Incidental Mutation 'R4429:Mrps10'
ID 328353
Institutional Source Beutler Lab
Gene Symbol Mrps10
Ensembl Gene ENSMUSG00000034729
Gene Name mitochondrial ribosomal protein S10
Synonyms Rpms10, 1110038B19Rik
MMRRC Submission 041699-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.931) question?
Stock # R4429 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 47679812-47692342 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 47689124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060752] [ENSMUST00000060752] [ENSMUST00000119841] [ENSMUST00000119945] [ENSMUST00000120737] [ENSMUST00000125963]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000060752
SMART Domains Protein: ENSMUSP00000055301
Gene: ENSMUSG00000034729

DomainStartEndE-ValueType
Pfam:Ribosomal_S10 35 133 9.8e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000060752
SMART Domains Protein: ENSMUSP00000055301
Gene: ENSMUSG00000034729

DomainStartEndE-ValueType
Pfam:Ribosomal_S10 35 133 9.8e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000119841
SMART Domains Protein: ENSMUSP00000112740
Gene: ENSMUSG00000034729

DomainStartEndE-ValueType
Pfam:Ribosomal_S10 35 133 9.8e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000119945
SMART Domains Protein: ENSMUSP00000113343
Gene: ENSMUSG00000034729

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
Pfam:Ribosomal_S10 77 173 3.1e-27 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000120737
SMART Domains Protein: ENSMUSP00000113460
Gene: ENSMUSG00000034729

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
Pfam:Ribosomal_S10 75 173 1.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125963
SMART Domains Protein: ENSMUSP00000116184
Gene: ENSMUSG00000034729

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
low complexity region 37 55 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135418
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136061
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152497
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141699
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154039
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143725
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Abca5 T C 11: 110,202,236 (GRCm39) T390A probably benign Het
Ahcyl2 T G 6: 29,894,874 (GRCm39) V452G probably damaging Het
Ano4 T A 10: 88,828,804 (GRCm39) N545I probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Catip T A 1: 74,407,891 (GRCm39) probably benign Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Cnpy3 T A 17: 47,058,070 (GRCm39) Q111L probably benign Het
Dnah8 A G 17: 30,971,120 (GRCm39) N2725D probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Ephb3 G A 16: 21,033,213 (GRCm39) E66K probably damaging Het
Gm6594 T A 17: 82,846,923 (GRCm39) D79E probably benign Het
Gtf2e2 T A 8: 34,242,521 (GRCm39) Y74* probably null Het
Hacd4 A T 4: 88,353,184 (GRCm39) F103I possibly damaging Het
Hap1 T C 11: 100,245,098 (GRCm39) T38A probably benign Het
Havcr2 T A 11: 46,347,387 (GRCm39) D72E probably damaging Het
Iqcg G A 16: 32,839,860 (GRCm39) T362I probably benign Het
Lect2 C T 13: 56,693,538 (GRCm39) probably null Het
Lemd3 T C 10: 120,813,893 (GRCm39) T447A probably benign Het
Lrrc72 T C 12: 36,258,623 (GRCm39) N78S probably damaging Het
Map3k14 A G 11: 103,118,410 (GRCm39) L592P probably damaging Het
Meioc T C 11: 102,566,546 (GRCm39) Y721H probably damaging Het
Myo5c A G 9: 75,201,283 (GRCm39) Y1406C probably damaging Het
Myo7a T C 7: 97,702,395 (GRCm39) Y2098C probably damaging Het
Nol9 C T 4: 152,125,631 (GRCm39) T194I probably damaging Het
Nox3 G A 17: 3,733,233 (GRCm39) T206I probably benign Het
Nsd2 T G 5: 34,000,546 (GRCm39) M21R probably damaging Het
Pcdh9 T C 14: 94,124,820 (GRCm39) N327S probably damaging Het
Pclo T G 5: 14,728,114 (GRCm39) probably benign Het
Pparg T A 6: 115,416,984 (GRCm39) M59K probably benign Het
Prag1 A G 8: 36,613,796 (GRCm39) K1116R probably damaging Het
Rhbdf1 C T 11: 32,163,369 (GRCm39) E368K probably benign Het
Rita1 A G 5: 120,747,626 (GRCm39) V224A probably damaging Het
Rsph6a T A 7: 18,807,988 (GRCm39) W384R probably damaging Het
Scn1a A T 2: 66,181,329 (GRCm39) Y65N possibly damaging Het
Serpina5 C A 12: 104,069,665 (GRCm39) F292L probably benign Het
Sf3b3 A C 8: 111,552,750 (GRCm39) L511V probably benign Het
Siglecg C T 7: 43,067,350 (GRCm39) P639L possibly damaging Het
Slc12a3 A T 8: 95,069,713 (GRCm39) I541F probably damaging Het
Slco6d1 T C 1: 98,424,091 (GRCm39) V581A possibly damaging Het
Sptbn2 T C 19: 4,788,383 (GRCm39) Y1121H probably damaging Het
Sytl5 A T X: 9,826,262 (GRCm39) N412Y probably damaging Het
Timm29 G C 9: 21,504,775 (GRCm39) A148P probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem67 T A 4: 12,051,473 (GRCm39) N785I possibly damaging Het
Trhde A T 10: 114,339,028 (GRCm39) L594Q probably damaging Het
Uba6 C T 5: 86,268,406 (GRCm39) V941I probably damaging Het
Vmn1r174 T C 7: 23,453,565 (GRCm39) V77A probably benign Het
Zfp661 A G 2: 127,420,628 (GRCm39) V57A probably damaging Het
Zfp867 C T 11: 59,355,863 (GRCm39) D64N possibly damaging Het
Zp3r T C 1: 130,519,128 (GRCm39) T294A possibly damaging Het
Other mutations in Mrps10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02536:Mrps10 APN 17 47,685,928 (GRCm39) missense probably damaging 1.00
BB001:Mrps10 UTSW 17 47,689,208 (GRCm39) makesense probably null
BB011:Mrps10 UTSW 17 47,689,208 (GRCm39) makesense probably null
R0746:Mrps10 UTSW 17 47,683,564 (GRCm39) missense probably benign 0.36
R1872:Mrps10 UTSW 17 47,683,377 (GRCm39) missense possibly damaging 0.82
R5617:Mrps10 UTSW 17 47,689,167 (GRCm39) missense probably benign 0.19
R6752:Mrps10 UTSW 17 47,688,740 (GRCm39) missense probably damaging 1.00
R7131:Mrps10 UTSW 17 47,685,940 (GRCm39) missense probably damaging 0.98
R7385:Mrps10 UTSW 17 47,689,146 (GRCm39) missense probably damaging 1.00
R7924:Mrps10 UTSW 17 47,689,208 (GRCm39) makesense probably null
R8525:Mrps10 UTSW 17 47,683,371 (GRCm39) missense probably damaging 1.00
R9324:Mrps10 UTSW 17 47,686,903 (GRCm39) nonsense probably null
R9752:Mrps10 UTSW 17 47,683,572 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GGGATCAGACAGCTTACACAC -3'
(R):5'- CTGCTATAGAGAACAGGTACAGC -3'

Sequencing Primer
(F):5'- GACAGCTTACACACTGGCCTTTATTC -3'
(R):5'- AACAGGTACAGCGGTGCTTC -3'
Posted On 2015-07-07