Incidental Mutation 'IGL01626:Scaper'
ID 92718
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scaper
Ensembl Gene ENSMUSG00000034007
Gene Name S phase cyclin A-associated protein in the ER
Synonyms D530014O03Rik, Zfp291
Accession Numbers
Essential gene? Possibly essential (E-score: 0.591) question?
Stock # IGL01626
Quality Score
Status
Chromosome 9
Chromosomal Location 55549879-55938119 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 55912051 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 127 (V127M)
Ref Sequence ENSEMBL: ENSMUSP00000149750 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037408] [ENSMUST00000214747] [ENSMUST00000216595] [ENSMUST00000217647]
AlphaFold F8VQ70
Predicted Effect possibly damaging
Transcript: ENSMUST00000037408
AA Change: V127M

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000043411
Gene: ENSMUSG00000034007
AA Change: V127M

DomainStartEndE-ValueType
Pfam:SCAPER_N 88 185 3.4e-47 PFAM
low complexity region 323 338 N/A INTRINSIC
coiled coil region 415 466 N/A INTRINSIC
coiled coil region 535 597 N/A INTRINSIC
SCOP:d1eq1a_ 605 769 3e-6 SMART
ZnF_C2H2 791 815 1.16e1 SMART
low complexity region 866 883 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000214747
AA Change: V127M

PolyPhen 2 Score 0.556 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect unknown
Transcript: ENSMUST00000216595
AA Change: V127M
Predicted Effect possibly damaging
Transcript: ENSMUST00000217647
AA Change: V127M

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 A G 3: 60,019,174 (GRCm38) D188G probably damaging Het
AI314180 G A 4: 58,832,814 (GRCm38) probably benign Het
Aoc1 A G 6: 48,906,531 (GRCm38) Y447C probably damaging Het
Brd1 A T 15: 88,700,887 (GRCm38) L915M probably damaging Het
Cacna2d3 T A 14: 28,943,607 (GRCm38) E152D possibly damaging Het
Dnase2b A G 3: 146,584,616 (GRCm38) probably null Het
Fat4 T C 3: 38,951,032 (GRCm38) V1860A probably damaging Het
Fbxl5 C A 5: 43,758,705 (GRCm38) G455V probably benign Het
Fpr-rs4 G A 17: 18,022,231 (GRCm38) V167M probably damaging Het
Fut7 C A 2: 25,425,331 (GRCm38) Y153* probably null Het
Gnptab A G 10: 88,437,495 (GRCm38) T1045A probably damaging Het
Gucy1a1 T A 3: 82,108,619 (GRCm38) D354V probably damaging Het
Gucy2e A G 11: 69,232,855 (GRCm38) V406A possibly damaging Het
Herc2 T C 7: 56,085,142 (GRCm38) F160S probably benign Het
Ice2 T G 9: 69,407,332 (GRCm38) V42G probably benign Het
L3mbtl4 A G 17: 68,630,202 (GRCm38) Y406C probably damaging Het
Lepr C T 4: 101,733,534 (GRCm38) T103I probably benign Het
Ly75 T A 2: 60,301,015 (GRCm38) M1589L probably benign Het
Map4k3 A G 17: 80,605,809 (GRCm38) V644A probably damaging Het
Micall1 A G 15: 79,130,512 (GRCm38) D696G possibly damaging Het
Muc4 T C 16: 32,736,402 (GRCm38) V8A possibly damaging Het
Myo1h A G 5: 114,314,966 (GRCm38) D9G probably damaging Het
Nop14 T A 5: 34,649,345 (GRCm38) K472* probably null Het
Npat T A 9: 53,556,571 (GRCm38) D275E possibly damaging Het
Nt5c1b A G 12: 10,374,798 (GRCm38) T115A probably benign Het
Olfr429 A G 1: 174,089,556 (GRCm38) N172S probably damaging Het
Olfr709-ps1 A T 7: 106,927,420 (GRCm38) I13N probably benign Het
Pnpla7 T A 2: 25,050,893 (GRCm38) S1086T possibly damaging Het
Pold1 C T 7: 44,533,372 (GRCm38) probably null Het
Ppfia1 A G 7: 144,481,719 (GRCm38) F1165L probably benign Het
Prlr T A 15: 10,328,718 (GRCm38) D426E probably benign Het
Ptgs2 G A 1: 150,103,727 (GRCm38) R231H probably damaging Het
Rorc A G 3: 94,388,787 (GRCm38) D91G probably damaging Het
Sema3g A T 14: 31,221,727 (GRCm38) Y188F probably damaging Het
Slc45a3 G T 1: 131,978,987 (GRCm38) A400S possibly damaging Het
Slc9b2 C A 3: 135,336,395 (GRCm38) H478Q probably benign Het
Spg11 T A 2: 122,060,971 (GRCm38) H1973L probably damaging Het
Srgap3 A G 6: 112,773,648 (GRCm38) Y359H probably damaging Het
Stx16 T G 2: 174,094,020 (GRCm38) I248S probably damaging Het
Sytl3 A G 17: 6,735,440 (GRCm38) R287G probably damaging Het
Tiam1 T C 16: 89,812,968 (GRCm38) T82A probably damaging Het
Trpm1 T C 7: 64,268,889 (GRCm38) L659P probably damaging Het
Ttc13 G A 8: 124,673,738 (GRCm38) probably benign Het
Unc80 T C 1: 66,551,054 (GRCm38) probably null Het
Vldlr G T 19: 27,243,773 (GRCm38) R613L probably damaging Het
Wdr77 C T 3: 105,959,686 (GRCm38) R35* probably null Het
Zc3h14 T G 12: 98,779,186 (GRCm38) I478R possibly damaging Het
Zfp366 A G 13: 99,228,412 (GRCm38) H27R probably damaging Het
Other mutations in Scaper
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00653:Scaper APN 9 55,859,859 (GRCm38) missense probably damaging 0.99
IGL00912:Scaper APN 9 55,685,955 (GRCm38) missense probably damaging 1.00
IGL01469:Scaper APN 9 55,859,767 (GRCm38) missense probably damaging 1.00
IGL01779:Scaper APN 9 55,892,240 (GRCm38) missense probably benign 0.20
IGL02011:Scaper APN 9 55,580,322 (GRCm38) missense probably damaging 1.00
IGL02997:Scaper APN 9 55,815,499 (GRCm38) missense probably damaging 1.00
IGL03107:Scaper APN 9 55,858,402 (GRCm38) splice site probably benign
IGL03167:Scaper APN 9 55,859,824 (GRCm38) missense probably damaging 1.00
IGL03293:Scaper APN 9 55,874,823 (GRCm38) missense probably benign
IGL03340:Scaper APN 9 55,602,832 (GRCm38) missense possibly damaging 0.88
IGL03368:Scaper APN 9 55,656,027 (GRCm38) missense possibly damaging 0.53
R0111:Scaper UTSW 9 55,602,790 (GRCm38) missense probably benign 0.01
R0510:Scaper UTSW 9 55,758,062 (GRCm38) splice site probably benign
R0531:Scaper UTSW 9 55,609,874 (GRCm38) missense possibly damaging 0.91
R0558:Scaper UTSW 9 55,685,923 (GRCm38) missense probably benign 0.08
R0605:Scaper UTSW 9 55,815,518 (GRCm38) splice site probably benign
R0646:Scaper UTSW 9 55,758,056 (GRCm38) missense probably damaging 1.00
R0837:Scaper UTSW 9 55,859,042 (GRCm38) nonsense probably null
R1440:Scaper UTSW 9 55,602,918 (GRCm38) nonsense probably null
R1548:Scaper UTSW 9 55,816,670 (GRCm38) missense probably damaging 1.00
R1777:Scaper UTSW 9 55,864,546 (GRCm38) missense probably benign 0.33
R1822:Scaper UTSW 9 55,859,900 (GRCm38) missense probably damaging 0.99
R1834:Scaper UTSW 9 55,816,734 (GRCm38) missense possibly damaging 0.90
R1870:Scaper UTSW 9 55,685,938 (GRCm38) missense probably damaging 1.00
R2102:Scaper UTSW 9 55,912,050 (GRCm38) missense probably benign 0.43
R2168:Scaper UTSW 9 55,743,639 (GRCm38) missense probably damaging 1.00
R2174:Scaper UTSW 9 55,859,037 (GRCm38) missense probably null 0.01
R3690:Scaper UTSW 9 55,883,921 (GRCm38) missense probably benign 0.00
R4392:Scaper UTSW 9 55,858,115 (GRCm38) missense probably damaging 0.99
R4418:Scaper UTSW 9 55,838,180 (GRCm38) missense probably damaging 1.00
R4606:Scaper UTSW 9 55,655,903 (GRCm38) critical splice donor site probably null
R4643:Scaper UTSW 9 55,838,179 (GRCm38) missense probably damaging 0.99
R4665:Scaper UTSW 9 55,912,055 (GRCm38) missense probably damaging 1.00
R4739:Scaper UTSW 9 55,743,648 (GRCm38) missense probably damaging 1.00
R4921:Scaper UTSW 9 55,892,235 (GRCm38) missense probably benign 0.02
R4934:Scaper UTSW 9 55,809,175 (GRCm38) missense probably damaging 1.00
R4956:Scaper UTSW 9 55,838,142 (GRCm38) missense probably damaging 1.00
R5055:Scaper UTSW 9 55,859,719 (GRCm38) splice site probably null
R5107:Scaper UTSW 9 55,580,332 (GRCm38) missense probably damaging 1.00
R5155:Scaper UTSW 9 55,556,086 (GRCm38) missense probably null 1.00
R5265:Scaper UTSW 9 55,864,546 (GRCm38) missense probably benign
R5408:Scaper UTSW 9 55,586,224 (GRCm38) missense probably damaging 0.99
R5623:Scaper UTSW 9 55,864,507 (GRCm38) missense probably benign 0.02
R5665:Scaper UTSW 9 55,807,632 (GRCm38) missense probably damaging 1.00
R5748:Scaper UTSW 9 55,859,076 (GRCm38) critical splice acceptor site probably null
R5771:Scaper UTSW 9 55,816,791 (GRCm38) missense probably damaging 1.00
R6534:Scaper UTSW 9 55,883,976 (GRCm38) missense probably benign 0.00
R6557:Scaper UTSW 9 55,550,850 (GRCm38) missense probably benign 0.02
R6651:Scaper UTSW 9 55,858,504 (GRCm38) missense probably benign 0.05
R6796:Scaper UTSW 9 55,864,427 (GRCm38) missense probably benign 0.00
R6962:Scaper UTSW 9 55,859,771 (GRCm38) missense probably benign 0.01
R7145:Scaper UTSW 9 55,912,111 (GRCm38) missense unknown
R7199:Scaper UTSW 9 55,838,176 (GRCm38) nonsense probably null
R7356:Scaper UTSW 9 55,892,211 (GRCm38) missense unknown
R7426:Scaper UTSW 9 55,762,277 (GRCm38) nonsense probably null
R7503:Scaper UTSW 9 55,807,754 (GRCm38) missense probably damaging 0.98
R7844:Scaper UTSW 9 55,815,448 (GRCm38) missense probably benign 0.04
R7966:Scaper UTSW 9 55,762,327 (GRCm38) missense probably damaging 0.98
R7992:Scaper UTSW 9 55,858,154 (GRCm38) missense probably benign 0.02
R8081:Scaper UTSW 9 55,916,046 (GRCm38) missense unknown
R8189:Scaper UTSW 9 55,912,120 (GRCm38) missense probably damaging 1.00
R8294:Scaper UTSW 9 55,609,996 (GRCm38) missense possibly damaging 0.62
R8351:Scaper UTSW 9 55,816,804 (GRCm38) missense possibly damaging 0.92
R8451:Scaper UTSW 9 55,816,804 (GRCm38) missense possibly damaging 0.92
R8473:Scaper UTSW 9 55,550,847 (GRCm38) missense probably damaging 1.00
R8476:Scaper UTSW 9 55,762,291 (GRCm38) missense probably damaging 1.00
R8504:Scaper UTSW 9 55,864,438 (GRCm38) missense probably benign
R9058:Scaper UTSW 9 55,815,478 (GRCm38) missense probably damaging 1.00
R9071:Scaper UTSW 9 55,864,519 (GRCm38) missense probably benign
R9099:Scaper UTSW 9 55,762,332 (GRCm38) missense probably damaging 0.98
R9104:Scaper UTSW 9 55,912,116 (GRCm38) missense unknown
R9516:Scaper UTSW 9 55,685,991 (GRCm38) missense probably benign 0.05
R9685:Scaper UTSW 9 55,864,551 (GRCm38) missense probably benign 0.10
X0012:Scaper UTSW 9 55,655,930 (GRCm38) missense probably damaging 0.98
X0052:Scaper UTSW 9 55,816,664 (GRCm38) missense probably damaging 1.00
Z1176:Scaper UTSW 9 55,556,248 (GRCm38) missense probably damaging 1.00
Posted On 2013-12-09