Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00095:Vmn2r28'

1539

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r28

Ensembl Gene

ENSMUSG00000066820

Gene Name

vomeronasal 2, receptor 28

Synonyms

EG665255

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL00095

Quality Score

Status

Chromosome

Chromosomal Location

5483455-5496850 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 5491068 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 393 (D393G)

Ref Sequence

ENSEMBL: ENSMUSP00000083477 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086297]

AlphaFold

L7N203

Predicted Effect

probably benign
Transcript: ENSMUST00000086297
AA Change: D393G

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000083477
Gene: ENSMUSG00000066820
AA Change: D393G

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	470	1.7e-26	PFAM
Pfam:NCD3G	512	565	9.8e-21	PFAM
Pfam:7tm_3	598	833	2.8e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cadm2	A	T	16: 66,679,639 (GRCm39)	Y65N	probably damaging	Het
Catsperg2	C	A	7: 29,397,483 (GRCm39)	C1042F	possibly damaging	Het
Cluh	T	C	11: 74,554,890 (GRCm39)	V776A	probably benign	Het
Crxos	T	A	7: 15,632,543 (GRCm39)	C116*	probably null	Het
Csmd1	A	G	8: 16,059,297 (GRCm39)		probably benign	Het
Cubn	C	A	2: 13,496,631 (GRCm39)		probably benign	Het
Exoc2	A	G	13: 31,004,609 (GRCm39)	I858T	probably benign	Het
Frmpd1	C	A	4: 45,279,456 (GRCm39)	T727K	possibly damaging	Het
Hapln3	T	C	7: 78,771,731 (GRCm39)	T53A	probably damaging	Het
Hnrnpul1	T	A	7: 25,425,579 (GRCm39)	Q584L	possibly damaging	Het
Ikbkb	A	T	8: 23,196,127 (GRCm39)	F26I	probably damaging	Het
Il31ra	A	T	13: 112,684,012 (GRCm39)	I120N	possibly damaging	Het
Itih1	C	T	14: 30,651,778 (GRCm39)	V855M	probably benign	Het
Krtap4-16	A	G	11: 99,742,032 (GRCm39)	S123P	possibly damaging	Het
Large1	C	T	8: 73,564,125 (GRCm39)	R547Q	probably damaging	Het
Madd	A	G	2: 91,006,111 (GRCm39)		probably benign	Het
Mark1	A	G	1: 184,630,800 (GRCm39)	V770A	probably damaging	Het
Mpeg1	T	C	19: 12,440,074 (GRCm39)	F511L	probably benign	Het
Mrgpra9	A	G	7: 46,884,839 (GRCm39)	V276A	possibly damaging	Het
Nav3	T	C	10: 109,677,594 (GRCm39)	T666A	probably damaging	Het
Ndufa8	T	C	2: 35,934,467 (GRCm39)	D37G	probably damaging	Het
Nlrx1	A	G	9: 44,164,576 (GRCm39)	L956P	probably damaging	Het
Nr5a1	T	C	2: 38,598,353 (GRCm39)	E148G	probably benign	Het
Or10ab5	A	T	7: 108,245,043 (GRCm39)	F247I	possibly damaging	Het
Or14c46	T	C	7: 85,918,877 (GRCm39)	N40S	probably damaging	Het
Otulinl	A	G	15: 27,658,202 (GRCm39)	S273P	possibly damaging	Het
Patj	A	C	4: 98,423,799 (GRCm39)	Q1184P	possibly damaging	Het
Phf20l1	A	G	15: 66,500,884 (GRCm39)	T619A	probably benign	Het
Pla2g6	T	C	15: 79,173,441 (GRCm39)	T643A	probably damaging	Het
Pramel42	T	C	5: 94,685,663 (GRCm39)	L441P	probably damaging	Het
Radil	A	G	5: 142,483,677 (GRCm39)	S510P	probably damaging	Het
Spock1	A	G	13: 57,735,552 (GRCm39)		probably benign	Het
Stag3	C	T	5: 138,297,400 (GRCm39)	T577M	probably damaging	Het
Tap2	C	T	17: 34,434,352 (GRCm39)	R613C	probably benign	Het
Tnn	A	G	1: 159,953,021 (GRCm39)	V673A	possibly damaging	Het
Trrap	T	C	5: 144,716,784 (GRCm39)		probably benign	Het
Zbtb48	T	C	4: 152,105,851 (GRCm39)	H418R	probably damaging	Het
Zc3h12d	T	C	10: 7,738,231 (GRCm39)	V179A	probably damaging	Het

Other mutations in Vmn2r28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01061:Vmn2r28	APN	7	5,491,183 (GRCm39)	missense	probably damaging	1.00
IGL01160:Vmn2r28	APN	7	5,489,477 (GRCm39)	missense	probably damaging	0.99
IGL01335:Vmn2r28	APN	7	5,484,087 (GRCm39)	missense	possibly damaging	0.67
IGL01532:Vmn2r28	APN	7	5,489,463 (GRCm39)	missense	probably benign	0.16
IGL01791:Vmn2r28	APN	7	5,491,161 (GRCm39)	missense	probably benign	0.00
IGL01875:Vmn2r28	APN	7	5,484,302 (GRCm39)	missense	probably benign	0.30
IGL02161:Vmn2r28	APN	7	5,491,123 (GRCm39)	missense	possibly damaging	0.88
IGL02499:Vmn2r28	APN	7	5,493,568 (GRCm39)	missense	probably damaging	0.98
IGL02858:Vmn2r28	APN	7	5,484,003 (GRCm39)	missense	probably damaging	0.99
IGL03061:Vmn2r28	APN	7	5,487,015 (GRCm39)	missense	probably damaging	0.98
G1patch:Vmn2r28	UTSW	7	5,491,408 (GRCm39)	missense	probably benign	0.13
R0288:Vmn2r28	UTSW	7	5,491,020 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r28	UTSW	7	5,496,715 (GRCm39)	missense	probably benign	0.00
R0396:Vmn2r28	UTSW	7	5,491,513 (GRCm39)	missense	probably benign	0.05
R0480:Vmn2r28	UTSW	7	5,493,456 (GRCm39)	missense	probably benign	0.00
R0485:Vmn2r28	UTSW	7	5,491,689 (GRCm39)	missense	probably damaging	1.00
R0837:Vmn2r28	UTSW	7	5,491,026 (GRCm39)	missense	probably damaging	0.99
R1282:Vmn2r28	UTSW	7	5,484,301 (GRCm39)	missense	probably damaging	0.99
R1296:Vmn2r28	UTSW	7	5,484,544 (GRCm39)	missense	possibly damaging	0.81
R1829:Vmn2r28	UTSW	7	5,496,810 (GRCm39)	missense	probably benign
R1853:Vmn2r28	UTSW	7	5,484,246 (GRCm39)	nonsense	probably null
R1869:Vmn2r28	UTSW	7	5,489,345 (GRCm39)	missense	probably benign	0.00
R1887:Vmn2r28	UTSW	7	5,491,288 (GRCm39)	missense	possibly damaging	0.90
R1961:Vmn2r28	UTSW	7	5,484,070 (GRCm39)	missense	possibly damaging	0.85
R1998:Vmn2r28	UTSW	7	5,491,313 (GRCm39)	missense	possibly damaging	0.87
R2392:Vmn2r28	UTSW	7	5,487,130 (GRCm39)	missense	probably damaging	0.98
R2432:Vmn2r28	UTSW	7	5,491,701 (GRCm39)	missense	probably damaging	0.99
R3055:Vmn2r28	UTSW	7	5,484,391 (GRCm39)	missense	probably damaging	0.98
R3753:Vmn2r28	UTSW	7	5,491,026 (GRCm39)	missense	probably damaging	0.99
R3877:Vmn2r28	UTSW	7	5,491,357 (GRCm39)	missense	probably damaging	1.00
R4307:Vmn2r28	UTSW	7	5,493,707 (GRCm39)	missense	probably damaging	0.99
R5023:Vmn2r28	UTSW	7	5,489,463 (GRCm39)	missense	probably benign	0.16
R5057:Vmn2r28	UTSW	7	5,489,463 (GRCm39)	missense	probably benign	0.16
R5083:Vmn2r28	UTSW	7	5,483,671 (GRCm39)	missense	possibly damaging	0.77
R5427:Vmn2r28	UTSW	7	5,489,376 (GRCm39)	missense	probably damaging	0.99
R5472:Vmn2r28	UTSW	7	5,490,943 (GRCm39)	critical splice donor site	probably null
R5511:Vmn2r28	UTSW	7	5,487,011 (GRCm39)	missense	possibly damaging	0.61
R5731:Vmn2r28	UTSW	7	5,491,668 (GRCm39)	missense	probably benign	0.41
R6091:Vmn2r28	UTSW	7	5,496,790 (GRCm39)	missense	possibly damaging	0.88
R6179:Vmn2r28	UTSW	7	5,491,003 (GRCm39)	nonsense	probably null
R6276:Vmn2r28	UTSW	7	5,493,730 (GRCm39)	missense	probably benign	0.01
R6441:Vmn2r28	UTSW	7	5,491,474 (GRCm39)	missense	probably benign	0.00
R6463:Vmn2r28	UTSW	7	5,489,435 (GRCm39)	missense	probably benign	0.07
R6528:Vmn2r28	UTSW	7	5,493,684 (GRCm39)	missense	probably benign	0.12
R6725:Vmn2r28	UTSW	7	5,491,408 (GRCm39)	missense	probably benign	0.13
R6760:Vmn2r28	UTSW	7	5,484,229 (GRCm39)	missense	probably damaging	0.97
R6849:Vmn2r28	UTSW	7	5,483,806 (GRCm39)	missense	probably damaging	1.00
R7110:Vmn2r28	UTSW	7	5,493,733 (GRCm39)	missense	probably benign	0.06
R7146:Vmn2r28	UTSW	7	5,484,495 (GRCm39)	missense	probably benign	0.05
R7407:Vmn2r28	UTSW	7	5,484,308 (GRCm39)	missense	probably damaging	1.00
R7563:Vmn2r28	UTSW	7	5,491,200 (GRCm39)	missense	probably benign	0.00
R7611:Vmn2r28	UTSW	7	5,484,255 (GRCm39)	missense	probably benign	0.02
R7808:Vmn2r28	UTSW	7	5,496,678 (GRCm39)	missense	probably damaging	0.98
R7862:Vmn2r28	UTSW	7	5,493,613 (GRCm39)	missense	probably benign	0.00
R7916:Vmn2r28	UTSW	7	5,483,818 (GRCm39)	missense	probably damaging	1.00
R8183:Vmn2r28	UTSW	7	5,491,147 (GRCm39)	missense	probably damaging	1.00
R8334:Vmn2r28	UTSW	7	5,487,059 (GRCm39)	missense	probably damaging	1.00
R8519:Vmn2r28	UTSW	7	5,489,347 (GRCm39)	missense	probably benign	0.31
R8989:Vmn2r28	UTSW	7	5,493,473 (GRCm39)	missense	probably benign	0.00
R9066:Vmn2r28	UTSW	7	5,491,596 (GRCm39)	missense	probably damaging	1.00
R9422:Vmn2r28	UTSW	7	5,483,747 (GRCm39)	missense	probably damaging	1.00
R9469:Vmn2r28	UTSW	7	5,487,118 (GRCm39)	missense	probably damaging	0.99
R9608:Vmn2r28	UTSW	7	5,491,220 (GRCm39)	missense	probably benign	0.05

Posted On

2011-07-12