Incidental Mutation 'R3878:Nlrp4g'
| ID |
276950 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nlrp4g
|
| Ensembl Gene |
ENSMUSG00000079741 |
| Gene Name |
NLR family, pyrin domain containing 4G |
| Synonyms |
nalp4g |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R3878 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
124117991-124126089 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
A to G
at 124349362 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000067621
|
| SMART Domains |
Protein: ENSMUSP00000065508
Gene: ENSMUSG00000079741
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:NACHT
|
69 |
238 |
1.5e-39 |
PFAM |
|
Blast:LRR
|
555 |
582 |
9e-10 |
BLAST |
|
Blast:LRR
|
610 |
637 |
7e-10 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214229
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215276
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215602
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216416
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000217178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000217183
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700020A23Rik |
C |
T |
2: 130,247,560 (GRCm39) |
T32M |
probably benign |
Het |
| A2ml1 |
T |
C |
6: 128,531,324 (GRCm39) |
S915G |
probably benign |
Het |
| Ablim1 |
T |
C |
19: 57,025,642 (GRCm39) |
|
probably null |
Het |
| Atosb |
T |
G |
4: 43,035,867 (GRCm39) |
H288P |
probably damaging |
Het |
| Cadm2 |
C |
T |
16: 66,612,329 (GRCm39) |
E78K |
probably damaging |
Het |
| Ceacam5 |
C |
T |
7: 17,484,506 (GRCm39) |
P416L |
probably damaging |
Het |
| Chsy3 |
T |
C |
18: 59,542,845 (GRCm39) |
F661S |
probably damaging |
Het |
| Clstn3 |
G |
A |
6: 124,434,901 (GRCm39) |
T338I |
probably damaging |
Het |
| Ctif |
A |
G |
18: 75,653,048 (GRCm39) |
I403T |
probably damaging |
Het |
| Dnaaf9 |
T |
C |
2: 130,620,423 (GRCm39) |
R237G |
possibly damaging |
Het |
| Eprs1 |
T |
A |
1: 185,148,150 (GRCm39) |
|
probably null |
Het |
| Frs2 |
A |
C |
10: 116,914,815 (GRCm39) |
S35A |
probably benign |
Het |
| Gpr155 |
C |
T |
2: 73,198,736 (GRCm39) |
W394* |
probably null |
Het |
| Ift140 |
G |
A |
17: 25,247,918 (GRCm39) |
V259M |
probably benign |
Het |
| Igkv9-124 |
A |
T |
6: 67,919,191 (GRCm39) |
S74T |
probably benign |
Het |
| Krt14 |
C |
T |
11: 100,097,915 (GRCm39) |
V123M |
possibly damaging |
Het |
| Mcm2 |
G |
A |
6: 88,869,990 (GRCm39) |
R60C |
probably damaging |
Het |
| Nebl |
T |
C |
2: 17,398,063 (GRCm39) |
T457A |
possibly damaging |
Het |
| Nsa2 |
C |
G |
13: 97,268,542 (GRCm39) |
G175A |
probably benign |
Het |
| Or8k40 |
T |
C |
2: 86,584,972 (GRCm39) |
T37A |
probably benign |
Het |
| Pax1 |
A |
T |
2: 147,204,228 (GRCm39) |
|
probably benign |
Het |
| Pdzd2 |
T |
C |
15: 12,376,262 (GRCm39) |
E1291G |
probably benign |
Het |
| Relb |
G |
A |
7: 19,351,769 (GRCm39) |
H115Y |
probably damaging |
Het |
| Rnase10 |
A |
G |
14: 51,246,889 (GRCm39) |
E52G |
probably damaging |
Het |
| Sla2 |
G |
A |
2: 156,717,862 (GRCm39) |
R137C |
probably damaging |
Het |
| Slc14a2 |
C |
T |
18: 78,202,289 (GRCm39) |
V614I |
probably benign |
Het |
| Slc20a2 |
T |
C |
8: 23,058,399 (GRCm39) |
L645P |
possibly damaging |
Het |
| Smoc2 |
A |
G |
17: 14,545,879 (GRCm39) |
D56G |
probably damaging |
Het |
| Szt2 |
A |
G |
4: 118,247,782 (GRCm39) |
S789P |
probably damaging |
Het |
| Tenm2 |
A |
G |
11: 36,030,401 (GRCm39) |
|
probably null |
Het |
| Tm9sf3 |
A |
G |
19: 41,235,152 (GRCm39) |
V169A |
probably damaging |
Het |
| Trbv13-1 |
C |
T |
6: 41,093,322 (GRCm39) |
T86I |
probably benign |
Het |
| Trim24 |
A |
G |
6: 37,941,708 (GRCm39) |
D886G |
probably benign |
Het |
| Trim33 |
A |
G |
3: 103,259,321 (GRCm39) |
I1003M |
probably damaging |
Het |
| Trim37 |
T |
C |
11: 87,096,828 (GRCm39) |
V777A |
probably benign |
Het |
| Ttc7 |
A |
C |
17: 87,678,166 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
C |
2: 76,596,364 (GRCm39) |
D11856G |
possibly damaging |
Het |
| Vmn1r226 |
A |
T |
17: 20,908,260 (GRCm39) |
D164V |
possibly damaging |
Het |
| Vmn1r34 |
G |
A |
6: 66,614,552 (GRCm39) |
T62I |
possibly damaging |
Het |
| Wapl |
T |
C |
14: 34,414,104 (GRCm39) |
L322P |
probably damaging |
Het |
| Zfp62 |
A |
G |
11: 49,105,960 (GRCm39) |
D17G |
probably damaging |
Het |
|
| Other mutations in Nlrp4g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01066:Nlrp4g
|
APN |
9 |
124,349,526 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL01087:Nlrp4g
|
APN |
9 |
124,353,858 (GRCm38) |
critical splice acceptor site |
noncoding transcript |
|
|
IGL01106:Nlrp4g
|
APN |
9 |
124,350,452 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL01938:Nlrp4g
|
APN |
9 |
124,349,068 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL02088:Nlrp4g
|
APN |
9 |
124,350,453 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL02170:Nlrp4g
|
APN |
9 |
124,348,980 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL02582:Nlrp4g
|
APN |
9 |
124,349,764 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL02588:Nlrp4g
|
APN |
9 |
124,348,843 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL02931:Nlrp4g
|
APN |
9 |
124,348,940 (GRCm38) |
unclassified |
noncoding transcript |
|
|
IGL03111:Nlrp4g
|
APN |
9 |
124,353,978 (GRCm38) |
exon |
noncoding transcript |
|
|
IGL03373:Nlrp4g
|
APN |
9 |
124,349,853 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R0617:Nlrp4g
|
UTSW |
9 |
124,349,540 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R1419:Nlrp4g
|
UTSW |
9 |
124,349,434 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R2060:Nlrp4g
|
UTSW |
9 |
124,349,693 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R2152:Nlrp4g
|
UTSW |
9 |
124,353,339 (GRCm38) |
exon |
noncoding transcript |
|
|
R2356:Nlrp4g
|
UTSW |
9 |
124,349,306 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R2384:Nlrp4g
|
UTSW |
9 |
124,349,707 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R2698:Nlrp4g
|
UTSW |
9 |
124,349,630 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R4640:Nlrp4g
|
UTSW |
9 |
124,349,153 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R4745:Nlrp4g
|
UTSW |
9 |
124,349,515 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R4754:Nlrp4g
|
UTSW |
9 |
124,349,788 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R4937:Nlrp4g
|
UTSW |
9 |
124,354,005 (GRCm38) |
exon |
noncoding transcript |
|
|
R5024:Nlrp4g
|
UTSW |
9 |
124,350,155 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R5162:Nlrp4g
|
UTSW |
9 |
124,350,394 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R5407:Nlrp4g
|
UTSW |
9 |
124,349,930 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R5521:Nlrp4g
|
UTSW |
9 |
124,350,020 (GRCm38) |
unclassified |
noncoding transcript |
|
|
R8224:Nlrp4g
|
UTSW |
9 |
124,353,374 (GRCm38) |
missense |
noncoding transcript |
|
|
R8259:Nlrp4g
|
UTSW |
9 |
124,353,392 (GRCm38) |
missense |
noncoding transcript |
|
|
Z1088:Nlrp4g
|
UTSW |
9 |
124,349,201 (GRCm38) |
unclassified |
noncoding transcript |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTGAAGACAGCCAGCCTTG -3'
(R):5'- CACCAAACTGAAGGCCTCTTG -3'
Sequencing Primer
(F):5'- GCTGAACTTATCTCCAGAGAGTG -3'
(R):5'- GGGCTCTGATCTTATCTTGGAAC -3'
|
| Posted On |
2015-04-06 |
Incidental Mutation