Mutagenetix > Incidental Mutation

Incidental Mutation 'R1637:Cyp2c37'

173275

Institutional Source

Beutler Lab

Gene Symbol

Cyp2c37

Ensembl Gene

ENSMUSG00000042248

Gene Name

cytochrome P450, family 2. subfamily c, polypeptide 37

Synonyms

MMRRC Submission

039673-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.104) question?

Stock #

R1637 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

39992424-40012243 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 40001982 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 375 (K375*)

Ref Sequence

ENSEMBL: ENSMUSP00000045362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049178]

AlphaFold

P56654

Predicted Effect

probably null
Transcript: ENSMUST00000049178
AA Change: K375*

SMART Domains

Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: K375*

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:p450	30	487	5e-160	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	T	A	5: 109,738,992	H50L	probably benign	Het
A2m	C	A	6: 121,654,612	L623M	probably benign	Het
Agpat5	A	G	8: 18,881,811	R316G	probably benign	Het
Ankrd39	G	A	1: 36,539,492	Q151*	probably null	Het
Arl13b	T	C	16: 62,830,784	D30G	probably damaging	Het
Atpaf1	A	G	4: 115,788,302	S123G	probably benign	Het
Bicra	A	G	7: 15,972,689	S1276P	probably benign	Het
Car1	T	C	3: 14,777,786	I60V	possibly damaging	Het
Cnbd2	A	G	2: 156,373,724	I411V	probably damaging	Het
Cysrt1	T	C	2: 25,239,285	I72V	probably benign	Het
Dock9	T	A	14: 121,651,775	D312V	possibly damaging	Het
Ecd	T	C	14: 20,346,692	I42V	probably damaging	Het
Ercc5	A	G	1: 44,167,534	T536A	probably benign	Het
Gjd2	A	T	2: 114,011,308	Y229*	probably null	Het
Gramd1b	A	T	9: 40,304,538		probably null	Het
Hcrtr2	T	C	9: 76,232,999	T336A	probably benign	Het
Hjurp	G	A	1: 88,266,121	S279F	probably benign	Het
Ift140	C	T	17: 25,025,634	L152F	probably benign	Het
Izumo1r	A	G	9: 14,901,809	C56R	probably damaging	Het
Kif7	T	C	7: 79,702,837	E850G	probably damaging	Het
Larp4b	C	G	13: 9,151,097	T335S	probably benign	Het
Lmo7	A	T	14: 101,880,832	R42S	probably damaging	Het
Lrrk2	T	G	15: 91,734,058	L920R	probably benign	Het
Mapk8	G	A	14: 33,410,962	R6C	probably benign	Het
Mpped1	C	T	15: 83,791,990		probably benign	Het
Myoc	A	G	1: 162,639,367	Y35C	probably damaging	Het
Ndufb8	C	T	19: 44,555,035	M66I	probably benign	Het
Nkpd1	T	C	7: 19,523,979	I411T	probably benign	Het
Nrxn3	A	G	12: 89,354,468	N382S	possibly damaging	Het
Olfr1219	A	T	2: 89,075,052	L13Q	probably damaging	Het
Olfr328	A	T	11: 58,551,420	V273E	possibly damaging	Het
Pear1	T	C	3: 87,756,753	E303G	probably damaging	Het
Plekhg4	T	A	8: 105,381,781	M1047K	probably benign	Het
Pofut1	T	G	2: 153,265,789	F268C	probably damaging	Het
Psrc1	G	T	3: 108,385,293	S134I	probably damaging	Het
Slc6a2	A	T	8: 92,981,990	I245F	probably benign	Het
Slc9a1	T	C	4: 133,422,223	S787P	probably benign	Het
Sorcs3	T	A	19: 48,748,359		probably null	Het
Syne2	C	A	12: 75,996,002	H3916N	probably damaging	Het
Taar6	A	G	10: 23,985,181	S156P	probably benign	Het
Tnn	A	G	1: 160,147,600	F86L	probably damaging	Het
Tspear	T	A	10: 77,870,419	L341H	possibly damaging	Het
Ttll8	A	G	15: 88,914,444	V696A	probably benign	Het
Utrn	C	A	10: 12,436,364	D616Y	probably damaging	Het
Vmn2r18	A	T	5: 151,584,757	C301S	probably damaging	Het
Xdh	T	C	17: 73,900,578	Y928C	probably benign	Het
Zfand1	G	A	3: 10,345,982	A104V	probably benign	Het

Other mutations in Cyp2c37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Cyp2c37	APN	19	40001997	missense	probably benign	0.00
IGL01307:Cyp2c37	APN	19	39992579	missense	probably benign	0.00
IGL01959:Cyp2c37	APN	19	39995833	nonsense	probably null
IGL02580:Cyp2c37	APN	19	39994498	missense	probably damaging	1.00
IGL02611:Cyp2c37	APN	19	39993865	missense	probably benign	0.00
R0124:Cyp2c37	UTSW	19	39994102	missense	probably damaging	1.00
R0391:Cyp2c37	UTSW	19	39994506	missense	probably damaging	1.00
R0420:Cyp2c37	UTSW	19	39995794	missense	probably benign	0.00
R0782:Cyp2c37	UTSW	19	39993825	missense	probably benign	0.00
R1413:Cyp2c37	UTSW	19	39994098	missense	probably benign	0.21
R1688:Cyp2c37	UTSW	19	39994443	splice site	probably null
R2258:Cyp2c37	UTSW	19	39995859	missense	possibly damaging	0.49
R4353:Cyp2c37	UTSW	19	40000545	missense	possibly damaging	0.66
R4640:Cyp2c37	UTSW	19	40011832	missense	possibly damaging	0.67
R4965:Cyp2c37	UTSW	19	40011762	missense	possibly damaging	0.79
R5053:Cyp2c37	UTSW	19	40001887	missense	probably benign	0.00
R5645:Cyp2c37	UTSW	19	39994152	missense	probably benign	0.04
R5847:Cyp2c37	UTSW	19	40011732	missense	probably damaging	0.98
R6487:Cyp2c37	UTSW	19	39994581	missense	probably benign
R6631:Cyp2c37	UTSW	19	40009843	missense	probably damaging	1.00
R7062:Cyp2c37	UTSW	19	39995546	splice site	probably null
R7937:Cyp2c37	UTSW	19	39993758	missense	probably damaging	1.00
R9640:Cyp2c37	UTSW	19	40011736	missense	probably benign	0.01
R9779:Cyp2c37	UTSW	19	40009879	missense	probably benign	0.09
R9784:Cyp2c37	UTSW	19	40000499	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AGGCACCTTCATTAGGCCCTAGATAG -3'
(R):5'- ATGACCCTGCTTCCTGTAGAGCTG -3'

Sequencing Primer
(F):5'- AAAAAACATGTCACTTCTCTCCTTTC -3'
(R):5'- TGCTATCCCATCCATGAATCAG -3'

Posted On

2014-04-24