|Institutional Source||Beutler Lab|
|Gene Name||hyperpolarization-activated, cyclic nucleotide-gated K+ 1|
|Synonyms||HAC2, Bcng1, C630013B14Rik|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1667 (G1)|
|Chromosomal Location||117602320-117987418 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 117603073 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 124 (I124F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000006991 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000006991]|
AA Change: I124F
AA Change: I124F
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.8385|
|Coding Region Coverage||
|Validation Efficiency||99% (76/77)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for disruptions in this allele display learning deficiencies but are otherwise normal. Mice homozygous for another targeted knock-out exhibit deficit in hyperpolarization-activated currents and cold allodynia following partial nerve ligation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hcn1||
(F):5'- TGGCAACTCCGTGTGCTTCAAG -3'
(R):5'- TGCTGTCCCCAAAGTTCACCAG -3'
(F):5'- TGCTTCAAGGTGGACGGC -3'
(R):5'- ACCCTAAACCTGTCGTCGG -3'