Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01385:Vmn1r238'

79001

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01385

Quality Score

Status

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 3122770 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 215 (Q215K)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165255
AA Change: Q215K

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: Q215K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016C15Rik	G	A	1: 177,741,074	G46R	probably benign	Het
Ablim1	A	T	19: 57,068,914	S292R	probably damaging	Het
Adamts19	A	G	18: 58,972,779	T749A	probably damaging	Het
Agap2	A	T	10: 127,087,996	I747F	unknown	Het
Arhgap35	T	A	7: 16,564,474	N222I	probably damaging	Het
Atp10b	A	G	11: 43,234,429	E1074G	probably damaging	Het
Brd3	T	C	2: 27,464,089	T4A	possibly damaging	Het
Col6a6	A	G	9: 105,783,666	S415P	probably damaging	Het
Dennd2a	A	G	6: 39,523,136	V165A	probably damaging	Het
Dnm1l	T	A	16: 16,341,453	E95V	probably damaging	Het
Dock9	A	G	14: 121,580,583	Y1609H	possibly damaging	Het
Esm1	A	C	13: 113,216,682	E166A	possibly damaging	Het
F2rl2	A	C	13: 95,701,328	I294L	probably benign	Het
Gstt3	A	G	10: 75,774,988	S187P	probably benign	Het
Katna1	T	C	10: 7,752,810	C268R	probably damaging	Het
Mbd5	T	A	2: 49,250,221	C66S	possibly damaging	Het
Naa35	G	A	13: 59,601,066	E167K	probably damaging	Het
Olfr1330	T	C	4: 118,893,551	L156S	probably benign	Het
Osbpl2	A	G	2: 180,137,080	N2S	probably benign	Het
Parp6	T	C	9: 59,630,612		probably benign	Het
Pcdhb5	T	A	18: 37,322,214	V549E	probably benign	Het
Pcnx4	T	C	12: 72,573,746	L780P	probably damaging	Het
Plcb3	A	T	19: 6,957,908	D851E	probably benign	Het
Ppfia2	A	G	10: 106,913,699	S1149G	probably damaging	Het
Prkca	A	G	11: 107,978,352	V469A	probably damaging	Het
Ryr1	A	T	7: 29,056,985	V3468D	probably damaging	Het
Stxbp4	A	G	11: 90,540,248	V412A	possibly damaging	Het
Wdr11	A	G	7: 129,607,913	M482V	probably benign	Het
Wdr72	T	C	9: 74,179,506		probably benign	Het
Xirp2	T	C	2: 67,509,677	L754P	probably damaging	Het
Zmym6	G	A	4: 127,124,106	G1135S	probably benign	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Posted On

2013-11-05