Incidental Mutation 'R1859:Brd10'
ID 204273
Institutional Source Beutler Lab
Gene Symbol Brd10
Ensembl Gene ENSMUSG00000046138
Gene Name bromodomain containing 10
Synonyms 9930021J03Rik, Gm9832
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R1859 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 29691802-29783389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 29732323 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Glycine at position 230 (C230G)
Ref Sequence ENSEMBL: ENSMUSP00000135473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177155]
AlphaFold H3BKP8
Predicted Effect probably benign
Transcript: ENSMUST00000059484
AA Change: C297G

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000054060
Gene: ENSMUSG00000046138
AA Change: C297G

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 225 235 N/A INTRINSIC
coiled coil region 248 289 N/A INTRINSIC
low complexity region 347 365 N/A INTRINSIC
low complexity region 495 508 N/A INTRINSIC
coiled coil region 673 705 N/A INTRINSIC
low complexity region 722 756 N/A INTRINSIC
coiled coil region 764 796 N/A INTRINSIC
low complexity region 1146 1160 N/A INTRINSIC
internal_repeat_1 1164 1293 9.57e-8 PROSPERO
low complexity region 1295 1304 N/A INTRINSIC
low complexity region 1386 1415 N/A INTRINSIC
low complexity region 1468 1483 N/A INTRINSIC
low complexity region 1602 1624 N/A INTRINSIC
low complexity region 1647 1663 N/A INTRINSIC
low complexity region 1732 1745 N/A INTRINSIC
internal_repeat_1 1766 1910 9.57e-8 PROSPERO
low complexity region 1987 1993 N/A INTRINSIC
low complexity region 2013 2027 N/A INTRINSIC
low complexity region 2053 2071 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000175726
AA Change: C174G
Predicted Effect probably benign
Transcript: ENSMUST00000175764
SMART Domains Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 379 393 N/A INTRINSIC
internal_repeat_1 397 526 2.65e-5 PROSPERO
low complexity region 528 537 N/A INTRINSIC
low complexity region 619 648 N/A INTRINSIC
low complexity region 701 716 N/A INTRINSIC
low complexity region 835 857 N/A INTRINSIC
low complexity region 880 896 N/A INTRINSIC
low complexity region 965 978 N/A INTRINSIC
internal_repeat_1 999 1143 2.65e-5 PROSPERO
low complexity region 1220 1226 N/A INTRINSIC
low complexity region 1246 1260 N/A INTRINSIC
low complexity region 1286 1304 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176773
Predicted Effect possibly damaging
Transcript: ENSMUST00000177155
AA Change: C230G

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: C230G

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 205 219 N/A INTRINSIC
low complexity region 280 298 N/A INTRINSIC
low complexity region 428 441 N/A INTRINSIC
coiled coil region 606 638 N/A INTRINSIC
low complexity region 655 689 N/A INTRINSIC
coiled coil region 697 729 N/A INTRINSIC
low complexity region 1079 1093 N/A INTRINSIC
internal_repeat_1 1097 1226 1.32e-7 PROSPERO
low complexity region 1228 1237 N/A INTRINSIC
low complexity region 1319 1348 N/A INTRINSIC
low complexity region 1401 1416 N/A INTRINSIC
low complexity region 1535 1557 N/A INTRINSIC
low complexity region 1580 1596 N/A INTRINSIC
low complexity region 1665 1678 N/A INTRINSIC
internal_repeat_1 1699 1843 1.32e-7 PROSPERO
low complexity region 1920 1926 N/A INTRINSIC
low complexity region 1946 1960 N/A INTRINSIC
low complexity region 1986 2004 N/A INTRINSIC
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001K19Rik C T 12: 110,637,268 (GRCm39) probably benign Het
Adcy10 A G 1: 165,349,530 (GRCm39) E467G probably damaging Het
Alkbh8 A G 9: 3,385,499 (GRCm39) D597G probably benign Het
Alpk1 T A 3: 127,474,749 (GRCm39) H418L possibly damaging Het
Ano5 G T 7: 51,196,581 (GRCm39) V138L probably damaging Het
Aspg T A 12: 112,087,606 (GRCm39) I319K possibly damaging Het
Atp9b T C 18: 80,793,135 (GRCm39) T970A possibly damaging Het
C4b T A 17: 34,954,527 (GRCm39) M881L probably benign Het
Cd209c A T 8: 3,994,953 (GRCm39) N70K probably benign Het
Cdca5 T C 19: 6,140,124 (GRCm39) V95A possibly damaging Het
Cds2 A G 2: 132,144,115 (GRCm39) Y297C probably damaging Het
Celsr2 C T 3: 108,303,946 (GRCm39) G2371S probably damaging Het
Cemip2 T C 19: 21,825,341 (GRCm39) V1213A possibly damaging Het
Chd5 T A 4: 152,464,980 (GRCm39) I1557N probably benign Het
Cntn5 C T 9: 9,972,839 (GRCm39) E266K probably damaging Het
Crtam G A 9: 40,884,900 (GRCm39) T363M possibly damaging Het
Dnah2 A G 11: 69,328,712 (GRCm39) S3298P probably damaging Het
Dok1 A T 6: 83,009,226 (GRCm39) Y209N probably damaging Het
Dpp10 T C 1: 123,281,333 (GRCm39) D561G possibly damaging Het
Drosha A G 15: 12,878,804 (GRCm39) K710R probably benign Het
Dse T C 10: 34,029,225 (GRCm39) T622A probably benign Het
Duxf4 A G 10: 58,071,602 (GRCm39) V204A probably benign Het
Ercc6 T C 14: 32,248,735 (GRCm39) S429P probably damaging Het
Fam135a A T 1: 24,069,306 (GRCm39) V521E probably damaging Het
Fbxl7 A T 15: 26,543,279 (GRCm39) L456Q probably damaging Het
Fbxo38 A G 18: 62,648,489 (GRCm39) I683T probably damaging Het
Foxc2 G T 8: 121,843,364 (GRCm39) R4L probably damaging Het
Glyctk C T 9: 106,034,731 (GRCm39) V112I probably benign Het
Guf1 G T 5: 69,725,803 (GRCm39) G481* probably null Het
Heatr1 T C 13: 12,418,040 (GRCm39) L324S probably damaging Het
Hectd1 A G 12: 51,853,350 (GRCm39) L57P probably damaging Het
Hmcn1 A T 1: 150,532,944 (GRCm39) C3080S probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ifit1 T A 19: 34,624,944 (GRCm39) F27I probably benign Het
Ift20 G T 11: 78,430,860 (GRCm39) E68* probably null Het
Itsn1 A G 16: 91,686,042 (GRCm39) probably benign Het
Ksr2 T A 5: 117,553,006 (GRCm39) L38Q probably damaging Het
Lama2 A T 10: 26,907,078 (GRCm39) M2361K possibly damaging Het
Lrrc56 A G 7: 140,787,421 (GRCm39) M353V probably benign Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Map3k9 A T 12: 81,771,256 (GRCm39) S800R possibly damaging Het
Mef2a A G 7: 66,915,766 (GRCm39) S179P probably damaging Het
Micall1 A G 15: 79,007,145 (GRCm39) probably benign Het
Mpg A G 11: 32,181,957 (GRCm39) probably null Het
Mpp7 A T 18: 7,350,967 (GRCm39) *577K probably null Het
Msh4 G T 3: 153,611,517 (GRCm39) H35Q probably benign Het
Mst1 G A 9: 107,961,545 (GRCm39) V601I probably benign Het
Myh10 T A 11: 68,636,239 (GRCm39) N246K probably benign Het
Myom3 C A 4: 135,506,707 (GRCm39) N493K probably benign Het
Mypn T C 10: 62,981,969 (GRCm39) D537G probably benign Het
Ncan A T 8: 70,567,998 (GRCm39) M38K possibly damaging Het
Ndufaf6 G T 4: 11,053,474 (GRCm39) H277Q probably benign Het
Nos1 A T 5: 118,043,527 (GRCm39) N601Y possibly damaging Het
Nrxn2 G A 19: 6,538,825 (GRCm39) V794I probably benign Het
Or10q12 T A 19: 13,746,088 (GRCm39) Y127* probably null Het
Or13a17 T A 7: 140,271,571 (GRCm39) V251E possibly damaging Het
Or13c7b A T 4: 43,820,779 (GRCm39) I194N possibly damaging Het
Or2y17 T C 11: 49,232,211 (GRCm39) L284P probably damaging Het
Or8h9 T C 2: 86,789,425 (GRCm39) I126V probably damaging Het
Parp4 T C 14: 56,886,372 (GRCm39) V1817A unknown Het
Pfdn1 C A 18: 36,584,153 (GRCm39) M60I probably benign Het
Ppp1r3c T C 19: 36,711,011 (GRCm39) N253S probably damaging Het
Prdm5 A G 6: 65,808,263 (GRCm39) I42V probably benign Het
Prom2 T G 2: 127,383,017 (GRCm39) Q75P probably damaging Het
Ptpn23 T C 9: 110,217,938 (GRCm39) D669G possibly damaging Het
Rag1 T C 2: 101,474,407 (GRCm39) D245G probably benign Het
Rpl22l1 T A 3: 28,860,747 (GRCm39) probably null Het
Sars2 T C 7: 28,443,737 (GRCm39) V113A probably damaging Het
Sbno2 T A 10: 79,894,473 (GRCm39) K1067* probably null Het
Sec61g A G 11: 16,456,371 (GRCm39) probably null Het
Slc4a11 A T 2: 130,529,932 (GRCm39) M282K probably benign Het
Slc5a4a T C 10: 76,002,569 (GRCm39) S242P probably benign Het
Sparc A T 11: 55,297,334 (GRCm39) probably null Het
Thra T A 11: 98,646,977 (GRCm39) C33S probably damaging Het
Trrap A T 5: 144,767,761 (GRCm39) T2293S probably benign Het
Ttn T A 2: 76,724,989 (GRCm39) probably benign Het
Vat1l T A 8: 114,998,041 (GRCm39) V195E probably damaging Het
Vmn1r60 T A 7: 5,547,549 (GRCm39) I184F possibly damaging Het
Wdfy4 A G 14: 32,825,940 (GRCm39) I1192T probably damaging Het
Zbtb10 T C 3: 9,345,446 (GRCm39) S737P possibly damaging Het
Zfp553 A G 7: 126,834,517 (GRCm39) E24G probably benign Het
Zscan30 A G 18: 24,104,524 (GRCm39) noncoding transcript Het
Other mutations in Brd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Brd10 APN 19 29,731,420 (GRCm39) missense probably benign 0.33
IGL01535:Brd10 APN 19 29,731,212 (GRCm39) missense possibly damaging 0.53
IGL02019:Brd10 APN 19 29,694,463 (GRCm39) missense probably benign 0.28
IGL02034:Brd10 APN 19 29,694,259 (GRCm39) missense possibly damaging 0.73
IGL03114:Brd10 APN 19 29,694,532 (GRCm39) missense probably benign 0.18
IGL03382:Brd10 APN 19 29,694,676 (GRCm39) missense probably damaging 1.00
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0142:Brd10 UTSW 19 29,695,654 (GRCm39) missense possibly damaging 0.93
R0178:Brd10 UTSW 19 29,732,188 (GRCm39) missense probably damaging 1.00
R0453:Brd10 UTSW 19 29,731,068 (GRCm39) missense probably damaging 1.00
R0730:Brd10 UTSW 19 29,695,381 (GRCm39) missense probably benign 0.00
R0735:Brd10 UTSW 19 29,695,038 (GRCm39) missense possibly damaging 0.92
R0891:Brd10 UTSW 19 29,695,053 (GRCm39) missense probably damaging 1.00
R0894:Brd10 UTSW 19 29,697,974 (GRCm39) splice site probably benign
R1289:Brd10 UTSW 19 29,700,852 (GRCm39) missense probably benign 0.07
R1368:Brd10 UTSW 19 29,693,796 (GRCm39) missense probably damaging 0.97
R1387:Brd10 UTSW 19 29,700,853 (GRCm39) missense probably benign 0.15
R1483:Brd10 UTSW 19 29,696,745 (GRCm39) missense possibly damaging 0.93
R1526:Brd10 UTSW 19 29,712,545 (GRCm39) missense probably damaging 1.00
R1612:Brd10 UTSW 19 29,695,245 (GRCm39) missense possibly damaging 0.86
R1721:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1764:Brd10 UTSW 19 29,696,560 (GRCm39) missense possibly damaging 0.53
R1822:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1824:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1868:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1880:Brd10 UTSW 19 29,695,523 (GRCm39) missense probably benign 0.06
R1898:Brd10 UTSW 19 29,712,532 (GRCm39) missense possibly damaging 0.74
R1936:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1939:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1969:Brd10 UTSW 19 29,694,075 (GRCm39) missense possibly damaging 0.95
R2153:Brd10 UTSW 19 29,694,229 (GRCm39) missense probably benign 0.01
R2366:Brd10 UTSW 19 29,731,035 (GRCm39) missense probably damaging 0.99
R2379:Brd10 UTSW 19 29,696,275 (GRCm39) missense probably benign 0.01
R3107:Brd10 UTSW 19 29,700,847 (GRCm39) missense probably damaging 1.00
R4012:Brd10 UTSW 19 29,720,990 (GRCm39) missense probably damaging 1.00
R4222:Brd10 UTSW 19 29,696,149 (GRCm39) missense probably benign 0.18
R4328:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4329:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4387:Brd10 UTSW 19 29,782,715 (GRCm39) unclassified probably benign
R4688:Brd10 UTSW 19 29,694,501 (GRCm39) missense probably benign 0.33
R4796:Brd10 UTSW 19 29,731,018 (GRCm39) missense probably benign 0.33
R4820:Brd10 UTSW 19 29,695,809 (GRCm39) missense possibly damaging 0.53
R4832:Brd10 UTSW 19 29,694,616 (GRCm39) missense possibly damaging 0.53
R5056:Brd10 UTSW 19 29,694,759 (GRCm39) missense probably benign
R5150:Brd10 UTSW 19 29,782,950 (GRCm39) missense probably damaging 0.96
R5224:Brd10 UTSW 19 29,696,450 (GRCm39) missense possibly damaging 0.73
R5306:Brd10 UTSW 19 29,707,230 (GRCm39) intron probably benign
R5460:Brd10 UTSW 19 29,732,250 (GRCm39) missense probably damaging 0.98
R5477:Brd10 UTSW 19 29,731,518 (GRCm39) missense probably benign 0.33
R5531:Brd10 UTSW 19 29,731,072 (GRCm39) missense possibly damaging 0.73
R5559:Brd10 UTSW 19 29,694,363 (GRCm39) missense possibly damaging 0.91
R5647:Brd10 UTSW 19 29,731,210 (GRCm39) missense possibly damaging 0.73
R5886:Brd10 UTSW 19 29,696,677 (GRCm39) missense probably benign 0.03
R6029:Brd10 UTSW 19 29,732,367 (GRCm39) unclassified probably benign
R6240:Brd10 UTSW 19 29,694,640 (GRCm39) missense probably benign 0.18
R6331:Brd10 UTSW 19 29,695,147 (GRCm39) missense probably benign 0.33
R6456:Brd10 UTSW 19 29,693,914 (GRCm39) missense possibly damaging 0.93
R6584:Brd10 UTSW 19 29,696,128 (GRCm39) missense possibly damaging 0.53
R6661:Brd10 UTSW 19 29,700,864 (GRCm39) missense possibly damaging 0.53
R6991:Brd10 UTSW 19 29,696,508 (GRCm39) missense possibly damaging 0.86
R7059:Brd10 UTSW 19 29,696,945 (GRCm39) missense probably benign 0.33
R7128:Brd10 UTSW 19 29,693,881 (GRCm39) missense possibly damaging 0.53
R7211:Brd10 UTSW 19 29,763,712 (GRCm39) missense
R7471:Brd10 UTSW 19 29,707,139 (GRCm39) splice site probably null
R7686:Brd10 UTSW 19 29,694,870 (GRCm39) missense probably benign 0.34
R8012:Brd10 UTSW 19 29,695,534 (GRCm39) missense possibly damaging 0.73
R8203:Brd10 UTSW 19 29,693,443 (GRCm39) missense probably benign 0.18
R8353:Brd10 UTSW 19 29,731,242 (GRCm39) missense possibly damaging 0.53
R8672:Brd10 UTSW 19 29,731,564 (GRCm39) missense probably benign
R8755:Brd10 UTSW 19 29,693,890 (GRCm39) missense probably benign 0.03
R8918:Brd10 UTSW 19 29,696,841 (GRCm39) missense possibly damaging 0.53
R8954:Brd10 UTSW 19 29,696,126 (GRCm39) missense possibly damaging 0.72
R9038:Brd10 UTSW 19 29,731,900 (GRCm39) missense possibly damaging 0.86
R9195:Brd10 UTSW 19 29,763,703 (GRCm39) missense
R9204:Brd10 UTSW 19 29,696,938 (GRCm39) missense possibly damaging 0.73
R9518:Brd10 UTSW 19 29,731,541 (GRCm39) missense possibly damaging 0.53
R9743:Brd10 UTSW 19 29,694,261 (GRCm39) missense probably benign
R9747:Brd10 UTSW 19 29,731,911 (GRCm39) missense possibly damaging 0.73
RF011:Brd10 UTSW 19 29,721,009 (GRCm39) missense possibly damaging 0.53
X0027:Brd10 UTSW 19 29,712,599 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CGATGTAAGGTAGGTCTGCG -3'
(R):5'- ACAGCATACTTTTAATGGGGCAC -3'

Sequencing Primer
(F):5'- AAGGTAGGTCTGCGATGGG -3'
(R):5'- TTTACTGATGTGGAAAAGTAGAACAG -3'
Posted On 2014-06-23