 (GRCm39) |
T394S |
possibly damaging |
Het |
| Zfp352 |
A |
G |
4: 90,112,943 (GRCm39) |
E361G |
probably damaging |
Het |
| Zfp54 |
C |
A |
17: 21,654,629 (GRCm39) |
Y374* |
probably null |
Het |
| Zfp869 |
C |
A |
8: 70,159,596 (GRCm39) |
G326W |
probably damaging |
Het |
| Zfyve28 |
C |
T |
5: 34,354,892 (GRCm39) |
A806T |
probably benign |
Het |
|
| Other mutations in Robo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01766:Robo1
|
APN |
16 |
72,801,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01937:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Robo1
|
APN |
16 |
72,786,504 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Robo1
|
APN |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02282:Robo1
|
APN |
16 |
72,539,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Robo1
|
APN |
16 |
72,840,020 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02874:Robo1
|
APN |
16 |
72,809,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02974:Robo1
|
APN |
16 |
72,803,750 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03233:Robo1
|
APN |
16 |
72,767,081 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Robo1
|
UTSW |
16 |
72,801,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Robo1
|
UTSW |
16 |
72,730,230 (GRCm39) |
splice site |
probably benign |
|
|
R0254:Robo1
|
UTSW |
16 |
72,461,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0366:Robo1
|
UTSW |
16 |
72,539,133 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0410:Robo1
|
UTSW |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0511:Robo1
|
UTSW |
16 |
72,810,013 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0563:Robo1
|
UTSW |
16 |
72,769,174 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0637:Robo1
|
UTSW |
16 |
72,798,839 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1239:Robo1
|
UTSW |
16 |
72,821,430 (GRCm39) |
splice site |
probably null |
|
|
R1773:Robo1
|
UTSW |
16 |
72,801,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1777:Robo1
|
UTSW |
16 |
72,801,555 (GRCm39) |
missense |
probably benign |
|
|
R1901:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1902:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1903:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1996:Robo1
|
UTSW |
16 |
72,767,067 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2040:Robo1
|
UTSW |
16 |
72,730,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2266:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2269:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2433:Robo1
|
UTSW |
16 |
72,767,127 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Robo1
|
UTSW |
16 |
72,801,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3085:Robo1
|
UTSW |
16 |
72,798,898 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3150:Robo1
|
UTSW |
16 |
72,767,157 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3418:Robo1
|
UTSW |
16 |
72,832,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3610:Robo1
|
UTSW |
16 |
72,780,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3940:Robo1
|
UTSW |
16 |
72,806,631 (GRCm39) |
missense |
probably benign |
|
|
R3953:Robo1
|
UTSW |
16 |
72,821,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Robo1
|
UTSW |
16 |
72,757,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Robo1
|
UTSW |
16 |
72,768,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4814:Robo1
|
UTSW |
16 |
72,768,923 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4884:Robo1
|
UTSW |
16 |
72,701,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Robo1
|
UTSW |
16 |
72,776,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5150:Robo1
|
UTSW |
16 |
72,769,192 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5183:Robo1
|
UTSW |
16 |
72,539,038 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5360:Robo1
|
UTSW |
16 |
72,732,665 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5629:Robo1
|
UTSW |
16 |
72,780,598 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5804:Robo1
|
UTSW |
16 |
72,840,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6107:Robo1
|
UTSW |
16 |
72,780,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6127:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6128:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6129:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6191:Robo1
|
UTSW |
16 |
72,730,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6357:Robo1
|
UTSW |
16 |
72,767,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6408:Robo1
|
UTSW |
16 |
72,768,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6516:Robo1
|
UTSW |
16 |
72,821,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6600:Robo1
|
UTSW |
16 |
72,786,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Robo1
|
UTSW |
16 |
72,730,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7105:Robo1
|
UTSW |
16 |
72,539,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7189:Robo1
|
UTSW |
16 |
72,757,039 (GRCm39) |
nonsense |
probably null |
|
|
R7290:Robo1
|
UTSW |
16 |
72,801,408 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7296:Robo1
|
UTSW |
16 |
72,786,519 (GRCm39) |
nonsense |
probably null |
|
|
R7576:Robo1
|
UTSW |
16 |
72,767,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7605:Robo1
|
UTSW |
16 |
72,821,189 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7607:Robo1
|
UTSW |
16 |
72,360,626 (GRCm39) |
missense |
|
|
|
R7634:Robo1
|
UTSW |
16 |
72,839,866 (GRCm39) |
splice site |
probably null |
|
|
R7636:Robo1
|
UTSW |
16 |
72,360,615 (GRCm39) |
missense |
|
|
|
R7857:Robo1
|
UTSW |
16 |
72,767,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7966:Robo1
|
UTSW |
16 |
72,780,760 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7997:Robo1
|
UTSW |
16 |
72,701,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8101:Robo1
|
UTSW |
16 |
72,775,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8191:Robo1
|
UTSW |
16 |
72,730,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Robo1
|
UTSW |
16 |
72,786,678 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8228:Robo1
|
UTSW |
16 |
72,809,768 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8292:Robo1
|
UTSW |
16 |
72,769,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8298:Robo1
|
UTSW |
16 |
72,769,020 (GRCm39) |
intron |
probably benign |
|
|
R8332:Robo1
|
UTSW |
16 |
72,775,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8402:Robo1
|
UTSW |
16 |
72,821,385 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8492:Robo1
|
UTSW |
16 |
72,809,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8730:Robo1
|
UTSW |
16 |
72,786,495 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8774:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8776:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8776-TAIL:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8905:Robo1
|
UTSW |
16 |
72,539,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Robo1
|
UTSW |
16 |
72,701,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9003:Robo1
|
UTSW |
16 |
72,539,002 (GRCm39) |
splice site |
probably benign |
|
|
R9246:Robo1
|
UTSW |
16 |
72,769,178 (GRCm39) |
missense |
probably benign |
|
|
R9451:Robo1
|
UTSW |
16 |
72,803,718 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9652:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9653:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9749:Robo1
|
UTSW |
16 |
72,105,257 (GRCm39) |
start gained |
probably benign |
|
|
Z1176:Robo1
|
UTSW |
16 |
72,774,688 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACTTCGCCACGCTCTTCAG -3'
(R):5'- AACAATAGAGTCGCTAAGTCGCTAG -3'
Sequencing Primer
(F):5'- TCAGACCTAGCGGTTAACCTG -3'
(R):5'- AGTCGCTAAGTCGCTAGTGCAC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation