Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01457:Oit3'

84852

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oit3

Ensembl Gene

ENSMUSG00000009654

Gene Name

oncoprotein induced transcript 3

Synonyms

EF-9

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.211) question?

Stock #

IGL01457

Quality Score

Status

Chromosome

Chromosomal Location

59422958-59441778 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 59425484 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000123842 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009790] [ENSMUST00000009798] [ENSMUST00000162643]

AlphaFold

Q8R4V5

Predicted Effect

probably benign
Transcript: ENSMUST00000009790

SMART Domains

Protein: ENSMUSP00000009790
Gene: ENSMUSG00000009646

Domain	Start	End	E-Value	Type
Pfam:PLA2G12	12	195	1.5e-89	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000009798

SMART Domains

Protein: ENSMUSP00000009798
Gene: ENSMUSG00000009654

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Blast:ZP	50	144	9e-24	BLAST
EGF	150	181	2.16e1	SMART
EGF	185	222	2.94e-3	SMART
EGF	226	263	2.35e-2	SMART
ZP	267	516	2.74e-30	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162493

Predicted Effect

probably benign
Transcript: ENSMUST00000162643

SMART Domains

Protein: ENSMUSP00000123842
Gene: ENSMUSG00000009646

Domain	Start	End	E-Value	Type
Pfam:PLA2G12	1	77	1.7e-36	PFAM
low complexity region	90	101	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bloord uric acid, increased urine uric acid and polyuria. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	A	14: 32,660,951	Y1019F	probably benign	Het
4930455H04Rik	T	G	3: 116,968,551		probably benign	Het
4930548H24Rik	A	T	5: 31,487,427	I175L	probably benign	Het
4932415D10Rik	C	A	10: 82,284,734	K4147N	probably damaging	Het
9830107B12Rik	A	T	17: 48,128,583		probably benign	Het
Abcc8	A	G	7: 46,135,493	V737A	possibly damaging	Het
Adamts20	T	A	15: 94,331,448	Y930F	probably damaging	Het
Alkbh8	T	A	9: 3,369,825	F365I	probably damaging	Het
App	G	A	16: 85,103,239	H108Y	probably damaging	Het
Bfsp1	T	C	2: 143,827,644		probably benign	Het
Cabin1	T	C	10: 75,742,429	N478S	probably damaging	Het
Camsap3	G	A	8: 3,604,795	V796I	probably damaging	Het
Carns1	A	T	19: 4,166,499		probably null	Het
Clca1	C	T	3: 145,007,778	M697I	probably benign	Het
Cltc	C	T	11: 86,702,248	M1600I	probably benign	Het
Cnot1	T	A	8: 95,741,009	N1499Y	probably damaging	Het
Crebbp	T	A	16: 4,124,768	I196L	probably damaging	Het
Drc3	C	A	11: 60,358,649		probably benign	Het
Fam161a	T	A	11: 23,020,702	Y234*	probably null	Het
Il1r1	C	A	1: 40,313,170	P500Q	probably damaging	Het
Katnal1	G	T	5: 148,893,797		probably benign	Het
Klhdc2	A	G	12: 69,297,053	N20S	probably benign	Het
Kmt2e	A	T	5: 23,502,019	T1527S	possibly damaging	Het
Magi1	C	T	6: 93,747,224	G270D	probably damaging	Het
Mdn1	T	A	4: 32,715,922	S2035T	possibly damaging	Het
Mki67	A	T	7: 135,699,546	M1253K	probably benign	Het
Myh7	T	C	14: 54,988,879	M435V	possibly damaging	Het
Myh8	A	G	11: 67,292,679	I739V	probably benign	Het
Npnt	T	C	3: 132,885,982	K430R	probably damaging	Het
Nrd1	A	G	4: 109,047,660	N696S	probably benign	Het
Olfr1350	A	G	7: 6,570,212	T74A	probably benign	Het
Olfr478	A	T	7: 108,032,121	I74K	possibly damaging	Het
Olfr571	A	G	7: 102,909,719	I40T	possibly damaging	Het
Olfr642	A	G	7: 104,050,169	Y62H	probably damaging	Het
Pkd1	G	A	17: 24,594,821		probably null	Het
Plat	A	G	8: 22,776,828	M279V	probably benign	Het
Prkd1	A	T	12: 50,392,910	L378*	probably null	Het
Rasgef1a	C	T	6: 118,084,545	T157I	probably benign	Het
Rbm22	A	G	18: 60,560,857	N11S	probably damaging	Het
Ros1	T	C	10: 52,046,330		probably benign	Het
Sema6d	T	A	2: 124,653,642	F3Y	unknown	Het
Sis	T	C	3: 72,961,021	D112G	probably benign	Het
Slit1	C	A	19: 41,611,044	G1023C	probably damaging	Het
Sptb	T	C	12: 76,612,555		probably benign	Het
Sspo	T	C	6: 48,498,343	I4881T	probably benign	Het
Supt6	C	A	11: 78,221,143	D1038Y	probably damaging	Het
Tbc1d2b	A	T	9: 90,205,091	L945Q	probably damaging	Het
Tgfbr3	G	T	5: 107,149,898	A212E	probably damaging	Het
Tipin	A	G	9: 64,304,408	T259A	probably benign	Het
Traip	T	C	9: 107,970,472	S365P	probably benign	Het
Tst	T	C	15: 78,399,767	T287A	probably benign	Het
Tube1	C	T	10: 39,145,722		probably benign	Het
Uhrf1bp1l	T	C	10: 89,805,762	S932P	probably benign	Het
Vmn1r37	T	A	6: 66,731,409	N6K	probably damaging	Het
Vmn2r111	C	A	17: 22,571,985	E111*	probably null	Het
Vmn2r17	C	T	5: 109,453,032	T732I	probably benign	Het
Vmn2r69	A	T	7: 85,406,628	D767E	possibly damaging	Het

Other mutations in Oit3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01665:Oit3	APN	10	59438909	missense	probably damaging	1.00
IGL01839:Oit3	APN	10	59429496	missense	probably damaging	0.98
IGL02028:Oit3	APN	10	59438655	missense	probably damaging	0.98
PIT4585001:Oit3	UTSW	10	59431013	missense	possibly damaging	0.54
R0567:Oit3	UTSW	10	59435978	missense	probably damaging	0.99
R0781:Oit3	UTSW	10	59428194	missense	probably damaging	1.00
R1110:Oit3	UTSW	10	59428194	missense	probably damaging	1.00
R1563:Oit3	UTSW	10	59428074	missense	probably damaging	1.00
R1623:Oit3	UTSW	10	59428239	missense	probably damaging	0.99
R1693:Oit3	UTSW	10	59425417	missense	probably damaging	1.00
R1754:Oit3	UTSW	10	59427940	splice site	probably null
R1853:Oit3	UTSW	10	59441622	critical splice donor site	probably null
R2070:Oit3	UTSW	10	59431013	missense	probably benign	0.03
R2211:Oit3	UTSW	10	59428070	missense	probably damaging	1.00
R2516:Oit3	UTSW	10	59428345	missense	probably damaging	1.00
R2516:Oit3	UTSW	10	59441685	start gained	probably benign
R3103:Oit3	UTSW	10	59438891	missense	probably damaging	0.98
R4414:Oit3	UTSW	10	59428103	missense	probably damaging	1.00
R4415:Oit3	UTSW	10	59428103	missense	probably damaging	1.00
R4416:Oit3	UTSW	10	59428103	missense	probably damaging	1.00
R4417:Oit3	UTSW	10	59428103	missense	probably damaging	1.00
R4584:Oit3	UTSW	10	59425462	missense	probably damaging	1.00
R4734:Oit3	UTSW	10	59424082	missense	probably damaging	0.99
R4748:Oit3	UTSW	10	59424082	missense	probably damaging	0.99
R4749:Oit3	UTSW	10	59424082	missense	probably damaging	0.99
R5070:Oit3	UTSW	10	59424027	missense	probably damaging	1.00
R5521:Oit3	UTSW	10	59435914	missense	probably benign
R6326:Oit3	UTSW	10	59428239	missense	probably damaging	1.00
R6490:Oit3	UTSW	10	59438552	missense	possibly damaging	0.92
R6526:Oit3	UTSW	10	59429640	missense	probably damaging	1.00
R6766:Oit3	UTSW	10	59438712	missense	probably damaging	0.99
R6921:Oit3	UTSW	10	59435945	missense	probably damaging	0.99
R7129:Oit3	UTSW	10	59428344	missense	probably damaging	0.99
R7440:Oit3	UTSW	10	59429570	missense	probably damaging	0.99
R7495:Oit3	UTSW	10	59423943	missense	possibly damaging	0.74
R7512:Oit3	UTSW	10	59438894	missense	probably damaging	1.00
R7866:Oit3	UTSW	10	59424030	missense	probably benign	0.03
R8312:Oit3	UTSW	10	59438810	missense	probably benign	0.01
R8321:Oit3	UTSW	10	59428160	missense	probably benign	0.00
R8919:Oit3	UTSW	10	59441646	missense	unknown
R9131:Oit3	UTSW	10	59435929	missense	probably benign	0.01
R9457:Oit3	UTSW	10	59441683	start codon destroyed	unknown
R9478:Oit3	UTSW	10	59438642	missense	probably damaging	0.99
R9502:Oit3	UTSW	10	59428351	missense	probably damaging	1.00

Posted On

2013-11-11